LOCUS       NM_009367               5116 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus transforming growth factor, beta 2 (Tgfb2), transcript
            variant 1, mRNA.
ACCESSION   NM_009367
VERSION     NM_009367.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5116)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   2  (bases 1 to 5116)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Jan 27;112:105573. doi:
            10.1016/j.ebiom.2025.105573.. PMID: 39874704]
REFERENCE   3  (bases 1 to 5116)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   4  (bases 1 to 5116)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5116)
  AUTHORS   Yang,J., Zhang,Y.N., Wang,R.X., Hao,C.Z., Qiu,Y., Chi,H.,
            Luan,W.S., Tang,H., Zhang,X.J., Sun,X., Sheps,J.A., Ling,V., Cao,M.
            and Wang,J.S.
  TITLE     ZFYVE19 deficiency: a ciliopathy involving failure of cell
            division, with cell death
  JOURNAL   J Med Genet 61 (8), 750-758 (2024)
   PUBMED   38816193
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5116)
  AUTHORS   Ferguson,M.W., Sharpe,P.M., Thomas,B.L. and Beck,F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   7  (bases 1 to 5116)
  AUTHORS   Das,S.K., Flanders,K.C., Andrews,G.K. and Dey,S.K.
  TITLE     Expression of transforming growth factor-beta isoforms (beta 2 and
            beta 3) in the mouse uterus: analysis of the periimplantation
            period and effects of ovarian steroids
  JOURNAL   Endocrinology 130 (6), 3459-3466 (1992)
   PUBMED   1375903
REFERENCE   8  (bases 1 to 5116)
  AUTHORS   Paria,B.C., Jones,K.L., Flanders,K.C. and Dey,S.K.
  TITLE     Localization and binding of transforming growth factor-beta
            isoforms in mouse preimplantation embryos and in delayed and
            activated blastocysts
  JOURNAL   Dev Biol 151 (1), 91-104 (1992)
   PUBMED   1577201
REFERENCE   9  (bases 1 to 5116)
  AUTHORS   Manova,K., Paynton,B.V. and Bachvarova,R.F.
  TITLE     Expression of activins and TGF beta 1 and beta 2 RNAs in early
            postimplantation mouse embryos and uterine decidua
  JOURNAL   Mech Dev 36 (3), 141-152 (1992)
   PUBMED   1373953
REFERENCE   10 (bases 1 to 5116)
  AUTHORS   Taketo,M., Howard,T.A. and Seldin,M.F.
  TITLE     Mapping of recombinant retrovirus integration sites that cause
            expression of the viral genome in murine embryonal carcinoma cells
  JOURNAL   Mamm Genome 2 (4), 240-245 (1992)
   PUBMED   1543915
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154879.10, AK159690.1,
            AK163286.1 and AK029306.1.
            
            On Jul 2, 2016 this sequence version replaced NM_009367.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate a latency-associated peptide
            (LAP) and a mature peptide, and is found in either a latent form
            composed of a mature peptide homodimer, a LAP homodimer, and a
            latent TGF-beta binding protein, or in an active form consisting
            solely of the mature peptide homodimer. The mature peptide may also
            form heterodimers with other TGF-beta family members. Mice lacking
            a functional copy of this gene display developmental defects in
            multiple organs and perinatal lethality. Heterozygous mutant mice
            exhibit aortic root aneurysm. This gene encodes multiple isoforms
            that may undergo similar proteolytic processing. [provided by
            RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57413.1, AK159690.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1434              AC154879.10        166663-168096       c
            1435-2599           AK159690.1         2-1166
            2600-3674           AK163286.1         49-1123
            3675-5116           AK029306.1         1888-3329
FEATURES             Location/Qualifiers
     source          1..5116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 89.95 cM"
     gene            1..5116
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /note="transforming growth factor, beta 2"
                     /db_xref="GeneID:21808"
