LOCUS       NM_009378               3718 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus thrombomodulin (Thbd), mRNA.
ACCESSION   NM_009378
VERSION     NM_009378.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3718)
  AUTHORS   Turan,A., Tarique,M., Zhang,L., Kazmi,S., Ulker,V., Tedla,M.G.,
            Badal,D., Yolcu,E.S. and Shirwan,H.
  TITLE     Engineering Pancreatic Islets to Transiently Codisplay on Their
            Surface Thrombomodulin and CD47 Immunomodulatory Proteins as a
            Means of Mitigating Instant Blood-Mediated Inflammatory Reaction
            following Intraportal Transplantation
  JOURNAL   J Immunol 212 (12), 1971-1980 (2024)
   PUBMED   38709159
  REMARK    GeneRIF: Engineering Pancreatic Islets to Transiently Codisplay on
            Their Surface Thrombomodulin and CD47 Immunomodulatory Proteins as
            a Means of Mitigating Instant Blood-Mediated Inflammatory Reaction
            following Intraportal Transplantation.
REFERENCE   2  (bases 1 to 3718)
  AUTHORS   Ma,J.K., Su,L.D., Feng,L.L., Li,J.L., Pan,L., Danzeng,Q., Li,Y.,
            Shang,T., Zhan,X.L., Chen,S.Y., Ying,S., Hu,J.R., Chen,X.Q.,
            Zhang,Q., Liang,T. and Lu,X.J.
  TITLE     TFPI from erythroblasts drives heme production in central
            macrophages promoting erythropoiesis in polycythemia
  JOURNAL   Nat Commun 15 (1), 3976 (2024)
   PUBMED   38729948
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3718)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3718)
  AUTHORS   Wu,T., Kong,M., Xin,X.J., Liu,R.Q., Wang,H.D., Song,M.Z., Xu,W.P.,
            Yuan,Y.B., Yang,Y.Y. and Xiao,P.X.
  TITLE     Epigenetic repression of THBD transcription by BRG1 contributes to
            deep vein thrombosis
  JOURNAL   Thromb Res 219, 121-132 (2022)
   PUBMED   36162255
  REMARK    GeneRIF: Epigenetic repression of THBD transcription by BRG1
            contributes to deep vein thrombosis.
REFERENCE   5  (bases 1 to 3718)
  AUTHORS   Al-Dabet,M.M., Shahzad,K., Elwakiel,A., Sulaj,A., Kopf,S., Bock,F.,
            Gadi,I., Zimmermann,S., Rana,R., Krishnan,S., Gupta,D.,
            Manoharan,J., Fatima,S., Nazir,S., Schwab,C., Baber,R., Scholz,M.,
            Geffers,R., Mertens,P.R., Nawroth,P.P., Griffin,J.H., Keller,M.,
            Dockendorff,C., Kohli,S. and Isermann,B.
  TITLE     Reversal of the renal hyperglycemic memory in diabetic kidney
            disease by targeting sustained tubular p21 expression
  JOURNAL   Nat Commun 13 (1), 5062 (2022)
   PUBMED   36030260
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3718)
  AUTHORS   Ford,V.A., Stringer,C. and Kennel,S.J.
  TITLE     Thrombomodulin is preferentially expressed in Balb/c lung
            microvessels
  JOURNAL   J Biol Chem 267 (8), 5446-5450 (1992)
   PUBMED   1372003
REFERENCE   7  (bases 1 to 3718)
  AUTHORS   Imada,S., Yamaguchi,H., Nagumo,M., Katayanagi,S., Iwasaki,H. and
            Imada,M.
  TITLE     Identification of fetomodulin, a surface marker protein of fetal
            development, as thrombomodulin by gene cloning and functional
            assays
  JOURNAL   Dev Biol 140 (1), 113-122 (1990)
   PUBMED   2162790
REFERENCE   8  (bases 1 to 3718)
  AUTHORS   Dittman,W.A. and Majerus,P.W.
  TITLE     Sequence of a cDNA for mouse thrombomodulin and comparison of the
            predicted mouse and human amino acid sequences
  JOURNAL   Nucleic Acids Res 17 (2), 802 (1989)
   PUBMED   2536925
REFERENCE   9  (bases 1 to 3718)
  AUTHORS   Dittman,W.A., Kumada,T., Sadler,J.E. and Majerus,P.W.
