LOCUS       NM_021513               1848 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus THAP domain containing 11 (Thap11), mRNA.
ACCESSION   NM_021513
VERSION     NM_021513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1848)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    GeneRIF: Mutations in Hcfc1 and Ronin result in an inborn error of
            cobalamin metabolism and ribosomopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1848)
  AUTHORS   Zwaka,T.P., Skowronska,M., Richman,R. and Dejosez,M.
  TITLE     Ronin overexpression induces cerebellar degeneration in a mouse
            model of ataxia
  JOURNAL   Dis Model Mech 14 (6) (2021)
   PUBMED   34165550
  REMARK    GeneRIF: Ronin overexpression induces cerebellar degeneration in a
            mouse model of ataxia.
REFERENCE   3  (bases 1 to 1848)
  AUTHORS   Fujita,J., Freire,P., Coarfa,C., Benham,A.L., Gunaratne,P.,
            Schneider,M.D., Dejosez,M. and Zwaka,T.P.
  TITLE     Ronin Governs Early Heart Development by Controlling Core Gene
            Expression Programs
  JOURNAL   Cell Rep 21 (6), 1562-1573 (2017)
   PUBMED   29117561
  REMARK    GeneRIF: The activity of Ronin coincided with the recruitment of
            its cofactor, Hcf-1, and the elevation of H3K4me3 levels at
            specific target genes, suggesting the involvement of an epigenetic
            mechanism.
REFERENCE   4  (bases 1 to 1848)
  AUTHORS   Seifert,B.A., Dejosez,M. and Zwaka,T.P.
  TITLE     Ronin influences the DNA damage response in pluripotent stem cells
  JOURNAL   Stem Cell Res 23, 98-104 (2017)
   PUBMED   28715716
  REMARK    GeneRIF: Ronin binds to and regulates the genes encoding several
            DNA repair factors, including Gtf2h4 and Rad18, providing a
            potential mechanism for this phenotype.
REFERENCE   5  (bases 1 to 1848)
  AUTHORS   Poche,R.A., Zhang,M., Rueda,E.M., Tong,X., McElwee,M.L., Wong,L.,
            Hsu,C.W., Dejosez,M., Burns,A.R., Fox,D.A., Martin,J.F., Zwaka,T.P.
            and Dickinson,M.E.
  TITLE     RONIN Is an Essential Transcriptional Regulator of Genes Required
            for Mitochondrial Function in the Developing Retina
  JOURNAL   Cell Rep 14 (7), 1684-1697 (2016)
   PUBMED   26876175
  REMARK    GeneRIF: Ronin is a positive regulator of mitochondrial gene
            expression that coordinates mitochondrial activity and cell cycle
            progression in the developing retina.
REFERENCE   6  (bases 1 to 1848)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (bases 1 to 1848)
  AUTHORS   Ngondo-Mbongo,R.P., Myslinski,E., Aster,J.C. and Carbon,P.
  TITLE     Modulation of gene expression via overlapping binding sites exerted
            by ZNF143, Notch1 and THAP11
  JOURNAL   Nucleic Acids Res 41 (7), 4000-4014 (2013)
   PUBMED   23408857
REFERENCE   8  (bases 1 to 1848)
  AUTHORS   Dejosez,M., Levine,S.S., Frampton,G.M., Whyte,W.A., Stratton,S.A.,
            Barton,M.C., Gunaratne,P.H., Young,R.A. and Zwaka,T.P.
  TITLE     Ronin/Hcf-1 binds to a hyperconserved enhancer element and
            regulates genes involved in the growth of embryonic stem cells
  JOURNAL   Genes Dev 24 (14), 1479-1484 (2010)
   PUBMED   20581084
  REMARK    GeneRIF: Ronin/Hcf-1 controls a genetic program that contributes to
            the unimpeded growth of embryonic stem cells.
REFERENCE   9  (bases 1 to 1848)
  AUTHORS   Dejosez,M., Krumenacker,J.S., Zitur,L.J., Passeri,M., Chu,L.F.,
            Songyang,Z., Thomson,J.A. and Zwaka,T.P.
  TITLE     Ronin is essential for embryogenesis and the pluripotency of mouse
            embryonic stem cells
  JOURNAL   Cell 133 (7), 1162-1174 (2008)
   PUBMED   18585351
  REMARK    GeneRIF: Findings identify Ronin as an essential factor underlying
            embryogenesis and ES cell pluripotency; its association with HCF-1
            suggests an epigenetic mechanism of gene repression in pluripotent
            cells.
            Erratum:[Cell. 2008 Aug 22;134(4):692]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116569.6.
