LOCUS       NM_183021               7896 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus thyroid adenoma associated (Thada), transcript variant
            1, mRNA.
ACCESSION   NM_183021 XM_619495 XM_916970
VERSION     NM_183021.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7896)
  AUTHORS   Zhang,Y., Han,S., Liu,C., Zheng,Y., Li,H., Gao,F., Bian,Y., Liu,X.,
            Liu,H., Hu,S., Li,Y., Chen,Z.J., Zhao,S. and Zhao,H.
  TITLE     THADA inhibition in mice protects against type 2 diabetes mellitus
            by improving pancreatic beta-cell function and preserving beta-cell
            mass
  JOURNAL   Nat Commun 14 (1), 1020 (2023)
   PUBMED   36823211
  REMARK    GeneRIF: THADA inhibition in mice protects against type 2 diabetes
            mellitus by improving pancreatic beta-cell function and preserving
            beta-cell mass.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7896)
  AUTHORS   Han,S., Zhang,Y., Zheng,Y., Liu,C., Jiang,Y., Zhao,S. and Zhao,H.
  TITLE     Thada Is Dispensable for Female Fertility in Mice
  JOURNAL   Front Endocrinol (Lausanne) 13, 787733 (2022)
   PUBMED   35480478
  REMARK    GeneRIF: Thada Is Dispensable for Female Fertility in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7896)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 7896)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 7896)
  AUTHORS   Drieschner,N., Kerschling,S., Soller,J.T., Rippe,V., Belge,G.,
            Bullerdiek,J. and Nimzyk,R.
  TITLE     A domain of the thyroid adenoma associated gene (THADA) conserved
            in vertebrates becomes destroyed by chromosomal rearrangements
            observed in thyroid adenomas
  JOURNAL   Gene 403 (1-2), 110-117 (2007)
   PUBMED   17889454
  REMARK    GeneRIF: A domain of Thada conserved in vertebrates becomes
            destroyed by chromosomal rerrangements observed in thyroid
            adenomas.
REFERENCE   7  (bases 1 to 7896)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 7896)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044550.1, EF222207.1 and AC132455.3.
            
            On Apr 6, 2010 this sequence version replaced NM_183021.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF222207.1, SRR1660813.164553.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AK044550.1         1-92
            93-6006             EF222207.1         1-5914
            6007-7896           AC132455.3         177761-179650       c
FEATURES             Location/Qualifiers
     source          1..7896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.02 cM"
     gene            1..7896
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /note="thyroid adenoma associated"
                     /db_xref="GeneID:240174"
                     /db_xref="MGI:MGI:3039623"
     exon            1..115
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            116..260
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            261..355
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            356..486
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            487..635
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            636..668
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            669..717
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            718..905
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1000
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1221
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1913
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2065
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2221
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2344
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2468
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2623
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2831
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2967