  TITLE     The structure and function of mouse thrombomodulin. Phorbol
            myristate acetate stimulates degradation and synthesis of
            thrombomodulin without affecting mRNA levels in hemangioma cells
  JOURNAL   J Biol Chem 263 (30), 15815-15822 (1988)
   PUBMED   2844823
REFERENCE   10 (bases 1 to 3718)
  AUTHORS   Imada,M., Imada,S., Iwasaki,H., Kume,A., Yamaguchi,H. and
            Moore,E.E.
  TITLE     Fetomodulin: marker surface protein of fetal development which is
            modulatable by cyclic AMP
  JOURNAL   Dev Biol 122 (2), 483-491 (1987)
   PUBMED   3036632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935149.16.
            
            On Dec 3, 2008 this sequence version replaced NM_009378.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3718              AL935149.16        44951-48668         c
FEATURES             Location/Qualifiers
     source          1..3718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.45 cM"
     gene            1..3718
                     /gene="Thbd"
                     /gene_synonym="CD141; TM"
                     /note="thrombomodulin"
                     /db_xref="GeneID:21824"
                     /db_xref="MGI:MGI:98736"
     exon            1..3718
                     /gene="Thbd"
                     /gene_synonym="CD141; TM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thbd"
                     /gene_synonym="CD141; TM"
ORIGIN      
        1 ccttcctttt cccgaacgtg caaagaggga gggccgcgca tttataaact ggagcttcag
       61 cggagtggca tgttagaggc tgcctcgcag ggactaggag cctgggctag aaacgtctag
      121 gttgtgatag aggctagctg ctgtcgccgc aggcatacgg aaacccctct gcctggactg
      181 ggtgtctgca ccagcgcagg gctagctttt ctcggaactt gcacggtgca cccctggaca
      241 gcatgcttgg gattttcttt ctgggtgtgc tggctccagc tagcctgggg ctctccgcac
      301 tagccaagct gcagcccaca ggcagtcaat gcgtggagca tgagtgcttc gcgcttttcc
      361 agggccccgc gaccttcctc gatgccagcc aggcctgcca gcgcctgcaa ggacatttga
      421 tgacagtgcg ctcctcagtg gctgccgatg tcatctccct tctgctgagc cagagcagta
      481 tggatttagg gccctggatc ggtttacagc tcccgcaggg ctgtgacgac ccggtgcatc
      541 tcgggcccct gcgcggcttc cagtgggtta ctggcgataa ccacaccagt tacagcaggt
      601 gggcgcggcc caacgaccag acggctccac tctgcggccc tctgtgcgtc acggtctcga
      661 cagcaactga agctgcaccc ggcgagccgg cctgggaaga gaagccatgc gagactgaga
      721 cccagggttt cctctgtgag ttttacttca cagcttcctg caggcctctg acggtgaata
      781 ctcgcgatcc tgaggctgcc cacatctcta gtacctacaa caccccgttc ggggtcagtg
      841 gtgcggactt tcaaacgctg ccggtaggca gttccgccgc ggtggagccc cttggcttgg
      901 agctggtgtg cagggccccg cccggaactt cagagggaca ctgggcttgg gaagcgacag
      961 gagcctggaa ttgcagcgtg gagaatggtg gctgtgagta cttgtgcaat aggagcacga
     1021 atgaacccag atgcctctgc cccagagaca tggacctgca ggccgatgga cgttcgtgtg
     1081 caagacctgt ggttcaatcg tgcaacgaac tctgcgagca tttttgtgtc agcaacgctg
     1141 aagtgccagg ctcttactcc tgtatgtgtg agacaggcta ccagttggct gcagacggac
     1201 accggtgtga ggacgtggat gactgtaagc aggggcccaa tccatgtccc cagctctgtg
