LOCUS       NM_028799               2614 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transglutaminase 5 (Tgm5), transcript variant 1, mRNA.
ACCESSION   NM_028799
VERSION     NM_028799.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Cangkrama,M., Darido,C., Georgy,S.R., Partridge,D., Auden,A.,
            Srivastava,S., Wilanowski,T. and Jane,S.M.
  TITLE     Two Ancient Gene Families Are Critical for Maintenance of the
            Mammalian Skin Barrier in Postnatal Life
  JOURNAL   J Invest Dermatol 136 (7), 1438-1448 (2016)
   PUBMED   26975724
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Nakagawa,N., Yamamoto,M., Imai,Y., Sakaguchi,Y., Takizawa,T.,
            Ohta,N., Yagi,N., Hatta,I., Hitomi,K., Takizawa,T., Takeda,J.,
            Tsuda,T., Matsuki,M. and Yamanishi,K.
  TITLE     Knocking-in the R142C mutation in transglutaminase 1 disrupts the
            stratum corneum barrier and postnatal survival of mice
  JOURNAL   J Dermatol Sci 65 (3), 196-206 (2012)
   PUBMED   22258055
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Grenard,P., Bates,M.K. and Aeschlimann,D.
  TITLE     Evolution of transglutaminase genes: identification of a
            transglutaminase gene cluster on human chromosome 15q15. Structure
            of the gene encoding transglutaminase X and a novel gene family
            member, transglutaminase Z
  JOURNAL   J Biol Chem 276 (35), 33066-33078 (2001)
   PUBMED   11390390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844548.7.
            
            On Mar 9, 2022 this sequence version replaced NM_028799.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132482.1, AK009196.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AL844548.7         194650-194829       c
            181-375             AL844548.7         186477-186671       c
            376-621             AL844548.7         185778-186023       c
            622-740             AL844548.7         184091-184209       c
            741-869             AL844548.7         180476-180604       c
            870-1047            AL844548.7         179720-179897       c
            1048-1186           AL844548.7         162483-162621       c
            1187-1290           AL844548.7         161727-161830       c
            1291-1530           AL844548.7         161403-161642       c
            1531-1896           AL844548.7         157816-158181       c
            1897-2057           AL844548.7         157361-157521       c
            2058-2191           AL844548.7         155669-155802       c
            2192-2614           AL844548.7         155098-155520       c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..2614
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /note="transglutaminase 5"
                     /db_xref="GeneID:74176"
                     /db_xref="MGI:MGI:1921426"
     exon            1..180
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2345
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /EC_number="2.3.2.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein-glutamine gamma-glutamyltransferase 5"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 5
                     isoform 1"
                     /protein_id="NP_083075.1"
                     /db_xref="CCDS:CCDS16632.1"
                     /db_xref="GeneID:74176"
                     /db_xref="MGI:MGI:1921426"
                     /translation="MAQGCPITGLEVALTDLQSSQNNVRHHTEEISVDRLVVRRGQAF
                     SITLYFKNRGFQPGMDSIMFVAETGPLPDLAKGTRAVFSFTGSGGPSPWIASLEANRA
                     NSLEVSLCAPPIAAVGRYLLKIRIDSYQGFVTAYQLGEFILLFNPWCPADSVYLESEP
                     QRQEYVVNDYGFIYQGSKSWIRPCPWNYGQFEENIIDICLELLEKSLNFQVDPSTDCA
                     LRGSPVYTSRVVCAMINSNDDNGVLNGNWSENYVDGINPAEWTGSVAILKQWHATGCQ
                     PVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRILENMK
                     KDTVWNFHVWNECWMARKDLPPGYGGWQVLDATPQETSNGLYCCGPASVKAIKEGEID
                     LNYDTRFAFSMVNADCMSWLVYGGKEQKLHQDTATVGNFISTKSIQSDERDDITESYK
                     YEEGSLQEREVFLKALQKLQATRSQGPHQANSNPFSSVPPRHNSARSPDSPSLQPSDV
                     LQVSLKFELLDSPKMGQDINFVLLAVNMSPQFKDLKLNLSAQSLLHDGSPLVPFWQDT
                     AFITLFPEEEKSYPCKILYSQYSQYLSTDKLIRISALGEEKNSPEKILVNKIITLTFP
                     GIMINVLGAAFVNQPLTVQVVFSNPLSEPVEDCVLTLEGSGLFRKQQRVLIGVLKPHH
