LOCUS       NM_001145164            2816 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus T cell specific GTPase 2 (Tgtp2), mRNA.
ACCESSION   NM_001145164 XM_006537467 XM_011251340 XR_031267
VERSION     NM_001145164.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Khaminets,A., Hunn,J.P., Konen-Waisman,S., Zhao,Y.O.,
            Preukschat,D., Coers,J., Boyle,J.P., Ong,Y.C., Boothroyd,J.C.,
            Reichmann,G. and Howard,J.C.
  TITLE     Coordinated loading of IRG resistance GTPases on to the Toxoplasma
            gondii parasitophorous vacuole
  JOURNAL   Cell Microbiol 12 (7), 939-961 (2010)
   PUBMED   20109161
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Carlow,D.A., Marth,J., Clark-Lewis,I. and Teh,H.S.
  TITLE     Isolation of a gene encoding a developmentally regulated T
            cell-specific protein with a guanine nucleotide
            triphosphate-binding motif
  JOURNAL   J Immunol 154 (4), 1724-1734 (1995)
   PUBMED   7836757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645688.12.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011251340.1, XM_006537467.1, XR_031267.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088858.1, AK172580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AL645688.12        35731-35980         c
            251-2816            AL645688.12        28964-31529         c
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.06 cM"
     gene            1..2816
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /note="T cell specific GTPase 2"
                     /db_xref="GeneID:100039796"
                     /db_xref="MGI:MGI:3710083"
     exon            1..250
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /inference="alignment:Splign:2.1.0"
     exon            251..2816
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1516
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /note="Irgb6 homologue; interferon-gamma-inducible GTPase
                     Ifggb6 protein"
                     /codon_start=1
                     /product="T-cell-specific guanine nucleotide
                     triphosphate-binding protein 2"
                     /protein_id="NP_001138636.1"
                     /db_xref="CCDS:CCDS48781.1"
                     /db_xref="GeneID:100039796"
                     /db_xref="MGI:MGI:3710083"
                     /translation="MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSV
                     IEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYP
                     HPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQ
                     MGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVS
                     NVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKA
                     GALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFP
                     HLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALL
                     NSKALFEKKVGPYISEPPEYWEA"
     regulatory      1758..1763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /note="hexamer: AATAAA"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /note="hexamer: AACAAA"
     polyA_site      1781
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
                     /note="major polyA site"
     polyA_site      1806
                     /gene="Tgtp2"
                     /gene_synonym="100039796; TGTP"
ORIGIN      
        1 agaaaagtgt agagagcaag ggctgtgtgt ggaccagtaa ggacaaagaa actcagggag
