LOCUS       NM_177588               3899 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus threonine synthase-like 1 (bacterial) (Thnsl1),
            transcript variant 1, mRNA.
ACCESSION   NM_177588
VERSION     NM_177588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029518.1 and AK083895.1.
            
            On Jul 2, 2005 this sequence version replaced NM_177588.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083895.1, SRR1660821.105241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2617              AK029518.1         2-2618
            2618-3899           AK083895.1         2618-3899
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 14.83 cM"
     gene            1..3899
                     /gene="Thnsl1"
                     /note="threonine synthase-like 1 (bacterial)"
                     /db_xref="GeneID:208967"
                     /db_xref="MGI:MGI:2139347"
     exon            1..122
                     /gene="Thnsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..279
                     /gene="Thnsl1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..3899
                     /gene="Thnsl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2570
                     /gene="Thnsl1"
                     /note="isoform a is encoded by transcript variant 1; TSH1"
                     /codon_start=1
                     /product="threonine synthase-like 1 isoform a"
                     /protein_id="NP_808256.1"
                     /db_xref="CCDS:CCDS15720.1"
                     /db_xref="GeneID:208967"
                     /db_xref="MGI:MGI:2139347"
                     /translation="MLTLTRCHHLKQIAQECLSSLLVKVQSRTQLLLPRASARAESGK
                     SWHSTHSLVGDKNIVLMGPPGSGKTTVGRILGDKLGCCVIDVDSDVLEKAWNMSASEK
                     LQDVGNERFLEEEGKTVLNLSASGSVISLSGSNPMHDASMWHLKKNGIVVYLDVPLTD
                     IISRLKSMRIDRIVGQNTGASLRDSLKHVRLYYKKWYDARVFCESGASAEEVADKVLD
                     VVKRYQDVDSETFISTRHVCLKDHDKKFPPKYFSEAVVEGLASDGGLFVPEKEFPKLS
                     PGEWNNLIGATYIERAQVLLERCIHPADIPAAKLGEMIETAYGENFACSKVAPVRHLS
                     GNQFILELFYGPTGSFKDLSLQLMPHIFAYCIPPGCNYVILVATSGDTGSAVLNGFSH
                     LNKNDKERIAVVTFFPENGVSDFQKAEIIGSQRENGWAIGVRSDFDFCQTAIRKIFND
                     SDFTGFLAVEYGTILSSANSINWARLLPQIVYHASAYLELVNQRFISFGSPVDVCVPT
                     GNFGNVLAAVYAKMMGIPIRKFICASNQNHVLTDFIKTGHYDLRNRKLAQTFSPSIDI
                     LKSSNLERHLYLMANKDGQLMANLYHQLESQLHFRIEKMLVEKLQQEFVADWCSEGEC
                     LAAISTTYNASGYILDPHTAVAKVVADKMQDKSCPVLIASTAHYSKFAPAIMQALGIK
                     ELNQTSSSQLYLLSSYNALPPPHEALLERMKQKEKMDYQVCVADVDVLKSHAEKLIQN
                     WFVRKSE"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thnsl1"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="Thnsl1"
                     /note="major polyA site"
     regulatory      3178..3183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thnsl1"
                     /note="hexamer: ATTAAA"
     polyA_site      3201
                     /gene="Thnsl1"
     regulatory      3557..3562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thnsl1"
                     /note="hexamer: ATTAAA"
     polyA_site      3577
                     /gene="Thnsl1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcgca ggcgcagaag cagcagcttg gggcgggctt gccggctgag gttgccaggc
       61 ggtgccgaag gcgcttccct ttctcccttt ctctctttcc tcttctttgg gtggttttct
      121 tgaccctgct ttttgcaaag atcgactttg cctcagactc agtacactct tcgtctgtgg
      181 ttcctgtaat ggtgtgcttc cacttcagtg agttaagcac agcaccacac aaagccaaat
      241 aaggaaatga agttttcctc ttgacaggcc agcttgcttg gctgaagcca acccctaggt
      301 tggcctggtc agaaaactga aaagaaatgc tgaccttgac cagatgtcac catttgaaac
      361 agatagcaca ggagtgtctt tctagcctgc tggttaaagt gcagagccgc acacagctcc
      421 tgcttccacg agcctctgca cgtgcagaat cagggaagtc atggcactcc acccactctc
      481 ttgttggaga caaaaatatt gtcctgatgg ggccgcctgg ttctgggaaa acaacagttg
      541 gcagaatatt aggtgacaaa ctaggctgtt gtgtcatcga tgtagatagt gatgtccttg
      601 agaaagcctg gaatatgagc gcatctgaaa aattgcagga tgttggtaat gagcgatttt
