LOCUS       NM_001161714            2755 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transglutaminase 1, K polypeptide (Tgm1), transcript
            variant 3, mRNA.
ACCESSION   NM_001161714
VERSION     NM_001161714.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2755)
  AUTHORS   Blumenreich,S., Ben-Yashar,D.P., Shalit,T., Kupervaser,M.,
            Milenkovic,I., Joseph,T. and Futerman,A.H.
  TITLE     Proteomics analysis of the brain from a Gaucher disease mouse
            identifies pathological pathways including a possible role for
            transglutaminase 1
  JOURNAL   J Neurochem 168 (1), 52-65 (2024)
   PUBMED   38071490
  REMARK    GeneRIF: Proteomics analysis of the brain from a Gaucher disease
            mouse identifies pathological pathways including a possible role
            for transglutaminase 1.
REFERENCE   2  (bases 1 to 2755)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   3  (bases 1 to 2755)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   4  (bases 1 to 2755)
  AUTHORS   Kuribayashi,M., Kawaguchi,Y., Teshima,H., Yamaguchi,H.,
            Tatsukawa,H. and Hitomi,K.
  TITLE     Investigation of mouse amniotic fluid for stimulating ability of
            keratinocyte differentiation depending on the fetal stage
  JOURNAL   Arch Biochem Biophys 711, 109003 (2021)
   PUBMED   34390735
REFERENCE   5  (bases 1 to 2755)
  AUTHORS   Sun,H. and Kaartinen,M.T.
  TITLE     Assessment of expression and specific activities of
            transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis
  JOURNAL   Anal Biochem 591, 113512 (2020)
   PUBMED   31786225
  REMARK    GeneRIF: Assessment of expression and specific activities of
            transglutaminases TG1, TG2, and FXIII-A during osteoclastogenesis.
REFERENCE   6  (bases 1 to 2755)
  AUTHORS   Verderio,E., Nicholas,B., Gross,S. and Griffin,M.
  TITLE     Regulated expression of tissue transglutaminase in Swiss 3T3
            fibroblasts: effects on the processing of fibronectin, cell
            attachment, and cell death
  JOURNAL   Exp Cell Res 239 (1), 119-138 (1998)
   PUBMED   9511731
REFERENCE   7  (bases 1 to 2755)
  AUTHORS   Matsuki,M., Yamashita,F., Ishida-Yamamoto,A., Yamada,K.,
            Kinoshita,C., Fushiki,S., Ueda,E., Morishima,Y., Tabata,K.,
            Yasuno,H., Hashida,M., Iizuka,H., Ikawa,M., Okabe,M., Kondoh,G.,
            Kinoshita,T., Takeda,J. and Yamanishi,K.
  TITLE     Defective stratum corneum and early neonatal death in mice lacking
            the gene for transglutaminase 1 (keratinocyte transglutaminase)
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 1044-1049 (1998)
   PUBMED   9448282
REFERENCE   8  (bases 1 to 2755)
  AUTHORS   Adel Moallem,S. and Hales,B.F.
  TITLE     Transglutaminase and clusterin induction during normal and abnormal
            limb development in the mouse
  JOURNAL   Biol Reprod 55 (2), 281-290 (1996)
   PUBMED   8828830
REFERENCE   9  (bases 1 to 2755)
  AUTHORS   Nagy,L., Saydak,M., Shipley,N., Lu,S., Basilion,J.P., Yan,Z.H.,
            Syka,P., Chandraratna,R.A., Stein,J.P., Heyman,R.A. and Davies,P.J.
  TITLE     Identification and characterization of a versatile retinoid
            response element (retinoic acid receptor response element-retinoid
            X receptor response element) in the mouse tissue transglutaminase
            gene promoter
  JOURNAL   J Biol Chem 271 (8), 4355-4365 (1996)
   PUBMED   8626785
REFERENCE   10 (bases 1 to 2755)
  AUTHORS   Rajagopalan,S., Wan,D.F., Habib,G.M., Sepulveda,A.R., McLeod,M.R.,
            Lebovitz,R.M. and Lieberman,M.W.
