LOCUS       NM_013691               3207 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus thrombospondin 3 (Thbs3), transcript variant 1, mRNA.
ACCESSION   NM_013691 XR_104846 XR_107514
VERSION     NM_013691.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3207)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3207)
  AUTHORS   Schips,T.G., Vanhoutte,D., Vo,A., Correll,R.N., Brody,M.J.,
            Khalil,H., Karch,J., Tjondrokoesoemo,A., Sargent,M.A., Maillet,M.,
            Ross,R.S. and Molkentin,J.D.
  TITLE     Thrombospondin-3 augments injury-induced cardiomyopathy by
            intracellular integrin inhibition and sarcolemmal instability
  JOURNAL   Nat Commun 10 (1), 76 (2019)
   PUBMED   30622267
  REMARK    GeneRIF: Study shows that Thbs3 reduces integrin trafficking to the
            sarcolemma in the heart, while Thbs4 is cardioprotective by
            augmenting membrane residence of select integrins and
            beta-dystroglycan of the glycoprotein attachment complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3207)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 3207)
  AUTHORS   Mendus,D., Sundaresan,S., Grillet,N., Wangsawihardja,F., Leu,R.,
            Muller,U., Jones,S.M. and Mustapha,M.
  TITLE     Thrombospondins 1 and 2 are important for afferent synapse
            formation and function in the inner ear
  JOURNAL   Eur J Neurosci 39 (8), 1256-1267 (2014)
   PUBMED   24460873
REFERENCE   5  (bases 1 to 3207)
  AUTHORS   Hankenson,K.D., Sweetwyne,M.T., Shitaye,H. and Posey,K.L.
  TITLE     Thrombospondins and novel TSR-containing proteins, R-spondins,
            regulate bone formation and remodeling
  JOURNAL   Curr Osteoporos Rep 8 (2), 68-76 (2010)
   PUBMED   20425613
  REMARK    Review article
REFERENCE   6  (bases 1 to 3207)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   7  (bases 1 to 3207)
  AUTHORS   Bornstein,P., McKinney,C.E., LaMarca,M.E., Winfield,S., Shingu,T.,
            Devarayalu,S., Vos,H.L. and Ginns,E.I.
  TITLE     Metaxin, a gene contiguous to both thrombospondin 3 and
            glucocerebrosidase, is required for embryonic development in the
            mouse: implications for Gaucher disease
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4547-4551 (1995)
   PUBMED   7753840
REFERENCE   8  (bases 1 to 3207)
  AUTHORS   Kingsmore,S.F., Spicer,A.P., Gendler,S.J. and Seldin,M.F.
  TITLE     Genetic mapping of the tumor-associated mucin 1 gene on mouse
            chromosome 3
  JOURNAL   Mamm Genome 6 (5), 378-379 (1995)
   PUBMED   7626896
REFERENCE   9  (bases 1 to 3207)
  AUTHORS   Vos,H.L., Devarayalu,S., de Vries,Y. and Bornstein,P.
  TITLE     Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene
            family
  JOURNAL   J Biol Chem 267 (17), 12192-12196 (1992)
   PUBMED   1601886
REFERENCE   10 (bases 1 to 3207)
  AUTHORS   Chou,H.S., Nelson,C.A., Godambe,S.A., Chaplin,D.D. and Loh,D.Y.
  TITLE     Germline organization of the murine T cell receptor beta-chain
            genes
  JOURNAL   Science 238 (4826), 545-548 (1987)
   PUBMED   2821625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161600.6, CJ064850.1, BC053023.1 and BP754474.1.
