LOCUS       NM_001080969            3797 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tRNA-histidine guanylyltransferase 1-like (S.
            cerevisiae) (Thg1l), transcript variant 1, mRNA.
ACCESSION   NM_001080969 XM_126359
VERSION     NM_001080969.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3797)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645948.10 and AK010876.1.
            
            On Mar 19, 2014 this sequence version replaced NM_001080969.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092541.1, AK017532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL645948.10        179733-179741       c
            10-948              AK010876.1         2-940
            949-3797            AL645948.10        169543-172391       c
FEATURES             Location/Qualifiers
     source          1..3797
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.47 cM"
     gene            1..3797
                     /gene="Thg1l"
                     /note="tRNA-histidine guanylyltransferase 1-like (S.
                     cerevisiae)"
                     /db_xref="GeneID:66628"
                     /db_xref="MGI:MGI:1913878"
     exon            1..229
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..935
                     /gene="Thg1l"
                     /EC_number="2.7.7.79"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable tRNA(His) guanylyltransferase; interphase
                     cyctoplasmic foci protein 45"
                     /codon_start=1
                     /product="probable tRNA(His) guanylyltransferase isoform
                     1"
                     /protein_id="NP_001074438.1"
                     /db_xref="CCDS:CCDS36132.1"
                     /db_xref="GeneID:66628"
                     /db_xref="MGI:MGI:1913878"
                     /translation="MWAFRTARIGSLLAATSVILRRCLRLGVAMAKSKFEYVRNFEVQ
                     DTCLPHCWVVVRLDGRNFHRFAEEHNFAKPNDSRALHLMTKCAQTVMEELEDIVIAYG
                     QSDEYSFVFRKKSNWFKRRASKFMTLVASQFASSYVFYWRDYFEDQPLRYPPGFDGRV
                     VLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQQRLKGTLTADKNE
                     ILFSEFHINYNNEPHMYRKGTVLVWQKVEEVRTQEVRLPAEMEGEKKAVARTRTRVVA
                     LNCDLIGDAFWKEHPEILAEEN"
     exon            230..406
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            407..576
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            577..665
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            666..773
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     exon            774..3797
                     /gene="Thg1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1221..1226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thg1l"
                     /note="hexamer: AAGAAA"
     polyA_site      1240
                     /gene="Thg1l"
                     /note="major polyA site"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thg1l"
                     /note="hexamer: AATAAA"
     polyA_site      2259
                     /gene="Thg1l"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thg1l"
                     /note="hexamer: AATAAA"
     polyA_site      3797
                     /gene="Thg1l"
ORIGIN      
        1 ttccggggtg gggcccgtcc attgcttcct tatggcgaat gtgggctttc cgcacagcga
       61 ggatcggcag tcttttggct gctacttccg ttattttaag acggtgcctg agattggggg
      121 tggccatggc caagagcaag tttgagtacg tgcggaattt tgaggttcag gacacatgcc
      181 tgccgcactg ctgggtggtg gtgcggctgg acggccggaa tttccaccgg tttgctgagg
      241 agcacaactt tgccaaacct aatgacagtc gggccctcca tctgatgacc aaatgtgccc
      301 agacagtaat ggaggagctg gaggacattg tgattgcgta cggccagagt gacgagtaca
      361 gctttgtgtt caggaagaag agcaattggt tcaaaagaag agccagtaag ttcatgactc
      421 tcgtggcctc ccagtttgcc tccagttacg tattttactg gcgggattac tttgaggacc
      481 agccccttcg gtatcctcca ggatttgatg ggagagtcgt gttgtatcct agcaaccaga
      541 ctttgaagga ctacctcagc tggcgacagg cagactgtca catcaataat ctttataata
