LOCUS       NM_009369               2715 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus transforming growth factor, beta induced (Tgfbi),
            transcript variant 1, mRNA.
ACCESSION   NM_009369
VERSION     NM_009369.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2715)
  AUTHORS   Pan,T., Liu,F., Hao,X., Wang,S., Wasi,M., Song,J.H., Lewis,V.O.,
            Lin,P.P., Moon,B., Bird,J.E., Panaretakis,T., Lin,S.H., Wu,D.,
            Farach-Carson,M.C., Wang,L., Zhang,N., An,Z., Zhang,X.H. and
            Satcher,R.L.
  TITLE     BIGH3 mediates apoptosis and gap junction failure in osteocytes
            during renal cell carcinoma bone metastasis progression
  JOURNAL   Cancer Lett 596, 217009 (2024)
   PUBMED   38849015
  REMARK    GeneRIF: BIGH3 mediates apoptosis and gap junction failure in
            osteocytes during renal cell carcinoma bone metastasis progression.
REFERENCE   2  (bases 1 to 2715)
  AUTHORS   Zanini,F., Che,X., Suresh,N.E., Knutsen,C., Klavina,P., Xie,Y.,
            Domingo-Gonzalez,R., Liu,M., Kum,A., Jones,R.C., Quake,S.R.,
            Alvira,C.M. and Cornfield,D.N.
  TITLE     Hyperoxia prevents the dynamic neonatal increases in lung
            mesenchymal cell diversity
  JOURNAL   Sci Rep 14 (1), 2033 (2024)
   PUBMED   38263350
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2715)
  AUTHORS   Zhou,J., Lyu,N., Wang,Q., Yang,M., Kimchi,E.T., Cheng,K., Joshi,T.,
            Tukuli,A.R., Staveley-O'Carroll,K.F. and Li,G.
  TITLE     A novel role of TGFBI in macrophage polarization and
            macrophage-induced pancreatic cancer growth and therapeutic
            resistance
  JOURNAL   Cancer Lett 578, 216457 (2023)
   PUBMED   37865162
  REMARK    GeneRIF: A novel role of TGFBI in macrophage polarization and
            macrophage-induced pancreatic cancer growth and therapeutic
            resistance.
REFERENCE   4  (bases 1 to 2715)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   5  (bases 1 to 2715)
  AUTHORS   Zhang,S., Mo,X., Jin,Y., Niu,Z., Yao,M., Zhang,Y., Li,L., Hu,G. and
            Ning,W.
  TITLE     Single-cell transcriptome analysis reveals cellular heterogeneity
            and highlights Fstl1-regulated alveolar myofibroblasts in mouse
            lung at birth
  JOURNAL   Genomics 115 (5), 110677 (2023)
   PUBMED   37406975
REFERENCE   6  (bases 1 to 2715)
  AUTHORS   Nam,J.O., Kim,J.E., Jeong,H.W., Lee,S.J., Lee,B.H., Choi,J.Y.,
            Park,R.W., Park,J.Y. and Kim,I.S.
  TITLE     Identification of the alphavbeta3 integrin-interacting motif of
            betaig-h3 and its anti-angiogenic effect
  JOURNAL   J Biol Chem 278 (28), 25902-25909 (2003)
   PUBMED   12704192
  REMARK    GeneRIF: betaig-h3 bears alphavbeta3 integrin-interacting motifs
            that mediate endothelial cell adhesion and migration and
            angiogenesis
REFERENCE   7  (bases 1 to 2715)
  AUTHORS   Juriloff,D.M., Gunn,T.M., Harris,M.J., Mah,D.G., Wu,M.K. and
            Dewell,S.L.
  TITLE     Multifactorial genetics of exencephaly in SELH/Bc mice
  JOURNAL   Teratology 64 (4), 189-200 (2001)
   PUBMED   11598925
REFERENCE   8  (bases 1 to 2715)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Brown,C.J.
  TITLE     Unravelling the complex genetics of cleft lip in the mouse model
  JOURNAL   Mamm Genome 12 (6), 426-435 (2001)
   PUBMED   11353389
REFERENCE   9  (bases 1 to 2715)
  AUTHORS   Schorderet,D.F., Menasche,M., Morand,S., Bonnel,S., Buchillier,V.,
            Marchant,D., Auderset,K., Bonny,C., Abitbol,M. and Munier,F.L.
