LOCUS       NM_029431               1706 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus thioesterase superfamily member 4 (Them4), mRNA.
ACCESSION   NM_029431 XM_001003887 XM_131022 XM_895350 XM_904515 XM_918859
            XM_918865 XM_972946 XM_972982 XM_973023 XM_993608
VERSION     NM_029431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Wang,J., Tierney,L., Wilson,C., Phillips,V., Goldman,L., Mumaw,C.,
            Muang,E. and Walker,C.L.
  TITLE     Carboxyl-terminal modulator protein (CTMP) deficiency mitigates
            denervation-induced skeletal muscle atrophy
  JOURNAL   Biochem Biophys Res Commun 644, 155-161 (2023)
   PUBMED   36652767
  REMARK    GeneRIF: Carboxyl-terminal modulator protein (CTMP) deficiency
            mitigates denervation-induced skeletal muscle atrophy.
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Wang,J., Fry,C.M.E. and Walker,C.L.
  TITLE     Carboxyl-terminal modulator protein regulates Akt signaling during
            skeletal muscle atrophy in vitro and a mouse model of amyotrophic
            lateral sclerosis
  JOURNAL   Sci Rep 9 (1), 3920 (2019)
   PUBMED   30850672
  REMARK    GeneRIF: Carboxyl-terminal modulator protein regulates Akt
            signaling during skeletal muscle atrophy in vitro and a mouse model
            of amyotrophic lateral sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Liu,X., Yang,Q., Zhu,L.H., Liu,J., Deng,K.Q., Zhu,X.Y., Liu,Y.,
            Gong,J., Zhang,P., Li,S., Xia,H. and She,Z.G.
  TITLE     Carboxyl-Terminal Modulator Protein Ameliorates Pathological
            Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling
            Pathway
  JOURNAL   J Am Heart Assoc 7 (13), e008654 (2018)
   PUBMED   29945911
  REMARK    GeneRIF: Increased cardiac expression of CTMP protects against
            cardiac hypertrophy by suppressing the protein kinase B signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Zhao,S., Fu,J., Liu,F., Rastogi,R., Zhang,J. and Zhao,Y.
  TITLE     Small interfering RNA directed against CTMP reduces acute traumatic
            brain injury in a mouse model by activating Akt
  JOURNAL   Neurol Res 36 (5), 483-490 (2014)
   PUBMED   24670215
  REMARK    GeneRIF: Results suggest that Akt is phosphorylated and
            translocated to nucleus after traumatic brain injury (TBI) to exert
            neuroprotective effects; however, CTMP is simultaneously triggered
            to inhibit the phosphorylation of Akt
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Parcellier,A., Tintignac,L.A., Zhuravleva,E., Dummler,B.,
            Brazil,D.P., Hynx,D., Cron,P., Schenk,S., Olivieri,V. and
            Hemmings,B.A.
  TITLE     The Carboxy-Terminal Modulator Protein (CTMP) regulates
            mitochondrial dynamics
  JOURNAL   PLoS One 4 (5), e5471 (2009)
   PUBMED   19421406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164562.4.
