LOCUS       NM_001418151            2277 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus THO complex 5 (Thoc5), transcript variant 2, mRNA.
ACCESSION   NM_001418151 XM_006514448
VERSION     NM_001418151.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Bhattacharjee,R., Jolly,L.A., Corbett,M.A., Wee,I.C., Rao,S.R.,
            Gardner,A.E., Ritchie,T., van Hugte,E.J.H., Ciptasari,U., Piltz,S.,
            Noll,J.E., Nazri,N., van Eyk,C.L., White,M., Fornarino,D.,
            Poulton,C., Baynam,G., Collins-Praino,L.E., Snel,M.F., Nadif
            Kasri,N., Hemsley,K.M., Thomas,P.Q., Kumar,R. and Gecz,J.
  TITLE     Compromised transcription-mRNA export factor THOC2 causes R-loop
            accumulation, DNA damage and adverse neurodevelopment
  JOURNAL   Nat Commun 15 (1), 1210 (2024)
   PUBMED   38331934
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Maeder,C.I., Kim,J.I., Liang,X., Kaganovsky,K., Shen,A., Li,Q.,
            Li,Z., Wang,S., Xu,X.Z.S., Li,J.B., Xiang,Y.K., Ding,J.B. and
            Shen,K.
  TITLE     The THO Complex Coordinates Transcripts for Synapse Development and
            Dopamine Neuron Survival
  JOURNAL   Cell 174 (6), 1436-1449 (2018)
   PUBMED   30146163
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Klein,A.D., Ferreira,N.S., Ben-Dor,S., Duan,J., Hardy,J., Cox,T.M.,
            Merrill,A.H. Jr. and Futerman,A.H.
  TITLE     Identification of Modifier Genes in a Mouse Model of Gaucher
            Disease
  JOURNAL   Cell Rep 16 (10), 2546-2553 (2016)
   PUBMED   27568557
REFERENCE   4  (bases 1 to 2277)
  AUTHORS   Sakuma,T., Tonne,J.M. and Ikeda,Y.
  TITLE     Murine leukemia virus uses TREX components for efficient nuclear
            export of unspliced viral transcripts
  JOURNAL   Viruses 6 (3), 1135-1148 (2014)
   PUBMED   24618812
  REMARK    GeneRIF: These results imply that murine leukemia virus requires
            UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of
            viral transcripts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2277)
  AUTHORS   Wang,L., Miao,Y.L., Zheng,X., Lackford,B., Zhou,B., Han,L., Yao,C.,
            Ward,J.M., Burkholder,A., Lipchina,I., Fargo,D.C., Hochedlinger,K.,
            Shi,Y., Williams,C.J. and Hu,G.
  TITLE     The THO complex regulates pluripotency gene mRNA export and
            controls embryonic stem cell self-renewal and somatic cell
            reprogramming
  JOURNAL   Cell Stem Cell 13 (6), 676-690 (2013)
   PUBMED   24315442
REFERENCE   6  (bases 1 to 2277)
  AUTHORS   Mancini,A., Niemann-Seyde,S.C., Pankow,R., El Bounkari,O.,
            Klebba-Farber,S., Koch,A., Jaworska,E., Spooncer,E., Gruber,A.D.,
            Whetton,A.D. and Tamura,T.
  TITLE     THOC5/FMIP, an mRNA export TREX complex protein, is essential for
            hematopoietic primitive cell survival in vivo
  JOURNAL   BMC Biol 8, 1 (2010)
   PUBMED   20051105
  REMARK    GeneRIF: THOC5/Fms interacting protein is an essential element in
            the maintenance of hematopoiesis, and depletion of THOC5/Fms
            interacting protein causes the down-regulation of THOC1, which may
            contribute to altered THO complex function and cell death
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2277)
  AUTHORS   Mancini,A., El Bounkari,O., Norrenbrock,A.F., Scherr,M.,
            Schaefer,D., Eder,M., Banham,A.H., Pulford,K., Lyne,L.,
            Whetton,A.D. and Tamura,T.
  TITLE     FMIP controls the adipocyte lineage commitment of C2C12 cells by
            downmodulation of C/EBP alpha
  JOURNAL   Oncogene 26 (7), 1020-1027 (2007)
   PUBMED   16909111
  REMARK    GeneRIF: FMIP influences the differentiation of C/EBP alpha gene
            during adipocyte differentiation of multipotent C2C12 cells.