                     /db_xref="MGI:MGI:98726"
     exon            1..1561
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1216..2460
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; transforming growth factor beta-2 proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-2 proprotein
                     isoform 1 preproprotein"
                     /protein_id="NP_033393.2"
                     /db_xref="CCDS:CCDS15601.1"
                     /db_xref="GeneID:21808"
                     /db_xref="MGI:MGI:98726"
                     /translation="MHYCVLSTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQI
                     LSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKE
                     VYKIDMPSHLPSENAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKAR
                     VAEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQEWLHHKDRNL
                     GFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYASGDQKTIKSTRKKTSG
                     KTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKW
                     IHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILY
                     YIGNTPKIEQLSNMIVKSCKCS"
     exon            1562..1725
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1858
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1969
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2147
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2301
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..5116
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3657..3662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
                     /note="hexamer: AATAAA"
     polyA_site      3683
                     /gene="Tgfb2"
                     /gene_synonym="Tgf-beta2; Tgfb-2"
ORIGIN      
        1 gttatctgct ggcagcaggt ttgctcggag cagagctgct gaaactgccg gcaggagagc
       61 gagtgggaga gaaagagaga aggcgctgag agctgagctc tggggcaggc gtcagggatg
      121 gagagaagta ttagggttta aagagccatt ctggagcaac ccatctgcgg agagaaggat
      181 cggcagaggt ctattttagg gtcgcaagta cctacttacc ctaagcgaga aagtgcaacc
      241 ttggtggaag ctaggagaag ctagggaagg gtgcgagtcc cggggcagcc cgcagccaac
      301 gcgcccagga ggcggtgttg ttccacaggg gttaaggagg tggccgatcg ctgtcgccct
      361 tggccgcctg gagcaagaaa aggaggatct gaaggaccga gctggaggct ggccctcttt
      421 gcaggcagca gcggcggctg caacgtggag cgacccagcc gggtgtaggc cacagcgcgg
      481 ccggcaggag cgggatcctc gccgcctgct ccggcctctg tggatctccg gggcggacag
      541 tatcccaccg agtctccgag tgagccgctc cggggcgcat ctgcctcccc gcggctcgcc
      601 aggctcgccc tcggcgcgcg cgcacgcacg cgcgcacacg cgcacacatc cacacgcaca
      661 ctcatccaca cacgtgtgga aggcagggcc gagccgctcg gtctttgaac ttctcagtta
      721 gagcccggcg cagccccggc cgccgctcag cgctccccgc ggccctgcgt gcctcctgcc
      781 agcccccgga ccttctcgtc tcgtcccttt tggccggagg atcggagttc agatcagcca
      841 ctccgcaccg agcctgacac actgaactcc atttcttcct cttaagttta tttctacttc
      901 agagccactc accctctccc ttccaggaga aaaaaaaaac aaacctttct tactccttaa
      961 agtgagagat tcccccccca ccccgcccca gcatcgcata ttaatatctc cacgttggga
     1021 acgcgttgca ttttcttttt taaaggaatc ccagccaggg acgtttttct attgggcatt
     1081 aactttcgac tgctttgcaa aagtttcgta ttaaaaacaa ctctacctga ccgctctgag
     1141 aattactagt ttctttttta tatatatttt ttcttacttt aaataacaac atcaacgttt
     1201 cttcctttta aaaacatgca ctactgtgtg ctgagcacct ttttgctcct gcatctggtc
     1261 ccggtggcgc tcagtctgtc tacctgcagc accctcgaca tggatcagtt tatgcgcaag
     1321 aggatcgagg ccatccgcgg gcagatcctg agcaagctga agctcaccag ccccccggaa
     1381 gactatccgg agccggatga ggtccccccg gaggtgattt ccatctacaa cagtaccagg
     1441 gacttactgc aggagaaggc aagccggagg gcagccgcct gcgagcgcga gcggagcgac
     1501 gaggagtact acgccaagga ggtttataaa atcgacatgc cgtcccacct cccctccgaa
     1561 aatgccatcc cgcccacttt ctacagaccc tacttcagaa tcgtccgctt tgatgtctca
     1621 acaatggaga aaaatgcttc gaatctggtg aaggcagagt tcagggtctt ccgcttgcaa
     1681 aaccccaaag ccagagtggc cgagcagcgg attgaactgt atcagatcct taaatccaaa
     1741 gacttaacat ctcccaccca gcgctacatc gatagcaagg ttgtgaaaac cagagcggag
     1801 ggtgaatggc tctccttcga cgtgacagac gctgtgcagg agtggcttca ccacaaagac
