LOCUS       NM_028410               3579 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus THAP domain containing 12 (Thap12), transcript variant
            1, mRNA.
ACCESSION   NM_028410
VERSION     NM_028410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Zhong,X., Moresco,J.J., SoRelle,J.A., Song,R., Jiang,Y.,
            Nguyen,M.T., Wang,J., Bu,C.H., Moresco,E.M.Y., Beutler,B. and
            Choi,J.H.
  TITLE     Disruption of the ZFP574-THAP12 complex suppresses B cell
            malignancies in mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (31), e2409232121 (2024)
   PUBMED   39047044
  REMARK    GeneRIF: Disruption of the ZFP574-THAP12 complex suppresses B cell
            malignancies in mice.
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Farini,D., Cesari,E., Weatheritt,R.J., La Sala,G., Naro,C.,
            Pagliarini,V., Bonvissuto,D., Medici,V., Guerra,M., Di Pietro,C.,
            Rizzo,F.R., Musella,A., Carola,V., Centonze,D., Blencowe,B.J.,
            Marazziti,D. and Sette,C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Prescott,K., Ivins,S., Hubank,M., Lindsay,E., Baldini,A. and
            Scambler,P.
  TITLE     Microarray analysis of the Df1 mouse model of the 22q11 deletion
            syndrome
  JOURNAL   Hum Genet 116 (6), 486-496 (2005)
   PUBMED   15778864
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Roussigne,M., Kossida,S., Lavigne,A.C., Clouaire,T., Ecochard,V.,
            Glories,A., Amalric,F. and Girard,J.P.
  TITLE     The THAP domain: a novel protein motif with similarity to the
            DNA-binding domain of P element transposase
  JOURNAL   Trends Biochem Sci 28 (2), 66-69 (2003)
   PUBMED   12575992
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Lin,Y., Khokhlatchev,A., Figeys,D. and Avruch,J.
  TITLE     Death-associated protein 4 binds MST1 and augments MST1-induced
            apoptosis
  JOURNAL   J Biol Chem 277 (50), 47991-48001 (2002)
   PUBMED   12384512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111124.8.
            
            On Sep 8, 2017 this sequence version replaced NM_028410.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049103.1, SRR7652917.252070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC111124.8         28892-29123         c
            233-353             AC111124.8         25253-25373         c
            354-461             AC111124.8         22137-22244         c
            462-498             AC111124.8         19475-19511         c
            499-3579            AC111124.8         14308-17388         c
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.86 cM"
     gene            1..3579
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /note="THAP domain containing 12"
                     /db_xref="GeneID:72981"
                     /db_xref="MGI:MGI:1920231"
     exon            1..232
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2420
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon-inducible, double stranded RNA dependent
                     inhibitor, protein-kinase; protein-kinase,
                     interferon-inducible double stranded RNA dependent
                     inhibitor, repressor of (P58 repressor); 52 kDa repressor
                     of the inhibitor of the protein kinase; 58 kDa
                     interferon-induced protein kinase-interacting protein;
                     P52rIPK; p58IPK-interacting protein; THAP
                     domain-containing protein 0; THAP domain-containing
                     protein 12"
                     /codon_start=1
                     /product="52 kDa repressor of the inhibitor of the protein
                     kinase isoform 1"
                     /protein_id="NP_082686.1"
                     /db_xref="CCDS:CCDS21474.1"
                     /db_xref="GeneID:72981"
                     /db_xref="MGI:MGI:1920231"
                     /translation="MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLE
                     DKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKR
                     IKELSEDEIRTLKQKKIEETSEQEQETNTNAQNPSAEAVNQQDANVLPLTLEEKENKE
                     YLKSLFEILVLMGKQNIPLDGHEADEVPEGLFAPDNFQALLECRINSGEEVLRKRFEA
                     TAVNTLFCSKTQQRHMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLV
                     RFVDDAHNLREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCRGQAYIVSSGFSS
                     KMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFFHRSPQ
                     LLLELDSVISVLFQNSEERAKELKEICHSQWTGRHDAFEILVDLLQALVLCLDGIINS
                     DTNVRWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAA
                     SSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAQQGNLESQLT
                     SESYYKDTLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADM
                     YRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLC
                     ILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKL
                     YTNKSELPTINSETIENT"
     exon            233..353
