LOCUS       NM_001291124            2783 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TGFB-induced factor homeobox 2 (Tgif2), transcript
            variant 2, mRNA.
ACCESSION   NM_001291124 XM_006499355
VERSION     NM_001291124.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Lei,J., Deng,Y. and Ma,S.
  TITLE     Downregulation of TGIF2 is possibly correlated with neuronal
            apoptosis and autism-like symptoms in mice
  JOURNAL   Brain Behav 12 (6), e2610 (2022)
   PUBMED   35592894
  REMARK    GeneRIF: Downregulation of TGIF2 is possibly correlated with
            neuronal apoptosis and autism-like symptoms in mice.
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Tao,W., Cao,C., Ren,G. and Zhou,D.
  TITLE     Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer
  JOURNAL   Thorac Cancer 12 (24), 3356-3369 (2021)
   PUBMED   34741437
  REMARK    GeneRIF: Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer.
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Yu,X., Shen,G., Ren,H., Zhang,Z., Shang,Q., Zhao,W., Huang,J.,
            Yang,Z., Liang,D. and Jiang,X.
  TITLE     TGFbeta-induced factor homeobox 2 blocks osteoblastic
            differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis
  JOURNAL   J Cell Physiol 234 (11), 21284-21293 (2019)
   PUBMED   31066043
  REMARK    GeneRIF: Tgif2 plays an important role in the regulation of
            osteoblastic differentiation in vitro
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Tano,A., Kadota,Y., Morimune,T., Jam,F.A., Yukiue,H., Bellier,J.P.,
            Sokoda,T., Maruo,Y., Tooyama,I. and Mori,M.
  TITLE     The juvenility-associated long noncoding RNA Gm14230 maintains
            cellular juvenescence
  JOURNAL   J Cell Sci 132 (8) (2019)
   PUBMED   30872457
  REMARK    GeneRIF: Gm14230 safeguards cellular juvenescence through
            recruiting the histone methyltransferase Ezh2 to Tgif2, thereby
            repressing the functional role of Tgif2 in cellular senescence.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Melhuish,T.A. and Wotton,D.
  TITLE     The Tgif2 gene contains a retained intron within the coding
            sequence
  JOURNAL   BMC Mol Biol 7, 2 (2006)
   PUBMED   16436215
  REMARK    GeneRIF: The Tgif2 gene contains a retained intron, within the
            second coding exon. One splice variant encodes the full length 237
            amino acid Tgif2, whereas the shorter form results in the removal
            of 39 codons from the centre of the coding region.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Shen,J. and Walsh,C.A.
  TITLE     Targeted disruption of Tgif, the mouse ortholog of a human
            holoprosencephaly gene, does not result in holoprosencephaly in
            mice
  JOURNAL   Mol Cell Biol 25 (9), 3639-3647 (2005)
   PUBMED   15831469
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Jin,L., Zhou,Y., Kuang,C., Lin,L. and Chen,Y.
  TITLE     Expression pattern of TG-interacting factor 2 during mouse
            development
  JOURNAL   Gene Expr Patterns 5 (4), 457-462 (2005)
   PUBMED   15749073
  REMARK    GeneRIF: TGIF2 has a wide but well controlled expression pattern
            during mouse development.
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935150.10, AK029490.1, CF731285.1 and BQ030806.1.
            
            On Mar 26, 2014 this sequence version replaced XM_006499355.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment in the central coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157623.1, SRR7652917.850729.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL935150.10        65843-65942
            101-430             AK029490.1         31-360
            431-1001            CF731285.1         49-619
            1002-2778           AK029490.1         1049-2825
            2779-2783           BQ030806.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.86 cM"
     gene            1..2783
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="TGFB-induced factor homeobox 2"
                     /db_xref="GeneID:228839"
                     /db_xref="MGI:MGI:1915299"
     exon            1..232
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..458
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..863
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="isoform b is encoded by transcript variant 2;
                     TGFB-induced factor 2; homeobox protein TGIF2;
                     5'-TG-3'-interacting factor 2; TGF-beta-induced
