LOCUS       NM_177726               3315 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transglutaminase 6 (Tgm6), transcript variant 1, mRNA.
ACCESSION   NM_177726 XM_917859
VERSION     NM_177726.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3315)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3315)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3315)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   4  (bases 1 to 3315)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3315)
  AUTHORS   Zheng,R., Li,Z., He,F., Liu,H., Chen,J., Chen,J., Xie,X., Zhou,J.,
            Chen,H., Wu,X., Wu,J., Chen,B., Liu,Y., Cui,H., Fan,L., Sha,W.,
            Liu,Y., Wang,J., Huang,X., Zhang,L., Xu,F., Wang,J., Feng,Y.,
            Qin,L., Yang,H., Liu,Z., Cui,Z., Liu,F., Chen,X., Gao,S., Sun,S.,
            Shi,Y. and Ge,B.
  TITLE     Genome-wide association study identifies two risk loci for
            tuberculosis in Han Chinese
  JOURNAL   Nat Commun 9 (1), 4072 (2018)
   PUBMED   30287856
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3315)
  AUTHORS   Fukui,M., Kuramoto,K., Yamasaki,R., Shimizu,Y., Itoh,M.,
            Kawamoto,T. and Hitomi,K.
  TITLE     Identification of a highly reactive substrate peptide for
            transglutaminase 6 and its use in detecting transglutaminase
            activity in the skin epidermis
  JOURNAL   FEBS J 280 (6), 1420-1429 (2013)
   PUBMED   23331848
  REMARK    GeneRIF: TG6 is an active enzyme and reacts to glutamine donor
            substrates in the skin.
REFERENCE   7  (bases 1 to 3315)
  AUTHORS   Guan,W.J., Wang,J.L., Liu,Y.T., Ma,Y.T., Zhou,Y., Jiang,H.,
            Shen,L., Guo,J.F., Xia,K., Li,J.D. and Tang,B.S.
  TITLE     Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase
            6 mutants sensitize cells to apoptosis
  JOURNAL   Biochem Biophys Res Commun 430 (2), 780-786 (2013)
   PUBMED   23206699
REFERENCE   8  (bases 1 to 3315)
  AUTHORS   Thomas,H., Beck,K., Adamczyk,M., Aeschlimann,P., Langley,M.,
            Oita,R.C., Thiebach,L., Hils,M. and Aeschlimann,D.
  TITLE     Transglutaminase 6: a protein associated with central nervous
            system development and motor function
  JOURNAL   Amino Acids 44 (1), 161-177 (2013)
   PUBMED   21984379
  REMARK    GeneRIF: Localization of mRNA and protein in the mouse identified
            abundant expression of TG6 in the central nervous system.
REFERENCE   9  (bases 1 to 3315)
  AUTHORS   Nakagawa,N., Yamamoto,M., Imai,Y., Sakaguchi,Y., Takizawa,T.,
            Ohta,N., Yagi,N., Hatta,I., Hitomi,K., Takizawa,T., Takeda,J.,
            Tsuda,T., Matsuki,M. and Yamanishi,K.
  TITLE     Knocking-in the R142C mutation in transglutaminase 1 disrupts the
            stratum corneum barrier and postnatal survival of mice
  JOURNAL   J Dermatol Sci 65 (3), 196-206 (2012)
   PUBMED   22258055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833804.16.