REFERENCE   8  (bases 1 to 2277)
  AUTHORS   Mancini,A., Koch,A., Whetton,A.D. and Tamura,T.
  TITLE     The M-CSF receptor substrate and interacting protein FMIP is
            governed in its subcellular localization by protein kinase
            C-mediated phosphorylation, and thereby potentiates M-CSF-mediated
            differentiation
  JOURNAL   Oncogene 23 (39), 6581-6589 (2004)
   PUBMED   15221008
  REMARK    GeneRIF: Wild-type FMIP and FMIPSS5,6AA inhibited M-CSF-mediated
            survival signaling, while FMIPSS5,6EE-expressing cells survived and
            differentiated into macrophages more efficiently than wild-type
            cells in the presence of M-CSF or TPA
REFERENCE   9  (bases 1 to 2277)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 2277)
  AUTHORS   Tamura,T., Mancini,A., Joos,H., Koch,A., Hakim,C., Dumanski,J.,
            Weidner,K.M. and Niemann,H.
  TITLE     FMIP, a novel Fms-interacting protein, affects
            granulocyte/macrophage differentiation
  JOURNAL   Oncogene 18 (47), 6488-6495 (1999)
   PUBMED   10597251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645522.12.
            
            On Mar 15, 2023 this sequence version replaced XM_006514448.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.743998.1,
                                           SRR17784647.147352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AL645522.12        9603-9642
            41-156              AL645522.12        14055-14170
            157-300             AL645522.12        15416-15559
            301-414             AL645522.12        16350-16463
            415-512             AL645522.12        16599-16696
            513-659             AL645522.12        18359-18505
            660-774             AL645522.12        19905-20019
            775-907             AL645522.12        24891-25023
            908-943             AL645522.12        25699-25734
            944-1021            AL645522.12        27045-27122
            1022-1062           AL645522.12        28534-28574
            1063-1162           AL645522.12        28786-28885
            1163-1271           AL645522.12        29753-29861
            1272-1373           AL645522.12        32388-32489
            1374-1470           AL645522.12        33997-34093
            1471-1585           AL645522.12        34641-34755
            1586-1689           AL645522.12        36186-36289
            1690-1777           AL645522.12        36403-36490
            1778-1893           AL645522.12        39012-39127
            1894-2084           AL645522.12        40310-40500
            2085-2277           AL645522.12        42939-43131
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.09 cM"
     gene            1..2277
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /note="THO complex 5"
                     /db_xref="GeneID:107829"
                     /db_xref="MGI:MGI:1351333"
     exon            1..40
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            41..156
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2148
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     serum/glucocorticoid regulated kinase 2; THO complex
                     subunit 5 homolog; fms-interacting protein; Fms
                     interacting protein"
                     /codon_start=1
                     /product="THO complex subunit 5 homolog isoform 2"
                     /protein_id="NP_001405080.1"
                     /db_xref="GeneID:107829"
                     /db_xref="MGI:MGI:1351333"
                     /translation="MSSESSKKRKPKVIRSDGTPTEGKRNRSDTEQEGKYYSEEAEVD
                     LRDPGRDYELYKYTCQELQRLMAEIQDLKSKGSKDLAIEIEERRIQSCVHFMTLKKLN
                     RLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLV
                     SLEEFYSEAPPSISKAEITMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKE
                     IEVKRDYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQAT
                     AYGQACAHMKSSSQPPRQDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTT
                     KRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFYYLMNLNIMTVKAKVT
                     TAVELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLELG
                     HPYLWVQKLGGLHFPKEQPQQTVMPDHSQSASHMETTMKLLKTRVQSRLALHKQFASL
                     EHGIVPVTSDCQDLFPAKVVSRLVKWVIITHEDYMELHFTKDIVEAGLAGDTNLYYLA
