LOCUS       NM_011578               6090 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus transforming growth factor, beta receptor III
            (Tgfbr3), mRNA.
ACCESSION   NM_011578
VERSION     NM_011578.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6090)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   2  (bases 1 to 6090)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6090)
  AUTHORS   Lu,P., Wu,B., Wang,Y., Russell,M., Liu,Y., Bernard,D.J., Zheng,D.
            and Zhou,B.
  TITLE     Prerequisite endocardial-mesenchymal transition for murine cardiac
            trabecular angiogenesis
  JOURNAL   Dev Cell 58 (9), 791-805 (2023)
   PUBMED   37023750
REFERENCE   4  (bases 1 to 6090)
  AUTHORS   Duesman,S.J., Ortega-Francisco,S., Olguin-Alor,R.,
            Acevedo-Dominguez,N.A., Sestero,C.M., Chellappan,R., De Sarno,P.,
            Yusuf,N., Salgado-Lopez,A., Segundo-Liberato,M., de
            Oca-Lagunas,S.M., Raman,C. and Soldevila,G.
  TITLE     Transforming growth factor receptor III (Betaglycan) regulates the
            generation of pathogenic Th17 cells in EAE
  JOURNAL   Front Immunol 14, 1088039 (2023)
   PUBMED   36855628
  REMARK    GeneRIF: Transforming growth factor receptor III (Betaglycan)
            regulates the generation of pathogenic Th17 cells in EAE.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6090)
  AUTHORS   Brule,E., Wang,Y., Li,Y., Lin,Y.F., Zhou,X., Ongaro,L.,
            Alonso,C.A.I., Buddle,E.R.S., Schneyer,A.L., Byeon,C.H.,
            Hinck,C.S., Mendelev,N., Russell,J.P., Cowan,M., Boehm,U.,
            Ruf-Zamojski,F., Zamojski,M., Andoniadou,C.L., Sealfon,S.C.,
            Harrison,C.A., Walton,K.L., Hinck,A.P. and Bernard,D.J.
  TITLE     TGFBR3L is an inhibin B co-receptor that regulates female fertility
  JOURNAL   Sci Adv 7 (51), eabl4391 (2021)
   PUBMED   34910520
REFERENCE   6  (bases 1 to 6090)
  AUTHORS   Roelen,B.A., Goumans,M.J., Zwijsen,A. and Mummery,C.L.
  TITLE     Identification of two distinct functions for TGF-beta in early
            mouse development
  JOURNAL   Differentiation 64 (1), 19-31 (1998)
   PUBMED   9921650
REFERENCE   7  (bases 1 to 6090)
  AUTHORS   Ponce-Castaneda,M.V., Esparza-Lopez,J., Vilchis-Landeros,M.M.,
            Mendoza,V. and Lopez-Casillas,F.
  TITLE     Murine betaglycan primary structure, expression and
            glycosaminoglycan attachment sites
  JOURNAL   Biochim Biophys Acta 1384 (2), 189-196 (1998)
   PUBMED   9659379
REFERENCE   8  (bases 1 to 6090)
  AUTHORS   Kolodziejczyk,S.M. and Hall,B.K.
  TITLE     Signal transduction and TGF-beta superfamily receptors
  JOURNAL   Biochem Cell Biol 74 (3), 299-314 (1996)
   PUBMED   8883836
  REMARK    Review article
REFERENCE   9  (bases 1 to 6090)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   10 (bases 1 to 6090)
  AUTHORS   Segarini,P.R.
  TITLE     TGF-beta receptors: a complicated system of multiple binding
            proteins
  JOURNAL   Biochim Biophys Acta 1155 (3), 269-275 (1993)
   PUBMED   8268187
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133897.15 and AC166776.6.