     1261 ttaacaccaa gggcggcttc gaatgcttct gctatgatgg ctatgagttg gtggatggag
     1321 agtgcgtgga gcttctggat ccgtgtttcg gatctaactg cgagtttcag tgccagccag
     1381 tgagccccac cgactaccga tgcatctgcg ctccaggctt cgcacccaag ccggatgaac
     1441 cgcacaagtg cgaaatgttc tgcaatgaaa cttcgtgccc agcagactgt gaccctaact
     1501 ctcctactgt ttgtgaatgc cctgaaggct tcatcctgga cgagggttcc gtatgcacgg
     1561 acattgatga gtgcagtcaa ggcgaatgct tcaccagtga atgtcgaaac ttccctggct
     1621 cctatgagtg tatctgcggg cctgacacag cccttgctgg tcagattagc aaagactgtg
     1681 accccatccc tgttagggaa gacaccaagg aagaggaggg ctctggggag cctccagtca
     1741 gccctacgcc aggctctccg acaggtcccc cttctgcaag gccagtgcac tctggcgtgc
     1801 tcattggcat ctccattgcc agcctgtccc tggtggtggc gcttttggcg cttctctgtc
     1861 acctgcgcaa gaagcagggc gctgctcgtg cagagctgga gtacaagtgc gcatcttccg
     1921 ccaaggaggt agtgctgcag cacgtcagga ctgatcggac gctgcagaag ttctgaggga
     1981 tttgctccag agacccaggt ggcctttgtc tttccgggct ctgtacctct cctctcctct
     2041 ctctctctcc agcctcccag ctgtgttctc tggcaactta aaagcaccct ggctggtata
     2101 ataaccagag aagagcccat cctctcagga caagcgaggg tagggaggac ttgaagcagg
     2161 acagcccagt ttcttccaag tagatactgg acaactgggc ggaggtggca aatacagcgg
     2221 agatcccaga gtaccccagt ccctcacctc acctcctagt gctgctgatc tgtaggcttg
     2281 aaggcaaacc ttgaccccat gggctggaga tgacccagat atttattttt tttaaagtat
     2341 ttagtatttt cttccctcca gttttcttct gcttgtaagt ctccagcccc ccacagcttt
     2401 ctcagtccct ccattccccc cctcctgtca ttctcctccc caaacctgat cataactttg
     2461 cccttaccgt tgtttccaaa ctcttatgtg aaacagaaaa gaaacactaa aagcagaaaa
     2521 cgttcttttt cactggcttt gggtatttag tcagaaattt caggtaacca aagcaaaaga
     2581 attttaacaa aagctaaaat atttcagctg aacactaact agtcaatagt gctggaatgt
     2641 cacagaaaat aaacttaagg aagtagggtt tttttttttt ttgaaatctt tgtttttgaa
     2701 agggtgagcc tgggttttat gattgttgct gttgttttga atgggaatga caaaagaggt
     2761 cattattgtt aagattttta tgcaggctct acagtgttat taatttttga cagtgttcaa
     2821 aatgtgcaga ggatcctttg tccaaccctt tgacatgaca ataggacatt gctatcttga
     2881 gacatactgg gccacattca tagctttcca aggatgtatg tggtcctgcc tcaacatatc
     2941 agagcctgac agatggaagc accttccagt aaagcatgag ttgtgtgctt cgtgccgagc
     3001 tgactctcaa ctgtgcctgc cccttgtagt cccgaaatac aagcaatgtg ctgctgaggg
     3061 aaacatggaa acttgggaat ggagtctggg ggtgcctaga tggggctttc ttttaatgag
     3121 actcttgaac aatatctcgt aattcagagg gatcttctag ccctggccac tggcctgtac
     3181 acaagaattg ggacctcgct tgggatctgg ctagaattgc aaaatcctag cccccacccc
     3241 tgccccaccc cagtgtgcca gttcataaga atctgcattt tgacaacatc cacagggaca
     3301 ttgtccagtc atttcaggac aactggtctt aagagtttcc aacctttgta gaacatttaa
     3361 atgtcggtta ataataagta gcaggccatg ttaaggccat ttattatcaa gaaactgagg
     3421 aattttctct gcatagcttt gctttctgga tacaataaaa tgagaaggta cacacctcta
     3481 gatagtgcca cacagagtcc agaagggttt tgttttaagt aagctaggaa tgagttcata
     3541 tgttagtgta aggaacaaat gtattatatg tgtatctttt gtaaagaaag gtttttcttt
     3601 acggttttgt aagctcagca tatttgtaca tatttattta ttggagtttc gctagaacac
     3661 aagcaaagcc tttgcttatg acgtcacatg tacaaaataa atagatgaca gtgtactg
//