      661 tagaagagga aggaaaaaca gtgttaaact tgtctgcatc tggaagtgtg atttccctca
      721 gtgggtccaa tcccatgcat gatgctagca tgtggcatct gaagaaaaat ggaattgttg
      781 tatacctaga tgtgcctcta acagatataa ttagtcgtct gaaatcaatg agaattgata
      841 ggattgttgg ccagaacact ggagcatctc tgagagactc gctgaagcac gtaagactgt
      901 actataagaa gtggtacgat gcccgagtct tctgtgagag tggggcttca gctgaggagg
      961 ttgcagacaa agtgcttgat gtggttaaaa gataccaaga cgtggattca gagacattca
     1021 tttcaacaag gcatgtttgt cttaaagatc atgacaagaa gtttccacca aaatacttca
     1081 gtgaagctgt agttgaggga ttggcttctg atggtggcct ctttgttcct gagaaggagt
     1141 ttccaaaact aagtcctggg gagtggaata acctaatagg agcaacctac atagaaagag
     1201 cacaggtgct cttggaaagg tgcattcacc ctgcggacat acctgctgcc aaattaggag
     1261 aaatgattga aactgcttat ggggaaaact ttgcctgctc caaagttgcc cctgtcaggc
     1321 acctttctgg caatcagttc atcttggagt tgttctatgg cccaacgggg tcctttaagg
     1381 atttgtcttt acagcttatg cctcatattt ttgcctactg tatcccacca ggttgcaatt
     1441 atgtgatact tgtagccact tcaggagaca ctgggagtgc agtcttaaat gggtttagcc
     1501 atcttaataa aaatgataag gaaagaatag ctgtggtcac attttttcca gagaacggag
     1561 ttagtgattt ccagaaagca gagataattg gcagtcagag agaaaatggt tgggcaatag
     1621 gtgtcaggtc agattttgat ttttgccaga cagctattag aaaaatattt aatgattctg
     1681 attttactgg ctttctggct gtggaatatg gaacaatctt aagttcagct aattctataa
     1741 attgggctcg actacttccg cagatagttt atcatgcctc tgcatacctt gagcttgtta
     1801 accaacggtt tatttctttt ggaagcccag tagatgtctg tgttcccaca ggaaactttg
     1861 ggaacgtgtt ggcggcagtg tatgccaaga tgatgggaat ccctattcga aaatttatct
     1921 gtgcctctaa tcagaaccac gttttgactg acttcataaa aactggacat tatgatctaa
     1981 ggaataggaa attagcacaa accttttcac catcaataga tattctcaag tcttccaacc
     2041 tggagcgaca tttatacttg atggctaaca aagacggaca gttaatggca aatttatacc
     2101 atcagttaga gagtcagctt cacttccgga ttgagaagat gctggtcgag aagctgcagc
     2161 aagagtttgt tgccgactgg tgctctgagg gagaatgcct cgcagctatc agcactacct
     2221 acaatgcatc aggctatatt ttggatccac ataccgctgt tgcaaaagtg gttgcagaca
     2281 agatgcaaga caaaagctgc ccagtgctca ttgcatccac agctcactac tccaagtttg
     2341 cccctgctat catgcaggca ctggggatta aagaactcaa ccagacgtcg tccagccagc
     2401 tttacttact gagctcgtac aatgcattgc cccctcctca cgaggctctg ctagagagaa
     2461 tgaagcagaa ggagaagatg gattaccagg tttgtgtagc tgatgtggat gtcctgaaga
     2521 gtcatgcaga aaaactcatc caaaattggt ttgtaaggaa gtctgagtag gggtttttct
     2581 tggaaaggag caataataaa tctcaaacat tgatttggac tacaatagca tttgctttat
     2641 tttatgtaaa tgtttatgtg tgcatctgat ctctggacta agagacggag gccagcatag
     2701 tacctggaac cctctgctat catgctttat tttctgcact tgttggtatg gcagtttctc
     2761 ctttacccaa cacttctgag tggaacaaaa tatctggtat ttagcatagc atttacaaat
     2821 atttaaatgc agttaggtgc tgcatatcta gtcatttagt gtttattgaa caatttgtgc
     2881 ttgagatagt tagctaacat agaggaagta gtaagctcac taggattaga atcatcgttt
     2941 ttaacccctt tcaaattcca ttttggacaa tacttgatga catgtacact gtccagctag
     3001 agatttcgtg gcccattcac tgctctttga atgtctgtag ttagtgctgg tgaagtttga
     3061 aaatcaggcc gatgtaggat gtagcagttg acagaactgt gaagtagtga acacggaaac
     3121 aaagtcacct acttcaagag aaaggtgatc caagattagt aatgtttaag atgctttatt
     3181 aaagttcagt tatagacagc agctcttctg tattattttt agtctggtcc tatttgtttc
     3241 acttaaaaaa acattttggg gtacctaaat ccacacaaaa tggtaactgt gtttcatttc
     3301 cattgctgtg tagtgacagt gatcttaatt gtggtttgta tatttcctga gtatttactt
     3361 tctggattga agggtgtgac tgaatgaaga catgcaatgg gctgctcccc accacaagat
     3421 ggcattcctc acagcatttg ctattgccca tgacagtctg cttctggtta cctttcagag
     3481 aaatgttcaa cattgaaatg atgaaaaagg ttaatagttt taatgggcaa taagcaattt
     3541 gttatacaag ttttaaatta aaccatttac atgttaatat cagctctctg gttttgcttc
     3601 taaaatgtag ttctagggct tataatggag gccagggatg tccctgtaca gtgcacaaaa
     3661 ccctgggttc catccttagc acctaggaag gtagacgcag taggaaaagg tcatgtttag
     3721 tcacacagtt tgaggccagc ctgggataca tgaggtcctg tttaaaacaa acaaacaaac
     3781 aaacaaacaa acaaacaata cttgaaacac tttttgttaa tagagactca aagctctgta
     3841 tttgtgtaca cattctatca tttcagaata tttgtttcag tagacttaga aaattatcc
//