            
            On Aug 23, 2022 this sequence version replaced NM_177726.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112420.1, AY159126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL833804.16        33487-33567
            82-255              AL833804.16        45949-46122
            256-498             AL833804.16        46628-46870
            499-617             AL833804.16        47575-47693
            618-746             AL833804.16        49027-49155
            747-924             AL833804.16        51364-51541
            925-1063            AL833804.16        51972-52110
            1064-1167           AL833804.16        53400-53503
            1168-1410           AL833804.16        53571-53813
            1411-1752           AL833804.16        55149-55490
            1753-1907           AL833804.16        61473-61627
            1908-2041           AL833804.16        61875-62008
            2042-3315           AL833804.16        63159-64432
FEATURES             Location/Qualifiers
     source          1..3315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.19 cM"
     gene            1..3315
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /note="transglutaminase 6"
                     /db_xref="GeneID:241636"
                     /db_xref="MGI:MGI:3044321"
     exon            1..81
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2195
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /EC_number="2.3.2.13"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 6
                     isoform 1"
                     /protein_id="NP_808394.1"
                     /db_xref="CCDS:CCDS16734.1"
                     /db_xref="GeneID:241636"
                     /db_xref="MGI:MGI:3044321"
                     /translation="MAGVRITKVDWQHSKNGAAHHTQDYPCSELVVRRGQLFSLTLDL
                     SRVLDSEEALIFTVETGPHASEALHTKAVFQTAELEIGDTWTAAKEEQTENTITVSLS
                     SPSNAVIGRYLLSVRPSSRRKHSDRKLGQFILLFNPWCPEDDVFLDSEEERQEYVLND
                     SGVIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPSHQEDPATDVSHRHDPVYVT
                     RIISAMVNSNNDRGVVQGQWQGKYGGGTNPLNWRGSVAILQKWFKGRYKPVKYGQCWV
                     FAGVMCTVLRCLGIATRVVSNFNSAHDTDGNLSVDKYVDSYGRTLEDLTEDSMWNFHV
                     WNESWFARQDLGPSYDGWQVLDATPQEESEGMFRCGPASVTAIREGDVHLAHDGPFVF
                     AEVNADYITWLWHEDKRRERVYSDTKKIGRCISTKAVGSDSRVDITGLYKYPEGSRKE
                     RQVYSKAVKKLLSVEAWGRRRRIRRASVRGVWRDDLLEPVTKPSITGKFKVLEPPVLG
                     QDLKLALCLTNLTARAQRVRVNVSGATILYTRKPVAEILRESHTVKLGPLEEKKIPVT
                     ISYSQYKGDLTEDKKILLAAMCLVSKGEKLLVEKDITLEDFITIKVLGPAVVGVTVTV
                     EVLVINPLSESVKDCVLMVEGSGLLQGQLSIEVPSLQPQEKALIQFNITPSKSGPRQL
                     QVDLVSSQFPDIKGFVIIHVATAK"
     exon            82..255
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            256..498
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            499..617
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            618..746
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            747..924
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1063
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1167
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1410
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1752
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1907
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2041
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..3315
                     /gene="Tgm6"
                     /gene_synonym="TGM3L; TGY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatgtggatc tggctggaga tcctgacgaa ctacactctg ctgcccaggg agcaggcgtc
       61 catctggctg ttgcatggca ggggtcagaa tcaccaaggt cgactggcag cattcgaaaa
      121 atggtgctgc ccaccacacc caagattacc cttgctctga actggtggtt cgaagaggcc
      181 agttattcag tctcaccctg gatctgagta gagtcctgga cagcgaggag gccctcatct