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3104
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3263
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3421
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3531
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3664
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3778
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3901
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..3993
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4083
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4215
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..4384
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4385..4503
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4598
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4972
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            4973..5091
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            5092..5164
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5318
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            5319..5450
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            5451..5620
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     exon            5621..7896
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6464..6469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /note="hexamer: TATAAA"
     polyA_site      6485
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /note="major polyA site"
     polyA_site      6535
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
     regulatory      7855..7860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
                     /note="hexamer: AATAAA"
     polyA_site      7881
                     /gene="Thada"
                     /gene_synonym="6530405K19; A930021O22; GITA"
ORIGIN      
        1 ggaccggttt ttggatcgcg caccacgtta caagccgcag ggacgcggta gacttgacgg
       61 gcttccgggt ctcgtccaga ggtggcgacg ctttgcagac gtcctcgggc acgaggagaa
      121 actctccact ggaccactgc ctcaagttct tccttcttgc agagcgctgt tcatcctgtg
      181 taagatgggt gtgaagaaga aaagagaaat gcaggttgct gcgctgactg tctgtcatca
      241 ggacatggaa actttgagat cttttgctga tatggaaggg aaaaatctag cctctttgct
      301 gttacattgt gtacagctca cagatggagt gtcacaaatc cactctatta aacagattgt
      361 gcctctcttg gagaaggtcg ataaaaacgg tgtgtgcgat cctgctattc agagttgttt
      421 ggatattcta gcaggcattt atttttcctt gactctgaag aaccccttga agaaagtttt
      481 ggccagctca ctcaatggcc tacctgaggt ttttctaact caggcaacac acagttttac
      541 ttttcatctt caagaagaat tagatactgc tgacttatat tcttatagaa aagtaatgga
      601 taacatatct tcctgcatgg agaactttaa cctgggtaga gcaagtgtgg ttaatctgct
      661 taaagatgtg cttcattttc tgcagaagag tttaattgaa atcctggaag aaaacaggaa
      721 gtttgctgga aatcgtattg ttcaaacaca gttaatgagt gacttgctgg taggtgttag
      781 agttgccatg acattggtac agaaagtaca ggggccccag ggcagcctct ggaatgactc
      841 cagctcaccc atctggcaga gtatgtgtgg cttgctgagc atcttcacca agttcttaaa
      901 tgacgatgac ctactgcaga ctgttgagag tacatctgga ttagctgtta ttcttttcat
      961 taagaccatg ttccggccat ctgaaaagct tcctggattg atcagcagct tgcttctccg
     1021 gtctgctgag tgcactagca tccctgagtg gctcatgaat agctgtagga gcctttgctg
     1081 tactgatgtg ccagcctcaa ctctcttatt cctgtgtcag ggaacacttg ctatgctgga
     1141 ctggcaggat gggagcatgg gccccagcgg ggaggctttg ctcttggata tagtgcatgt
     1201 tttgttcacc ttgagttcac agattaagga gtccacatta gatatgttcc tgtctagaat
     1261 cctggcatct tggaccagtt cagccataca gatccttgaa tcaggctcct caggcttaaa
     1321 gggtcatctg aacggggact catgcgtacc taggagactt ctggagtatg tctacacaca
     1381 ctgggagcac ccgttagacg ctctgagaca tcaaaccaaa gtcatgttca ggaatctctt
     1441 gcaaatgcac cggctcacta tggaaggggc agatttggcc actgacccct tctgtctgga
     1501 gttgactaag agtcttctgc agctggaatg gcacattaaa gggaagtacg cttgccttgg
     1561 ctgtttggtg gagactcttg gaattgaaca tattttggca atagataaaa ccattccatc
     1621 tcaaattcta gaggtgatgg gagaccagtc attggtacct tatgcaagtg acctcttgga