                     KASITLKTVPFKSGQRQIQANLRSNRFKDIKGYKNVYVDIGL"
     exon            181..375
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            376..621
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            622..740
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            741..869
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1047
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1186
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1290
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1530
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1896
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2057
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2191
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2614
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /note="hexamer: AATAAA"
     polyA_site      2614
                     /gene="Tgm5"
                     /gene_synonym="2310007C07Rik; TGase-5; TGMX; TGx"
                     /note="major polyA site"
ORIGIN      
        1 agttgtgctc tgccctgtca gaggtggcag tgcagcagct ggccccacct ccagtgtctc
       61 tcggagcctc ggcatggaag gggaagcagc cactccagga tcagtttcct gaagctccaa
      121 tccatccagc tgtctgtggg ggagcagccc aggagccaga aggagccacc atggcccaag
      181 gctgccccat cacaggacta gaggtggccc tcacagacct ccagagctcc cagaataatg
      241 ttcggcacca cacggaagag atcagtgttg accggcttgt tgtccgccga ggccaggcct
      301 tctccatcac cctgtacttt aagaatcggg gcttccagcc aggcatggac agtatcatgt
      361 ttgtggctga gactggaccc ttgcccgatc tggccaaagg gactcgggca gtattcagct
      421 tcacaggcag tggtggccca agcccctgga ttgcgtccct ggaagccaac agggccaact
      481 ccctggaagt gagcctctgt gctcctccca tagcagccgt gggccgatac ctcctgaaaa
      541 ttcggatcga ctcctaccag ggttttgtca ctgcctacca gctgggggag tttatcctgc
      601 tcttcaatcc ctggtgccca gcggattcag tgtatctgga gagtgagccc cagaggcagg
      661 agtatgttgt gaacgattat ggcttcatct accaagggag caagagttgg atccgcccat
      721 gcccctggaa ctatgggcag tttgaagaga atatcataga tatctgcttg gagctgctag
      781 agaagagcct gaacttccag gttgacccat ccacagactg tgcccttcgg ggaagccctg
      841 tctacaccag cagagttgtg tgtgccatga taaacagcaa tgatgacaac ggagtgctca
      901 atggcaactg gagtgagaat tatgtggacg gcatcaaccc cgcggaatgg actggcagcg
      961 tggccatcct taagcagtgg catgccacag gctgccaacc agtgcgctat gggcaatgct
     1021 gggtctttgc tgctgtcatg tgcacagtga tgaggtgcct ggggatcccc acccgcgtga
     1081 tcaccaactt tgactctggc catgacaccg atgggaacct gatcattgat gagtattacg
     1141 acaacacagg caggattctg gagaatatga agaaggacac cgtctggaat ttccatgtgt
     1201 ggaatgagtg ttggatggca cgcaaggacc tccctcctgg atacggaggc tggcaggtgc
     1261 ttgatgctac acctcaggaa accagcaatg gtctctactg ctgtggccct gcttctgtca
     1321 aagccatcaa agagggagaa attgatctaa actatgacac acgctttgca ttttctatgg
     1381 tgaatgctga ctgcatgtcc tggcttgtct atggcgggaa ggagcagaaa cttcaccagg
     1441 acacagctac tgttgggaat tttatcagca ccaagagcat ccagagtgat gagcgtgatg
     1501 acatcaccga gagctacaag tatgaagaag gttcccttca agagagagag gtgttcctaa
     1561 aggctctgca gaagctacag gctacaaggt ctcaagggcc tcaccaagca aactccaatc
     1621 ccttcagctc cgtgccacca aggcacaaca gtgccaggag tcctgattca ccttcccttc
     1681 aacccagtga tgtcctccag gtctctctga agtttgagct gctcgactca cccaaaatgg
     1741 gccaagacat aaactttgtc ctgttggctg tcaatatgtc acctcagttc aaggatctca
     1801 aactcaactt gagtgcccag tctctgttgc atgatggcag ccccctggtt ccattctggc
     1861 aggacacagc attcatcaca ctgttccctg aagaagaaaa gagctaccct tgcaaaatcc
     1921 tctactcaca gtacagccag tatctgtcga cggacaagct aatccgcatc agtgccctgg
     1981 gtgaagagaa gaacagtcct gagaaaatcc tggtgaacaa gatcatcacc ttgactttcc
     2041 cgggcatcat gattaatgtt ctaggagctg cctttgtgaa tcagccgctc acagtccagg
     2101 tggtcttctc aaacccgctc tcagagccgg ttgaggactg tgtgctgacc ttggaaggaa
     2161 gtggtctctt tagaaagcag cagagagttc tcattggcgt cctcaaaccc catcacaaag
     2221 ccagcatcac tctgaagacc gtccccttca agagtggcca aaggcagatc caagctaatc
     2281 tgaggagcaa taggtttaaa gacatcaagg gctacaagaa cgtgtatgta gacattggct
     2341 tataaactct gagacagagg ctggagagat ggctcagcgg ttgacaggat gtgacagtcc
     2401 tttgcaaagg acttgggttc aattttccag aacccacaag gtggctcaca atcctctgta
     2461 accccatttt caggggaatc caaccagcat acatggtgca catacatgca tgcagaaaaa
     2521 aaaaaaaaac cccgactttc atacacataa agtgaaaata aataaatcta aaatttttta
     2581 aaatttcatt taaaataaac tccgagatat ggca
//
