LOCUS       NM_009368               3401 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transforming growth factor, beta 3 (Tgfb3), mRNA.
ACCESSION   NM_009368 XM_994378 XM_994396
VERSION     NM_009368.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3401)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   2  (bases 1 to 3401)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   3  (bases 1 to 3401)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3401)
  AUTHORS   Jang,J., Bentsen,M., Kim,Y.J., Kim,E., Garg,V., Cai,C.L., Looso,M.
            and Li,D.
  TITLE     Endocardial HDAC3 is required for myocardial trabeculation
  JOURNAL   Nat Commun 15 (1), 4166 (2024)
   PUBMED   38755146
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3401)
  AUTHORS   Ferguson,M.W., Sharpe,P.M., Thomas,B.L. and Beck,F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   6  (bases 1 to 3401)
  AUTHORS   Das,S.K., Flanders,K.C., Andrews,G.K. and Dey,S.K.
  TITLE     Expression of transforming growth factor-beta isoforms (beta 2 and
            beta 3) in the mouse uterus: analysis of the periimplantation
            period and effects of ovarian steroids
  JOURNAL   Endocrinology 130 (6), 3459-3466 (1992)
   PUBMED   1375903
REFERENCE   7  (bases 1 to 3401)
  AUTHORS   Paria,B.C., Jones,K.L., Flanders,K.C. and Dey,S.K.
  TITLE     Localization and binding of transforming growth factor-beta
            isoforms in mouse preimplantation embryos and in delayed and
            activated blastocysts
  JOURNAL   Dev Biol 151 (1), 91-104 (1992)
   PUBMED   1577201
REFERENCE   8  (bases 1 to 3401)
  AUTHORS   Millan,F.A., Denhez,F., Kondaiah,P. and Akhurst,R.J.
  TITLE     Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3
            suggest different developmental functions in vivo
  JOURNAL   Development 111 (1), 131-143 (1991)
   PUBMED   1707784
REFERENCE   9  (bases 1 to 3401)
  AUTHORS   Denhez,F., Lafyatis,R., Kondaiah,P., Roberts,A.B. and Sporn,M.B.
  TITLE     Cloning by polymerase chain reaction of a new mouse TGF-beta,
            mTGF-beta 3
  JOURNAL   Growth Factors 3 (2), 139-146 (1990)
   PUBMED   2206556
REFERENCE   10 (bases 1 to 3401)
  AUTHORS   Miller,D.A., Lee,A., Matsui,Y., Chen,E.Y., Moses,H.L. and
            Derynck,R.
  TITLE     Complementary DNA cloning of the murine transforming growth
            factor-beta 3 (TGF beta 3) precursor and the comparative expression
            of TGF beta 3 and TGF beta 1 messenger RNA in murine embryos and
            adult tissues
  JOURNAL   Mol Endocrinol 3 (12), 1926-1934 (1989)
   PUBMED   2628730
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134328.2, BC089347.1,
            AK162560.1 and AW122646.1.