            
            On Sep 21, 2017 this sequence version replaced NM_013691.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053023.1, L04302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC161600.6         208972-208978
            8-53                CJ064850.1         2-47
            54-3190             BC053023.1         1-3137
            3191-3207           BP754474.1         15-31               c
FEATURES             Location/Qualifiers
     source          1..3207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.01 cM"
     gene            1..3207
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /note="thrombospondin 3"
                     /db_xref="GeneID:21827"
                     /db_xref="MGI:MGI:98739"
     exon            1..145
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2937
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /codon_start=1
                     /product="thrombospondin-3 precursor"
                     /protein_id="NP_038719.2"
                     /db_xref="CCDS:CCDS17495.1"
                     /db_xref="GeneID:21827"
                     /db_xref="MGI:MGI:98739"
                     /translation="MEKPELWGVLALLLLCSYTCGSQDLQVIDLLTVGESRQMVAVAE
                     KIRTALLTAGDIYLLSTFRLPPKQGGVLFGLYSRQDNTRWLEASVVGKINKVLVRYQR
                     EDGKVHAVNLQQAGLADGRTHTALLRLRGPSRPSPGLQLYVDCKLGDQHAGLPALAPI
                     PPAEVSGLEIRTGQKAYLRMQGFVESMKIILGGSMARVGALSECPFQGDDSIHNAVTS
                     ALQSILGEQTKALVTQLTLFNQILVELRDDIRDQVKEMSLIRNTIMECQVCGFHEQRS
                     HCSPSPCFRGVDCMEVYEYPGYRCGPCPPGLQGNGTHCDDINECAHADPCFPGSSCIN
                     TMPGFHCEACPPGYKGTRVSGVGIDYARASKQVCNDIDECNDGNNGGCDPNSICTNTV
                     GSFKCGPCRLGFLGNQSQGCVPARTCHSPAHSPCHIHAHCLFERNGAVSCQCNVGWAG
                     NGNVCGPDTDIDGYPDQALPCMDNNKHCKQDNCLLTPNSGQEDADNDGVGDQCDDDAD
                     GDGIKNVEDNCRLFPNKDQQNSDTDSFGDACDNCPNVPNNDQKDTDGNGEGDACDNDV
                     DGDGIPNGLDNCPKVPNPLQTDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCDTN
                     EDSDGDGHQDTKDNCPQLPNSSQLDSDNDGLGDECDGDDDNDGVPDYIPPGPDNCRLV
                     PNPNQKDSDGNGVGDVCEDDFDNDAVVDPLDVCPESAEVTLTDFRAYQTVILDPEGDA
                     QIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFLFSY
                     QDSGRFYVVMWKQTEQTYWQATPFRAVAQPGLQLKAVTSISGPGEHLRNALWHTGHTP
                     DQVRLLWTDPRNVGWRDKTSYRWRLLHRPQVGYIRVKLYEGPQLVADSGVIIDTSMRG
                     GRLGVFCFSQENIIWSNLQYRCNDTVPEDFEPFRRQLLQGRV"
     exon            146..352
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..609
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..712
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..739
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..822
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..874
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1023
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1164
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1242
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1395
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1506
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1614
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1774
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1893
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1946
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2140
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2319
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2368
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2565
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2738
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2878
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3194
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /note="hexamer: CATAAA"
     polyA_site      3190
                     /gene="Thbs3"
                     /gene_synonym="Thbs-3; TSP3"
                     /note="major polyA site"
ORIGIN      
