LOCUS       NM_009373               3549 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus transglutaminase 2, C polypeptide (Tgm2), mRNA.
ACCESSION   NM_009373
VERSION     NM_009373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3549)
  AUTHORS   Zhang,M., Li,L., Zhang,W., Li,M., Yan,G. and Tang,C.
  TITLE     TG2 participates in pulmonary vascular remodelling by regulating
            the senescence of pulmonary artery smooth muscle cells
  JOURNAL   Cell Signal 121, 111296 (2024)
   PUBMED   39009200
  REMARK    GeneRIF: TG2 participates in pulmonary vascular remodelling by
            regulating the senescence of pulmonary artery smooth muscle cells.
REFERENCE   2  (bases 1 to 3549)
  AUTHORS   Mo,C., Li,H., Yan,M., Xu,S., Wu,J., Li,J., Yang,X., Li,Y., Yang,J.,
            Su,X., Liu,J., Wu,C., Wang,Y., Dong,H., Chen,L., Dai,L., Zhang,M.,
            Pu,Q., Yang,L., Ye,T., Cao,Z. and Ding,B.S.
  TITLE     Dopaminylation of endothelial TPI1 suppresses ferroptotic
            angiocrine signals to promote lung regeneration over fibrosis
  JOURNAL   Cell Metab 36 (8), 1839-1857 (2024)
   PUBMED   39111287
REFERENCE   3  (bases 1 to 3549)
  AUTHORS   Freeberg,M.A.T., Thatcher,T.H., Camus,S.V., Huang,L., Atkinson,J.,
            Narrow,W., Haak,J., Dylag,A.M., Cowart,L.A., Johnson,T.S. and
            Sime,P.J.
  TITLE     Transglutaminase 2 knockout mice are protected from
            bleomycin-induced lung fibrosis with preserved lung function and
            reduced metabolic derangements
  JOURNAL   Physiol Rep 12 (12), e16012 (2024)
   PUBMED   38959068
  REMARK    GeneRIF: Transglutaminase 2 knockout mice are protected from
            bleomycin-induced lung fibrosis with preserved lung function and
            reduced metabolic derangements.
REFERENCE   4  (bases 1 to 3549)
  AUTHORS   Penumatsa,K.C., Sharma,Y., Warburton,R.R., Singhal,A., Toksoz,D.,
            Bhedi,C.D., Qi,G., Preston,I.R., Anderlind,C., Hill,N.S. and
            Fanburg,B.L.
  TITLE     Lung-specific interleukin 6 mediated transglutaminase 2 activation
            and cardiopulmonary fibrogenesis
  JOURNAL   Front Immunol 15, 1371706 (2024)
   PUBMED   38650935
  REMARK    GeneRIF: Lung-specific interleukin 6 mediated transglutaminase 2
            activation and cardiopulmonary fibrogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3549)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   6  (bases 1 to 3549)
  AUTHORS   Adel Moallem,S. and Hales,B.F.
  TITLE     Transglutaminase and clusterin induction during normal and abnormal
            limb development in the mouse
  JOURNAL   Biol Reprod 55 (2), 281-290 (1996)
   PUBMED   8828830
REFERENCE   7  (bases 1 to 3549)
  AUTHORS   Nagy,L., Saydak,M., Shipley,N., Lu,S., Basilion,J.P., Yan,Z.H.,
            Syka,P., Chandraratna,R.A., Stein,J.P., Heyman,R.A. and Davies,P.J.
  TITLE     Identification and characterization of a versatile retinoid
            response element (retinoic acid receptor response element-retinoid
            X receptor response element) in the mouse tissue transglutaminase
            gene promoter
  JOURNAL   J Biol Chem 271 (8), 4355-4365 (1996)
   PUBMED   8626785
REFERENCE   8  (bases 1 to 3549)
  AUTHORS   Ishii,I. and Ui,M.
  TITLE     Possible involvement of GTP-binding proteins in 1
            alpha,25-dihydroxyvitamin D3 induction of tissue transglutaminase
            in mouse peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 203 (3), 1773-1780 (1994)
   PUBMED   7945328
REFERENCE   9  (bases 1 to 3549)
  AUTHORS   Nakaoka,H., Perez,D.M., Baek,K.J., Das,T., Husain,A., Misono,K.,
            Im,M.J. and Graham,R.M.
  TITLE     Gh: a GTP-binding protein with transglutaminase activity and
            receptor signaling function
  JOURNAL   Science 264 (5165), 1593-1596 (1994)
   PUBMED   7911253
REFERENCE   10 (bases 1 to 3549)
  AUTHORS   Gentile,V., Saydak,M., Chiocca,E.A., Akande,O., Birckbichler,P.J.,
            Lee,K.N., Stein,J.P. and Davies,P.J.
  TITLE     Isolation and characterization of cDNA clones to mouse macrophage
            and human endothelial cell tissue transglutaminases
  JOURNAL   J Biol Chem 266 (1), 478-483 (1991)
   PUBMED   1670766
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL669824.13.
