LOCUS       NM_001417328            1806 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus transforming growth factor beta 1 induced transcript 1
            (Tgfb1i1), transcript variant 5, mRNA.
ACCESSION   NM_001417328 XM_036152885
VERSION     NM_001417328.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Wang,L., He,X., Hu,G., Liu,J., Kang,X., Yu,L., Dong,K., Zhao,J.,
            Zhang,A., Zhang,W., Brands,M.W., Su,H., Zheng,Z. and Zhou,J.
  TITLE     A novel mouse model carrying a gene trap insertion into the Hmgxb4
            gene locus to examine Hmgxb4 expression in vivo
  JOURNAL   Physiol Rep 12 (8), e16014 (2024)
   PUBMED   38644513
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Xu,W., Goreczny,G.J., Forsythe,I., Brennan,G., Stowell,T.,
            Brock,K., Capella,B. and Turner,C.E.
  TITLE     Hic-5 regulates extracellular matrix-associated gene expression and
            cytokine secretion in cancer associated fibroblasts
  JOURNAL   Exp Cell Res 435 (2), 113930 (2024)
   PUBMED   38237846
  REMARK    GeneRIF: Hic-5 regulates extracellular matrix-associated gene
            expression and cytokine secretion in cancer associated fibroblasts.
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Gao,L., Lei,X.F., Miyauchi,A., Noguchi,M., Omoto,T., Haraguchi,S.,
            Miyazaki,T., Miyazaki,A. and Kim-Kaneyama,J.R.
  TITLE     Hic-5 is required for activation of pancreatic stellate cells and
            development of pancreatic fibrosis in chronic pancreatitis
  JOURNAL   Sci Rep 10 (1), 19105 (2020)
   PUBMED   33154390
  REMARK    GeneRIF: Hic-5 is required for activation of pancreatic stellate
            cells and development of pancreatic fibrosis in chronic
            pancreatitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Mashimo,J., Shibanuma,M., Satoh,H., Chida,K. and Nose,K.
  TITLE     Genomic structure and chromosomal mapping of the mouse hic-5 gene
            that encodes a focal adhesion protein
  JOURNAL   Gene 249 (1-2), 99-103 (2000)
   PUBMED   10831843
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   Nishiya,N., Iwabuchi,Y., Shibanuma,M., Cote,J.F., Tremblay,M.L. and
            Nose,K.
  TITLE     Hic-5, a paxillin homologue, binds to the protein-tyrosine
            phosphatase PEST (PTP-PEST) through its LIM 3 domain
  JOURNAL   J Biol Chem 274 (14), 9847-9853 (1999)
   PUBMED   10092676
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Fujita,H., Kamiguchi,K., Cho,D., Shibanuma,M., Morimoto,C. and
            Tachibana,K.
  TITLE     Interaction of Hic-5, A senescence-related protein, with focal
            adhesion kinase
  JOURNAL   J Biol Chem 273 (41), 26516-26521 (1998)
   PUBMED   9756887
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Shibanuma,M., Mashimo,J., Kuroki,T. and Nose,K.
  TITLE     Characterization of the TGF beta 1-inducible hic-5 gene that
            encodes a putative novel zinc finger protein and its possible
            involvement in cellular senescence
  JOURNAL   J Biol Chem 269 (43), 26767-26774 (1994)
   PUBMED   7929412
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   Shibanuma,M., Mashimo,J., Mita,A., Kuroki,T. and Nose,K.
  TITLE     Cloning from a mouse osteoblastic cell line of a set of
            transforming-growth-factor-beta 1-regulated genes, one of which
            seems to encode a follistatin-related polypeptide
  JOURNAL   Eur J Biochem 217 (1), 13-19 (1993)
   PUBMED   7901004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124566.5.