            
            On Mar 25, 2009 this sequence version replaced NM_009368.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate a latency-associated peptide
            (LAP) and a mature peptide, and is found in either a latent form
            composed of a mature peptide homodimer, a LAP homodimer, and a
            latent TGF-beta binding protein, or in an active form consisting
            solely of the mature peptide homodimer. The mature peptide may also
            form heterodimers with other TGF-beta family members. This protein
            is involved in embryogenesis and cell differentiation, and may play
            a role in wound healing. Homozygous knockout mice for this gene
            exhibit cleft palate, delayed pulmonary development and neonatal
            death. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108426.1, AK148385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC134328.2         155465-155507       c
            44-1239             BC089347.1         1-1196
            1240-3286           AK162560.1         4-2050
            3287-3401           AW122646.1         1-115               c
FEATURES             Location/Qualifiers
     source          1..3401
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 40.09 cM"
     gene            1..3401
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /note="transforming growth factor, beta 3"
                     /db_xref="GeneID:21809"
                     /db_xref="MGI:MGI:98727"
     exon            1..1461
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1110..2348
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /note="transforming growth factor beta-3 proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-3 proprotein
                     precursor"
                     /protein_id="NP_033394.2"
                     /db_xref="CCDS:CCDS49116.1"
                     /db_xref="GeneID:21809"
                     /db_xref="MGI:MGI:98727"
                     /translation="MKMHLQRALVVLALLNLATISLSLSTCTTLDFGHIKKKRVEAIR
                     GQILSKLRLTSPPEPSVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQETSESEYYA
                     KEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNGTNLFRAEFRVLRVPNPS
                     SKRTEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESN
                     LGLEISIHCPCHTFQPNGDILENVHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNP
                     HLILMMIPPHRLDSPGQGSQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVH
                     EPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYV
                     GRTPKVEQLSNMVVKSCKCS"
     exon            1462..1625
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1755
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1863
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2035
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2189
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..3385
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
     regulatory      3361..3366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /note="hexamer: AGTAAA"
     polyA_site      3385
                     /gene="Tgfb3"
                     /gene_synonym="TGF-beta-3; Tgfb-3"
                     /note="major polyA site"
ORIGIN      
        1 gagaaataga gaaagcagtg tgtgtgtgca tgtgtgtgtg agagagagag ggaggagaga
       61 gagagagaag gggagagaga aagggaggga agaagagggc cgagtgtagg gggctgagcc
      121 acagagaggc gagacgcgca cgggaaaagc tttgcggagg acggagtaac gctttccgga
      181 gtcagctgcg gtgaatcggc ttctattttc ttttcctttt gatttttttt ttctttttaa
      241 attcctaaag agaagcaagg gacagaagcc atggccgaga gagaaaacaa gctgagatgc
      301 tggtgactgt gggtccaagt ggattatcgg acgagccgtc tccaacaggc ctgccctccc