            
            On Nov 17, 2006 this sequence version replaced NM_009373.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152627.1, AK151776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL669824.13        135707-135808       c
            103-282             AL669824.13        132411-132590       c
            283-525             AL669824.13        128123-128365       c
            526-644             AL669824.13        123667-123785       c
            645-773             AL669824.13        121845-121973       c
            774-951             AL669824.13        120747-120924       c
            952-1087            AL669824.13        118739-118874       c
            1088-1191           AL669824.13        118055-118158       c
            1192-1434           AL669824.13        116528-116770       c
            1435-1704           AL669824.13        113537-113806       c
            1705-1865           AL669824.13        109541-109701       c
            1866-2002           AL669824.13        108263-108399       c
            2003-3549           AL669824.13        105821-107367       c
FEATURES             Location/Qualifiers
     source          1..3549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..3549
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /note="transglutaminase 2, C polypeptide"
                     /db_xref="GeneID:21817"
                     /db_xref="MGI:MGI:98731"
     exon            1..102
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2153
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /EC_number="2.3.2.13"
                     /EC_number="3.5.1.44"
                     /note="TGC; TG(C); TGase C; transglutaminase-2; TGase-2;
                     transglutaminase C; C polypeptide; tissue
                     transglutaminase;
                     protein-glutamine-gamma-glutamyltransferase; TGase II;
                     isopeptidase TGM2; transglutaminase II; protein-glutamine
                     deamidase TGM2; protein-glutamine dopaminyltransferase
                     TGM2; protein-glutamine serotonyltransferase TGM2;
                     protein-glutamine histaminyltransferase TGM2;
                     protein-glutamine noradrenalinyltransferase TGM2"
                     /codon_start=1
                     /product="protein-glutamine gamma-glutamyltransferase 2"
                     /protein_id="NP_033399.1"
                     /db_xref="CCDS:CCDS16985.1"
                     /db_xref="GeneID:21817"
                     /db_xref="MGI:MGI:98731"
                     /translation="MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLY
                     FEGRGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSL
                     QLCTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYV
                     LTQQGFIYQGSVKFIKSVPWNFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPI
                     YVGRVVSAMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQ
                     CWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNF
                     HCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPF
                     VFAEVNADVVDWIRQEDGSVLKSINRSLVVGQKISTKSVGRDDREDITHTYKYPEGSP
                     EEREVFTKANHLNKLAEKEETGVAMRIRVGDSMSMGNDFDVFAHIGNDTSETRECRLL
                     LCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLL
                     IEPAANSYLLAERDLYLENPEIKIRVLGEPKQNRKLVAEVSLKNPLSDPLYDCIFTVE
                     GAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNVI
                     IGPA"
     exon            103..282
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            283..525
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            526..644
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            645..773
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            774..951
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1087
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1191
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1434
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1704
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1865
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2002
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..3549
                     /gene="Tgm2"
                     /gene_synonym="G[a]h; TG2; TGase2; tTG; tTGas"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttcgcgc cgcgcggctg gtccgcagca ccgcgctggt gatcctcgct tgagtgtccc
