LOCUS       NM_011579               2809 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus T cell specific GTPase 1 (Tgtp1), mRNA.
ACCESSION   NM_011579
VERSION     NM_011579.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2809)
  AUTHORS   Lee,Y., Yamada,H., Pradipta,A., Ma,J.S., Okamoto,M., Nagaoka,H.,
            Takashima,E., Standley,D.M., Sasai,M., Takei,K. and Yamamoto,M.
  TITLE     Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii
            vacuoles mediates host defense
  JOURNAL   Life Sci Alliance 3 (1), e201900549 (2019)
   PUBMED   31852733
  REMARK    GeneRIF: Initial phospholipid-dependent Irgb6 targeting to
            Toxoplasma gondii vacuoles mediates host defense.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2809)
  AUTHORS   Langlais,D., Barreiro,L.B. and Gros,P.
  TITLE     The macrophage IRF8/IRF1 regulome is required for protection
            against infections and is associated with chronic inflammation
  JOURNAL   J Exp Med 213 (4), 585-603 (2016)
   PUBMED   27001747
REFERENCE   3  (bases 1 to 2809)
  AUTHORS   Budry,L., Balsalobre,A., Gauthier,Y., Khetchoumian,K., L'honore,A.,
            Vallette,S., Brue,T., Figarella-Branger,D., Meij,B. and Drouin,J.
  TITLE     The selector gene Pax7 dictates alternate pituitary cell fates
            through its pioneer action on chromatin remodeling
  JOURNAL   Genes Dev 26 (20), 2299-2310 (2012)
   PUBMED   23070814
REFERENCE   4  (bases 1 to 2809)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 2809)
  AUTHORS   Traver,M.K., Henry,S.C., Cantillana,V., Oliver,T., Hunn,J.P.,
            Howard,J.C., Beer,S., Pfeffer,K., Coers,J. and Taylor,G.A.
  TITLE     Immunity-related GTPase M (IRGM) proteins influence the
            localization of guanylate-binding protein 2 (GBP2) by modulating
            macroautophagy
  JOURNAL   J Biol Chem 286 (35), 30471-30480 (2011)
   PUBMED   21757726
  REMARK    Erratum:[J Biol Chem. 2013 Apr 19;288(16):11504]
REFERENCE   6  (bases 1 to 2809)
  AUTHORS   Hussain,S., Zwilling,B.S. and Lafuse,W.P.
  TITLE     Mycobacterium avium infection of mouse macrophages inhibits
            IFN-gamma Janus kinase-STAT signaling and gene induction by
            down-regulation of the IFN-gamma receptor
  JOURNAL   J Immunol 163 (4), 2041-2048 (1999)
   PUBMED   10438942
REFERENCE   7  (bases 1 to 2809)
  AUTHORS   Carlow,D.A., Teh,S.J. and Teh,H.S.
  TITLE     Specific antiviral activity demonstrated by TGTP, a member of a new
            family of interferon-induced GTPases
  JOURNAL   J Immunol 161 (5), 2348-2355 (1998)
   PUBMED   9725230
REFERENCE   8  (bases 1 to 2809)
  AUTHORS   Sorace,J.M., Johnson,R.J., Howard,D.L. and Drysdale,B.E.
  TITLE     Identification of an endotoxin and IFN-inducible cDNA: possible
            identification of a novel protein family
  JOURNAL   J Leukoc Biol 58 (4), 477-484 (1995)
   PUBMED   7561525
REFERENCE   9  (bases 1 to 2809)
  AUTHORS   Lafuse,W.P., Brown,D., Castle,L. and Zwilling,B.S.
  TITLE     Cloning and characterization of a novel cDNA that is
            IFN-gamma-induced in mouse peritoneal macrophages and encodes a
            putative GTP-binding protein
  JOURNAL   J Leukoc Biol 57 (3), 477-483 (1995)
   PUBMED   7884320
REFERENCE   10 (bases 1 to 2809)
  AUTHORS   Carlow,D.A., Marth,J., Clark-Lewis,I. and Teh,H.S.
  TITLE     Isolation of a gene encoding a developmentally regulated T
            cell-specific protein with a guanine nucleotide
            triphosphate-binding motif
  JOURNAL   J Immunol 154 (4), 1724-1734 (1995)
   PUBMED   7836757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163978.1, BY238768.1, AL627237.44 and AA177827.1.
