LOCUS       NM_011582               3202 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thrombospondin 4 (Thbs4), mRNA.
ACCESSION   NM_011582
VERSION     NM_011582.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3202)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3202)
  AUTHORS   Meng,X.M., Pang,Q.Y., Zhou,Z.F., Yuan,J.H., You,L., Feng,Q.P. and
            Zhu,B.M.
  TITLE     Histone methyltransferase MLL4 protects against pressure
            overload-induced heart failure via a THBS4-mediated protection in
            ER stress
  JOURNAL   Pharmacol Res 205, 107263 (2024)
   PUBMED   38876442
  REMARK    GeneRIF: Histone methyltransferase MLL4 protects against pressure
            overload-induced heart failure via a THBS4-mediated protection in
            ER stress.
REFERENCE   3  (bases 1 to 3202)
  AUTHORS   Zaren,P. and Gawlik,K.I.
  TITLE     Thrombospondin-4 deletion does not exacerbate muscular dystrophy in
            beta-sarcoglycan-deficient and laminin alpha2 chain-deficient mice
  JOURNAL   Sci Rep 14 (1), 14757 (2024)
   PUBMED   38926599
  REMARK    GeneRIF: Thrombospondin-4 deletion does not exacerbate muscular
            dystrophy in beta-sarcoglycan-deficient and laminin alpha2
            chain-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3202)
  AUTHORS   Vanhoutte,D., Schips,T.G., Minerath,R.A., Huo,J., Kavuri,N.S.S.,
            Prasad,V., Lin,S.C., Bround,M.J., Sargent,M.A., Adams,C.M. and
            Molkentin,J.D.
  TITLE     Thbs1 regulates skeletal muscle mass in a
            TGFbeta-Smad2/3-ATF4-dependent manner
  JOURNAL   Cell Rep 43 (5), 114149 (2024)
   PUBMED   38678560
REFERENCE   5  (bases 1 to 3202)
  AUTHORS   Lipp,S.N., Jacobson,K.R., Colling,H.A., Tuttle,T.G., Miles,D.T.,
            McCreery,K.P. and Calve,S.
  TITLE     Mechanical loading is required for initiation of extracellular
            matrix deposition at the developing murine myotendinous junction
  JOURNAL   Matrix Biol 116, 28-48 (2023)
   PUBMED   36709857
REFERENCE   6  (bases 1 to 3202)
  AUTHORS   Margagliotti,S., Clotman,F., Pierreux,C.E., Beaudry,J.B.,
            Jacquemin,P., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early
            liver expansion by controlling hepatoblast migration
  JOURNAL   Dev Biol 311 (2), 579-589 (2007)
   PUBMED   17936262
REFERENCE   7  (bases 1 to 3202)
  AUTHORS   Dunkle,E.T., Zaucke,F. and Clegg,D.O.
  TITLE     Thrombospondin-4 and matrix three-dimensionality in axon outgrowth
            and adhesion in the developing retina
  JOURNAL   Exp Eye Res 84 (4), 707-717 (2007)
   PUBMED   17320079
REFERENCE   8  (bases 1 to 3202)
  AUTHORS   Li,J., Willingham,E. and Baskin,L.S.
  TITLE     Gene expression profiles in mouse urethral development
  JOURNAL   BJU Int 98 (4), 880-885 (2006)
   PUBMED   16978288
REFERENCE   9  (bases 1 to 3202)
  AUTHORS   Newton,G., Weremowicz,S., Morton,C.C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Lawler,J.
  TITLE     The thrombospondin-4 gene
  JOURNAL   Mamm Genome 10 (10), 1010-1016 (1999)
   PUBMED   10501972
REFERENCE   10 (bases 1 to 3202)
  AUTHORS   Baumeister,A., Arber,S. and Caroni,P.
  TITLE     Accumulation of muscle ankyrin repeat protein transcript reveals
            local activation of primary myotube endcompartments during muscle
            morphogenesis
  JOURNAL   J Cell Biol 139 (5), 1231-1242 (1997)
   PUBMED   9382869
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025667.9 and CT009509.7.
