LOCUS       NM_009374               4144 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus transglutaminase 3, E polypeptide (Tgm3), mRNA.
ACCESSION   NM_009374
VERSION     NM_009374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Ling S, Xu B, Luo Y, Fang X, Liu X, Wang A, Zhou Y, Zhang S, Zong
            W, Li W and Yao X.
  TITLE     Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by
            Inhibiting NF-kappaB Activation through Phosphorylated STAT3-TET3
            Signaling
  JOURNAL   J Invest Dermatol 142 (11), 2968-2977 (2022)
   PUBMED   35545140
  REMARK    GeneRIF: Transglutaminase 3 Attenuates Skin Inflammation in
            Psoriasis by Inhibiting NF-kappaB Activation through Phosphorylated
            STAT3-TET3 Signaling.
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Kuribayashi M, Kawaguchi Y, Teshima H, Yamaguchi H, Tatsukawa H and
            Hitomi K.
  TITLE     Investigation of mouse amniotic fluid for stimulating ability of
            keratinocyte differentiation depending on the fetal stage
  JOURNAL   Arch Biochem Biophys 711, 109003 (2021)
   PUBMED   34390735
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Frezza V, Terrinoni A, Pitolli C, Mauriello A, Melino G and Candi
            E.
  TITLE     Transglutaminase 3 Protects against Photodamage
  JOURNAL   J Invest Dermatol 137 (7), 1590-1594 (2017)
   PUBMED   28315658
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Cangkrama M, Darido C, Georgy SR, Partridge D, Auden A, Srivastava
            S, Wilanowski T and Jane SM.
  TITLE     Two Ancient Gene Families Are Critical for Maintenance of the
            Mammalian Skin Barrier in Postnatal Life
  JOURNAL   J Invest Dermatol 136 (7), 1438-1448 (2016)
   PUBMED   26975724
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Brennan BM, Huynh MT, Rabah MA, Shaw HE, Bisaillon JJ, Radden LA
            2nd, Nguyen TV and King TR.
  TITLE     The mouse wellhaarig (we) mutations result from defects in
            epidermal-type transglutaminase 3 (Tgm3)
  JOURNAL   Mol Genet Metab 116 (3), 187-191 (2015)
   PUBMED   26194162
  REMARK    GeneRIF: study concludes that the classic wellhaarig mutations
            result from defects in Tgm3
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Graff RJ, Kurtz ME, Paul R, Martin D and Roopenian DC.
  TITLE     Additional mapping of mouse chromosome 2 genes
  JOURNAL   Immunogenetics 33 (2), 96-100 (1991)
   PUBMED   1999355
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Koniukhov,B.V. and Kupriianov,S.D.
  TITLE     [The mutant gene wellhaarig disturbs the differentiation of hair
            follicle cells in the mouse]
  JOURNAL   Ontogenez 21 (1), 56-62 (1990)
   PUBMED   1694022
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Peters J, Ball ST and von Deimling A.
  TITLE     Localization of Blvr, biliverdin reductase, on mouse chromosome 2
  JOURNAL   Genomics 5 (2), 270-274 (1989)
   PUBMED   2793182
REFERENCE   9  (bases 1 to 4144)
  AUTHORS   Roopenian DC and Davis AP.
  TITLE     Responses against antigens encoded by the H-3 histocompatibility
            locus: antigens stimulating class I MHC- and class II
            MHC-restricted T cells are encoded by separate genes
  JOURNAL   Immunogenetics 30 (5), 335-343 (1989)
   PUBMED   2530167
REFERENCE   10 (bases 1 to 4144)
  AUTHORS   Graff,R.J., Martin-Morgan,D. and Kurtz,M.E.
  TITLE     Multiplicity of chromosome 2 histocompatibility genes: new loci,
            H-44 and H-45
  JOURNAL   Immunogenetics 26 (1-2), 111-114 (1987)
   PUBMED   3301647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808127.4.
            
            [WARNING] On May 11, 2023 this sequence was replaced by
            NM_009374.4.