       61 atccaactgt ccatcccacg gtctcctcct ttctatgtgc agttcttcct gggacaccag
      121 aactccacac ctcatgtcct ctcttcataa acatcctgaa tctgaattca gttttagata
      181 aagacgttcc ctaagaggaa agccatcaca gaagtgttat tgccaccaga tcaaggtcac
      241 cactgctgag cttctaccat acagagccat ggcttgggcc tccagctttg atgcattctt
      301 taagaatttt aaaagggaaa gcaaaatcat ctctgaatat gacatcacct tgattatgac
      361 ttacatagag gaaaataagc tacagaaagc tgtttctgta attgaaaagg tactgagaga
      421 catcgagagt gctcctctgc acatagctgt gacaggggaa acaggcgcag ggaagtccac
      481 tttcatcaat accctgaggg gggtggggca tgaagaaaaa ggtgcagccc ccactggcgc
      541 aatagagaca accatgaaga gaactccata cccacaccca aagcttccca acgtgacaat
      601 atgggacctg cctggcattg ggaccactaa cttcacacca caaaactatc tgacagaaat
      661 gaagtttggt gagtatgact tcttcattat catctcagct acacgtttca aagaaaatga
      721 tgcacaactg gccaaagcca ttgcacagat ggggatgaat ttctactttg tcagaaccaa
      781 gatagacagc gacttagata atgaacagaa gtttaagcct aagagtttca ataaggagga
      841 agtcctcaag aatattaagg attactgctc taatcatctt caggagtctc tcgacagtga
      901 gcctccagtc ttcctagtct ctaacgttga tatatcgaag tatgacttcc caaagctgga
      961 aactaaactc ctacaggatc tcccagccca caagcgtcac gtattctcac tgtctttgca
     1021 aagtcttact gaggccacca ttaactacaa gagagattcc ctgaagcaaa aagtcttcct
     1081 agaagccatg aaggctggag cattagccac cattccactt ggtggcatga tcagtgatat
     1141 cttagagaat ctggatgaaa cattcaatct ctacaggtct tactttgggc tggatgatgc
     1201 ttcactggaa aacattgccc aggatttgaa catgtctgtg gatgacttca aggtacacct
     1261 tcgatttccc catttgtttg cagaacacaa tgatgagtcc ttagaagaca agctatttaa
     1321 atatatcaaa cacatttctt cagttactgg tgggccagtc gctgcagtca cttactatcg
     1381 catggcttat tatttgcaga atctctttct tgatactgca gccaatgatg ccatagctct
     1441 tctgaatagt aaagcacttt ttgagaagaa ggtgggacca tatatatctg agccccccga
     1501 gtactgggaa gcttgaaaaa ataaggcatg agttccaatc agtgttcact cttagcttca
     1561 ccttgggcac gatttttagc ctagtcccga tgggggaaaa agtctcagtg gcaggccaga
     1621 ggattcatgc tttcccttct cctgatccag aagatcacca tggcaaaggc ttatagtgct
     1681 tagagtagaa aagaagtgtc ttcaacatcg tgcaaatatg acagcaaagt atatttgcat
     1741 taaaatcatt tcttaaaaat aaaacaaaca catgatgcgg atttggtttg catttttctc
     1801 ctcaaatgaa tcctgaatct tttactccta tgaaagtttt catgtgcttt tacattctca
     1861 ctggcagccc tgattgtcac attgccaagt ggtattttgg aaacagggac atcgggtacc
     1921 ctacagagtg tagacaaaca cgttttgacc cagaactggg tgttccagga gattctacat
     1981 gttgtcaagt gaacaactaa cattaataac cccatgtgct aaccaaaccc aggctctttg
     2041 ctgaccatgg tagtattggt gctttgtcac taaggcatgt aagcacctcc acattgcttc
     2101 ttcataggtg tatagatgta tggaagattg ttttaagcta gtcactccga tgtgccctgc
     2161 cacactagac ttcatttatt ctttgcatct attgattccc tgaactctgt ggtcctccct
     2221 ctctccagcc tccactgaca cctttctcca gtcagttcaa ccatcaactc acgtgagaga
     2281 acagagtgaa cctgcctctc tgtcctgtgg cagagcttgt aacacctaca ttgtggcctg
     2341 aagatgaatg tgagcctgtg gagagatgtg cccacccaca ctcctaaaat ataaacccct
     2401 gactcagtat agaaaacact cactgcccaa agttcggtca gactctaatc tacttctgtg
     2461 tgtttcaata cttcacagag gaaagctatt gctgacatct tgcagaaaga agttgtcagc
     2521 agctggcatg gactctgaag ggaagctaga cagcccatga tggcaaacat ggctctgcca
     2581 ggccttgccc ttctcttcca ttccctctgc cttgctaaaa aactaacaaa caaacaaaac
     2641 ccattacatt ctattcctaa agctagcctc caaggcctat cttgtttatt tgatcacttc
     2701 ctcttcctga ggtcaactac caatgtgtag ttatcaaaga attgatgtcc agcaatcaaa
     2761 agcccctttt ggctccccta attaatatgc acaattaaaa ttaaacactt catcct
//
