LOCUS       NM_025416               1251 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus thioesterase superfamily member 5 (Them5), mRNA.
ACCESSION   NM_025416
VERSION     NM_025416.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Zhuravleva,E., Gut,H., Hynx,D., Marcellin,D., Bleck,C.K.,
            Genoud,C., Cron,P., Keusch,J.J., Dummler,B., Esposti,M.D. and
            Hemmings,B.A.
  TITLE     Acyl coenzyme A thioesterase Them5/Acot15 is involved in
            cardiolipin remodeling and fatty liver development
  JOURNAL   Mol Cell Biol 32 (14), 2685-2697 (2012)
   PUBMED   22586271
  REMARK    GeneRIF: Loss of Them5 specifically alters the remodeling process
            of the mitochondrial phospholipid cardiolipin. Them5(-/-) mice show
            deregulation of lipid metabolism and the development of fatty
            liver, exacerbated by a high-fat diet.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004155.1, AK009228.1 and AV021934.1.
            
            On Apr 9, 2011 this sequence version replaced NM_025416.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046437.1, AK004155.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1076              AK004155.1         2-1077
            1077-1224           AK009228.1         1076-1223
            1225-1251           AV021934.1         258-284
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.52 cM"
     gene            1..1251
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /note="thioesterase superfamily member 5"
                     /db_xref="GeneID:66198"
                     /db_xref="MGI:MGI:1913448"
     exon            1..283
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..907
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase THEM5; acyl-coenzyme A
                     thioesterase 15"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase THEM5"
                     /protein_id="NP_079692.1"
                     /db_xref="CCDS:CCDS17590.1"
                     /db_xref="GeneID:66198"
                     /db_xref="MGI:MGI:1913448"
                     /translation="MLRTSFQGVARLVRHKALYRSPCLLPRVHLASAFGSSTESLVAR
                     FCPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSGGWIKLPSFKSNRDHIQGLKLPF
                     GLETASDKQDWRLFTRSIQLEGQGYEYVIFFHPSEKKSVCLFQPGPYLEGAPGFAHGG
                     SLAALMDETYSKTAYLAGEGLFTLSLNIKFKNLIPVGSLAVLDIQVEKIEDQKLYMSC
                     IAQSRDKQTVYAKSSGVFLQLQLEEQSQEQ"
     exon            284..485
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..624
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            625..735
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..860
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1251
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
     polyA_site      1251
                     /gene="Them5"
                     /gene_synonym="1110007B02Rik; 1110038F21Rik"
ORIGIN      
        1 ccagcccagt cttgcacagt ttcttcttca gcaggaactc tctgctagaa gaaagcccgt
       61 gttaggtgtg cctggtccaa gcaaggctgc ctggcactca cttgtcctct ggagtcagcc
      121 actatttatc caagcaaagc cgggatcctg gcactcagcc atgttgagga caagtttcca
      181 gggagtggca agacttgtcc gccacaaagc tctttacaga agcccctgtc tcctgcccag
      241 agtccacctg gcctcagcat ttggttcctc cacagagtcc ctggttgcaa gattctgccc
      301 agagaagaca gatttgaaag attatgccct tcccaatgcc agctggtgtt cagatatgct
      361 gagtctgtat caagaatttc tggaaaaaac caaatcaggc ggctggatta aactaccctc
      421 cttcaaatcc aacagagatc atatccaggg ccttaagctc ccatttgggc tggaaactgc
      481 ctcagacaaa caggactggc gcctctttac caggtccata caactggaag gacaaggcta
      541 tgaatacgtc atctttttcc acccatctga gaagaagtct gtctgtcttt tccagccagg
      601 cccctacctg gagggggcac cagggtttgc tcacggaggg tcactggcag ccttgatgga
      661 tgagacatat tcgaaaactg catatctggc tggagaagga ctattcacac taagtctaaa
      721 catcaagttc aaaaacttga tccccgtggg ctctttggct gtcctggaca ttcaagtaga
      781 aaagattgaa gaccagaaac tctacatgtc ctgcatcgcc cagagcagag acaagcagac
      841 cgtctatgcc aagtcctccg gtgttttcct tcagctgcag ttggaagaac agtcccagga
      901 gcaatgacct tgaccttgat gactcagtgg ccacataaca gacaagggtc cccaggaatc
      961 aggtggcaga ggagggagaa aaaggcattt ttaccacccc acggtcagtc caagaacctt
     1021 ctgtagttgg aatcaaaatc gtccgtaggc cacagataac tcagcagtta agaaccctag
     1081 ctgctgcttg atttccagca ccaacaaggt ggttcacaac catctgtaac tcctgtccca
     1141 gggaatccaa tacccttttc tggcctccat ggagtaccag gtacacgtcc agtgccttcc
     1201 gtacaaaccc aacacccgta tacctaaaaa taaatgaatg ttttaaacct t
//