     1681 aaccatgttt aaaaatcata agagccattt gaagtcccaa actgtcacca atacctggat
     1741 ggacaagtgg catgagactt gggttttccc tgtcctttct gtactgtgtg gaggaaactt
     1801 ggatcagaga tcttatgtga ttgattatta cctgccacgg atactgaatt acagccccga
     1861 gagcctgcac tacatggtgc acattcttca ggcatctact gatactggaa ctgggtcttg
     1921 taatcacaga ggagctctgg gagctttgat ggcgtgtctc cgaacagcta gagctcatgg
     1981 acatcttcag tctgcaactc aggcctggga gaaccttgtg tgcagtgcaa gggtaaagca
     2041 aggcttaatt caccaacact gccaagtgcg gatagataca ctaggcttgc tttgtgaaag
     2101 taatcggagt acagaagtgg tctctacaga agaaatgcag tgggttcagt tttttatcac
     2161 ttacaacctc aacagccagt ctccaggggt gcgccagcag atttgctcac tccttaaaaa
     2221 gttgttttgc aggatacaag aaagttcaca ggtactttat aaattggaac agagaaaatc
     2281 tacacctgac tcagagaacg ggtccatcag agagcagcct tctgtcactt tacagcagta
     2341 taagaatttc atgtcgtctg tttgcaacat tctctttgaa gcattgtttc ctgggtcttc
     2401 ctactcgact agattttcag ctttaactat cttaggatca gtagctgaag tgtttcctga
     2461 tccagaaggt aacatccaaa cagtgtatca gctgagtcat gatattgatg ctggccgtta
     2521 ccaaatactt atggagtgtt tcactagtac ttttgaagaa gtgaaaacct tagcatttga
     2581 tcttctgatg aagctgtcgt cagtaacagc tggacagttc caggattctg agaagctgca
     2641 agacctgttc caggcagcgc tggaactcag cactagcacc aagccttatg attgtgtgac
     2701 agcctcctac ctgctgaact tgctgatacg gcaggatgct ctgccagccg tcctgtctgc
     2761 ctcttcccca cagcagctca cacgtggagc aggagagacg tctgctgtgc tggaaaggaa
     2821 cacattagtg gttattaaat gcttgatgga aaaccttgag gatgaaatat ctcaagctga
     2881 gaactctctg cttcaggctg cgtcttcatt tccaatgtat gggagagtcc actgtataac
     2941 aagagctttt cagaggttgc ctctaaatga cctgcggctg gcgagcgagt ggaggccgct
     3001 gctggggagg cttctgctgc tgtcctacag gctttccact gtggtggccc ctgtcatcca
     3061 gagctcctct cctgaaggcc tcatccctgt ggacactgac tcagcgtcag caagccgctt
     3121 gcagctcatt ctcaatgaga tccagccacg ggatactaac gattacttca accacaccaa
     3181 aatactgaaa gaatgtgata gctttgattt ggaggacttg agtaccagtg tctcaaatat
     3241 tgatagttct gcagaagtta aaggtaaaga agaaaaagcg tgtgacgtaa ctgctcagat
     3301 ggtcctcgcg tgctgctgga ggagcatgaa ggaagtggct ttgcttctcg gcacgctctg
     3361 ccagcttctc cctgtgcagc ctgggccaga atcttctaat gtgttcctaa cagtgcagca
     3421 ggttaaagaa ataggagatt actttaaaca acaccttttg cagtccagac acagaggagc
     3481 atttgaactg gcttatactg gttttgtgaa actcactgaa atattgaaca ggtgctctaa
     3541 tgtgagtctg caaaagctgc cagagcagtg gctgcggagc gttctggagg aaattaaagg
     3601 cagtgatccc tcatccaaac tttgtgctac aaggcgcagt gctgggattc ccttctacat
     3661 acaggcattg ttggcatctg aaccaaagaa gagtagaatg gacttgctga aaataacaat
     3721 gagggagctg atctccttgg ctttgtctgc agatgactca aagggcagag tccctcaggt
     3781 tcatgcttta aacattctcc gagccttgtt cagagacacc cgtctgggag aaaacattat
     3841 cccctatgtt gctggtggag ctaaggctgc aattctgggc tttacatccc ctgtctgggc
     3901 agtgagaaat tcatccacac ttctctttag ttccttgatc acaagagttt ttggcgttaa
     3961 gagaggaaag gatgaagttt ccaaaacaaa tagaatgaca ggaagagagt ttttctctcg
     4021 tttcccagaa ctgtacccat ttcttctcaa acagttggaa actgtggcca gtacagtaga
     4081 cagtgaactg ggagagcctg atcgccaccc tggcatgttc ctcttactcc tggtgttgga
     4141 gagactgtac ccatcgccga tggacggcac atcatctgcg ctcagcttgg ccccttttgt
     4201 tcctttcatt atcaggtgtg gtcgctcacc tatttaccgc tcccgggaaa tggcagctcg
     4261 tgcgttggtc cccttcatta tgatagacca aataccgagt accctctgtg ctctactgaa
     4321 ctcactcccc aacagcactg accagtgttt ccgacaaaac cacattcatg ggacacttct
     4381 gcaagttttt catctgttac aagcctacat tacagactgc agacacagaa caaatgcaga
     4441 tttcctgcaa gagctgagtg atgtcactgc ttgtaccaaa gccaaactct ggctggccat
     4501 gaggcaaaat ccatgcctgg taaccagagc tgtgtatatt gatattctct tcctgctgac
     4561 taactgcctg gacagacctg aggaaggcaa gcagacagct ctggagagtc ttggcttctg
     4621 ggaagatgtg agaagaatta tcctggaatc agagctgatt aaggggttcc cctggacctt
     4681 caaggtgcca ggcttgcccc agtatctgca gagccttacc aaactagcca tccctgaagt
     4741 gtgggcgtcg cttgctgaag ctaaagggca ggcgactgct gttcctctct ccttctctcg