     1861 aggaacctgg ggtttaaaat aagtttacac tgcccctgct gtaccttcgt gccgtctaat
     1921 aattacatca tcccgaataa aagcgaagag ctcgaggcga gatttgcagg tattgatggc
     1981 acctctacat atgccagtgg tgatcagaaa actataaagt ccactaggaa aaaaaccagt
     2041 gggaagaccc cacatctcct gctaatgttg ttgccctcct acagactgga gtcacaacag
     2101 tccagccggc ggaagaagcg cgctttggat gctgcctact gctttagaaa tgtgcaggat
     2161 aattgctgcc ttcgccctct ttacattgat tttaagaggg atcttggatg gaaatggatc
     2221 catgaaccca aagggtacaa tgctaacttc tgtgctgggg catgcccata tctatggagt
     2281 tcagacactc aacacaccaa agtcctcagc ctgtacaaca ccataaatcc cgaagcttcc
     2341 gcttcccctt gctgtgtgtc ccaggatctg gaaccactga ccattctcta ttacattgga
     2401 aatacgccca agatcgaaca gctttccaat atgattgtca agtcttgtaa atgcagctaa
     2461 agtccttggg aaagccagga cacgaaaatc acggtgacaa tgacatataa tgacaacgat
     2521 gacgaccatg atgtttgtga caggagggag ggagttttga ttcatcagtg tttaaaaaaa
     2581 aaaaaattgg agaaaaaaaa tcggtactag ttcaaacatt ttgcaagctt gtgttctgtt
     2641 tgttaaaact ggcatctgag attacagcaa caacaaccac aaaaatggaa ggcgttagtc
     2701 tgcatctcac ctacttccta agagacacaa aaagaaaaca tctttttttt ttttaaggaa
     2761 aaaaataaac actggaagaa tttgttagtg ttaattatgt gaaaaaaaaa aacatcaaaa
     2821 caaaacagga aaatccgttc agtggagttg tacgtattgt ttccagcccg catttcaccc
     2881 cacgcctctc ctggttcctc tgtattgctc tctgcagtgg gtgccctccc cgtcccttcc
     2941 tccaagctaa cagtgggtta tttattgtgt gttactatat aatgaacctt tcattaccct
     3001 tggaaaacaa aacaggtgta taaatggaga ccaaatactt tgccacaaac tcatggatgg
     3061 cttaaggagt ttgaactcaa ataagccagg gggaaggagg tcatagtgga tgaccccctg
     3121 tgagttgtta taggactaag caagtcttct gtggaaaaat caaagcccca gcaaacacgt
     3181 gtctgccgaa gcttcatgga cgccatatgc ccagaaggcc tgttaacaaa gaaaacttgg
     3241 aatcagtggc aatctggaag attttttttt ccttttaatt gtaaatggtt ctttgccagt
     3301 ttaagcaagc cggtgaaatg ttgacctgtt ttgatatgta ttgtcagact tttgaccgtg
     3361 aagtggctgt tgatctacaa tacaggtttt tcctttgtct tggtatatgt aattacatgg
     3421 atactattaa aatagacggg tctagaagcc agcatgattg aaaacacact gcagatctgt
     3481 ttttccaaac tattaaatcg aaacagtaac tactttacat gtaatgtgta gatcttacca
     3541 catttttaat attctgtaat aatggttatg atttagattg aacttaaatt tggacttttt
     3601 tttttaatga tcattcagat tgtatatttg tttcctttag ctggccagta cctttgaata
     3661 aaacccctag attttgactt gcactacaaa ttcaattttt tttatatact atcttctctg
     3721 cctgtatttt atgtattgtc catttaatga catgagctac ctgggtccat tcctccccca
     3781 accccagttc cttctatttt ccaaaagata aaaaccaaag cccaaaaagc taggtttgag
     3841 ctccacagtg tttcagcctt ttctgcgtca gtgtgagtca tgtggcgggt gagcggtggg
     3901 gcttctggga tggatgttct gtgtgaacac agaagattgc gcacaaatgt aggcttagct
     3961 agggtttaag aatctcaact cagagtctta gtgactgggc taggaaaagt ttctttaact
     4021 cctatattta tggactctct ttgccgttca aaagcagaca gttcaaagga agcacctttt
     4081 tctttaattg gtttttttgg tgctcatggg gtgtattaaa agacacacag tttggttgag
     4141 tttttcaaag ggggaaaaag tccaggccag cactcgtcat tttattcata atttcatcca
     4201 ttatttccct gatttcattg aaatacaggt tttgaaagac attctttgca ggctgattaa
     4261 aaaaaaaaaa aaaagcacaa accaaaattg cccttgtcaa aatatcctta cacacacaca
     4321 cacacacaca cacacacaca cacacccagc agtcatgctc ttcagccgag gctctggctt
     4381 tcatttggct tgagatggtt ggcgagcttt gcagggtggg tatcctcgtc acagagcttc
     4441 aagatataaa ccagtccatg aaatgatgga ctatttgtgg tctcacccga agggccgccc
     4501 actgaggtgt gaatgcaagg agaatttctt tgaaattgta cacttatctg aggagctgtc
     4561 cttgaattca ctaagatgaa gaacgaaatt tgcaagccag aagacagaca gagagcaact
     4621 gctagtgaat ggcccccgtg tcgggtgcaa cacagcccca gatctgcccc ctgggctcca
     4681 attctttccc cttccacttc actgtcactt ctgtataact ccccaccacc cccacttctg
     4741 cagatatttt cctctcggat aaaataacat tttttgtttt gtatgatttg tctctccttc
     4801 tgaatgcact gactgctatt ttaagggttc ttgaatcttt ttttgtttaa gtctgtgggt
     4861 tctacaggtc ttctttcccg ttagtaaata ttgccacggg agcggtggta gtagggaggg
     4921 gagaggggtg ttagcatatg ggtggggcag caggttgtat ttgttaagca acagtacaat
     4981 gatatgcttg gcatggattt taaagaatgg gatataagaa cagatgttac gtgttttgat
     5041 gaccaattat gctgtatttt ttaacacgat gcatgtccgg ttttgtggtg ctctagtggt
     5101 aaataaatta tttcag
//