        1 tctccgccta gtctttttcc ctcccagtcg ccttgcctgc caggggtagt gaaccggcta
       61 agcggcatgg agaagccgga actttggggt gtcctggctc tcctcctcct ctgctcttac
      121 acgtgtggca gtcaggacct tcaggtaatt gacctgctga cagtgggcga atccaggcag
      181 atggtagctg tggcagagaa gattcggaca gctttactca ctgctgggga tatctacctc
      241 ttgtccactt tccgcctccc tccaaagcaa ggtggtgtcc tctttggcct ctactctcgc
      301 caagacaaca cacgatggct ggaggcctct gttgtgggca agatcaacaa agtgctggtg
      361 cggtaccagc gggaagatgg caaagtccat gcagtgaacc tacagcaagc aggcctggct
      421 gatgggcgca cacacacggc tctcctgcga ctccgaggac cttctcgacc cagccctggc
      481 ctgcagctgt atgtggactg taaactgggt gaccaacatg ctggccttcc agcactggcc
      541 ccgatccctc cagcagaggt cagtggactg gagattagaa ctggacaaaa ggcttatctg
      601 aggatgcagg gctttgtgga atcgatgaaa attattctgg gtggatccat ggctcgggta
      661 ggagccctga gtgaatgtcc attccaagga gacgactcca ttcacaatgc agtgaccagc
      721 gcactgcaat ccattctagg ggagcagacc aaggcattgg tcacccagct caccctcttc
      781 aaccagatcc tagtggagct tcgggacgac atccgagacc aggtgaagga aatgtcactc
      841 atccggaaca ccatcatgga gtgtcaggtg tgcggtttcc acgagcagcg ttcacactgc
      901 agccccagcc cctgcttccg aggcgtggac tgtatggaag tgtatgagta cccgggctat
      961 cgctgtgggc cctgcccacc tggcctgcag ggcaatggca cccactgtga tgacatcaac
     1021 gagtgtgctc acgctgaccc ctgtttcccg gggtccagct gcatcaacac catgcctggc
     1081 ttccactgcg aggcctgtcc tccagggtac aagggcaccc gagtgtctgg tgtgggcatc
     1141 gactatgctc gagccagcaa acaggtctgc aatgacattg atgaatgtaa tgatggtaac
     1201 aacggaggct gtgacccaaa ttccatctgc accaacacgg tggggtcttt caaatgtggt
     1261 ccctgccgcc tgggtttcct ggggaaccag agccagggct gcgttccagc aaggacctgc
     1321 cacagccctg cccacagccc ctgccacatc cacgcccact gtctctttga acgcaatggc
     1381 gctgtgtcat gccagtgtaa cgtgggctgg gcagggaatg ggaacgtgtg tgggcctgac
     1441 acagatatag acggctatcc ggaccaggct cttccctgca tggataacaa caagcactgc
     1501 aagcaggaca attgcctttt gacacccaac tctgggcaag aagatgctga taacgatggt
     1561 gtcggggacc agtgtgatga cgatgctgac ggggatggta tcaagaatgt ggaggacaat
     1621 tgtcgactgt tccccaacaa ggaccagcag aattcagaca cagactcgtt tggtgatgcc
     1681 tgcgacaact gtcccaatgt tcccaacaat gaccagaagg acacggatgg caatggagaa
     1741 ggagatgcct gtgacaacga tgtggacggg gatggcatcc ccaacgggtt ggacaattgc
     1801 cctaaagtac ccaacccact gcagacagac cgggatgaag acggagtggg agatgcttgc
     1861 gacagctgcc ctgaaatgag caatcctacc cagacagatg cagacagcga cctggtgggg
     1921 gatgtctgtg acaccaacga agacagcgac ggagacgggc accaggacac caaggacaac
     1981 tgtcctcagc tgccaaatag ctctcagctg gactcagaca atgacgggct tggagatgag
     2041 tgtgacgggg acgatgacaa tgacggtgtc ccagattaca ttcctcccgg gcctgataac
     2101 tgtcgcctgg tacccaatcc taatcagaag gactcagatg gcaacggtgt gggtgatgtc
     2161 tgtgaagatg actttgacaa tgacgcagtg gttgaccctc tggatgtgtg cccggagagt
     2221 gcagaagtta ccctcacaga cttccgggcc tatcagactg tgatcctgga tcccgagggt
     2281 gacgcccaga tcgatccaaa ctgggtagtg ctcaaccagg gcatggaaat tgttcagact
     2341 atgaacagtg acccgggtct tgcagttggg tacacggcct ttaatggcgt ggactttgaa
     2401 ggcaccttcc acgtgaacac agtcactgat gatgactatg cgggcttcct cttcagttac
     2461 caggacagtg gccgcttcta tgtggtcatg tggaaacaga cggagcagac ctactggcag
     2521 gccacgcctt tccgagcagt ggcccaacca gggcttcagc tcaaggcagt gacatccata
     2581 tctggcccag gtgagcacct ccggaatgct ctgtggcata ctggccacac ccctgatcag
     2641 gtacgactgc tgtggactga cccacggaat gtgggttggc gagacaagac atcctataga
     2701 tggcggctgc tccaccggcc ccaagttggc tacattcggg tgaagctcta tgagggtccc
     2761 cagctagtgg cggattctgg ggtgattatt gacacgtcca tgcgaggggg gcgtctcggc
     2821 gtattctgct tctcccaaga aaacatcatt tggtccaatc tccagtaccg atgcaatgac
     2881 acagtgcctg aggactttga gccattccgg aggcagctgc tccagggaag agtgtgagga
     2941 ggtggccacg ggacccagat cctgatcgga gacctttggc cattgaactc tgttctggag
     3001 accctggggt ctaacctaca gcccctcagc ctaacggatg gctctctggc acccaccagg
     3061 gagctcagcc ccagaggggt ggcgacccca ttgtgcaggg gttgggagac tttcaagggg
     3121 tattattact caggttctaa ccccaggaaa gacaacagca cattgccata aagtttcagt
     3181 tattttctaa gtcaaaaaaa aaaaaaa
//