     4801 gcttctgaag tcttcctttc ctgaagtgcg cttgctagcc ctagacacct tgctggaaag
     4861 ggcaaggtcc tctgaacagg agcagaagga gccacttcct ctgctctgca gtatgggaga
     4921 ggagcttcta ctgctggcga tgaaggaaga ccaccccgga tgtttctgca gggtcctaaa
     4981 gattctctat cacttgaacc ccagcgaatg gcttccccag acagagtgct atgctcacct
     5041 ctccccaaag gagttcctca tgtggagtat ggatattgct tccaatgaca gatctgaaat
     5101 ccagggagta gctctgaagc ttgcctctaa aataattgcc taccgtgtac agagttgcga
     5161 gaagaacaaa gattcactcg cccctgagct gaggcagtgg gtccagctgg ttgtctggtc
     5221 ctgtggagac catcttccta ctgcatctag actggctgtt gctgaagtcc tcacaagcac
     5281 cgcacccctg ttcctcacca gtccccagcc cattctcgaa ctgcagggca cactttctct
     5341 ctggaggtgt gttcttaccc ttctgcagag tgaggagcaa accgtcagag aggcagccac
     5401 agaaatcgtg acaacagcca tgtcacaagg aaacacttgc cagtcaacag aatttgcctt
     5461 ctgccaggtg gatgcctcca ttgctctgac cctggcctta gctgttctgt gtgacttgct
     5521 ccagcagtgg gaccagctgg agccaggact gcctattcta ctgggatggc tactggaaga
     5581 gggtgatgac ctcgagggcc acgtgcagag cccacatcag ggggaagaag agcatatctt
     5641 tgaaaaatca gaagtcaact tctgggctga gactctgacc ttcgtgaaat ccctgtgtag
     5701 gcaactcttc catctcctct gtcaatctgg ctggcagtcc cctcactccc agaagctctg
     5761 tcacttgcaa aggatagcat cagagcagag tcacctcatc tctcagctct tcagagaact
     5821 tccactctca gctgagtttt tgaagacagt ggaatacacg aggctgcgca ttcaggagga
     5881 aaggactttg gctgtcctga ggctgttggc ctgcctggaa ggaaaggagg gtctcagagc
     5941 cgaagactgc cctagggaat ggagacaagt aatggcccca agaacagaag cagcatgctg
     6001 aagaaaggtg gctgggcctc agctcaggtc tgcaagacac atacatggtg gacaccaatt
     6061 gaaactcttt tcctcaggtg cctccccact tctgggagtc taggcttctg tcccttccta
     6121 ctgaggacct tgtctgcagc acactcattc aaggcaaccc aattagttgc agctacctag
     6181 gaagtgaagc tgctgtctgc aggtttactg tctccaggtg caagccacct gcaggcctga
     6241 actagtcagt tctatcccaa agccagcgcc catttcccca tacactgact gcattgaatt
     6301 cagtcttagc ttacatgtct ctctctctct ccctctctct ctctctctct ctctctcaca
     6361 cacacacaca cacacagtgc tctttctctc tctctcacac acacacacac acacagtgct
     6421 cttttgtttg gttttgttta gcaaatacct atttggtcat atttataaac ttttattcca
     6481 ttttagtaaa gggtatgttt gattctggga atattaagaa cctacaacat gcaaatactt
     6541 gcattttact atctacctgc ccaagtcctt cagtggtcca tattaagagt ccccactgtc
     6601 ttacccagaa atgcctgcga aggctaggaa cccttgtcac ccatcactgg cctcagctat
     6661 tggacagagc ctggggaaag ggaagcctga gcaaatgctt aattcattcg gtgccaccac
     6721 tgtacaccgt cctgtgattg gtggagacag cagagtgcca agaaacacat ttacccactt
     6781 taggtgattc catatagaaa ccggaagggt ttgtcacttc aggcccagcc cagctggcat
     6841 cctcgaacac cagcaggtgg cgctcttgca cacattatgc tgctggtcta gcgcttttag
     6901 cctactcttt taaaactttt taaaactatt atcagcacct gtacatgata ggagggcacc
     6961 catgccccag catggatgtc tgaggaagtt gagggacaac tttatagagc cagctctctc
     7021 ctcccgcctc tgcatgggct tcagagatcg actcaggctc aggcttgcag agcacgcacg
     7081 tttatccact gagccgcatc atgtggccca gcttaccatg ctacgtgtgc ttccagagta
     7141 cgtgacaccc gcagacgctt gccttcaatt cacggcgtgg atgtgttgct gtagtgtgat
     7201 ccacattccc agttatccac aaagaccatg ccagccatag aaggaacttg tagggcctat
     7261 agctatgttc agatacttct cagtgagtag tcacttagaa tcatgaggaa aagggagaga
     7321 ggcattctat atgctagctc ctcctgcaga gacgctgaca tttcacatgt aattggtctc
     7381 agaagaaaac catcctgcac cacagaaaca cggctgtgct ggagtagaga cctgtacgca
     7441 gggagaggga agtcaggagc tgtgtccttc ctggccatga agaggaacag aaatcccctg
     7501 ggtggtctta gaaacactca gcaccctggg gtctgtgtgg ccctgtagta attacctagt
     7561 taggcagtgc aacccactgc tgatgaaaaa ttgaaaacct aacattgttt agtttgtttt
     7621 gggctttgct tttagttttc tgagtcaggc ttgctattta cactaggctg gcctcaaact
     7681 tgtgttaatc ctcctgcctt tgcctcctga gtgccaggat tccaggcata caccactata
     7741 cccagcatta cactacttta agatctagtt ggtgagaggg gctggtggtg acaaccttgg
     7801 gagattaatt ctgaacagga cccaaccttc cctctcccct tccatctaaa atgaaataaa
     7861 agcagttaca tgacaataaa accatctcac attggc
//