            
            On Dec 15, 2009 this sequence version replaced NM_011582.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102887.1, BC139414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               CT025667.9         32650-32888         c
            240-443             CT025667.9         28752-28955         c
            444-691             CT025667.9         14935-15182         c
            692-800             CT025667.9         14169-14277         c
            801-883             CT025667.9         13553-13635         c
            884-935             CT025667.9         13187-13238         c
            936-1138            CT025667.9         12751-12953         c
            1139-1276           CT025667.9         11227-11364         c
            1277-1345           CT025667.9         7602-7670           c
            1346-1498           CT025667.9         5224-5376           c
            1499-1603           CT009509.7         217743-217847       c
            1604-1711           CT009509.7         217390-217497       c
            1712-1871           CT009509.7         216974-217133       c
            1872-1990           CT009509.7         215679-215797       c
            1991-2043           CT009509.7         214746-214798       c
            2044-2237           CT009509.7         212136-212329       c
            2238-2416           CT009509.7         210622-210800       c
            2417-2465           CT009509.7         209583-209631       c
            2466-2662           CT009509.7         209303-209499       c
            2663-2835           CT009509.7         208482-208654       c
            2836-2975           CT009509.7         206568-206707       c
            2976-3202           CT009509.7         205800-206026       c
FEATURES             Location/Qualifiers
     source          1..3202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.75 cM"
     gene            1..3202
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /note="thrombospondin 4"
                     /db_xref="GeneID:21828"
                     /db_xref="MGI:MGI:1101779"
     exon            1..239
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3037
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /codon_start=1
                     /product="thrombospondin-4 precursor"
                     /protein_id="NP_035712.1"
                     /db_xref="CCDS:CCDS26684.1"
                     /db_xref="GeneID:21828"
                     /db_xref="MGI:MGI:1101779"
                     /translation="MPAPRAAAAAFLLLHLVLQPWQRTSAQATPQVFDLLPSSSQRLN
                     PSALQPVLTDPTLHEVYLISTFKLQSKSSATIFGLYSSSDNSKYFEFTVMGRLNKAIL
                     RYLKNDGKIHLVVFNNLQLADGRRHRVLLRLSNLQRGDGSVELYLDCAQADSVRNLPR
                     AFSGLTQNPESIELRTFQRKPQDFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATST
                     GDFNRQFLGQMTQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLSFQSPTPNTL
                     VPIAPPAPPTRPTRHCDSSPCFRGVRCTDTRDGFQCGPCPDGYTGNGITCSDVDECKY
                     HPCYPGVRCVNLAPGFRCDACPVGFTGPMVQGVGINFAKTNKQVCTDVDECQNGACVL
                     NSICINTLGSYRCGPCKPGYTGDQTRGCKTERSCRNPEQNPCSVHAQCIEERQGDVTC
                     VCGVGWAGDGYVCGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDA
                     CDEDADGDGILNEQDNCVLTHNIDQRNSDKDIFGDACDNCRMVLNNDQKDTDGDGRGD
                     ACDDDMDGDGIKNILDNCPRVPNRDQQDRDGDDVGDACDSCPDVSNPNQSDVDNDLVG
                     DSCDTNQDSDGDGHQDSTDNCPTVINSSQLDTDKDGIGDECDDDDDNDGIPDLVPPGP
                     DNCRLVPNPAQEDSNNDGVGDICEADFDQDQVIDHIDVCPENAEITLTDFRAYQTVVL
                     DPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYA
                     GFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLW
                     HTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTI
                     DTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQSFDRLDN"
     exon            240..443
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..691
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            692..800
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            801..883
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..935
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1138
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1276
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1345
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1498
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1603
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1711
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1871
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1990
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2043