            
            On Mar 29, 2023 this sequence version replaced NM_029431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138397.1, SRR7652917.1217486.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC164562.4         111244-111368
            126-312             AC164562.4         118470-118656
            313-472             AC164562.4         124662-124821
            473-580             AC164562.4         125357-125464
            581-705             AC164562.4         130842-130966
            706-1706            AC164562.4         132620-133620
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.51 cM"
     gene            1..1706
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /note="thioesterase superfamily member 4"
                     /db_xref="GeneID:75778"
                     /db_xref="MGI:MGI:1923028"
     exon            1..125
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..746
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /EC_number="3.1.2.2"
                     /note="carboxyl-terminal modulator protein; acyl-CoA
                     thioesterase THEM4"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase THEM4"
                     /protein_id="NP_083707.1"
                     /db_xref="CCDS:CCDS38533.1"
                     /db_xref="GeneID:75778"
                     /db_xref="MGI:MGI:1923028"
                     /translation="MLRNCAMRLRTLGATPARRPGAARRLFSSEKVIRKDYALPNPSW
                     TKDLRLLFDQFMKKCEDGSWKRMPSHRQNPTRAIQEFQTLFVDSKFKKEEQMSKAQQF
                     TRSFEEGLGFEYAMFYNKVEKRTVSLFQGGLHLQGVPGFVHGGAIATIIDVTTGTCAI
                     SEGVAMTANLNITYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSIDEKTLYTEATA
                     LFIKLDPEKPLT"
     exon            126..312
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            313..472
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            473..580
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..705
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1706
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1325
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="Them4"
                     /gene_synonym="2700077M13Rik; 4921507I02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggctcttt ctggaacaga gcagagagca gcgtcctgcc ctcggcttga gcaatgctga
       61 gaaactgcgc tatgcgcctg cgcactcttg gggccacgcc tgcgaggcgg ccaggagcag
      121 ctaggaggtt attttcttct gagaaagtca ttcgtaagga ctatgctctc cctaacccca
      181 gctggactaa ggacctcaga ctcctttttg atcagttcat gaagaaatgt gaagatggct
      241 cctggaaacg catgccttca cacagacaaa accctactcg agctattcaa gagttccaaa
      301 ccctttttgt tgactcgaag tttaagaaag aagaacaaat gtcaaaggcc caacagttca
      361 ccagaagttt cgaggaaggg ctaggctttg agtatgcgat gttctataat aaagttgaga
      421 agaggacggt ctccttgttt caaggaggac ttcacctgca aggagtacct ggatttgttc
      481 acggaggtgc cattgcaacc atcattgatg tcactactgg cacgtgtgca atttccgaag
      541 gcgttgccat gactgccaac ctcaacatca cctataaaaa gcctatcccc cttctttctg
      601 ttgttgtggt aaatagccaa cttcaaaaaa ttgaaggaag gaaacttttt gtttcctgta
      661 ctattcaaag tattgatgag aagactttat acacagaggc aacggcctta tttataaagc
      721 tggatcctga gaaacctttg acataaaaga acttctgatg agttccacac tgttctgcat
      781 gaggctctcc ccctccagaa gcagcaccca tctccactcc tgtcacagct gctgaatctc
      841 ccagggaaag cctgctctca cagacccttc agaacagcct ctgaaatatg gctgcaggaa
      901 ctcactctcc accttccaga ttttttgtaa gaagtacttc ctgggagagt cacaacaata
      961 atctgtatct ctctaggaca aatgtgtagt tctaacacat gaacagactt taaagctaac
     1021 aagcatagga cctgctctgc tgtggactgc agaagaaaaa gacaaaaaga aaaaaagact
     1081 gtattgaaac tttgactgca aatgtggaaa ttcaagaaaa ccaaaggcag ggataaatat
     1141 atgaagtgtt gtgagtgagg tgcgtgtgtg cgtaagccac actgcgtgtt acaaagctag
     1201 gtttgttgta tctgaacaaa catctctctg gctgtattag ggaacacagc tcacttctgt
     1261 gggaatggcc cccacatctc agttgtctgg ggcccttgag attaaaatac tgctcttttt
     1321 tcctacctgt gcaattgtat cttaaacaat ttgtcatccc tggaagaagg ttctattagc
     1381 tttctgggac tataatgaag aactacaagt taggtggttt aagcaaacaa aaacatccct
     1441 gtcgcagtcc cagacaccag aagtctaaaa gtattaacaa aatgttgctt cttaaagttg
     1501 tgggcaggaa ctctctcctg gcttctacca aggaagcgtc cagctttccc tggttttcag
     1561 acacagcata atttctaatt gtaattcttt atcgtctgct ctctgttgta tccaaatttc
     1621 tctttgtgaa tgtttattta tttgtctgag tgtgtgtgtg tgttcaggtg ctaaaataaa
     1681 ttgggagatt aatgttctag aaagca
//