      601 cagttttctg ggcccttatc cagcagtctg gactaacacc agtccaagcc cagcagagat
      661 taaagggaac tctgacggcc gacaagaatg agattctgtt ctctgagttc cacatcaact
      721 acaacaatga gccacacatg tacaggaaag ggacggtgtt ggtgtggcaa aaggtggaag
      781 aagtcagaac acaagaagtc aggctgccag cagaaatgga aggggaaaag aaggccgtgg
      841 ctcggaccag aacccgggtg gtggccttga actgtgatct tattggggat gccttctgga
      901 aggaacaccc agagattctg gcggaagaga actgacctca cgctctgcag ttctagcatg
      961 cttaatcaca caaggctccc cgagtctccc cctaacccta ggtggttcaa gcactcctgg
     1021 tcccaagaac actgtaagga aggacatgac tggagatggg tggagacaga tgaaggaggg
     1081 atatatgggg gtggtgtatc ttgttctgct taagcagaac accttttttt tttttttttt
     1141 ttttttttaa aaaaaaaaag aaaactgtgt tagaacatga cttctttggc tcttttcaaa
     1201 atcatggtcc tatttttata aagaaactat tcatactttg ctggaggagt catttttagc
     1261 tgtggtataa gccttacaaa aaactgtcac ctctttccac ctctgataaa gaggagccca
     1321 aactttaccc tcacccactt aactagcaaa tgcagcgact aaaaaacccc acttctcaca
     1381 cccaactgct tgcagttatc ttttggcatg cagttaaata tgggttgctg cctgcacaat
     1441 gcctccagat tgagaaatcc cagggaacac tcaagactct gtgccagttc ccagggtggc
     1501 agctttgcct gaactgaaca caggaggaat ggtttgggga tcctgcacca ttccaggatt
     1561 gatttttctg gaattgttac cataatcatt gacatctctt accgaacaac atagtttcca
     1621 gtcgcttaac tctctttaag aaaaggtatt ttaggaaggt atatgtgtgt acatccaaga
     1681 gggaagtgtg tgtgtgtgtg tgtgtgtgtg aatgcgaatg tgaatgagga tggagaagcc
     1741 aaatatttga agccaaactg catgacatgg caaggctctc aaaaaggagt cgagtcgggc
     1801 ttggggtcac tggtgattgc agaggttttt aaatagctcc tcccaccaat ggcaggatgg
     1861 gaactggcaa ggggcagaga gtggggatgg gaaggcattt gttcccaagg tgttgaactc
     1921 agtggggaaa tcatgatttc ccttgaccct gtttcatatc ttagagggaa aagtttattt
     1981 ggctccatta ggaattaatt aaaagacaac ccgtgtcctg ctgctgcctg gtcttgcatt
     2041 tacaggattt tcagccaaga agaaaatgta tttttgaaag agcagcgtct ggcctcatcc
     2101 ctcactaatt gacactccat ctgccgatgc cggtgttttt ccttcccatt ctcccctctc
     2161 cccaggaaga agcaatagag ctcatgtttg gtaactgcta aaatcttttt aagaggaaaa
     2221 aaaagtataa taaagacttc agctccttgg cctacttaat tggttcctac agaatgagtt
     2281 taacttgtgt gtttgtctta agctaggatg catgtcccca catagcagac atccagagac
     2341 ctctgggtac atttttttaa aatgttcatt tgaatgttga atttgaaagt gccaatgtaa
     2401 gatatccatg tggatgtttg ggactcttca gtgatttttt taaaagccca aatgtttctg
     2461 atacacagct atgaacatta tagcactttg ggcaagcaat tccctcagca tactagagag
     2521 gcagtaagat cattagctcc tgatgagcaa atttaactta atggtaggtt gatagcatgt
     2581 tatatcaaaa ttggccaagt agggaataaa gacccaagtt tcattgacaa ccgctggaga
     2641 aagtgtgtgc tttcagatcc agggaagtct ccctctgggc atgccctgag atagtcattg
     2701 aatggtgctg gaagttttca gtcattgaat ggtgctggaa gttttcatgc aggcagggga
     2761 tttttaaagc aataaaccgg ggttgaacac aagtgtcatc aagtaccatt acctacccaa
     2821 agcttgctct ttatttcgtc tgtgtgtttc cctcctacga tgcagctcac acggtggtgg
     2881 cagtgtgcta agtttcatct ctgtcttaaa gatagtcaag tgttcttttg ggccacattt
     2941 tcaaacttac agaaagtaaa gaagacccca aagcagctag cgcgggctga atgccggttg
     3001 atactttgag aaggtggtgg cacttcggag aatgacttgt gtggctggag atggcaagaa
     3061 gcaagacagc tatgctggat ggggagggac ttacctccag gagtctcact tttaaaacca
     3121 ttcctttggg gttgaagaga tggctattct tccgaaggaa gacccagaac ccacatggta
     3181 gctcacaacg agcacaactc aggggatcca gcattctctg gcctctgtgt gtatgtctga
     3241 ttgctcatag tgcacaggca tacatgccga caagcataca catgaaatat atcttaaaga
     3301 gtttttgctg aactagagct aaaaaatagt gttgattctt tggattttgc agtagtcagg
     3361 agaacatcaa ggagtcagtt ttcttttctt tgataccaag tgttctctaa acttagtggg
     3421 cagggaaagg aagtgaggat gtagtcaccc gtcttttata gcactcaacc atctagcatg
     3481 cacccactgt atactctgta cccttcctgt catatttcag acgacaataa gaactcaaaa
     3541 gaggctcagt aatttgagct tagacaggct agcctgatcc acatcaggaa tatacttaac
     3601 aggaatgaaa aatgggatat gtcttgtctt cctgtccttt gcctccagct caagccgaac
     3661 aacagagaac atcctgggac tttaaaatgc tgctcttggg gtctaccccc cgagtctgga
     3721 gcatcaacca ttctaagctg tctgtgaata tcagtgagtt ttactaaata aatggttaat
     3781 tgttactgcc tccaaaa
//
