LOCUS       NM_001008425            1556 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus THO complex 6 (Thoc6), transcript variant 1, mRNA.
ACCESSION   NM_001008425 XM_484610
VERSION     NM_001008425.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1556)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1556)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1556)
  AUTHORS   Bhattacharjee,R., Jolly,L.A., Corbett,M.A., Wee,I.C., Rao,S.R.,
            Gardner,A.E., Ritchie,T., van Hugte,E.J.H., Ciptasari,U., Piltz,S.,
            Noll,J.E., Nazri,N., van Eyk,C.L., White,M., Fornarino,D.,
            Poulton,C., Baynam,G., Collins-Praino,L.E., Snel,M.F., Nadif
            Kasri,N., Hemsley,K.M., Thomas,P.Q., Kumar,R. and Gecz,J.
  TITLE     Compromised transcription-mRNA export factor THOC2 causes R-loop
            accumulation, DNA damage and adverse neurodevelopment
  JOURNAL   Nat Commun 15 (1), 1210 (2024)
   PUBMED   38331934
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1556)
  AUTHORS   Wang,L., Miao,Y.L., Zheng,X., Lackford,B., Zhou,B., Han,L., Yao,C.,
            Ward,J.M., Burkholder,A., Lipchina,I., Fargo,D.C., Hochedlinger,K.,
            Shi,Y., Williams,C.J. and Hu,G.
  TITLE     The THO complex regulates pluripotency gene mRNA export and
            controls embryonic stem cell self-renewal and somatic cell
            reprogramming
  JOURNAL   Cell Stem Cell 13 (6), 676-690 (2013)
   PUBMED   24315442
REFERENCE   5  (bases 1 to 1556)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   6  (bases 1 to 1556)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154766.2, CX224561.1, BC085131.1 and AI850888.1.
            
            On Oct 26, 2017 this sequence version replaced NM_001008425.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.5200631.1, BC085131.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC154766.2         19243-19259
            18-107              CX224561.1         1-90
            108-1538            BC085131.1         1-1431
            1539-1556           AI850888.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.97 cM"
     gene            1..1556
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /note="THO complex 6"
                     /db_xref="GeneID:386612"
                     /db_xref="MGI:MGI:2677480"
     exon            1..364
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1351
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /note="WD repeat domain 58; WD repeat-containing protein
                     58"
                     /codon_start=1
                     /product="THO complex subunit 6 homolog"
                     /protein_id="NP_001008425.1"
                     /db_xref="CCDS:CCDS28454.1"
                     /db_xref="GeneID:386612"
                     /db_xref="MGI:MGI:2677480"
                     /translation="MEHAAPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNN
                     YGQIAIFSLSAALSSEAKEESKKPVVVFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLW
                     AEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAF
                     TRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPH
                     NGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQ
                     GCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGY
                     RAFSLSF"
     exon            365..480
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            481..545
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            546..649
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            650..687
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            688..736
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            737..808
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            809..911
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            912..961
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1024
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1135
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1270
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1539
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /note="hexamer: AATAAA"
     polyA_site      1539
                     /gene="Thoc6"
                     /gene_synonym="F830014G06Rik; Wdr58"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgttt tacgcaggcg cggaagacag gaatcaggtt agaggttaga aggcgggaca
       61 ggtcggcgcg gtgggggagg ggatccggcg tggctggata gttctgggcg ctttttagca
      121 taagggtgct tcgtgtagtt ctcctaggtt tctgtggttc gagacagcac ggacctgccg
      181 ccttagttgc tgggcgacag gcagtgctag gtcttggggc gtaacgagaa gagccaccat
      241 caggcacgtc cggaatcgag aggttgtgtc gtgcgtcgag agattgtgtc acacgtagag
      301 ccctctggga cttgtagttc tcaagatgga gcatgccgca ccgctcgcgg tgcctctggg
      361 tcaggctgag gtatttcagg ccctgcagcg actgcacatg accatctttt cccagagtgt
      421 ctccccctgc gggaagtttc tggcagctgg caacaattac gggcagattg ccatcttcag
      481 tttgtctgct gccttaagtt cagaggccaa agaagaaagc aaaaaaccgg tggtggtctt
      541 ccacgcccat gacgggcctg tctacagcat ggtctccaca gatcgacacc tactcagtgc
      601 tggcgatgga gaggtcaagg gttggctttg ggcagaaatt ctcaagaagg gctgtaagga
      661 actgtggcgt cgccagcctc catacaggac cagtctggaa gtacccgaaa tcaatgcctt
      721 gctgcttgtc cccaaggaga attcgctcat cctggctggg ggagattgtc agctgcacag
      781 tatggatctg gaaactgggg ccttcacacg ggccctccgg ggccacacag actacatcca
      841 ttgcctggca ctgagggagc gcagccctga ggtattgtct ggcggtgagg atggagctgt
      901 acggctttgg gatctccgta tagccaaaga ggtccagacc atcgaagtct acaagcatga
      961 ggagtgctcg aggccccata atgggcgctg gattggctgc ttggccactg actcagactg
     1021 gatggtctgt ggagggggcc cagccctcac cctctggcac ctcaggtctt ccacacccac
     1081 taccgtcttt cctattcgag caccacagaa gcacgtcacc ttctaccagg atctgatcct
     1141 gtctgctggc cagggctgtt gtgtcaatca ctggcaactg agcggggagc ttaaggccca
     1201 ggtgcctggc tcctccccag ggctgctcag cctgagcctc aaccagcagc cagcagcccc
     1261 agagtgcaag gtcctgactg catcgggcaa cagctgtcga gtagatgtct ttaccaacct
     1321 gggctaccga gccttctctt tgtccttttg acatcatgac cctgtatttc aggagctaga
     1381 gtgatgcttg tgttttggga taggggtttt aaactttagc tcaggctggc ctggaactca
     1441 tttggcttag cttgatctca aactcctgta tgagatttag cttggtgaac cgttacattc
     1501 agcttttgtt gtcctgtcaa aataaaattt taggctttta aaaaaaaaaa aaaaaa
//
