LOCUS       NM_173396               2900 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TGFB-induced factor homeobox 2 (Tgif2), transcript
            variant 1, mRNA.
ACCESSION   NM_173396
VERSION     NM_173396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2900)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2900)
  AUTHORS   Lei,J., Deng,Y. and Ma,S.
  TITLE     Downregulation of TGIF2 is possibly correlated with neuronal
            apoptosis and autism-like symptoms in mice
  JOURNAL   Brain Behav 12 (6), e2610 (2022)
   PUBMED   35592894
  REMARK    GeneRIF: Downregulation of TGIF2 is possibly correlated with
            neuronal apoptosis and autism-like symptoms in mice.
REFERENCE   3  (bases 1 to 2900)
  AUTHORS   Tao,W., Cao,C., Ren,G. and Zhou,D.
  TITLE     Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer
  JOURNAL   Thorac Cancer 12 (24), 3356-3369 (2021)
   PUBMED   34741437
  REMARK    GeneRIF: Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer.
REFERENCE   4  (bases 1 to 2900)
  AUTHORS   Yu,X., Shen,G., Ren,H., Zhang,Z., Shang,Q., Zhao,W., Huang,J.,
            Yang,Z., Liang,D. and Jiang,X.
  TITLE     TGFbeta-induced factor homeobox 2 blocks osteoblastic
            differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis
  JOURNAL   J Cell Physiol 234 (11), 21284-21293 (2019)
   PUBMED   31066043
  REMARK    GeneRIF: Tgif2 plays an important role in the regulation of
            osteoblastic differentiation in vitro
REFERENCE   5  (bases 1 to 2900)
  AUTHORS   Tano,A., Kadota,Y., Morimune,T., Jam,F.A., Yukiue,H., Bellier,J.P.,
            Sokoda,T., Maruo,Y., Tooyama,I. and Mori,M.
  TITLE     The juvenility-associated long noncoding RNA Gm14230 maintains
            cellular juvenescence
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30872457
  REMARK    GeneRIF: Gm14230 safeguards cellular juvenescence through
            recruiting the histone methyltransferase Ezh2 to Tgif2, thereby
            repressing the functional role of Tgif2 in cellular senescence.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2900)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   7  (bases 1 to 2900)
  AUTHORS   Melhuish,T.A. and Wotton,D.
  TITLE     The Tgif2 gene contains a retained intron within the coding
            sequence
  JOURNAL   BMC Mol Biol 7, 2 (2006)
   PUBMED   16436215
  REMARK    GeneRIF: The Tgif2 gene contains a retained intron, within the
            second coding exon. One splice variant encodes the full length 237
            amino acid Tgif2, whereas the shorter form results in the removal
            of 39 codons from the centre of the coding region.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2900)
  AUTHORS   Shen,J. and Walsh,C.A.
  TITLE     Targeted disruption of Tgif, the mouse ortholog of a human
            holoprosencephaly gene, does not result in holoprosencephaly in
            mice
  JOURNAL   Mol Cell Biol 25 (9), 3639-3647 (2005)
   PUBMED   15831469
REFERENCE   9  (bases 1 to 2900)
  AUTHORS   Jin,L., Zhou,Y., Kuang,C., Lin,L. and Chen,Y.
  TITLE     Expression pattern of TG-interacting factor 2 during mouse
            development
  JOURNAL   Gene Expr Patterns 5 (4), 457-462 (2005)
   PUBMED   15749073
  REMARK    GeneRIF: TGIF2 has a wide but well controlled expression pattern
            during mouse development.
REFERENCE   10 (bases 1 to 2900)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935150.10, AK029490.1 and BQ030806.1.
            
            On Mar 26, 2014 this sequence version replaced NM_173396.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029490.1, BC138706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL935150.10        65843-65942
            101-2895            AK029490.1         31-2825
            2896-2900           BQ030806.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..2900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.86 cM"
     gene            1..2900
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="TGFB-induced factor homeobox 2"
                     /db_xref="GeneID:228839"
                     /db_xref="MGI:MGI:1915299"
     exon            1..232
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..458
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..980
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     TGFB-induced factor 2; homeobox protein TGIF2;
                     5'-TG-3'-interacting factor 2; TGF-beta-induced
                     transcription factor 2; TALE family homeobox"
