LOCUS       NM_009372               1634 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus TGFB-induced factor homeobox 1 (Tgif1), transcript
            variant 2, mRNA.
ACCESSION   NM_009372
VERSION     NM_009372.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Cong,M., Li,J., Wang,L., Liu,C., Zheng,M., Zhou,Q., Du,M., Ye,X.,
            Feng,M., Ye,Y., Zhang,S., Xu,W., Lu,Y., Wang,C., Xia,Y., Xie,H.,
            Zhang,Y., He,Q., Gong,L., Gu,Y., Sun,H., Zhang,Q., Zhao,J.,
            Ding,F., Gu,X. and Zhou,S.
  TITLE     MircoRNA-25-3p in skin precursor cell-induced Schwann cell-derived
            extracellular vesicles promotes axon regeneration by targeting
            Tgif1
  JOURNAL   Exp Neurol 376, 114750 (2024)
   PUBMED   38492636
  REMARK    GeneRIF: MircoRNA-25-3p in skin precursor cell-induced Schwann
            cell-derived extracellular vesicles promotes axon regeneration by
            targeting Tgif1.
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Bolamperti,S., Saito,H., Heerdmann,S., Hesse,E. and
            Taipaleenmaki,H.
  TITLE     Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts
            by activating PAK3 signaling
  JOURNAL   Elife 13, 94265 (2024)
   PUBMED   38661167
  REMARK    GeneRIF: Tgif1-deficiency impairs cytoskeletal architecture in
            osteoblasts by activating PAK3 signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Taipaleenmaki,H., Saito,H., Schroder,S., Maeda,M., Mettler,R.,
            Ring,M., Rollmann,E., Gasser,A., Haasper,C., Gehrke,T., Weiss,A.,
            Grimm,S.K. and Hesse,E.
  TITLE     Antagonizing microRNA-19a/b augments PTH anabolic action and
            restores bone mass in osteoporosis in mice
  JOURNAL   EMBO Mol Med 14 (11), e13617 (2022)
   PUBMED   36193848
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Astanina,E., Doronzo,G., Cora,D., Neri,F., Oliviero,S., Genova,T.,
            Mussano,F., Middonti,E., Vallariello,E., Cencioni,C., Valdembri,D.,
            Serini,G., Limana,F., Foglio,E., Ballabio,A. and Bussolino,F.
  TITLE     The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells
  JOURNAL   Nat Commun 13 (1), 5191 (2022)
   PUBMED   36057632
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Zhang,X., Friedman,A., Heaney,S., Purcell,P. and Maas,R.L.
  TITLE     Meis homeoproteins directly regulate Pax6 during vertebrate lens
            morphogenesis
  JOURNAL   Genes Dev 16 (16), 2097-2107 (2002)
   PUBMED   12183364
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Melhuish,T.A. and Wotton,D.
  TITLE     The interaction of the carboxyl terminus-binding protein with the
            Smad corepressor TGIF is disrupted by a holoprosencephaly mutation
            in TGIF
  JOURNAL   J Biol Chem 275 (50), 39762-39766 (2000)
   PUBMED   10995736
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Bertolino,E., Wildt,S., Richards,G. and Clerc,R.G.
  TITLE     Expression of a novel murine homeobox gene in the developing
            cerebellar external granular layer during its proliferation
  JOURNAL   Dev Dyn 205 (4), 410-420 (1996)
   PUBMED   8901052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008909.1, CD563532.1, AK160193.1 and AC079441.37.