      241 tcaccgtgga gacaggacct cacgcatccg aggctctcca caccaaagcc gtattccaga
      301 cagcagagct agaaataggg gacacttgga cagctgcaaa agaggaacag acagagaaca
      361 caatcaccgt cagcctctcg agcccttcca atgcagtcat tggccgatac ctgctgagtg
      421 tcaggccctc ttcccgcagg aaacacagtg accgaaagct gggccagttt attctcctgt
      481 tcaatccctg gtgcccagag gacgatgtgt ttctggactc agaggaagag aggcaggagt
      541 acgtgcttaa cgacagtggc gtcatcttcc gaggcgtgga gaagcacatc cgagcccagg
      601 gctggaacta cgggcagttt gaagaggaca tcctgaacat ctgcctctcc attctggacc
      661 gaagtcctag tcaccaggag gacccagcca ccgatgtgtc ccaccgccat gacccagtct
      721 atgtcaccag gatcatcagt gccatggtga acagcaacaa tgaccgaggt gtggtacaag
      781 gccagtggca gggcaaatat ggaggtggta ccaacccact gaactggcgt ggcagtgtgg
      841 ccatcctaca gaagtggttc aagggcaggt acaagccagt caaatatggc cagtgctggg
      901 tcttcgctgg agtcatgtgc acagtcctca ggtgcctggg gatcgcaacc agggtggtgt
      961 ccaacttcaa ctcagcccac gacaccgatg gcaatctgag tgtggacaaa tatgtggact
     1021 cttatggccg aaccctggag gacctgacag aagacagcat gtggaacttc cacgtctgga
     1081 atgagagctg gtttgcacga caggacctgg gcccatccta tgatggctgg caggttctgg
     1141 atgccactcc ccaagaggag agcgaaggta tgttccggtg tggtcctgcc tcggtcactg
     1201 ccatccgtga aggtgacgtg catctagccc atgatggccc cttcgtcttt gcggaggtca
     1261 atgcagacta catcacctgg ctatggcacg aggacaagag gcgggagcgt gtgtactcgg
     1321 acaccaagaa gatcggcagg tgcatcagta ccaaggcagt gggcagtgac tctcgtgtgg
     1381 acattacagg cctctacaag tatccagaag ggtcccggaa ggagaggcag gtgtacagca
     1441 aagctgtgaa gaaactgcta agtgtggaag cctgggggag gaggaggcgg atccgcaggg
     1501 ccagcgtgcg cggtgtctgg cgcgacgacc tcctggaacc ggtcaccaaa cccagcatca
     1561 ctggcaagtt caaagtgctg gagccaccgg tgctcggcca ggacctgaag ctggctctgt
     1621 gcttgaccaa cctcaccgcc agggcccagc gggtccgagt caatgtgagc ggcgccacca
     1681 tcctctatac ccgcaagcct gtggcagaga tcctgcgtga atcccacacc gtgaagctgg
     1741 ggccactaga agaaaagaag atcccagtca caatatctta ctctcagtac aaaggagacc
     1801 tgacagaaga caagaagatc ctgttggctg ccatgtgcct tgtcagtaag ggcgagaagc
     1861 tcctggtgga gaaggacatt accctggagg acttcatcac catcaaggtg ctggggccag
     1921 cagtggtagg agtgacagtc actgtggaag tcttggtgat caaccccctc tcggagagcg
     1981 taaaggactg tgtgctgatg gtagagggca gtggccttct ccaaggacag ctaagtattg
     2041 aggtgcccag cttgcagcct caggagaagg ccttgattca attcaacata accccttcca
     2101 agagtggccc caggcagctg caggtggacc ttgtcagctc acagttccca gacatcaagg
     2161 gctttgtgat catccacgtg gctacagcca agtgatgggc cacgaggaac tggggaggac
     2221 tttgtccatc tgtctgtttc tcccatataa gagacagggg tctcaggttg gtcctgcttc
     2281 tgtctttggc ctccatgagc ttcggcaagg tccttcccag tgcattgatg gaggtgctgg
     2341 actcagtaac ccttcaccct caggacaagt ggctgatgta agagcagagg gaccctccaa
     2401 ctcttgtcac ccttctgctg ggagagtggc atgtcccaga tttctgagag ccctggccca
     2461 agagctcagc cagctcagcc caggtaactc accacttctt gcctttctat catctcttca
     2521 aatgtcctga ccacatttgg acccaagaat tctccaagcc ggagcatccc cattatagag
     2581 gagcctttct gaagccataa gacaaagcag aaacaaggtt gagaaccaag tggtccccca
     2641 actcatgttc ttaaaagagc actggatttt aagcaacagg agattcttcc ctatgtggaa
     2701 acactgactc tggatttggg tgatggagct aaaactgcct gagaacagct gaagaagaca
     2761 aaggagttct cccccaaact gggcagcatg gatatactcc agctctggcc atcctggagt
     2821 tcacaggact gccccagatc actcagccac tccttcttgg aactagaatg gcttgcacgg
     2881 tgccgatcct acacttggag tcaaagcagg acatggatgc ctggaatcag gaccagagta
     2941 gacacaacaa ggccatgaag aatatgccac tagatatgaa attcagcact gaaatttcta
     3001 gacagacatt aaaattaagc tacagtttaa gaacattaaa caaacaacag gtgcatctgc
     3061 aactcagtgc ctcttggata caaatgacgg tgagggaatt gcagagatgg ctcagctgtt
     3121 aagagtactt tctgatcttc tagaggggtt gagtttggtt cccagcactg gtgtcagaca
     3181 gctcacatac tataactcca actccagggc tccaacattt ctggtctctg tgggcaccca
     3241 cacttacctg ctgcatgtac accctcctcc caaacacatg caattaaaat aaaataaatc
     3301 cttttttaaa ataca
//