            
            On Oct 27, 2007 this sequence version replaced NM_011579.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY215777.1, AK089836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AK163978.1         2-57
            57-404              BY238768.1         60-407
            405-1747            AK163978.1         406-1748
            1748-2068           AL627237.44        45234-45554         c
            2069-2570           AA177827.1         1-502
            2571-2809           AL627237.44        44493-44731         c
FEATURES             Location/Qualifiers
     source          1..2809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.98 cM"
     gene            1..2809
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /note="T cell specific GTPase 1"
                     /db_xref="GeneID:21822"
                     /db_xref="MGI:MGI:98734"
     exon            1..243
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /inference="alignment:Splign:2.1.0"
     exon            244..2809
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1509
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /EC_number="3.6.5.-"
                     /note="interferon-gamma-inducible GTPase Ifggb5; T-cell
                     specific GTPase; T-cell-specific guanine nucleotide
                     triphosphate-binding protein 2; Interferon-gamma-inducible
                     GTPase Ifggb6 protein"
                     /codon_start=1
                     /product="T-cell-specific guanine nucleotide
                     triphosphate-binding protein 1"
                     /protein_id="NP_035709.3"
                     /db_xref="CCDS:CCDS24593.1"
                     /db_xref="GeneID:21822"
                     /db_xref="MGI:MGI:98734"
                     /translation="MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSV
                     IEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYP
                     HPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQ
                     MGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVS
                     NVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKA
                     GALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFP
                     HLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALL
                     NSKALFEKKVGPYISEPPEYWEA"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /note="hexamer: AATAAA"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /note="hexamer: AACAAA"
     polyA_site      1774
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
                     /note="major polyA site"
     polyA_site      1785
                     /gene="Tgtp1"
                     /gene_synonym="Gtp2; Ifggb6; Irgb6; Mg21; Tgtp; Tgtp2"
ORIGIN      
        1 gtagagagca agggctgtgt gtggacaagt aaggacaaag aaactcaggg agatccaact
       61 gtccatccca cggtctcctc ctttctatgt gcagttcttc ctgggacacc agaactccac
      121 acctcatgtc ctctcttcat aaacatcctg aatctgaatt ccagttttag ataaagacgt
      181 tccctaagag gaaagccatc acagaagtgt tattgccacc agatcaaggt caccactgct
      241 gagcttctac catacagagc catggcttgg gcctccagct ttgatgcatt ctttaagaat
      301 tttaaaaggg aaagcaaaat catctctgaa tatgacatca ccttgattat gacttacata
      361 gaggaaaata agctacagaa agctgtttct gtaattgaaa aggtactgag agacatcgag
      421 agtgctcctc tgcacatagc tgtgacaggg gaaacaggcg cagggaagtc cactttcatc
      481 aataccctga ggggggtggg gcatgaagaa aaaggtgcag cccccactgg ggcaatagag
      541 acaaccatga agagaactcc atacccacac ccaaagcttc ccaacgtgac aatatgggac
      601 ctgcctggca ttgggaccac taacttcaca ccacaaaact atctgacaga aatgaagttt
      661 ggtgagtacg acttcttcat tatcatctca gctacacgtt tcaaagaaaa tgatgcacaa
      721 ctggccaaag ccattgcaca gatggggatg aatttctact ttgtcagaac caagatagac
      781 agcgacttag ataatgaaca gaagtttaag cctaagagtt tcaataagga ggaagtcctc
      841 aagaatatta aggattactg ctctaatcat cttcaggagt ctctcgacag tgagcctcca
      901 gtcttcctag tctctaacgt tgatatatcg aagtatgact tcccaaagct ggaaactaaa
      961 ctcctacagg atctcccagc ccacaagcgc cacgtcttct cactgtcttt gcaaagtctt
     1021 actgaggcca ccattaacta caagagagat tccctgaagc aaaaagtctt cctagaagcc
     1081 atgaaggctg gagcattagc caccattcca cttggtggca tgatcagtga tatcttagag
     1141 aatctggatg aaacattcaa tctctacagg tcttactttg ggctggatga tgcttcactg
     1201 gaaaacattg cccaggattt gaacatgtct gtggatgact tcaaggtaca ccttcgattt
     1261 ccccatttgt ttgcagaaca caatgatgag tccttagaag acaagctatt taaatatatc
     1321 aaacacattt cttcagttac tggtgggcca gtcgctgcag tcacttacta tcgcatggct
     1381 tattatttgc agaatctctt tcttgatact gcagccaatg atgccatagc tcttctgaat
     1441 agtaaagcac tttttgagaa gaaggtggga ccatatatat ctgagccccc cgagtactgg
     1501 gaagcttgaa aaaataaggc atgagttcca atcagtgttc actcttagct tcaccttggg
     1561 cacgattttt agcctagtcc cgatggggga aaaagtctca gtggcaggcc agaggattca
     1621 tgctttccct tctcctgatc cagaagatca ccatggcaaa ggcttatagt gcttagagta
     1681 gaaaagaagt gtcttcaaca tcgtgcaaat atgacagcaa agtatatttg cattaaaatc
     1741 atttcttaaa aataaaacaa acacatgatg tggatttggt ttgcattttt ctcctcaaat
     1801 gaatcctgaa tcttttactc ctatgaaagt tttcatgtgc ttttacattc tcactggcag
     1861 ccctgattgt cacattgcca agtggtattt tggaaacagg gacatcgggt accctacaga
     1921 gtgtagacaa acacgttttg acccagaact gggtgttcca ggagattcta catgttgtca
     1981 agtgaacaac taacattaat aaccccatgt gctaaccaaa cccaggctct ttgctgacca
     2041 tggtagtatt ggtgctttgt cactaaggca tgtaagcacc tccacattgc ttcttcatag
     2101 gtgtatagat gtatggaaga ttgttttaag ctagtcactc cgatgtgccc tgccacacta
     2161 gacttcattt attctttgca tctattgatt ccctgaactc tgtggtcctc cctctctcca
     2221 gcctccactg acacctttct ccagtcagtt caaccatcaa ctcacgtgag agaacagagt
     2281 gaacctgcct ctctgtcctg tggcagagct tgtaacacct acattgtggc ctgaagatga
     2341 atgtgagcct gtggagagat gtgcccaccc acactcctaa aatataaacc cctgactcag
     2401 tatagaaaac actcactgcc caaagttcgg tcagactcta atctacttct gtgtgtttca
     2461 atacttcaca gaggaaagct attgctgaca tcttgcagaa agaagttgtc agcagctggc
     2521 atggactctg aagggaagct agacagccca tgatggcaaa catggctctg ccaggccttg
     2581 cccttctctt ccattccctc tgccttgcta aaaaactaac aaacaaacaa aacccattac
     2641 attctattcc taaagctagc ctccaaggcc tatcttgttt atttgatcac ttcctcttcc
     2701 tgaggtcaac taccaatgtg tagttatcaa agaattgatg tccagcaatc aaaagcccct
     2761 tttggctccc ctaattaata tgcacaatta aaattaaaca cttcatcct
//