            
            On Nov 30, 2013 this sequence version replaced NM_009374.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL808127.4         79393-79462         c
            71-244              AL808127.4         67940-68113         c
            245-484             AL808127.4         67218-67457         c
            485-603             AL808127.4         66426-66544         c
            604-732             AL808127.4         64989-65117         c
            733-910             AL808127.4         62000-62177         c
            911-1046            AL808127.4         61766-61901         c
            1047-1150           AL808127.4         54226-54329         c
            1151-1396           AL808127.4         53194-53439         c
            1397-1705           AL808127.4         49737-50045         c
            1706-1863           AL808127.4         47142-47299         c
            1864-1997           AL808127.4         43981-44114         c
            1998-4144           AL808127.4         41403-43549         c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..4144
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /note="transglutaminase 3, E polypeptide"
                     /db_xref="GeneID:21818"
                     /db_xref="MGI:MGI:98732"
     exon            1..70
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2145
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /EC_number="2.3.2.13"
                     /note="protein-glutamine gamma-glutamyltransferase E;
                     transglutaminase-3; transglutaminase E; E polypeptide;
                     protein-glutamine-gamma-glutamyltransferase"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase E
                     precursor"
                     /protein_id="NP_033400.2"
                     /db_xref="CCDS:CCDS38240.1"
                     /db_xref="GeneID:21818"
                     /db_xref="MGI:MGI:98732"
                     /translation="MSALQIQNVNWQVPMNRRAHHTDKFSSQDSIVRRGQPWEIILVC
                     NRSLESGEDLNFIVSTGPQPSESARTKAVFSISGRSTGGWNAALKANSGNNLAIAIAS
                     PVSAPIGLYTLSVEISSRGRASSLKLGTFIMLFNPWLQADDVFMSNHAERQEYVEEDS
                     GIIYVGSTNRIGMVGWNFGQFEEDILNISLSILDRSLNFRRDPVTDVARRNDPKYVCR
                     VLSAMINGNDDNGVISGNWSGNYTGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVF
                     AGTLNTVLRCLGVPSRVITNFNSAHDTDRNLSVDVYYDAMGNPLEKGSDSVWNFHVWN
                     EGWFVRTDLGPTYNGWQVLDATPQERSQGVFQCGPASVNAIKAGDVDRNFDMIFIFAE
                     VNADRITWIYNNRNNTQKQNSVDTHSIGKYISTKAVGSNSRMDVTDKYKYPEGSSEER
                     QVHQKALDKLKPNASFGATSSRNPEGEDKEPSISGKFKVTGILAVGKEVSLSLMLKNM
                     TNDRKTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQYERYLKA
                     DNMIRITAVCKVPDEAEVVVERDVILDNPALTLEVLEQAHVRKPVNVQMLFSNPLDQP
                     VNNCVLLVEGSGLLRGSLKIDVPSLRPKEKSRIRFEIFPTRSGTKQLLADFSCNKFPA
                     IKAMLPIDVSE"
     exon            71..244
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            245..484
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            485..603
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            604..732
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            733..910
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1046
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1150
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1396
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1705
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1863
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1997
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..4144
                     /gene="Tgm3"
                     /gene_synonym="TG E; TG(E); TGase E; TGase-3; TGE; we"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctcccca caccatctct gtcattccca gaggagcccc aggaaaggca gaagaagctg
       61 accatgagtg ctttacagat ccaaaacgtc aactggcagg tgcctatgaa tcgaagggcg
      121 catcacacag acaagttctc cagccaggat tccattgtgc ggagaggaca gccctgggag
      181 ataatattag tctgcaaccg aagtcttgag tctggagaag atctgaattt cattgtttcc
      241 acaggtcccc aaccctctga gtcagccagg acaaaggctg tattttccat ctctgggaga
      301 agcacgggtg gctggaatgc agcgctcaaa gccaacagtg gcaataatct ggccattgct
      361 attgccagtc ctgtcagtgc tcccatcgga ttgtacacac tgagtgttga gatctcctcc
      421 aggggcaggg cctcctctct gaaacttggc acgtttataa tgctcttcaa cccgtggttg
      481 caagcggatg atgtctttat gagtaaccac gccgaaagac aagagtatgt tgaagaagat