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2237
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2416
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2465
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2662
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2835
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2975
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2976..3202
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /note="hexamer: AATAAA"
     polyA_site      3202
                     /gene="Thbs4"
                     /gene_synonym="TSP4"
                     /note="major polyA site"
ORIGIN      
        1 agcagccagc gcccctccga cggctgcgca ctgccctgcc cgccacctgc gcgctcactg
       61 cccgaggcca gcaaacagcg ccctacgccg gcaaagccac gccacattgt cgcctgcaca
      121 gccctcaggg agcagaagag tcaccatgcc ggccccacgc gcggccgcgg ccgccttcct
      181 cctgctgcac ctggtcctgc agccgtggca gcggacgagc gcccaggcca caccccaggt
      241 ctttgatctt ctaccgtcct ccagccagag gctgaacccc agcgccctgc agccagtcct
      301 gacagatccc accctgcacg aagtctatct catctccacc ttcaagctgc agagtaaaag
      361 ctcagccacc atctttggcc tctactcctc aagtgacaac agcaaatact ttgaattcac
      421 tgtgatggga cggctgaaca aagccatcct ccgctacctg aagaatgatg gaaagatcca
      481 tctggtggtg ttcaacaact tgcagctggc tgatgggagg cgccacaggg ttctcctgag
      541 actgagcaat ttgcagagag gagatggctc tgtagaactc tacctggact gcgctcaggc
      601 ggactcggtg cgcaacctcc ccagagcctt ttctggcctc acccagaacc cagagtccat
      661 tgaattgcgg acattccaga ggaagcccca ggacttcttg gaagagctga agctggtggt
      721 gcggggctcg ctgttccagg tggccagcct ccaagactgc ttcctgcagc agagtgagcc
      781 tctggctgcc acaagcacag gagactttaa tcgacagttc ttgggtcaaa tgacacaact
      841 gaaccagctc cttggagagg tgaaagatct tctgaggcag caggtcaagg aaacatcgtt
      901 tttgcgaaac accattgctg aatgccaagc ttgtggtcct ctcagctttc agtccccaac
      961 tccaaacaca ctggtgccca tagctcctcc agcaccccca actcgcccaa cacgccactg
     1021 tgactccagc ccttgtttcc gaggtgtccg atgtacggac accagggatg gcttccagtg
     1081 tggaccctgc ccagatggtt acacgggaaa cgggatcacc tgctctgacg tggatgagtg
     1141 caaataccat ccctgctatc caggtgtgcg ctgtgtgaat ttggctccgg gtttcagatg
     1201 tgacgcctgt ccagtaggtt tcacagggcc catggtgcag ggtgtcggga tcaactttgc
     1261 taaaacaaac aagcaggtgt gcactgatgt tgatgagtgt cagaatggag cgtgtgttct
     1321 gaattctatc tgcattaaca ctttgggatc ttatcgctgt gggccttgca aaccagggta
     1381 cactggtgat cagacgaggg gatgcaagac tgaaaggagc tgccggaacc cagagcagaa
     1441 cccatgcagt gtgcatgcgc agtgcattga ggagcggcaa ggggatgtga cgtgtgtgtg
     1501 tggtgttggc tgggctggtg acggctatgt ctgtggaaag gatgtggaca ttgacagtta
     1561 ccctgatgaa gaactgccat gctctgccag gaactgcaag aaggataact gcaagtatgt
     1621 gccaaactct ggccaggaag atgcagacag agatggcatc ggagacgcgt gtgatgagga
     1681 tgcagatgga gatgggatct tgaatgaaca ggacaactgt gtcctgactc acaatataga
     1741 ccaaaggaac agtgataaag atatctttgg ggatgcctgt gacaactgcc ggatggtcct
     1801 gaataatgac cagaaggata ctgacgggga tgggagagga gacgcctgtg atgacgacat
     1861 ggatggagat ggaataaaaa acattttgga caactgtccc agagttccca accgtgacca
     1921 gcaggatcgg gatggtgatg atgtcggaga tgcttgtgac agctgtcctg atgtcagtaa
     1981 ccctaaccag tcggatgtgg ataacgatct ggttggggac tcctgtgaca ccaaccaaga
     2041 cagtgacggg gatggccacc aggacagcac agacaactgc cccacagtca ttaacagctc
     2101 ccagctggac actgacaaag atgggatcgg cgatgaatgt gatgacgatg acgataacga
     2161 tggcatccca gacctggtgc ctcctggccc agacaactgc aggctcgtcc ccaacccagc
     2221 ccaggaagat agcaacaatg acggggtagg agatatctgt gaagctgact tcgaccagga
     2281 ccaggtcatc gatcacattg atgtgtgccc tgagaatgcg gagatcaccc tgactgactt
     2341 cagggcctac cagacagtgg tcctggaccc tgaaggggat gctcagatcg accccaactg
     2401 ggtggtcctg aaccagggca tggaaattgt gcagaccatg aacagtgacc ctggcctagc
     2461 tgttgggtac acggcattta acggagttga ctttgaaggg accttccacg taaacaccca
     2521 gacagatgat gactatgctg gctttatttt tggttaccaa gacagctcca gcttctatgt
     2581 agtcatgtgg aagcaaacgg agcagacata ctggcaggct acaccgttcc gtgcagtagc
     2641 agaacctggt attcagctca aggctgtgaa gtctaaaact ggcccagggg aacatctccg
     2701 aaactccctg tggcacacag gggacaccag cgaccaggtc aggctgctgt ggaaggactc
     2761 caggaatgtg ggctggaagg acaaggtctc ctaccgctgg ttcctgcagc ataggcccca
     2821 ggtgggctac atcagggtgc gcttttatga aggctcggag ttggtggctg actctggggt
     2881 caccatagac accaccatgc gtggaggccg acttggtgtg ttctgcttct ctcaagaaaa
     2941 catcatctgg tccaacctca agtaccgctg caacgacacc ataccagagg acttccagga
     3001 gttccagacc cagagtttcg accgcttgga taattgagcc aagaagcaat cccacaactg
     3061 ccttctcaaa caccaaaagc aacatctttt ttaaaacttc ctataattct ctttatatta
     3121 tcatggcttt tcttttacca gcccaaatac gtcaaaactt tttatatgaa tgtggaaata
     3181 aagaagagac tatttctaat aa
//