                     transcription factor 2; TALE family homeobox"
                     /codon_start=1
                     /product="homeobox protein TGIF2 isoform b"
                     /protein_id="NP_001278053.1"
                     /db_xref="CCDS:CCDS71173.1"
                     /db_xref="GeneID:228839"
                     /db_xref="MGI:MGI:1915299"
                     /translation="MSDSDLGEDEGLLSLTGKRKRRGNLPKESVKILRDWLYLHRYNA
                     YPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGQGEK
                     PAAPFPQVELESPKALVTPASTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKDDFSSFQ
                     LLVEVALQRAAEMELQKQQEPAPPLLHTPLPFVSENAK"
     exon            459..558
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..2783
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1543
                     /gene="Tgif2"
                     /gene_synonym="4921501K24; 5730599O09Rik"
ORIGIN      
        1 ccacgctctg cacaaagttt gtttctgcct cggggcggtg ggggagggtg cggcaggcgg
       61 gatgggagga gaggggatct gacgtcaggt cgcgaggtgc tttccagccg cgagctgtca
      121 ggcgggtgtc agacccggca ggtacgcggc gcgttccccc ggtgcccccc gccccggccg
      181 ggtggtccca caccccaccg aggccgcgtg ggccggaaag ccgccaggga aggctcccca
      241 gaggtccagc ttagccccta agcatcatgt cggacagcga tctaggcgag gatgaggggc
      301 tcctgtcact gaccggcaag aggaagcgca gagggaacct gcccaaggag tcagtaaaga
      361 tcctccggga ctggctctat ctgcaccgct acaacgccta cccctcagag caggagaagc
      421 taagtctctc tggacagacc aacctctcgg tgctgcagat atgtaactgg ttcatcaatg
      481 cccgtcgtcg ccttctccct gacatgcttc ggaaggatgg caaagaccct aatcagttca
      541 ccatctcccg tcgtgggggc caaggtgaaa agccagcagc acccttccca caagtggagc
      601 tggaatcccc caaggccctg gtgacccctg ctagcacact caccctgctg actagggcag
      661 aggctggaag ccccacgggt ggactcttca atacgccacc acccacaccc ccagagcagg
      721 acaaggatga cttcagcagc ttccagttgc tggtggaggt ggcgctgcag agggctgccg
      781 agatggagct tcagaagcag caagagccag cgccaccttt gctacacact ccgctgcctt
      841 tcgtctcaga aaacgccaag taggcacctg ctcccgggtg gcttgaggtt cctggctcac
      901 tgccctttca tgcagagggt tatccaagta cggatcactg ccaagcatca ggaccattct
      961 gtccagtcct cagcggatgt cgctgcgctg cactgttacg gggcctgtac tctgctgagt
     1021 gccattcctt caagcgtcct ctccgaggag accaaggcac cagagccagg catggtgttg
     1081 ctgctgctcc tccagagagc cctgggacac ctgcactcca gcctgctttc ctaggcaggc
     1141 tcaggaaagc tgccaagtcc agacttgagc tgggtccaag ccgcccctaa gctgtgcctc
     1201 ttttggtcga gccaggtgtg cacattccaa cctattcaaa ggacaaagga aatgcccagc
     1261 agatgtcaca gaaccgactc cagttgaatg tttagatttt tgctaaattg ttttattttc
     1321 cttttgctgt ggtttgtgtt aatgcagtag gtagcccaga agcacaggtg tggggagaga
     1381 gcaccttaca cggtgggtgg agctcggtaa gtgggtaatc tacttcccac aggatggttg
     1441 tatagggacc agcagattct ctgcagtggt gctgagttca gactagagtg gttgtttaat
     1501 tcttggtttg gtcttcccta ttataaaaga cagaaggaaa atatccacag gtggtgggtt
     1561 atttgcacca gacggtcatt tagacacagc agagacagat gacaaaacca gaggcacacg
     1621 tgtttctatt gtcgtggtta agctagagtg aaacagctct gtttttctct ctgttctgag
     1681 taactcccct caccccaccc cagcgacccc caccctgcac cacctttgta gcttgtttcg
     1741 gatttattct ggagcttggc aagaatgtcg tgtgccagca tctacttggg aggagtgagc
     1801 catctgctgg tcattaggcc cttcggaaag ctgcttgttc acagaggcag ctggaacctt
     1861 cctggaggag aggctgctga ggctaccgac tggcccacct cccttcaggg tgggattgca
     1921 agggcctgcc taaatttccc ggggaaacag accacacttg gtcttaatct ctcccctttt
     1981 cccgtttact ttgcttagtt ttcagcaaca gtatacccca tctttatatc ctaagaaaca
     2041 ctaatcctag atttgtatta accaaaatac ttgtgttctg aataaccaga agatgtgagg
     2101 agccctgact gtggtctgag gttcacccgg gtgtgagcac agacggggct cttggatgtt
     2161 gactggcttg gagtgcctgt tccgaggaag gcagagacca ctctggcctt tccagggagc
     2221 ccctgaggct tagcaggctt ccatacctct cctgagtgac ttcacccatc ccttgctgtg
     2281 caagtgggcg cgagaatggc tatttgtaag gggctgcttc cctgggctct gcctcatgcc
     2341 tccctctggc ttcctgtcct gtaggagacc cagcaggctc aactctctgt caccctgagg
     2401 cactgctggg aagggaacat ggcttcattg actttgtggt ttgcccactg ctaccccacc
     2461 tgtctgtgag accccatgat ggctgtagga tgctaaggcg ggggtgatac taggatgagg
     2521 gatttctttt ccccccacag tgcactgagc aagggaggag ggagggagcc atgctgctga
     2581 catattctgg cattccccct cctgggataa aacagggcat cagaaaggta gagcggtctc
     2641 tgcttaggtt gcctgtaaga taaatgtgga gaagcacggt tgtcccattg aacaatattt
     2701 gagcaaaaaa ctactgtaaa taactggttt ttgtcttttg tcaaataaaa ttgttttggt
     2761 tttgtttatg ttttaaagtc aaa
//
