LOCUS       NM_009370               5779 bp    mRNA    linear   ROD 29-AUG-2023
DEFINITION  Mus musculus transforming growth factor, beta receptor I (Tgfbr1),
            transcript variant 1, mRNA.
ACCESSION   NM_009370 XM_977763 XM_977795 XM_988573 XM_988612
VERSION     NM_009370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5779)
  AUTHORS   Wei H, Du S, Parksong J, Pasolli HA, Matte-Martone C, Regot S,
            Gonzalez LE, Xin T and Greco V.
  TITLE     Organ function is preserved despite reorganization of niche
            architecture in the hair follicle
  JOURNAL   Cell Stem Cell 30 (7), 962-972 (2023)
   PUBMED   37419106
REFERENCE   2  (bases 1 to 5779)
  AUTHORS   Saroya G, Hu J, Hu M, Panaretos C, Mann J, Kim S, Bush JO and
            Kaartinen V.
  TITLE     Periderm Fate during Palatogenesis: TGF-beta and Periderm
            Dedifferentiation
  JOURNAL   J Dent Res 102 (4), 459-466 (2023)
   PUBMED   36751050
REFERENCE   3  (bases 1 to 5779)
  AUTHORS   Zhou J, Tian G, Quan Y, Kong Q, Huang F, Li J, Wu W, Tang Y, Zhou Z
            and Liu X.
  TITLE     The long noncoding RNA THBS1-AS1 promotes cardiac fibroblast
            activation in cardiac fibrosis by regulating TGFBR1
  JOURNAL   JCI Insight 8 (6), e160745 (2023)
   PUBMED   36787190
  REMARK    GeneRIF: The long noncoding RNA THBS1-AS1 promotes cardiac
            fibroblast activation in cardiac fibrosis by regulating TGFBR1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5779)
  AUTHORS   McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour
            N, Butcher LD, Fisch K and Prince LS.
  TITLE     Sp3 is essential for normal lung morphogenesis and cell cycle
            progression during mouse embryonic development
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36762637
REFERENCE   5  (bases 1 to 5779)
  AUTHORS   Laky K, Kinard JL, Li JM, Moore IN, Lack J, Fischer ER, Kabat J,
            Latanich R, Zachos NC, Limkar AR, Weissler KA, Thompson RW, Wynn
            TA, Dietz HC, Guerrerio AL and Frischmeyer-Guerrerio PA.
  TITLE     Epithelial-intrinsic defects in TGFbetaR signaling drive local
            allergic inflammation manifesting as eosinophilic esophagitis
  JOURNAL   Sci Immunol 8 (79), eabp9940 (2023)
   PUBMED   36608150
REFERENCE   6  (bases 1 to 5779)
  AUTHORS   Iseki S, Osumi-Yamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani
            H, Hayashi Y and Eto K.
  TITLE     Localization of transforming growth factor-beta type I and type II
            receptors in mouse development
  JOURNAL   Exp Cell Res 219 (2), 339-347 (1995)
   PUBMED   7641785
REFERENCE   7  (bases 1 to 5779)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   8  (bases 1 to 5779)
  AUTHORS   ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K
            and Heldin CH.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   9  (bases 1 to 5779)
  AUTHORS   Suzuki A, Shioda N, Maeda T, Tada M and Ueno N.
  TITLE     A mouse TGF-beta type I receptor that requires type II receptor for
            ligand binding
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1063-1069 (1994)
   PUBMED   8117262
REFERENCE   10 (bases 1 to 5779)
  AUTHORS   Tomoda T, Kudoh T, Noma T, Nakazawa A, Muramatsu M and Arai K.
  TITLE     Molecular cloning of a mouse counterpart for human TGF-beta type I
            receptor
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1054-1062 (1994)
   PUBMED   8117261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY200044.1 and BC063260.1.
            
            [WARNING] On Oct 16, 2023 this sequence was replaced by
            NM_009370.4.
            
            On Aug 19, 2015 this sequence version replaced NM_009370.2.