      361 agcttgccag ttgtacataa tccctcatcc cagccaatga agacgagagg cagcgtgaac
      421 agagtcattt agaaagcccc cgaggaagtg taaacaaaag ggaaagcatg aatggagcgc
      481 tccagagaca agtgtgtcct gcactgcccc cacctttagc tgggcctgcg gccgcccagc
      541 cctgcctctc cccacatacc cactggtgat tttttttttt ttgaaaaaac attctttttt
      601 ttcttcgctt ttcttatttt cccttcaggg caaggcaaag agcttgattt tttgggaccc
      661 agccatcctc ttctgcactt tctttaaaat actcactttc tcctcgccaa gcagcgttgg
      721 gcgatatcag atatccgctc tatttatttt tacctaagga aaaactccag ctctcttccc
      781 actcccagct gccttgccac ccctcccaac cctcggcttg ccctccacct ggcctgctgg
      841 gagtcagagc ccggcagaac ctgtttagac atatggacaa ggatcctagc tctacccagc
      901 acacggtccg gtcccgctac ttcgtccagg ggttgccagc gcttcctggg agtcctgaag
      961 ctcacccagc gcagtgagtt catgcaccct cttgccaagc ctcaggcttt gggatctggg
     1021 gaggacgcct ggttttcctc cccctttcta ctggggtctc ctccttgcca ggcctcccca
     1081 gtcccctggc ctcgttcctg ggctcacaca tgaagatgca cttgcaaagg gctctggtag
     1141 tcctggccct gctgaacttg gccacaatca gcctctctct gtccacttgc accacgttgg
     1201 acttcggcca catcaagaag aagagggtgg aagccattag gggacagatc ttgagcaagc
     1261 tcaggctcac cagcccccct gagccatcgg tgatgaccca cgtcccctat caggtcctgg
     1321 cactttacaa cagcacccgg gagttgctgg aagagatgca cggggagagg gaggaaggct
     1381 gcactcagga gacctcggag tctgagtact atgccaaaga gatccataaa ttcgacatga
     1441 tccagggact ggcggagcac aatgaactgg ccgtctgccc caaaggaatt acctctaagg
     1501 tttttcgttt caatgtgtcc tcagtggaga aaaatggaac caatctgttc cgggcagagt
     1561 tccgggtctt gcgggtgccc aaccccagct ccaagcgcac agagcagaga attgagctct
     1621 tccagatact tcgaccggat gagcacatag ccaagcagcg ctacataggt ggcaagaatc
     1681 tgcccacaag gggcaccgct gaatggctgt ctttcgatgt cactgacact gtgcgcgagt
     1741 ggctgttgag gagagagtcc aacttgggtc tggaaatcag catccactgt ccatgtcaca
     1801 cctttcagcc caatggagac atactggaaa atgttcatga ggtgatggaa atcaaattca
     1861 aaggagtgga caatgaagat gaccatggcc gtggagacct ggggcgtctc aagaagcaaa
     1921 aggatcacca caacccacac ctgatcctca tgatgatccc cccacaccga ctggacagcc
     1981 caggccaggg cagtcagagg aagaagaggg ccctggacac caattactgc ttccgcaacc
     2041 tggaggagaa ctgctgtgta cgcccccttt atattgactt ccggcaggat ctaggctgga
     2101 aatgggtcca cgaacctaag ggttactatg ccaacttctg ctcaggccct tgcccatacc
     2161 tccgcagcgc agacacaacc catagcacgg tgcttggact atacaacacc ctgaacccag
     2221 aggcgtctgc ctcgccatgc tgcgtccccc aggacctgga gcccctgacc atcttgtact
     2281 atgtgggcag aacccccaag gtggagcagc tgtccaacat ggtggtgaag tcgtgtaagt
     2341 gcagctgagg ccagcctgcc acagaggagg gaaaactgcc accacagact gctgctcctt
     2401 ggaaaaccaa agcgacagac ctcaccctag aggcctggag cccagaagcc ctggctcccg
     2461 gcgaaaggcc gagagggagg cttccttctg gaacatttct ttctgctagc tttgagaatc
     2521 actgtggtaa agaaagtgtg ggttggttag gggaaggcac actgttgaga acatggaatt
     2581 tctgtggtgc aggcagaggt ggtggggtag agaacggata gcgagtggac attgtgagtg
     2641 gcaatgggcc tcgggctacc ctacaaaaga tgaagggtag agtggtcagt caggtgaagg
     2701 ccagactgga aggcatttca ggtctgaggt cagctttgct cactgcagta catctgctct
     2761 agggaattgg gatatcgtta gaggcggcca agcatttttc ttcagtttac caagccaaag
     2821 tcccctggaa tcatatcttg cactgcctgg aattaaggac aatccgttct ttctgcaact
     2881 gtcttttcac ctcgatcagc atcatgagtc atcacagatc atgtaattag tttctgggcc
     2941 agcaactagc tatctcaggt cccttagaga tgctggactc aaaagcagag gtcagaattg
     3001 gttctctcat gtattccctg ggggcccctc ctcctgcctt ccttcttggc cgcatttccc
     3061 cttggatatt tggctagaca ccttccgggt cagggtgtat tctccggatt cagagtccac
     3121 atagcctggg gcgccatttc cctcctaccc tagaccccgt tgctccccag gtgttcctgg
     3181 aagcaggtgc tacatgccaa gtatccgggg agcctcccat gtctgacatg atgactcggc
     3241 cccagatgca cagactgaag tataaagaca aatacaaata ttactctcag aatctttgta
     3301 taaataaata tttttgggga atcatggatg acttcatctc ctggaaggtt cttctaaaac
     3361 agtaaagacc tcactttaag gtgtaaaaaa aaaaaaaaaa a
//