            
            On Jan 5, 2017 this sequence version replaced NM_011578.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070428.1, AF039601.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AC133897.15        149068-149442       c
            376-532             AC133897.15        126007-126163       c
            533-717             AC133897.15        74706-74890         c
            718-855             AC133897.15        37618-37755         c
            856-1039            AC166776.6         18631-18814
            1040-1208           AC166776.6         23108-23276
            1209-1356           AC166776.6         24893-25040
            1357-1546           AC166776.6         30520-30709
            1547-1875           AC166776.6         32354-32682
            1876-2028           AC166776.6         33145-33297
            2029-2169           AC166776.6         35396-35536
            2170-2328           AC166776.6         35989-36147
            2329-2625           AC166776.6         40037-40333
            2626-2743           AC166776.6         42488-42605
            2744-2791           AC166776.6         51659-51706
            2792-2899           AC166776.6         54540-54647
            2900-6090           AC166776.6         63309-66499
FEATURES             Location/Qualifiers
     source          1..6090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 51.9 cM"
     gene            1..6090
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /note="transforming growth factor, beta receptor III"
                     /db_xref="GeneID:21814"
                     /db_xref="MGI:MGI:104637"
     exon            1..375
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            376..532
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            533..717
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            718..855
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1039
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1208
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1356
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1546
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1875
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2028
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2169
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2328
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2625
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2743
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2791
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2899
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..6090
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6063..6068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /note="hexamer: AATAAA"
     polyA_site      6087
                     /gene="Tgfbr3"
                     /gene_synonym="1110036H20Rik; TBRIII"
                     /note="major polyA site"
ORIGIN      
        1 ccctttcgct gattgctgtg gctgcgcgcc cgaccccgcc cgcgcgtgtg cgcggccgag
       61 ttagggcgcc gcacgggcct gatgggggtg atccaggctt tcggggacgc cgagcgccac
      121 tttcctcctc cctggcagtg agagagagag agaggtggag agggagaagc gggctgctgt
      181 ccttccaggc cactttcgct gcgcgattcc gcgagctccc ggcaggaggt gaaagtcccc
      241 ggcggggtcc ggatggcgca gttgaactgc ggctgctgag ctcgcggccg cctgcgcgcg
      301 ctgggcgcgg ggactcgtct gggctactcc cccacctcgc gttggacgac cggtcctgga
      361 cacaccgctt gcgaggcaag ttgaacattg cagagaagga tcttaaggct acacccgact
      421 tgccacactt gccatccagc tgaagaacca aaggctgttg gagagatggc agtgacatcc