            
            Summary: This gene encodes a member of the transforming growth
            factor beta (TGF-beta) receptor family of proteins. These proteins
            comprise one component of the TGF-beta signaling pathway, which
            transduces extracellular signals into gene expression changes to
            regulate a wide range of cellular responses, including
            proliferation, migration, differentiation and apoptosis. Homozygous
            knockout mice for this gene exhibit impaired angiogenesis and
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063260.1, D28526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BY200044.1         2-84
            84-5779             BC063260.1         1-5696
FEATURES             Location/Qualifiers
     source          1..5779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.02 cM"
     gene            1..5779
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /note="transforming growth factor, beta receptor I"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
     exon            1..175
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1602
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TGF-beta receptor type-1; TGF-beta receptor
                     type I; transforming growth factor-beta receptor type I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 1 precursor"
                     /protein_id="NP_033396.1"
                     /db_xref="CCDS:CCDS18160.1"
                     /db_xref="GeneID:21812"
                     /db_xref="MGI:MGI:98728"
                     /translation="MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTC
                     ETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHC
                     NKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPN
                     EEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGE
                     VWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQL
                     WLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDL
                     KSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKH
                     FESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKL
                     RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            176..421
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..664
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..895
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1063
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1220
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1345
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1476
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..5749
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5728..5733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
     polyA_site      5749
                     /gene="Tgfbr1"
                     /gene_synonym="Alk-5; ALK5; ESK2; TbetaR-I; TbetaRI;
                     TGFR-1"
ORIGIN      
        1 ggcggggagg tggggcgagg aggggcgagg cttcctgagg agaagctgcg gccggggccg
       61 ggccgggcca caaacagtgg cggcgggacc atggaggcgg cggccgctgc tccacgtcgt
      121 ccgcagctcc tcatcgtgtt ggtggcggcg gcgacgctgc tcccgggggc gaaggcatta
      181 cagtgtttct gccacctctg tacaaaggat aattttacct gtgagacaga tggtctttgc
      241 tttgtctcag tcactgagac cacagacaaa gttatacaca atagtatgtg tatagctgaa
      301 attgacctaa ttcctcgaga caggccattt gtatgtgcac catcttcaaa aacaggggca
