LOCUS       NM_009377               1809 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus tyrosine hydroxylase (Th), mRNA.
ACCESSION   NM_009377
VERSION     NM_009377.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1809)
  AUTHORS   Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
            Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
            Borowiak,M.
  TITLE     Pancreatic organogenesis mapped through space and time
  JOURNAL   Exp Mol Med 57 (1), 204-220 (2025)
   PUBMED   39779976
REFERENCE   2  (bases 1 to 1809)
  AUTHORS   Khan,M.S.H., Kim,S.Q., Ross,R.C., Corpodean,F., Spann,R.A.,
            Albarado,D.A., Fernandez-Kim,S.O., Clarke,B., Berthoud,H.R.,
            Munzberg,H., McDougal,D.H., He,Y., Yu,S., Albaugh,V.L., Soto,P.L.
            and Morrison,C.D.
  TITLE     FGF21 acts in the brain to drive macronutrient-specific changes in
            behavioral motivation and brain reward signaling
  JOURNAL   Mol Metab 91, 102068 (2025)
   PUBMED   39571902
REFERENCE   3  (bases 1 to 1809)
  AUTHORS   He,X.B., Guo,F., Zhang,W., Fan,J., Le,W., Chen,Q., Ma,Y., Zheng,Y.,
            Lee,S.H., Wang,H.J., Wu,Y., Zhou,Q. and Yang,R.
  TITLE     JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and
            aggravates chronic inflammatory pain
  JOURNAL   Acta Neuropathol Commun 12 (1), 201 (2024)
   PUBMED   39716224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1809)
  AUTHORS   Kaminski,C.L., Banik,D.D., Schmitd,L.B. and Pierchala,B.A.
  TITLE     Identification of a postnatal period of interdependent neurogenesis
            and apoptosis in peripheral neurons
  JOURNAL   Biol Open 13 (11) (2024)
   PUBMED   39527572
REFERENCE   5  (bases 1 to 1809)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1809)
  AUTHORS   Duncan,M., DiCicco-Bloom,E.M., Xiang,X., Benezra,R. and Chada,K.
  TITLE     The gene for the helix-loop-helix protein, Id, is specifically
            expressed in neural precursors
  JOURNAL   Dev Biol 154 (1), 1-10 (1992)
   PUBMED   1426618
REFERENCE   7  (bases 1 to 1809)
  AUTHORS   Jones,J.M., Meisler,M.H., Seldin,M.F., Lee,B.K. and Eicher,E.M.
  TITLE     Localization of insulin-2 (Ins-2) and the obesity mutant tubby
            (tub) to distinct regions of mouse chromosome 7
  JOURNAL   Genomics 14 (1), 197-199 (1992)
   PUBMED   1358794
REFERENCE   8  (bases 1 to 1809)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   9  (bases 1 to 1809)
  AUTHORS   Iwata,N., Kobayashi,K., Sasaoka,T., Hidaka,H. and Nagatsu,T.
  TITLE     Structure of the mouse tyrosine hydroxylase gene
  JOURNAL   Biochem Biophys Res Commun 182 (1), 348-354 (1992)
   PUBMED   1346248
REFERENCE   10 (bases 1 to 1809)
  AUTHORS   Yamada,K., Sakai,M., Okamura,H., Ibata,Y. and Nagatsu,I.
  TITLE     Detection of tyrosine hydroxylase and
            phenylethanolamine-N-methyltransferase messenger RNAs in the mouse
            adrenal gland and the brain by in situ hybridization
  JOURNAL   Histochemistry 97 (3), 201-206 (1992)
   PUBMED   1348741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB868869.1, AK139568.1 and CJ194802.1.