            
            On Aug 12, 2009 this sequence version replaced NM_009372.2.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, and uses a distinct start codon, compared to
            variant 1. The resulting isoform (b) has a shorter and distinct
            N-terminus, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008909.1, BC005724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AK008909.1         3-86
            85-629              CD563532.1         1-545
            630-1625            AK160193.1         335-1330
            1626-1634           AC079441.37        216141-216149       c
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 41.87 cM"
     gene            1..1634
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /note="TGFB-induced factor homeobox 1"
                     /db_xref="GeneID:21815"
                     /db_xref="MGI:MGI:1194497"
     exon            1..339
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1142
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /note="isoform b is encoded by transcript variant 2;
                     homeobox protein TGIF1; 5'-TG-3'-interacting factor 1;
                     TALE family homeobox; TG interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform b"
                     /protein_id="NP_033398.2"
                     /db_xref="CCDS:CCDS37683.1"
                     /db_xref="GeneID:21815"
                     /db_xref="MGI:MGI:1194497"
                     /translation="MKSKKGLVAASGSDSEDEDSMDSPLDLSSSAASGKRRRRGNLPK
                     ESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDG
                     KDPNQFTISRRGAKISEASSIEAAMGIKNFMPTLEESPFHSCVVGPNPTLGRPVSPKP
                     PSPGSILARPSVICHTTVTALKDGPFSLCQPIGVGQSTDVPQIAPSNFTDTSLVYPED
                     TCKSGPSPNPQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            340..566
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1634
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1604..1609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="Tgif1"
                     /gene_synonym="Tgif"
                     /note="major polyA site"
ORIGIN      
        1 cactctgaca gcgccgaggt gcgccgagtg gagcgggaaa caaaggagct gagtagggag
       61 ggagggaatt gggccaggga gaacccccgg ctggctgcca gaagatcccg actggaggaa
      121 gcccaagtgt cacttgaatt ccaacccaga agccagcgcc tgagaccgga gcaccttgtt
      181 tagcaatagt ggttggaaca ctctcttgta agttaccgga gcactagtat aggaggagga
      241 tcatcgacta ccctcccgcc actccacggc tgctggctcc tagaaacccc agcttcacct
      301 ctcactggga ctcgagttcc agaatgaaaa gcaagaaggg tcttgttgca gcatctggca
      361 gtgactctga ggatgaagac agcatggaca gtcccctgga cctttcctca tcagcagcct
      421 ctggcaagag aaggaggaga ggcaatctgc ccaaggagtc agtccagatt ctgcgagact
      481 ggctgtatga acacagatac aacgcctatc cctcagagca agagaaagca ctgctgtccc
      541 agcagacaca cctgtccaca ctacaggtct gtaactggtt catcaacgcc cgccgcaggc
      601 tccttcctga catgctgaga aaggatggca aagatccaaa tcagttcacg atttcccgcc
      661 gtggggccaa gatttcagaa gctagctcta ttgaagctgc aatgggtatc aaaaacttca
      721 tgccaactct agaagagagc ccatttcatt cctgcgtagt tggacccaac ccaaccctag
      781 ggagaccagt gtctcccaaa cctccctccc caggatccat tttggctcgc ccgtcagtga
      841 tctgccatac cactgtgact gcattgaagg atgggccttt ctctctctgt cagccgattg
      901 gtgtgggaca gagtacagat gtaccgcaaa tagcacccag caactttaca gacacctctc
      961 tcgtgtaccc agaggacact tgcaaatctg gacccagtcc aaaccctcag agtggtcttt
     1021 tcaacactcc tccccctact ccaccagacc tcaaccagga ttttagtgga ttccagcttc
     1081 tagtggatgt tgcactcaaa cgagcggcag agatggagct tcaggccaaa ctcacagctt
     1141 aaccgttttt tcaaacaaaa cagttctcca aaatacggtc ctgattgccg ggggtgatgg
     1201 caagagatgc attattttat atatttttct attaatattt gcacatggga ttgctcagac
     1261 gaagcttcct gttactaaga tgtcttaagt ggaatagagt cattccaaga actacaaact
     1321 aaagctactg tagaaacaaa gggttttctt ttcgaatgtt tcttggtagt ttctcataat
     1381 gtgagacggt tcccagtatc atgtgatctt ctcctccaga ctcctcttct ttatgttcca
     1441 agactgtgca atactttaga cgccctcgca cctctctctt cccatgtgga atgggacgcc
     1501 cacctacagt ctaatgagta aactttcagt tttttgtttg tttgtttttt tttagattca
     1561 agcaagtatg aatctagttg ttggatacct tttttcatga tgtaataaag tattttcttt
     1621 aaaagttatt gcaa
//