      481 caccacatgg tccctgtgtt tgtcctgatg agcgcctgcc tggccaccgc aggtccagag
      541 cccagcaccc ggtgtgaact gtcaccgatc agtgcctctc atccagtcca ggccctgatg
      601 gagagcttca ccgttctgtc tggctgtgcc agcagaggca ccactgggct gccaagggag
      661 gttcacatcc taaacctccg cagtacagac caaggactag gccagccgca gagagaggtt
      721 accctgcatc tgaaccccat tgcctccgtg cacactcacc acaagcctgt tgtgttcctg
      781 ctcaactccc cacagcccct ggtgtggcat gtgaagacag agagactggc tgctggtgtc
      841 cccagactct tcctggtttc ggagggttct gtggtccagt tttcatcagg aaacttctcc
      901 ttgacagcag aaacagagga aaggagtttc cctcaagaaa atgagcatct gctacactgg
      961 gcccaaaagg aatatggagc agtgacttca ttcaccgaac ttaagatagc aagaaatatc
     1021 tatattaaag tgggagaaga tcaagtgttc cctcccacgt gtaacatagg gaaaaatttt
     1081 ctctcgctca attaccttgc ggagtacctt caacccaaag ccgccgaagg ttgtgtcctg
     1141 gccagtcagc cccacgagaa ggaagtgcat atcattgagt taatctcccc caactccaat
     1201 ccttacagca ccttccaggt ggatataata attgacatac gacctgctcg agaggatcct
     1261 gaggtggtca aaaacctcgt cctgatcttg aagtgcaaaa aatctgtcaa ctgggtgatc
     1321 aagtcttttg acgtcaaggg aaacttgaaa gttattgctc ctgacagtat tggctttgga
     1381 aaagagagtg aacgatccat gacagtgacc aaattggtaa gaaatgacat cccttccacc
     1441 caagagaatc tgatgaagtg ggcattggac aatggctaca gcccagtgac gtcatacacc
     1501 atagctcctg tggccaatag atttcatctt cggcttgaga acaacgagga gatgagagat
     1561 gaggaagtcc acaccattcc tcctgagctt cggatcctgc tgggccctga ccacctgcct
     1621 gccctggaca gcccatcctt ccaaggggaa atcccaaatg gaggtttccc cttcccattc
     1681 ccggatatcc ccaggagagg ctggaaggag ggagaagata ggatcccccg gccaaaggaa
     1741 cccatcattc ccagagttca attgcttcca gaccacagag agccagaaga agtgcaaggg
     1801 ggcgtgaata tcgccctgtc agtcaaatgt gacaatgaaa agatggtggt agctgtagac
     1861 aaagattctt tccagaccaa tggctactcg gggatggagc tcaccctgtt ggatccttcc
     1921 tgcaaagcca agatgaatgg tacccacttt gtactggagt ctccgctgaa tggctgtggt
     1981 actagacata ggaggtcagc cccagatggt gtggtttact ataactctat tgtggtgcag
     2041 gctccatccc ctggggatag cagtggctgg ccagacggct acgaagattt ggagtcgggt
     2101 gataatggat ttcctggaga cacagatgaa ggagaaactg cccccctgag ccgtgctgga
     2161 gtggtagtgt ttaactgcag cttgcggcag ctgaggagtc ccagtggctt ccaggaccag
     2221 ctcgatggaa atgctacctt caacatggag ctgtataaca cagacctctt tctggtgccc
     2281 tccccagggg tcttctctgt ggcagagaat gagcatgtat atgttgaggt gtctgtcact
     2341 aaggctgacc aagatctggg atttgccatc caaacctgct ttatctctcc atactcaaac
     2401 ccagacagaa tgtctgatta caccatcatc gagaacatct gtccgaagga tgactctgtg
     2461 aagttctaca gctccaagag agtgcacttc cccatcccac atgctgaagt ggacaagaag
     2521 cggttcagct ttgtgttcaa gtccgtgttc aacacctccc tgctcttcct gcactgcgag
     2581 ctgacgctgt gctctaggaa gaagggctcc cagaagctgc caaagtgtgt gactcctgac
     2641 gacgcctgca cctctctaga tgccaccatg atctggacca tgatgcagaa taagaagaca
     2701 ttcaccaagc ccctggccgt ggtcctccaa gtagattata aagaaaatgt tccaaacatg
     2761 aaggagtcca gtccggttcc tcctcctcca cagattttcc acggcctgga cacgctcacc
     2821 gtgatgggca ttgcgtttgc agcatttgtg atcggagcac tcctgacggg ggccttgtgg
     2881 tatatctact cccacacagg ggagacggca cgaaggcagc aagtccctac ctcgccacca
     2941 gcctcggaga acagcagcgc agcccacagc atagggagca ctcagagcac tccctgctct
     3001 agcagcagca cggcctaggt ggacagatgg acgccgctgc ctaggtggac agacggatgc
     3061 ctgccaccgc cggggcaggg ccagatgccg atgctgggtg tccagactca gaaggcttga
     3121 tctgggttcc ctgtaaagag agagtgaatt tcagtataca gacagcctgc tctacccacc
     3181 ccttccttac cacggcccac gtaaatgtga ccctggacat ctgtcacacg aaagctaagc
     3241 tggtggcctt ccccgccagc ccctcgcagg atgggggttt caatgtgaaa catatgccag