            
            On May 22, 2009 this sequence version replaced NM_021513.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK170457.1, AK166109.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1848              AC116569.6         121501-123348
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.05 cM"
     gene            1..1848
                     /gene="Thap11"
                     /gene_synonym="2810036E22Rik; CTG-B43a; CTG-B45d; Ronin"
                     /note="THAP domain containing 11"
                     /db_xref="GeneID:59016"
                     /db_xref="MGI:MGI:1930964"
     exon            1..1848
                     /gene="Thap11"
                     /gene_synonym="2810036E22Rik; CTG-B43a; CTG-B45d; Ronin"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1176
                     /gene="Thap11"
                     /gene_synonym="2810036E22Rik; CTG-B43a; CTG-B45d; Ronin"
                     /codon_start=1
                     /product="THAP domain-containing protein 11"
                     /protein_id="NP_067488.1"
                     /db_xref="CCDS:CCDS22616.1"
                     /db_xref="GeneID:59016"
                     /db_xref="MGI:MGI:1930964"
                     /translation="MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAG
                     VSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARR
                     RQQQQQQQQQQQQQQQLQQQQPSPSSSTAQTTQLQPNLVSASAAVLLTLQAAVDSNQA
                     PGSVVPVSTTPSGDDVKPIDLTVQVEFAAAEGAAAAAAASELEAATAGLEAAECTLGP
                     QLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHL
                     RLTEAKLREELREKDRLLAMAVIRKKHGM"
ORIGIN      
        1 tttccaggcg gtccttcgcg gcgtcccccg ggccgactcc gaagcgcagg cggacggccg
       61 ggtgggtagc gcggcgcggg cggtccgcaa ccatattctg ggcacggggc ctcggcccgg
      121 gacgactgcg ccgggcggca atagtgagag gcctctgaga gcctcgcgcg gcgccgcccg
      181 tcgaggagct gagacagggg ccagacccgg ccgtcgaaga gctcgagagg ccggtgggcc
      241 gggccgcgcg tcgcagccat gcctggcttt acgtgctgcg ttccgggctg ctacaacaat
      301 tcacaccggg acaaggcgct gcacttctac acgtttccca aggacgctga gttgcggcgc
      361 ctctggctca agaacgtgtc ccgtgctggc gtcagtgggt gcttctccac cttccaaccc
      421 accaccggcc accgtctctg cagcgtccac tttcagggcg gccgcaagac ctacacggtg
      481 cgcgttccca ccattttccc gctgcgtggc gtcaatgagc gcaaagtagc tcggagacct
      541 gcgggagctg cggcagcccg ccgtaggcag cagcagcagc aacaacaaca gcagcagcag
      601 caacagcagc agctgcaaca gcagcagccg tctccgtcct cctccactgc ccagaccacc
      661 cagttgcagc cgaacctggt gtctgcctct gcagctgtgc ttcttacgct tcaggccgcc
      721 gtagacagca accaggctcc gggatccgtg gttcccgtgt ccacgactcc ctcgggagat
      781 gatgtgaagc ccatcgacct cacagtgcaa gtcgagtttg cagctgctga aggggcagcc
      841 gccgctgccg ccgcctcaga gctagaggct gctacggctg ggctggaggc cgctgagtgc
      901 actctgggcc ctcagctggt ggtggtaggg gaagagggct tccctgacac tggctctgac
      961 cactcgtact ccttgtcctc gggtaccacg gaggaggagc tcctgcgcaa gctgaacgag
     1021 cagcgggaca tcttggccct gatggaagtg aagatgaagg agatgaaggg tagcatccgc
     1081 catctgcgtc tcaccgaggc caagctccgt gaagaacttc gagagaagga tcgtctgctt
     1141 gccatggctg tcatccgtaa gaagcacggc atgtgaatgg ttccccccag aaacctgcag
     1201 aattcgtgac tccttccagc ccaaggaatc ctcaggcaaa tgttgtactc cccagtattc
     1261 ctgttgacag tgccgaggtt taggacagcg ggactccagt tggtcagttg gcaccttctt
     1321 tcgtctcctc gtgaagtaag agttggggac ttcagaatct ggtgacacca gcagttatga
     1381 ctttgtctct cactccccag tttatgttgc agattctggt tatacacagg cttcagaacc
     1441 actgaacttg gaacttaccc tggagggggt gcagatggaa ctcttaaggg actgtgggtt
     1501 tgaggaaacc acttcttcag gttggccagc aatcagagac agctttgctg tgtgtagtga
     1561 taagagatct cagtaacatc gtttctcctt tccatgctac ccggttcagg tgcagtctgt
     1621 gattctgatg gggactagct gatctgtgcc tctgtctctt aggacctctc tacccagaag
     1681 gtcatttatg agagggctct gggtgacttg ctgatggaga tccagctcac cagggactta
     1741 ggtttatctc gttatgtttg ctactggtta caaattctat tttctgtaca attagactga
     1801 agttttcact gtttggcaaa acaaattaaa caaaaaagta aggttttt
//