  TITLE     Genomic characterization and embryonic expression of the mouse
            Bigh3 (Tgfbi) gene
  JOURNAL   Biochem Biophys Res Commun 274 (2), 267-274 (2000)
   PUBMED   10913330
REFERENCE   10 (bases 1 to 2715)
  AUTHORS   Skonier,J., Bennett,K., Rothwell,V., Kosowski,S., Plowman,G.,
            Wallace,P., Edelhoff,S., Disteche,C., Neubauer,M., Marquardt,H. et
            al.
  TITLE     beta ig-h3: a transforming growth factor-beta-responsive gene
            encoding a secreted protein that inhibits cell attachment in vitro
            and suppresses the growth of CHO cells in nude mice
  JOURNAL   DNA Cell Biol 13 (6), 571-584 (1994)
   PUBMED   8024701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132901.11 and AC132886.18.
            
            On Apr 13, 2018 this sequence version replaced NM_009369.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084431.1, AK150833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC132901.11        176182-176376
            196-294             AC132901.11        180836-180934
            295-359             AC132886.18        11921-11985
            360-520             AC132886.18        13561-13721
            521-685             AC132886.18        14011-14175
            686-832             AC132886.18        14395-14541
            833-974             AC132886.18        16275-16416
            975-1187            AC132886.18        17979-18191
            1188-1325           AC132886.18        18905-19042
            1326-1471           AC132886.18        19591-19736
            1472-1608           AC132886.18        20411-20547
            1609-1739           AC132886.18        21220-21350
            1740-1864           AC132886.18        23927-24051
            1865-1967           AC132886.18        24927-25029
            1968-2047           AC132886.18        25499-25578
            2048-2072           AC132886.18        26382-26406
            2073-2715           AC132886.18        27078-27720
FEATURES             Location/Qualifiers
     source          1..2715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.09 cM"
     gene            1..2715
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /note="transforming growth factor, beta induced"
                     /db_xref="GeneID:21810"
                     /db_xref="MGI:MGI:99959"
     exon            1..195
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2113
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /note="transforming growth factor-beta-induced protein
                     ig-h3; transforming growth factor, beta induced, 68 kDa"
                     /codon_start=1
                     /product="transforming growth factor-beta-induced protein
                     ig-h3 precursor"
                     /protein_id="NP_033395.1"
                     /db_xref="CCDS:CCDS36680.1"
                     /db_xref="GeneID:21810"
                     /db_xref="MGI:MGI:99959"
                     /translation="MALLMRLLTLALALSVGPAGTLAGPAKSPYQLVLQHSRLRGRQH
                     GPNVCAVQKVIGTNKKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALP
                     LSNLYETMGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWSSLPAEVLDSLV
                     SNVNIELLNALRYHMVDRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLL
                     KADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTVLEGDGQFT
                     LLAPTNEAFEKIPAETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGMSMETLGGTT
                     LEVGCSGDKLTINGKAVISNKDILATNGVIHFIDELLIPDSAKTLLELAGESDVSTAI
                     DILKQAGLDTHLSGKEQLTFLAPLNSVFKDGVPRIDAQMKTLLLNHMVKEQLASKYLY
                     SGQTLDTLGGKKLRVFVYRNSLCIENSCIAAHDKRGRFGTLFTMDRMLTPPMGTVMDV
                     LKGDNRFSMLVAAIQSAGLMEILNREGVYTVFAPTNEAFQAMPPEELNKLLANAKELT
                     NILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSSKNNVVSVNKEPVAETDIMATNGV
                     VYAINTVLQPPANRPQERGDELADSALEIFKQASAYSRAAQRSVRLAPVYQRLLERMK
                     H"
     exon            196..294
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..359
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            360..520
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            521..685
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..832
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..974