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /inference="alignment:Splign:2.1.0"
     exon            354..461
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /inference="alignment:Splign:2.1.0"
     exon            462..498
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /inference="alignment:Splign:2.1.0"
     exon            499..3579
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3556..3561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="Thap12"
                     /gene_synonym="2900052B10Rik; Dap4; Prkrir; Rpkrir"
                     /note="major polyA site"
ORIGIN      
        1 cttcgcgcgc cagcccctcc tccgcgcgcg gccttgcgga gccggccggc cggcccagct
       61 cccctccccg gccccgcggg gcggccgcgc tgccctgacg aggcggggag gggagggctg
      121 gaccggccgg cggccggacg accatgccga acttctgcgc tgcccccaac tgcacacgga
      181 agagcacgca gtctgacctg gccttcttca ggttcccgcg ggacccggcc agatgccaga
      241 agtgggttga gaattgtagg agagcagact tagaagataa aacaccagat caactaaata
      301 aacattatcg actttgtgcc aaacactttg agacctctat gatttgtaga actagtcctt
      361 atcggacagt ccttcgagat aatgcaatac caacaatatt tgatcttacc agtcatttga
      421 acaacccgca tagcagacac agaaaacgaa taaaagaatt gagtgaagat gaaatcagga
      481 ctctgaaaca gaaaaaaatt gaggagactt ctgaacaaga gcaggaaact aacaccaatg
      541 ctcagaaccc cagtgcagaa gcggtgaacc agcaggatgc aaatgtgctg cctttaaccc
      601 ttgaagagaa ggagaacaaa gagtacctca agtctttatt tgagattctg gttctcatgg
      661 gaaagcagaa catccccttg gatgggcacg aggctgacga ggtccccgag ggcctctttg
      721 ccccagacaa cttccaggcg ctcctggagt gccgcatcaa ctctggcgag gaggtcctaa
      781 ggaagcgctt tgaggccaca gcggtcaaca cattattctg ctctaaaact cagcagaggc
      841 acatgctgga gatctgtgag agctgcattc gggaggagac tctcagggaa gtgagggact
      901 cacacttctt ttccattatc acagacgatg tggtggacat agcaggagaa gagcacctgc
      961 ccgtgctggt gaggtttgtc gatgacgccc ataacctgag agaggagttt gtgggatttc
     1021 tgccgtatga agctgatgcg gagattttgg ctgtgaaatt tcacactaca ataactgaga
     1081 aatggggatt gaatatggag tattgtcgtg gtcaggctta cattgtgtcc agtggatttt
     1141 cttccaaaat gaaagttgtt gcttcaagac ttttagaaaa atatccccag gctgtctata
     1201 ccctctgttc ttcctgtgcc ttaaatgcat ggttggcaaa gtctgtccct gtgatcgggg
     1261 tgtccgtggc tttaggaacc attgaggagg tctgttcttt tttccatcga tcaccacagc
     1321 tgcttttaga acttgacagt gtaatttctg ttctttttca gaatagtgaa gaacgggcta
     1381 aagaactgaa ggaaatttgt cattcccagt ggacaggcag gcatgatgcc tttgaaatct
     1441 tagtggatct cctacaagca cttgtcttat gtttagatgg tataataaat agtgacacaa
     1501 atgttaggtg gaataactat atagctgggc gagcatttgt cctctgtagt gcagtgacag
     1561 actttgattt cattgttacc attgttgttc ttaaaaatgt gttatctttt acaagagcct
     1621 ttgggaagaa cctccaggga cagacctctg acgtcttctt tgcagccagc agcctgactg
     1681 cagtactgca ttcacttaat gaggtcatgg aaaatattga agtttatcat gagttttggt
     1741 ttgaggaagc cacaaattta gcaaccaaac ttgacattca aatgaaactc ccagggaagt
     1801 tccggagagc ccagcaaggt aacctggaat ctcagctaac ctctgagagt tattataaag
     1861 acactctcag tgttccaaca gtagagcaca ttattcagga acttaaagat attttctctg
     1921 aacagcacct caaagctctg aaatgcctat ctctggtacc ctcagtgatg gggcagctca
     1981 aatttaacac atcagaagag caccatgctg acatgtacag aagtgaccta cccaaccctg
     2041 acacgctctc tgccgagctt cactgttgga gaatcaagtg gaaacacaga gggaaagata
     2101 tcgagctccc gtccaccatt tatgaagccc tccatcttcc tgacatcaag tttttcccta
     2161 atgtatatgc tttgctgaag gtcctgtgta ttctccctgt gatgaaagtt gagaatgagc
     2221 gctatgaaaa tggacggaag cgtctcaaag catacctgcg gaacactctg acagaccaga
     2281 ggtcaagcaa tttggctttg cttaacataa attttgatat aaaacatgat ttagatttaa
     2341 tggtggacac atacatcaaa ctctatacaa ataagtcaga gcttcctaca attaattcag
     2401 aaaccattga aaatacctag aagattttaa aaatggctgt tatcttattt tgctgtttgg
     2461 aagaaaagct gtaaggtata gtaggccaga taatgacttg ctgatagacc tccagtttaa
     2521 catactatta gctattggta atccacgtgt ttaaatggcc cctgtttgaa cactcatgct
     2581 ttcaatacct gtctgttctt ccagaagttg gcattaggag tgccaaaata cctctgctgg
     2641 tggcactctg aaaatgtttt acttaaaagt cgttttaggg gctggagaaa tggctcagcg
     2701 gttaagagca ctgactgcct ttccagaggt cctgagttca agtcccagtg accacatggt
     2761 ggctcacaac catctgtaat gggatccgat gccctcttct ggtgtgtctg aagagagcaa
     2821 cagtgtactc atatacgtaa aataaataaa tctcttaaaa agtcatttta gatatgacat
     2881 tatcactgtc gatccagttg tcagttatta agttatcagg tctttggaaa atgaattttg
     2941 tgagagaaat acattttata atgtgtcatg atgaaaaaca ccattgactt tgacttggag
     3001 tttcaggtgt ttccgagctg tggtagcagc acttgggagg cagaggcatg aggatgacag
     3061 gctttaggcc tggaccacat agtgagcctg cttcaaagaa cgagtgaggg ctgactgggg
     3121 tggagcctag tgtggagctc ttgcctcagt actcaaaagc aaaaagaaca gcaaaagtca
     3181 caggaagtaa cgagcagcct tctgtgtaga tcctgtcagg gcagaagaac ctcaaaggaa
     3241 caagttacag tagcagagcc agccctgctg ctcctcactt gattgctgct gtttgcattt
     3301 ctttgctgag cccacatttt cataggcttg tttgctattc acttgtgctt catggagaag
     3361 aaagacccag aggccatccc tataggcagc tgacttgtct gttgtctcct tacatgactg
     3421 tgtctgctgc cttggctcgg ttataagcaa aacctacaga aataaatgtt ttgtggttta
     3481 tctaaaaata atacagaaaa tattgctgtt atttttggtg aataaaatca attttgtata
     3541 gtttatttca acctaaataa aatgtgaatt ttgtttaaa
//