  TITLE     Six mRNAs with different 5' ends are encoded by a single
            gamma-glutamyltransferase gene in mouse
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6179-6183 (1993)
   PUBMED   8101000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY779293.1, AF186373.1 and BX639142.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY779293.1         1-17
            18-2729             AF186373.1         9-2720
            2730-2755           BX639142.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2755
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /note="transglutaminase 1, K polypeptide"
                     /db_xref="GeneID:21816"
                     /db_xref="MGI:MGI:98730"
     exon            1..106
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            107..427
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..616
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..865
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..984
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1092
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1267
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1406
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1510
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1599
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1753
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2035
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2196
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2333
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2753
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /note="hexamer: AATAAA"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /note="hexamer: AATAAA"
     polyA_site      2729
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /note="major polyA site"
     polyA_site      2743
                     /gene="Tgm1"
                     /gene_synonym="2310004J08Rik; Tgase1"
                     /note="major polyA site"
ORIGIN      
        1 ttccactcgc gtggctacgt ccagcctgtt ggtcccgtcc caaacgccct gacctgctcc
       61 acccgggccc gggacccggt ggtgccatca ccaacaccgc tgccaggcac aatggaaggt
      121 cctcgctcag acgtgggccg ctggggcagg agcccctggc agccccctac aacaccgtca
      181 ccggagccag agccggtgcc ggagccagac agacgctcgc gctcccgccg aggaggaggc
      241 cgctccttct gggctcgttg ttgtggctgc tgctcatgtg ggaacagagg ggacgatgac
      301 tggggacctg aaccttctgg ctccagaagc agagggacca gctcccgggg tagggactct
      361 cggggtggcc gaagacccga gtctcggggc agtggtgtaa atgcagctgg agatggcacc
      421 atccgagagg gaatgctggt tgtgactggt gtggatctgc tgtgctcacg atcagaccag
      481 aaccgccgag agcaccacac ggatgagttt gaatatgatg agctgattgt gcgccgtggg
      541 cagcccttcc acatgatcct tttcttgaac cgggaatatg agtcctctga tcgcattgcc
      601 cttgagctcc tcattggaag caatccggag gtgggcaagg gcacccacgt gatcatccca
      661 gtgggtaagg gaggcagtgg tggctggaag gcccaagtga ctaagaacaa cggacacaac
      721 ctaaacctac gcgtccacac ctcccccaat gccatcattg gcaagtttca gttcactgtc
      781 cgcacccgct ctgaagctgg agagttccag ttgccctttg acccccgcaa tgagatctac
      841 atcctcttca atccctggtg cccagaggac atagtgtatg tggaccatga ggactggcgg
      901 caagaatatg tgcttaatga gtctggaaga atctactatg gaacagaagc acagattggc
      961 gaacgaacct ggaactatgg tcagtttgac catggggtgc tggatgcctg cctgtacatc
     1021 ctggatcgga gggggatgcc atatggaggt cgtggggacc cagtcagtgt ctctcgggtt
     1081 gtctctgcca tggtgaactc cctggatgac aatggagttc tgattgggaa ctggaccggt
     1141 gactactctc gaggcaccaa cccctcagcg tgggtgggca gtgtggagat cctgctcagc
     1201 tacctacgca ccggctattc cgtcccctac ggccaatgct gggtctttgc cggtgtgacc
     1261 accacagtgc tccgatgtct gggcttcgct acccgtaccg tcaccaactt caactctgca
     1321 cacgacacag acacctccct cactatggac atctactttg atgagaacat gaagccactt
     1381 gaacatctga accatgattc tgtttggaac ttccacgtgt ggaacgactg ctggatgaag
     1441 aggccagatc tgccctcagg ctttgatggg tggcaggttg tggatgccac accccaggag
     1501 accagcagtg gcatcttctg ctgtggcccc tgttctgtgg agtccgtcaa gaatggctta
     1561 gtctacatga agtatgacac acctttcatt tttgctgagg taaatagcga taaggtatac
     1621 tggcagcggc aggatgatgg cagctttaag atagtgtacg tggaagagaa agccattggc
     1681 acactcattg tcacaaaggc gatccactcc aacaatcgag aggacatcac ccacatctat
     1741 aagcacccag aaggctcaga agcagagcgg agggctgtgg agaaggcggc agcccatggc
     1801 agcaaaccta atgtgtatgc cacccgggac tccgctgagg atgtggcaat gcaggtggag
     1861 gcgcaggacg ctgtgatggg gcaggatctg gctgtctctg tggtgctgac caatcgtggt
     1921 agtagccgac gcactgtgaa gttgcacctc tacctttgtg tcacctacta cactggtgtc
     1981 tctgggccta ccttcaagga ggccaaaaag gaagtgacat tagccccagg agcctcggac
     2041 tctgtgacca tgcctgtggc ctacaaggaa tacaagcccc accttgtgga ccagggggca
     2101 atgttgctca atgtctcagg ccatgtcaag gagagtgggc aggtactagc caagcaacac
     2161 accttccgtt tgcgcacccc agacctttct cttacgttac tgggagcagc agttgttggt
     2221 caggaatgtg gagtacagat cgtgttcaag aaccccctgc ctgtcaccct caccaacgtc
     2281 gtcttccggc tcgaaggttc tggattacag agacccaagg tcctcaatgt cggggacatc
     2341 gggggtaatg agacagtcac actgcgccag acgtttgttc ccgtgcgacc aggcccccgc
     2401 cagctcattg ccagcctgga cagtccacag ctttcccaag tgcacggtgt tattcaagtg
     2461 gatgtggccc cagcctctgg aggcagcggt ttctcagatg ctggaggtga cagtcgctct
     2521 ggggagaaca tacctatggc atatcgaggt ggagcttaac cctgggccag gagcaatggg
     2581 actggaatca gatgaacaag gacattgccc caagatgggg ccccaccaca gagtagctcc
     2641 ccaggctcag acaggaagac tggggcacct ggggaggcag tcgctcttca tttgtgctga
     2701 taataaactg gttttttttt tttaataaag atgctgttta gtagtcctgt ctgaa
//