      541 tctggcatca tctatgtggg cagcacaaat cgaattggca tggttggctg gaactttgga
      601 cagtttgaag aagacattct gaacatcagc ctctccattt tggataggag tctgaatttc
      661 cgtcgtgacc ctgtgactga tgtggctcgc agaaatgacc ccaaatatgt ttgccgggtg
      721 ctgagtgcca tgattaatgg caatgatgac aacggtgtta tttctgggaa ctggagtggt
      781 aattacaccg gtggtgtgga cccaaggacc tggaatggta gtgtggagat cctcaagaac
      841 tggaaaaaat ctggcttcag gccagtccaa tttggccagt gctgggtctt tgctggaacc
      901 ctcaacacag tgctgcggtg cttgggggtt ccctctcggg tgatcaccaa cttcaactcg
      961 gctcacgaca cagatcgaaa cctcagtgtg gatgtgtact acgatgccat gggaaatccc
     1021 ctggagaaag gcagtgatag cgtgtggaat tttcacgtct ggaatgaagg ctggttcgtg
     1081 cggactgacc taggccccac atacaatgga tggcaggtcc tggatgccac cccccaggag
     1141 agaagtcaag gtgtgttcca gtgcggtcca gcttccgtta atgcaatcaa agccggtgat
     1201 gtggaccgga attttgacat gatcttcatc ttcgcggagg ttaatgcaga tcgcatcact
     1261 tggatctata ataatagaaa taacacccag aagcagaatt ctgtggacac tcactccatt
     1321 ggcaaataca tcagcaccaa ggcagtaggc agcaactctc gcatggatgt cacagacaag
     1381 tacaagtatc cagaaggttc cagtgaggaa agacaagtgc accaaaaggc tttggacaaa
     1441 ctcaaaccta acgcatcttt cggcgcaaca tcttcgagga atccagaagg ggaagacaag
     1501 gagcccagca tttctgggaa gttcaaggtc acggggatac tggcagtagg caaagaagtc
     1561 agtctgtccc tgatgctcaa aaacatgact aatgacagga agacagtgac gatgaacatg
     1621 acagcctgga ccatcgtcta caatggtacc cttgtccacg aagtgtggaa ggactcagcc
     1681 acaatatcct tggatcctga agaagaaata cagtatcctg tgaagatcgc atactctcag
     1741 tatgagagat acctgaaggc agacaacatg atccggatca cagctgtttg caaggtgccc
     1801 gatgaggctg aggtggtggt ggaacgggat gtcatcctgg ataatcctgc tttgaccctg
     1861 gaggtgctgg aacaggctca tgtgcggaag cccgtgaacg tgcagatgct tttctccaac
     1921 cccctggacc agccggtgaa taactgcgtg ctgctggtgg agggcagcgg cctgctgcgt
     1981 ggcagcctca agattgatgt gccatccctg cgccccaagg agaagtcccg catccgattt
     2041 gagattttcc ccactcggag tggcaccaag caactgctcg ctgacttttc ctgcaataaa
     2101 ttccctgcaa tcaaggccat gctgcccatt gatgtctctg agtgaccgac ccagcagcac
     2161 tcccacagac gtcggtgaca cagaccagac agcgctctcc tgtggagtga aactgttgcc
     2221 tatgctgtcc agcctgagaa gccctccatg tccccaaggc tgccagacat ggacttctag
     2281 caagtccccc aaccccccat tcaaccccac ccccacccct cacttcaagc taggccaggt
     2341 ccctcctggt ctgggacttg atcagttttg cacatttcct gattgcttcc cttggagacg
     2401 gcctgttctg tgaacccttg accccactga tcccttatag ccggcaatgc tgcagacaga
     2461 gcagcatcgg agctcaacac aaattgggaa gaaggcagcc tagactgctt gctgatccca
     2521 gcctgcaaaa tggataccct gttcctccct cagcctctat ggaaggcagg gagtagtcac
     2581 ataccacacc actcgcaccc ttacagtcaa aataaatgcc aaacaagtgc aatcatacac
     2641 caccagttcc aaccggctgc tttgcctgag ggcgaggggc tggggtcccc tcctctagag
     2701 aaagcccaga ttcaggaagg ccttgtccat tggctcagat gtccacagga aatgtgttag
     2761 ccctttgcgg cttcaagggc aaaaataggg aaccactgcc agctggttct agaaaacttt
     2821 gccataatgc cccaagtgaa atgaggcagt agttctctga gccactagtt ctcaacctgt
     2881 gggtcccgac ccctttaggg attgagtgac cttttcaaag agattgccta cgaccatcag
     2941 aaaatgcaga tatttacatt atcattcgta acagtagcaa aattacagtt atgaagtagc
     3001 aatgaaaata atttgtggtt ggaggtcacc acaacatgag gaactgtatt aaagggccac
     3061 agcgttagga aggttgagaa cctctgccct aatcactgtg tgtgcttagg aaactctttg
     3121 ggacctttgt gcaggtctca gaaagagaaa gaacttccaa gtatttttca ggacacttaa
     3181 ggcaaagtgg gatctgccca cacaggactg ttctctgctg tgttggccca ttttctgtgg
     3241 ccctaccgaa atatctgggg ctggaccata tccaaagaag ggggctgttt cgctcacaaa
     3301 ttggaggaat gaaagttgaa acatgatgac agtggctcta atatggacat catggcagtt
     3361 ggtagacata tataaaagag gaaagagtta catggcaaga aaggaagaaa ggaacgtagg
     3421 gccactgctg ttatgtcaca acaatccatt ctcataacac tgggtctcat aagaactgtg
     3481 tatccctccg gaaagcagta cccataatgg ctgcctggta cccctttcct gaaactctcc
     3541 atcacctctt aacataacca cactgagaac ttggcttcca gttcatgagc ctccggtcaa
     3601 aactcaaacc ccctcaaact atagcactcc cctgggccag gctctgctcc ctgtagccag
     3661 aagagcctgt gtttgtcagc cagctacagc actgttgccc tcaacaaact caaacacaat
     3721 gcctcagcat ttgcctgttg aaataacccc cagcaactga gcacacacct gcattcccag
     3781 ctcttgggaa gttgtgacaa ggggatcatg agttcaaaac cagcttgaac gagctattga
     3841 gaccctatct caaacaacca aaatagtctc aggcagactc cattagttca cccatagatg
     3901 ttctgaccag tcccagtcag gccgttctgt ttcattttta caaatttcag gaactattcc
     3961 aaacagaaat tgccacttca catctggccc aaagcctgct ccctttatac tcagctcagg
     4021 cctccctggt gactgtgaag gaaaagtcat ccttgccttc cttcctttcc ttcctgttgt
     4081 ttgatctgca gaattacagc agggggggag tcacaaggaa aatgactaaa gtgactttca
     4141 ctgg
//