                     LIERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYKEL
                     CGPRPSHQLLTNQLQRLCVLLDVYLETESHDDSFEGPKEFPQEKMCLRLFRGPSRMKP
                     FKYNHPQGFFSHR"
     exon            157..300
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..414
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..512
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..659
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..774
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..907
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..943
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1021
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1062
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1162
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1271
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1373
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1470
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1585
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1689
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1777
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1893
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2084
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2277
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /note="hexamer: ATTAAA"
     polyA_site      2277
                     /gene="Thoc5"
                     /gene_synonym="1700060C24Rik; A430085L24Rik; Fmip; PK1.3;
                     Sgk2"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtggct acccggctgg aaggcgtgag gagcattctg ccttttcacc tggaagcaca
       61 atgtcatcag aatccagcaa aaaacggaaa cccaaagtga tccggagtga tggaacccca
      121 actgaaggga aacggaaccg gtctgacacg gagcaggaag gcaaatacta cagtgaggag
      181 gctgaagttg acctgcggga ccctggcaga gactatgagt tgtacaaata cacttgccag
      241 gagctacaaa ggctgatggc cgagatccag gacctgaaga gtaagggcag caaggacctg
      301 gccattgaaa ttgaagaacg aaggatccag agctgtgtgc acttcatgac tctaaagaag
      361 cttaaccgat tagcccacat cagattaaag aaaggaagag accagaccca cgaggccaag
      421 cagaaagtcg atgcctacca cctacagcta cagaacctgc tctacgaagt gatgcacctg
      481 cagaaggaga tcaccaaatg tctggagttc aagtcaaagc atgaagaaat tgatctggtc
      541 agcttagagg aattttattc agaggctcca ccaagcatca gcaaggccga gatcaccatg
      601 ggagaccctc accaacaaac attggcacgt ttggactggg agctggagca gcggaaaagg
      661 ctggcagaaa agtaccgaga atgtctgtct aacaaggaga agatcctgaa ggagattgag
      721 gtgaagaggg actatctgag cagcctccag cctcgcctca acagcatcat gcaggcttcc
      781 ctgccagtgc aagaatacct gttcatgcca tttgaccagg cgcacaaaca gtatgagact
      841 gccaggcacc tgccgcctcc cctctatgtg ctctttgtgc aggccactgc atacgggcag
      901 gcctgtgctc atatgaaatc ctcctcccag ccccctagac aggataagac gctgtccgtg
      961 gcaattgaag gcagtgtgga cgaagccaaa gctcttttca agccccctga ggactcccaa
     1021 gatgatgaga gcgactcaga tgctgaagag gagcagacga cgaagcggcg gcggcccact
     1081 ctcggggttc agttggatga caagcgcaag gagatgctaa aaaggcaccc actgtctgtc
     1141 ctgctggatc tgaagtgcaa agacaacagt gtgcttcatc tgactttcta ctatctcatg
     1201 aacctcaaca tcatgacagt gaaagccaaa gtgacgaccg ccgtggagct gatcaccccc
     1261 atcagtgcag gagacttact gtctcctgac tcggtcttga gctgcttgta tccgggagat
     1321 catgggaaaa aaactccaaa tccagccaat cagtatcagt ttgacaaagt tggcatcctg
     1381 actttgagag actatgtact tgagttaggt cacccctact tgtgggtaca gaagctgggt
     1441 ggcctccact tccccaaaga gcagccccag caaacagtga tgcctgacca ctcacagagc
     1501 gccagccaca tggagaccac catgaaactg ctgaagacca gggtacagtc ccgcctggct
     1561 ctccacaaac agtttgcatc tctggaacat ggcattgtgc ccgtcaccag cgattgccag
     1621 gacctcttcc ctgccaaggt tgtttctcgc ctggtaaagt gggtgataat tacccatgaa
     1681 gattacatgg agctgcactt cactaaggac attgtggagg caggactggc cggagacacc
     1741 aatctctact acctggcgct aattgaaagg ggaacagcta aacttcaggc tgctgtggta
     1801 ctaaaccctg gctactcctc catcccaccg gttttccgac tctgtctaaa ctggaaaggg
     1861 gagaaaacca acagcaacga tgacaatatt cgggctatgg agagtgaagt caacgtgtgc
     1921 tataaggagt tgtgtggccc tcggcccagt caccagctcc tgaccaacca gctgcagaga
     1981 ctgtgtgtgc tgctggacgt ctacctggag accgagagcc acgatgacag cttcgagggc
     2041 cccaaggagt ttccccagga gaagatgtgc ctgcggcttt ttaggggtcc gagtaggatg
     2101 aagccgttta aatacaacca tccccaaggg ttcttcagcc accgctgact cccctcgact
     2161 tgtcattccc caaagccctg tcctggctcc tgggtatctg ctttttgctt tggccacatg
     2221 tggttcttga tattttccaa agacaccagc taattaaaat gtcatctgac aaatgga
//