      361 gttactacaa catattgctg caatcaggac cactgcaata aaatagaact cccaactaca
      421 ggaccttttt cagaaaagca gtcagctggc cttggtcctg tggagctggc agctgtcatt
      481 gctggtccag tctgcttcgt ctgcattgca cttatgctga tggtctatat ctgccataac
      541 cgcactgtca ttcaccaccg tgtgccaaat gaagaggatc catcactaga tcgccctttc
      601 atttcagagg gcaccacctt aaaagattta atttatgata tgacaacatc agggtctgga
      661 tcaggtttac cactgcttgt tcaaagaaca attgccagga ccattgtgtt acaagaaagc
      721 attggcaaag gtcggtttgg agaagtttgg cgaggcaaat ggcggggaga agaagttgct
      781 gtgaagatat tctcttctag agaagagcgt tcatggttcc gagaggcaga gatttatcag
      841 actgtaatgt tacgccatga aaatatcctg ggatttatag cagcagacaa caaagacaat
      901 gggacatgga cgcagctgtg gttggtgtca gattatcatg agcatggatc ccttttcgat
      961 tacttgaata gatacactgt tactgtggaa ggaatgatca agcttgctct gtccacagca
     1021 agtggtcttg cccatcttca catggagatt gttggtaccc aaggaaaacc agctattgcc
     1081 catagagatt tgaaatcaaa gaatatcttg gtgaagaaaa atggaacctg ttgtattgca
     1141 gacttgggac ttgctgtgag acatgattct gccacagata caattgatat tgctccaaac
     1201 cacagagtag gcactaaaag gtacatggcc cctgaagttc tagatgattc cataaatatg
     1261 aaacattttg aatccttcaa acgcgctgac atctatgcaa tgggcttagt gttctgggaa
     1321 attgctcgac gctgttctat tggtggaatc catgaagact atcagttgcc ttattatgat
     1381 cttgtacctt ctgatccatc ggttgaagaa atgagaaaag tagtttgcga acagaagtta
     1441 aggccaaata ttccaaacag atggcagagc tgtgaggcct tgagagtgat ggctaaaatt
     1501 atgagagaat gctggtatgc caatggagca gcaaggctga cagctttgcg aattaaaaaa
     1561 acattgtcac aactcagcca acaggaaggc atcaaaatgt aactgaaaca ccgtgggaac
     1621 tctgctctct tcatatctgc tcctgggtgt ttaggaggct ggttgttcta cctcactgag
     1681 agaacagagg gctctgcttc ctcttgcagc agtggaatat ggtcaactga aagcttccca
     1741 gggtttctct gggcccagag gcagccgtgg ggtcctttct gtgcactatg gatacttctt
     1801 ccagacagtt acagaatgtt gtgtagtcta cttttgtttt tattaacaaa gcttgttttt
     1861 aaagacaact gccagccctt agggagctgc tgtgctgttg accttctgta agggtgaagg
     1921 agctggggtg tggcactaaa tgaagcactt ctgattttca ctcctagtag tacattctca
     1981 gaggactctg aaccactagt gtttccttgg ttcactttga atgtactgtt ctataatttt
     2041 tcaagatctt aaactaacac tttaaactct atagtctaaa aaatatgacc tcgtggaggc
     2101 gtgggggcac agttgctccg ttgtatttgt gcacagctcc ttcacactct gaacacaaca
     2161 caccttcaca gtagggttgt gctacaccag taagtgctac ttttgcatct gtctaagtgg
     2221 aaacgaacag aactacttaa aggcggtgtt aagtcctgta tcattttcat tcaaaaagtt
     2281 tatttttctg agtaacctaa accttttctg ggtttgtttt tgttttttga gggtttttgt
     2341 gatagatgtc attcagtctt catgcctttc tcctacccag atgtgcttga accactgagg
     2401 caaggctgta gcattgataa gcagtgactg ccatgcggga acaccccaca ggagcactgg
     2461 agctctgcag ttgagacgtt tagcctgagt ttattttaag aagtgaagtg gcactccaaa
     2521 catgtacagt gctttatgga tgtaatcatt atggtataca gactcctttt gaaaggggag
     2581 gcttgtctat tgccgaagga aaagttgtat gctgttctgt aagccatttc tttttcttta
     2641 tttgatcaaa gcagtgtttt gttttgtttt gatttttctt ttttggaaag gaattgcatt
     2701 taaaattcaa atgtggttaa tgttaaataa taggcctttt tctaggaagg cagatatagt
     2761 taatatgaat gtacaagtgt aggtgacttt cacatgttat gtagctgtaa gtatttgtgg
     2821 attctatctt gggaagggta gagttagtgg agttttgagg tctcactacc ctttgaggaa
     2881 ggcagctttt aattcagtct ttttatctca tatgtgcaga tcttgcaact gcttgattta
     2941 catggtagca atgaattcag tgccacgttg atactaggag aagcagcaac taatagctat
     3001 tctgagtaga ggctctcttc atatattctt ggtcatatta aatgtcaaag tcagtccgtt