     3301 tttttgttct tttttttttt ttttatgctg ctttgtccag gtgtccaaac atccatcatt
     3361 tggggtcgta tgttttaaag agtaaaggag acggtgaagg gatgtcagct agagtgtaga
     3421 gccagggaga gacagccagg gattctcgcc tagctgaacc aagatgtaaa ataggagaaa
     3481 tgctccctcc atagccaatc tgcatctcgc tctggatgcc cactcctgac ctgccacgcc
     3541 ctacatggtc ccctgtgtag cttgctagcc ttgggggcct gtcacttgcc aaagtaacat
     3601 tcctctcttg ggccaaaatg aatgctgact cctgatactc cgcacaagca caccaactcc
     3661 aaaagtgcct taaagccagg tttgtgtctc ctttcaggag agagcgtgta acgtcagatt
     3721 tgtgcctgtc tcgaacattc tgtcctaatc atacttaaac atcaggcagg tggggttcag
     3781 tggtaagcga agggattatt agcaaggtaa tgcctgtgta tggtcatata ggcacaaatg
     3841 cagaacaccc agcacattgg agagacgacc acttcctcct ttaaaatgtc ctatgcttcc
     3901 agagtcggaa cctgagttat atgtggtaga ttatattgac tccaaccatc agcctttctg
     3961 atgagcctgt agagaagcct agagagcccc gggccatctg atgatgtcac cagtgctgcc
     4021 tcagatgata cagagacagg gagtttcagg tgaacttctt cagcagaata aggtgatgcc
     4081 actctgacct ttgctgagct cagtgactct tcagtgttaa aactgaaccc cagaggggat
     4141 tctccatgcc agatccgctg caaattaaat aataccaatt ttctagagtc cctccctcct
     4201 cccccctccc ctgccaacca acttaagatt ccataagtag aacaagctag atcctaacct
     4261 gaaatagcca tgagcaaagc ccactgcctt tacagtcagg cagttgtgcc cagaccttca
     4321 tgaatgaaaa cgtcaacgtt gaagcgttgc tgatggaagc agcgtgtgaa gggatacgga
     4381 caatctctca gtcgatgagc cctcgtctga ctgaccagag tggcccagct tctattcaat
     4441 tgggaaaatt tgaaccaaag cagatttctt cagggctgag ggtctccaac cgatgcatag
     4501 atacattgaa atactttaga tttcccacat ggatggtttg agactagaga aatacttttc
     4561 tctagttcgt tggtttttaa catgaaggtg tctttgggga ggacctggat catgctacct
     4621 gtgtttaaaa ataatgcgct ttgcctaacc ttcagccgaa tgtaactgat aagtatattc
     4681 tatgtataaa aaaatgttta aagatgtctt caaggaagac tagagtcttt aaatcactta
     4741 tagctatatt ttactacaaa aattctgtat aaagatatat ttaaatattt tagagaaatt
     4801 taagttactc cttatgaaat gtttaatttc agttactgtg aattcttcta atcagttcgt
     4861 tctttgattt taaaaagaaa aaccttttcc atcatattaa agagaaaatt agctatggga
     4921 agatattaaa agatttctta gatggatgtg gttaaaattt ttgtaatata tttaaatgta
     4981 tatttttgag agagatacta cattgccaag gactttataa ataatcttaa attaacttac
     5041 aaatttataa gatgcaaacc aaaagacttt ttttttttta aagagagaga gaaaagagaa
     5101 aaaagctttt atttccttgg atctcattat cagaaatatt attcagctca agaaatctga
     5161 ccccatattg gaaaatgaat gtcctttagt attcctgaag ctaaagcttg ggtgtctcct
     5221 cccagctctt gttacagtgt ttctgactgc ttcacccttc acagatttaa tacaatgtat
     5281 aagccttact ttcataacat attctacaag tttccttaag actgttgtta tagtctggct
     5341 gaacccattt ccacctgcaa agtcttgtgt tgtgtctgca ggccacacca gtggccacag
     5401 gggccatttt gtcttgttga tgctgaaacc atgctggact gccccaggct aaggcaggac
     5461 tgtctgtgca aggcactaca gctattcacg tggagttacc gctgcatttt caaaggtcgg
     5521 agatctttct tctgcctgag ttggtcatgt agcaattttt tcctaaacac aaaatggcct
     5581 tttgcttgtc tggtaatgag attgtaaatc catttcctgc gtgtgttctc cgcaggcttg
     5641 cctgagtgtg tggggtgcgc aggcgcgtgc ctgtcttttt gtactgtaac tacctcatgg
     5701 tttgaatgat gagcgtactg ctggttgtat taacagagca catttgtcgg gtgagtcgtg
     5761 tatacaaact tttttttttt atcctgtttg ttttatctgg gggttcgttc attaaactga
     5821 cagatatttt tctaggaagg actattatca gtttccaaat gcaatactct attctggttt
     5881 ttcctgagtg agcctgattt tgttcctgtt tttcatctac gagggtaaaa gcataccccg
     5941 ggaaatccct gtggccagtt tgaacacccc tgctgtaacc ttccctctgt tccatggtct
     6001 ttgtgaacct gcttagaggt atagttttga taaccacagt tttaattctt ttatctgtgc
     6061 ataataaaga tatgtatcaa ttattaattt
//