                     /codon_start=1
                     /product="homeobox protein TGIF2 isoform a"
                     /protein_id="NP_775572.1"
                     /db_xref="CCDS:CCDS16969.1"
                     /db_xref="GeneID:228839"
                     /db_xref="MGI:MGI:1915299"
                     /translation="MSDSDLGEDEGLLSLTGKRKRRGNLPKESVKILRDWLYLHRYNA
                     YPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASD
                     VALPRGSSPSLLAVSVPAPTNMLSLSVCSMPLHSGQGEKPAAPFPQVELESPKALVTP
                     ASTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKDDFSSFQLLVEVALQRAAEMELQKQQ
                     EPAPPLLHTPLPFVSENAK"
     exon            459..2900
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1639..1644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1660
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
ORIGIN      
        1 ccacgctctg cacaaagttt gtttctgcct cggggcggtg ggggagggtg cggcaggcgg
       61 gatgggagga gaggggatct gacgtcaggt cgcgaggtgc tttccagccg cgagctgtca
      121 ggcgggtgtc agacccggca ggtacgcggc gcgttccccc ggtgcccccc gccccggccg
      181 ggtggtccca caccccaccg aggccgcgtg ggccggaaag ccgccaggga aggctcccca
      241 gaggtccagc ttagccccta agcatcatgt cggacagcga tctaggcgag gatgaggggc
      301 tcctgtcact gaccggcaag aggaagcgca gagggaacct gcccaaggag tcagtaaaga
      361 tcctccggga ctggctctat ctgcaccgct acaacgccta cccctcagag caggagaagc
      421 taagtctctc tggacagacc aacctctcgg tgctgcagat atgtaactgg ttcatcaatg
      481 cccgtcgtcg ccttctccct gacatgcttc ggaaggatgg caaagaccct aatcagttca
      541 ccatctcccg tcgtgggggt aaggcctctg atgtggctct ccccaggggc agcagcccct
      601 ctctgctggc tgtgtctgtt ccagccccca ctaacatgct ctccttgtct gtgtgctcca
      661 tgccactcca ctcaggccaa ggtgaaaagc cagcagcacc cttcccacaa gtggagctgg
      721 aatcccccaa ggccctggtg acccctgcta gcacactcac cctgctgact agggcagagg
      781 ctggaagccc cacgggtgga ctcttcaata cgccaccacc cacaccccca gagcaggaca
      841 aggatgactt cagcagcttc cagttgctgg tggaggtggc gctgcagagg gctgccgaga
      901 tggagcttca gaagcagcaa gagccagcgc cacctttgct acacactccg ctgcctttcg
      961 tctcagaaaa cgccaagtag gcacctgctc ccgggtggct tgaggttcct ggctcactgc
     1021 cctttcatgc agagggttat ccaagtacgg atcactgcca agcatcagga ccattctgtc
     1081 cagtcctcag cggatgtcgc tgcgctgcac tgttacgggg cctgtactct gctgagtgcc
     1141 attccttcaa gcgtcctctc cgaggagacc aaggcaccag agccaggcat ggtgttgctg
     1201 ctgctcctcc agagagccct gggacacctg cactccagcc tgctttccta ggcaggctca
     1261 ggaaagctgc caagtccaga cttgagctgg gtccaagccg cccctaagct gtgcctcttt
     1321 tggtcgagcc aggtgtgcac attccaacct attcaaagga caaaggaaat gcccagcaga
     1381 tgtcacagaa ccgactccag ttgaatgttt agatttttgc taaattgttt tattttcctt
     1441 ttgctgtggt ttgtgttaat gcagtaggta gcccagaagc acaggtgtgg ggagagagca
     1501 ccttacacgg tgggtggagc tcggtaagtg ggtaatctac ttcccacagg atggttgtat
     1561 agggaccagc agattctctg cagtggtgct gagttcagac tagagtggtt gtttaattct
     1621 tggtttggtc ttccctatta taaaagacag aaggaaaata tccacaggtg gtgggttatt
     1681 tgcaccagac ggtcatttag acacagcaga gacagatgac aaaaccagag gcacacgtgt
     1741 ttctattgtc gtggttaagc tagagtgaaa cagctctgtt tttctctctg ttctgagtaa
     1801 ctcccctcac cccaccccag cgacccccac cctgcaccac ctttgtagct tgtttcggat
     1861 ttattctgga gcttggcaag aatgtcgtgt gccagcatct acttgggagg agtgagccat
     1921 ctgctggtca ttaggccctt cggaaagctg cttgttcaca gaggcagctg gaaccttcct
     1981 ggaggagagg ctgctgaggc taccgactgg cccacctccc ttcagggtgg gattgcaagg
     2041 gcctgcctaa atttcccggg gaaacagacc acacttggtc ttaatctctc cccttttccc
     2101 gtttactttg cttagttttc agcaacagta taccccatct ttatatccta agaaacacta
     2161 atcctagatt tgtattaacc aaaatacttg tgttctgaat aaccagaaga tgtgaggagc
     2221 cctgactgtg gtctgaggtt cacccgggtg tgagcacaga cggggctctt ggatgttgac
     2281 tggcttggag tgcctgttcc gaggaaggca gagaccactc tggcctttcc agggagcccc
     2341 tgaggcttag caggcttcca tacctctcct gagtgacttc acccatccct tgctgtgcaa
     2401 gtgggcgcga gaatggctat ttgtaagggg ctgcttccct gggctctgcc tcatgcctcc
     2461 ctctggcttc ctgtcctgta ggagacccag caggctcaac tctctgtcac cctgaggcac
     2521 tgctgggaag ggaacatggc ttcattgact ttgtggtttg cccactgcta ccccacctgt
     2581 ctgtgagacc ccatgatggc tgtaggatgc taaggcgggg gtgatactag gatgagggat
     2641 ttcttttccc cccacagtgc actgagcaag ggaggaggga gggagccatg ctgctgacat
     2701 attctggcat tccccctcct gggataaaac agggcatcag aaaggtagag cggtctctgc
     2761 ttaggttgcc tgtaagataa atgtggagaa gcacggttgt cccattgaac aatatttgag
     2821 caaaaaacta ctgtaaataa ctggtttttg tcttttgtca aataaaattg ttttggtttt
     2881 gtttatgttt taaagtcaaa
//