     3061 gggtcttctc actgctgctg gagttaggtg gttgagcctg ggttttactt cagtgctgtc
     3121 aaatctttgc agggcttgtg tggctttcaa agtccttttt atcactgtga tcatattctg
     3181 ggcggggaaa tgttatcatc attgcttgag acgagatgtt gaacatagtg ataccaatcc
     3241 ccagataaaa aggtcaaaat aacctttagt gtttagccaa gaagagattg tgactattga
     3301 tctgaagcag ctgggctctg ttaatgtctt atttcaaacc tagcatacat ttgaagacta
     3361 tttggtctta aaccaaagta actgtaggac gaatgacata ctacctagac attagtgtcc
     3421 gtttcatacg tcagaaacac catgggaaaa agtacctaga gattagtatc tttaatacaa
     3481 atctgagttt tttctgtaat tatcatgatt tcatcaatgt aagtaagggt ttgttgttac
     3541 agttgtatca cctgcttaaa taagctcttg tgctataatc aggtactttt ggggcctttg
     3601 ttttcagttt tttccatttc taacccttcg agatctgctt tatagaaatc cagggaccaa
     3661 tgtattttat cactaaaact gtttttatat aattttaaga ccataccaaa agttatctga
     3721 gttaaagttg taatacgttt cttactttct tgcaaggaaa tgggttttta ctgaagacac
     3781 ttctcatgat atctgaagtt gaagaatcat tatgtttttc ttacctaagt ggataaaatg
     3841 tgctttgatg aatcagggaa ttttttaaag ttcgaattta gttctaaatt gagtttacat
     3901 gtttacagct aattttttgt gtagggatag tttgattctc taggtggcca atactgaata
     3961 taaaaataac ttaaaaattg agataggtca tggttaatgt ggctataact atatatacat
     4021 ctaattagag aaatatttct atgtaatttt gtagtgcagt ctgttgtttc tattgccaat
     4081 caaagacttc cccccagccc caaagtgtag tatggctaag acatatcttc tgacaaatta
     4141 catattatct tgtcaatacc ctggttaagc tagcatgaag gaagtatgac ttactgaggc
     4201 ttacacaact tgagtccctt atatcttcag ctctgttttt cccactctgc ctttctgctg
     4261 ccccctggct cagagactta gtgttcctga ccccacctcc agcctttgga cctaagagct
     4321 gcttttgaga cctaaaatga agtgattgat ggaagctgtg tgacattttt ccacttcctt
     4381 gagtcactgg gtgttatgag ggagtgatct gcaaattggg gtagggggtg cccctactgg
     4441 tagccctgct ttgatgtcag ctctgggcaa agattagggt gacagctaag tggcagtgga
     4501 agttggcctc agaagtagtg gccagctgtg tctctagtag gacagtaaag gcatgaagct
     4561 cagcctgtaa tcctgctact acagtagtac tccagaagtg ccttgaggcc ctgtgtgggg
     4621 ctgtggccat caagaattcc agattttggt tctcgctgca gacttaagtg gccatgtagc
     4681 catttttgta atccatacat gtttgactct tccctctgca aattgtcaga tacgtaaaac
     4741 caatgacaaa ctactactta acatgcacac caaaatctgc ccagaagaca ttgtgatttc
     4801 attccatgca ctgaaggaat gattgtaaat catttctttg ttccttggtc atgggagtgt
     4861 tctggttcta cattgtggag attccagctg ttgttctgtt atagcccagc agaacaagtc
     4921 gacgtgttga aattctgaag aatagtttgg gagtgcagta cagcttcatg tgttggatgt
     4981 tgaaactttc atgggccctc tttagaaaag cagaggactg tcagcacatt atttttaatc
     5041 ctgttatgca ctcgtactta ttgtcagtaa caataagtac gagtattgaa aatattgtca
     5101 gtaacattca gtctctttct taaagtgaat ttgcttattt ttcaatgaga tttgtgagtt
     5161 taatattatg aactgtgttt tgataatccc tttttcacat tgtgccaatg gaatggaata
     5221 tttgatattt ctttatatgt caaggagatg cttcaatatg tcatttgctt taaacttaaa
     5281 ttacctctca agagaccaag gtacatttac ctcattgtgt atataatgtt taatatttgt
     5341 cagcatccac caggtttgca attttatttc tataaagtgt gagtgttacg ttgctaagtt
     5401 actcagatgg tactgtattg tttatatctg taccccaaat gacatcatct agactttgtt
     5461 ttctgtgtct tattgtattt gtgcagtcct ttaaccctgt tggtgtgatt gctgcccttt
     5521 cagatatgtg caggtgtcta tagaaattct catttaaggt gaatggtttt gagaaacctg
     5581 tgaagagaga agcataaact gcatttcccc atcagttttt taaatgtaca ttgtatgtgt
     5641 agtaatattc cagatgaatt gtaaataaaa gctagggaga tgcttaaatt tcatcctaac
     5701 actacagtag aaaatggaag caatgcaaat aaacaacttt ttcccaccaa aaaaaaaaaa
     5761 aaaaaaaaaa aaaaaaaaa
//