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1187
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1325
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1471
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1608
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1739
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1864
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1967
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2047
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2072
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2715
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2694..2699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /note="hexamer: AATAAA"
     polyA_site      2713
                     /gene="Tgfbi"
                     /gene_synonym="68kDa; Beta-ig; big-h3"
                     /note="major polyA site"
ORIGIN      
        1 ctcacttcac cagcaccgcc cgcgcctgct ttcatcgtgg gtccgcgcgt gctccagctc
       61 catggcgctc ctcatgcgac tgctgaccct cgctctggca ctgtctgtgg gccccgctgg
      121 gacccttgca ggtcccgcca agtcacccta ccagctggtg ctgcagcata gccggctccg
      181 gggtcgccag cacggcccca atgtatgtgc tgtgcagaag gtcattggca ccaacaagaa
      241 atacttcacc aactgcaagc agtggtacca gaggaagatc tgcggcaagt cgacagtcat
      301 cagttatgag tgctgtcctg gatatgaaaa ggtcccagga gagaaaggtt gcccagcagc
      361 tcttccgctc tcaaatctgt atgagaccat gggagttgtg ggatcgacca ccacacagct
      421 gtatacagac cgcacagaaa agctgaggcc tgagatggag ggacccggaa gcttcaccat
      481 ctttgctcct agcaatgagg cctggtcttc cttgcctgcg gaagtgctgg actccctggt
      541 gagcaacgtc aacatcgaac tgctcaatgc tctccgctac cacatggtgg acaggcgggt
      601 cctgaccgat gagctcaagc acggcatgac cctcacctcc atgtaccaga attccaacat
      661 ccagatccat cactatccca atgggattgt aactgttaac tgtgcccggc tgctgaaggc
      721 tgaccaccat gcgaccaacg gcgtggtgca tctcattgac aaggtcattt ccaccatcac
      781 caacaacatc cagcagatca ttgaaatcga ggacaccttt gagacacttc gggccgccgt
      841 ggctgcatca ggactcaata ccgtgctgga gggcgacggc cagttcacac tcttggcccc
      901 aaccaacgag gcctttgaga agatccctgc cgagaccttg aaccgcatcc tgggtgaccc
      961 agaggcactg agagacctgc taaacaacca catcctgaag tcagccatgt gtgctgaggc
     1021 cattgtagct ggaatgtcca tggagaccct ggggggcacc acactggagg tgggctgcag
     1081 tggggacaag ctcaccatca acgggaaggc tgtcatctcc aacaaagaca tcctggccac
     1141 caacggtgtc attcatttca ttgatgagct gcttatccca gattcagcca agacactgct
     1201 tgagctggct ggggaatctg acgtctccac tgccattgac atcctcaaac aagctggcct
     1261 cgatactcat ctctctggga aagaacagtt gaccttcctg gcccccctga attctgtgtt
     1321 caaagatggt gtccctcgca tcgacgccca gatgaagact ttgcttctga accacatggt
     1381 caaagaacag ttggcctcca agtatctgta ctctggacag acactggaca cgctgggtgg
     1441 caaaaagctg cgagtctttg tttatcgaaa tagcctctgc attgaaaaca gctgcattgc
     1501 tgcccatgat aagaggggac ggtttgggac cctgttcacc atggaccgga tgttgacacc
     1561 cccaatgggg acagttatgg atgtcctgaa gggagacaat cgttttagca tgctggtggc
     1621 cgccatccag tctgcaggac tcatggagat cctcaaccgg gaaggggtct acactgtttt
     1681 tgctcccacc aatgaagcgt tccaagccat gcctccagaa gaactgaaca aactcttggc
     1741 aaatgccaag gaacttacca acatcctgaa gtaccacatt ggtgatgaaa tcctggttag
     1801 cggaggcatc ggggccctgg tgcggctgaa gtctctccaa ggggacaaac tggaagtcag
     1861 ctcgaaaaac aatgtagtga gtgtcaataa ggagcctgtt gccgaaaccg acatcatggc
     1921 cacaaacggt gtggtctatg ccatcaacac tgttctgcag ccgccagcca accgaccaca
     1981 agaacgagga gatgagctgg cagactctgc ccttgaaatc ttcaaacagg cgtcagcgta
     2041 ttccagggct gcccagaggt ctgtgcgact tgcccctgtc tatcagcggt tactggagag
     2101 gatgaagcat tagcaggaag accgaggagg agagccctgc agcagcttcc cgccagtttc
     2161 tctcagtttg ccaaagagac cattgaatgt ttttgaaacc aaagagcaca cttcaacata
     2221 catgggctgc accatattga gatctgagcc ttggacgggt agggaagggg ttaaggggag
     2281 aaaggttctt tttagctttc gatccctcca aacgtggttg ttaacccatt gaatatacag
     2341 atctggcagt catagcttgg caccaaattc ccgaaaggac ctctcgaaag catggaattt
     2401 cctgactgtg ccaagggcct ggataaaggg gaactacggc atcttggagc tcacaaatgt
     2461 gaatcaagca gtccggcatt ctggaaagcc ttggcatggt tctgtaaagc tcttgtaccg
     2521 ctggagaaac ggcatcacta taagctatga gttgaactgt ttctgtcaag tatgtcttgt
     2581 gtccacacat ggtttggatg cttctatatt ggccctgccc aggtagaaag ggtaagaaga
     2641 acatgtagaa tccagattcc ctgagtgtga gggacccatg gtgcatttgt aataataaaa
     2701 ccaaagaaac aaaca
//