       61 gctgcgtctg agctgtcgcc gctagcctgg ccatggcaga ggagctgctc ctggagaggt
      121 gtgatttgga gattcaggcc aatggccgtg accaccacac ggccgaccta tgccaagaga
      181 aactggtgct gcgtcgtggt cagcgcttcc ggctgactct gtacttcgag ggccgtggct
      241 acgaggccag cgtggacagc ctcacgttcg gtgctgtgac cggcccagat cccagtgaag
      301 aggcagggac caaggcccgc ttctcactgt ctgacaatgt ggaggaggga tcttggtcag
      361 cctcagtgct ggaccaacag gacaatgtcc tctcgctaca gctctgcacc ccagccaatg
      421 ctcctattgg cctgtaccgt ctcagcctag aggcttctac tggctaccag ggctccagct
      481 ttgtgctggg ccacttcatc ctgctctaca atgcctggtg cccagccgat gatgtgtacc
      541 tagactcaga ggaggagcga cgggaatatg tccttacgca acagggcttc atctaccaag
      601 gctctgtcaa gttcatcaag agtgtgcctt ggaactttgg gcagttcgag gatggaatcc
      661 tggatacctg cctgatgctc ttggatatga accccaagtt cctgaagaac cgtagtcggg
      721 actgctcacg ccgcagcagt cccatctatg tgggccgcgt ggtgagcgcc atggtcaact
      781 gcaatgatga ccagggtgtg cttctgggcc gctgggacaa caactatggg gatggtatca
      841 gtcccatggc ctggattggc agtgtggaca ttctgcggcg ctggaaggaa cacggctgtc
      901 agcaagtgaa gtacgggcag tgctgggtgt ttgcagcggt ggcctgcaca gtgctgcggt
      961 gcctcggcat ccctaccaga gtggtgacca actacaactc cgcccacgac cagaacagca
     1021 acctgctcat cgagtacttc cgaaatgagt tcggggagct ggagagcaac aagagcgaga
     1081 tgatctggaa cttccactgc tgggtggagt cctggatgac caggccagac ctacagccgg
     1141 gctatgaggg gtggcaggcc attgacccca caccacagga gaagagcgaa gggacatact
     1201 gttgtggccc agtctcagtg cgagccatca aggagggaga cctgagtacc aagtatgatg
     1261 cacccttcgt gtttgccgag gtcaacgctg atgtggtgga ctggatccgg caggaagatg
     1321 ggtctgtgct caaatccatc aaccgttcct tggtcgtggg gcagaagatc agcactaaga
     1381 gtgtgggccg tgatgaccgg gaggacatca cccataccta caagtaccca gaggggtcac
     1441 ccgaggagag ggaagtcttc accaaggcca accacctgaa caaactggca gagaaagagg
     1501 agacaggggt ggccatgcgc atccgagtgg gggacagtat gagcatgggc aacgacttcg
     1561 acgtgtttgc ccacatcggc aacgacacct cggagactcg agagtgtcgt ctcctgctct
     1621 gtgcccgcac tgtcagctac aacggggtgc tggggcccga gtgtggcact gaggacatca
     1681 acctgaccct ggatccctac tctgagaaca gcatcccact tcgaatcctc tacgagaagt
     1741 acagcgggtg cctgacagag tcaaacctca tcaaggtgcg gggccttctc atcgaaccag
     1801 ctgccaacag ctacctgctg gctgagagag atctctacct ggagaatccc gaaatcaaga
     1861 tccgggtcct gggagaaccc aagcaaaacc gcaaactggt ggctgaggtg tccctgaaga
     1921 acccactttc cgatcccctg tatgactgca tcttcactgt ggagggggct ggcctgacca
     1981 aggagcagaa gtctgtggaa gtctcagacc cggtgccagc gggcgatttg gtcaaggcac
     2041 gggtcgacct gttcccgact gatattggcc tccacaagct ggtggtgaac ttccagtgtg
     2101 acaagctgaa gtcggtgaag ggttaccgga atgttatcat cggcccggcc taagggaccc
     2161 cttcccagac tcaaccccac cacctgccaa cccccattca acctggtctt tatcctaaga
     2221 taatgagcaa cttcacccca ttcaggctga catggctgcc tggggcctct tcagaagaca
     2281 gtgtacttct ggcccaatcc tgttcctctg gatctatttc cccatctgtt cccttagctg
     2341 tgaggaaggt cctgtgccga cacagtgggt acctggcaag ggtaagagga gagccatcac
     2401 cagcactctg tatctctgca ttgtttgaac tgtctctgga gcctcagcgc aagcacaaag
     2461 ggaccgtgag cccactggct cgatgaagga accgaaggaa ccgcctgtcc cgtccaacaa
     2521 tttctcgccc gcctcccccc ctgaatggga accatatgtg ctaggcacct taagttctca
     2581 cagggacacc agcctgctga acatccatga gaaacttcag ggtacaaact gaggctgctg
     2641 tgctgtactg ggacagtagg caggccatca cttgcagggc cagtgggtga acttgaatac
     2701 agggactcca tctgtgacac cagctttgac ctgagcgggt cagagaggct atctggggat
     2761 gagcctggaa ggacgcggtt agggtgagga gttgagggag gggcggggag gccagagaac
     2821 tgggagtcag agcttgggtt taagccccaa ggagagctac actctatcct cctcttctgg
     2881 gcttgatcat tcttcaccag ggcagtgctt aaccaggggt ctcctggccc tatacttcta
     2941 aagcctgctg cccaggctca gtgcacttct gggaaggaga cactgcacca gacctgtacc
     3001 cgaggtgacc tgcttctcac ctatgactgg gttcctcaga tgcagttcca ggactatcca
     3061 caagctactc acacagtgcc tagactagat ttcacagaac gagccttaaa tatccacgct
     3121 ggtcgctaat cagcaggcca cacctccacc agcccctcct cctcagccag cacctctaga
     3181 cacagcacgt gtctccagaa aagcgtggaa gcctgtgtgg gggtcatcat cccaagttag
     3241 cccactccta cctctctgtg gctgggccct caaactagga aggctgcagt ggtggggggg
     3301 tctctgggtg atgaggtcag agtctctggg atcccctgaa atcccggaga agagcctggg
     3361 aagaatcaaa ctgatgcatt taacgtgttc tgctttacac agaggatcgc accgtgagcc
     3421 gtgctatctg tcctgtcccc acacggttct gtttcttttg gtctgtgcaa gcttcaggtt
     3481 ccaagcaggc agtaggcatg ctttcaaagc acatgtgaac actgaaataa aggtctattt
     3541 ttcacattc
//