            
            On Jun 5, 2018 this sequence version replaced NM_009377.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M69200.1, SRR1660811.193515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               BB868869.1         2-360
            360-1764            AK139568.1         548-1952
            1765-1809           CJ194802.1         406-450
FEATURES             Location/Qualifiers
     source          1..1809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.06 cM"
     gene            1..1809
                     /gene="Th"
                     /note="tyrosine hydroxylase"
                     /db_xref="GeneID:21823"
                     /db_xref="MGI:MGI:98735"
     exon            1..124
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1531
                     /gene="Th"
                     /EC_number="1.14.16.2"
                     /note="tyrosine 3-hydroxylase"
                     /codon_start=1
                     /product="tyrosine 3-monooxygenase"
                     /protein_id="NP_033403.1"
                     /db_xref="CCDS:CCDS22036.1"
                     /db_xref="GeneID:21823"
                     /db_xref="MGI:MGI:98735"
                     /translation="MPTPSASSPQPKGFRRAVSEQDTKQAEAVTSPRFIGRRQSLIED
                     ARKEREAAAAAAAAAVASAEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRALK
                     VFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAR
                     EDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRKLIAEIAFQYKQGE
                     PIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSIPQLEDV
                     SHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELL
                     GHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAG
                     LLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYAS
                     RIQRPFSVKFDPYTLAIDVLDSPHTIRRSLEGVQDELHTLTQALSAIS"
     exon            125..349
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            350..524
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            525..613
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            614..681
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            682..732
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            733..878
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1014
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1084
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1141
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1237
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1371
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1783
                     /gene="Th"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Th"
                     /note="hexamer: AATAAA"
     polyA_site      1783
                     /gene="Th"
                     /note="major polyA site"
ORIGIN      
        1 gtggagacag aactcgggac caccagcttg cactatgccc acccccagcg cctcctcgcc
       61 acagcccaag ggcttcagaa gagccgtctc agagcaggat accaagcagg ccgaggctgt
      121 cacgtcccca aggttcattg gacggcggca gagtctcatc gaggatgccc gcaaggagcg
      181 ggaggcagca gcagctgcag cagcggctgc ggtagcctcc gcggaacctg ggaacccatt
      241 ggaggctgtg gtattcgagg agagggatgg aaatgctgtt ctcaacctgc tcttctcctt
      301 gaggggtaca aaaccctcct cactgtctcg ggctttgaaa gtgtttgaga catttgaagc
      361 caaaatccac cacttagaga cccggcctgc ccagaggcca ctggcaggaa gcccccacct
      421 ggagtacttt gtgcgcttcg aggtgcccag tggcgacctg gctgccctcc tcagttctgt
      481 gcgtcgggtg tctgacgatg tgcgcagtgc cagagaggac aaggttccct ggttcccaag
      541 gaaagtgtca gagttggata agtgtcacca cctggtcacc aagtttgacc ctgacctgga
      601 cctggaccat ccgggcttct ctgaccaggc gtatcgccag cgccggaagc tgattgcaga
      661 gattgccttc caatacaagc agggtgagcc aattccccac gtggaataca caaaggagga
      721 aattgctacc tggaaggagg tatacgccac gctgaagggc ctctatgcta cccatgcctg
      781 ccgggaacac ctggaggctt tccagcttct ggaacggtac tgtggctacc gagaggacag
      841 cattccacag ctggaggatg tgtctcactt cttgaaggaa cggactggct tccagctgcg
      901 acccgtggcc ggtctactgt ctgcccgtga ttttctggcc agtctggcct tccgtgtgtt
      961 tcagtgcaca cagtacatcc gtcatgcctc ctcacctatg cactcacccg agccagactg
     1021 ctgccacgag ctgctgggac acgtacccat gttggctgac cgcacatttg cccagttctc
     1081 ccaggacatt ggacttgcat ctctgggggc ttcagatgaa gaaattgaaa aactctccac
     1141 ggtgtactgg ttcactgtgg agtttgggct gtgtaaacag aatggggagc tgaaggctta
     1201 cggtgcaggg ctgctgtctt cctatggaga gctcctgcac tccctgtcag aggagcccga
     1261 ggtccgggcc tttgacccag acacagcagc cgtgcagccc taccaagatc aaacctacca
     1321 gccggtgtac ttcgtgtcag agagcttcag tgatgccaag gacaagctca ggaactatgc
     1381 ctctcgtatc cagcgcccat tctctgtgaa gtttgacccg tacaccctgg ccattgatgt
     1441 actggacagt cctcacacca tccggcgctc cttagagggg gtccaggatg agctgcacac
     1501 cctgacccaa gcactgagtg ccattagcta aatgcatagg gtaccaccca caggtgccag
     1561 gggcctttcc caaagttccc agccccttct ccaacctttc ctggcccaga ggctttccca
     1621 tgtgtgtggc tggacccttt gatgggctgc tcttggtccc cctcctccac tgcttctcaa
     1681 ccacatctta ctactgcatg cgctccagga tggtcctgca ttcctcctgc ccttcatgct
     1741 gtattctacc ctgattatta tctcaataaa ggaaggaaag gtcaaaaaaa aaaaaaaaaa
     1801 aaaaaaaaa
//