            
            On Mar 2, 2023 this sequence version replaced XM_036152885.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.4022188.1,
                                           SRR17253014.1909264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC124566.5         42097-42143         c
            48-163              AC124566.5         40813-40928         c
            164-216             AC124566.5         40633-40685         c
            217-359             AC124566.5         40385-40527         c
            360-447             AC124566.5         40131-40218         c
            448-592             AC124566.5         39910-40054         c
            593-787             AC124566.5         39611-39805         c
            788-961             AC124566.5         36855-37028         c
            962-1043            AC124566.5         36546-36627         c
            1044-1192           AC124566.5         36173-36321         c
            1193-1806           AC124566.5         35393-36006         c
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.07 cM"
     gene            1..1806
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /note="transforming growth factor beta 1 induced
                     transcript 1"
                     /db_xref="GeneID:21804"
                     /db_xref="MGI:MGI:102784"
     exon            1..47
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1459
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /note="isoform e is encoded by transcript variant 5;
                     transforming growth factor beta-1-induced transcript 1
                     protein; TGF beta-stimulated clone 5; hydrogen
                     peroxide-inducible clone 5 protein; androgen
                     receptor-associated protein of 55 kDa"
                     /codon_start=1
                     /product="transforming growth factor beta-1-induced
                     transcript 1 protein isoform e"
                     /protein_id="NP_001404257.1"
                     /db_xref="GeneID:21804"
                     /db_xref="MGI:MGI:102784"
                     /translation="MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQT
                     GSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNA
                     TQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVLAGSEVIHGVLHSPPSPFPAPS
                     KPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLD
                     TMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGG
                     SSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG
                     EEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPF
                     SGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRP
                     LTKGSFQERASKPYCQPCFLKLFG"
     exon            48..163
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            164..216
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            217..359
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            360..447
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            448..592
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            593..787
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            788..961
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1043
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1192
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1806
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /note="hexamer: CATAAA"
     polyA_site      1806
                     /gene="Tgfb1i1"
                     /gene_synonym="ARA55; hic-5; Hic5; TSC-5"
                     /note="major polyA site"
ORIGIN      
        1 ctactctccc caagctgtcc gccagcgcac cgccatggag gacctggatg ccctgctctc
       61 tgacctggag accaccactt cacacatgtc acggttaggg gctccaaaag agcgcccacc
      121 agagacactc acacctcccc caccctatgg ccaccagcca cagacagggt ctggagaatc
      181 ttcaggaacc actggggaca aggatcatct atacagcaca gtatgcaagc ctcggtcccc
      241 aaagcctgtg gcccctgtgg ctcctccatt ctcctcttcc agtggtgtgt tgggcaatgg
      301 cctctgtgag ctagaccgtt tgcttcagga acttaatgcc acccagttca acattacaga
      361 tgaaatcatg tctcagttcc catctagtaa aatggctgaa ggggaagaga aggaggacca
      421 atctgaagac aagagctcac ccactgtgct ggcaggttct gaggtgattc acggtgtcct
      481 ccacagccct cccagcccat tccctgcccc ctcaaagcct tcagccacct ccgccactca
      541 ggaactggat agactgatgg cctcgctctc tgacttccgt gttcagaacc atcttccagc
      601 ctcagggcca cctcagcctc cagcagcgag ccccacccgt gaaggatgcc catctccacc
      661 aggacagact agcaaaggca gtctggacac catgctgggc ctgctgcagt ctgacctcag
      721 ccgtcgtggt gtccccacac aggccaaagg cctctgtggc tcctgcaata aacctatagc
      781 tgggcaagtg gttacagccc tgggcagagc ctggcacccg gagcacttcc tttgcagcgg
      841 ttgttccaca accctgggag gcagcagctt cttcgagaag gatggggctc ccttttgccc
      901 cgagtgctac tttgagcgct tctccccacg atgtggcttc tgtaaccaac ccatccgaca
      961 caaaatggtt accgccttgg gcacccactg gcacccagaa catttctgct gcgtcagctg
     1021 cggagagcct tttggagaag agggtttcca cgagcgggag ggtcgtccgt actgccggcg
     1081 ggacttcctg cagctgttcg ccccacgctg ccagggctgc caaggcccta ttttggataa
     1141 ctacatctcg gcactcagcg cgctctggca cccagactgc ttcgtgtgca gggaatgcct
     1201 tgcgcccttc tccggaggca gcttttttga gcacgagggt cgccctttgt gtgaaaacca
     1261 tttccatgct cagcgtggtt cgctgtgtgc cacgtgtggt ctcccagtga ccggccgctg
     1321 tgtgtccgct ctgggccgac gcttccatcc agaccacttc acctgcacat tctgcctgcg
     1381 cccactcacc aaaggctcct tccaggagcg cgccagcaag ccttactgcc agccttgctt
     1441 cctgaagctc ttcggctgac ctcctcttgg gatcagagat ctccaaaact aagccttcaa
     1501 aaacacattc gtgaaaaaga ctgagtcctc cagatccctg gctctggagc tacccaggca
     1561 tccttgctcc ttctcccacc cccatcccca ttgtggccca gccactggag aggcctaccc
     1621 ctaagatgct ctaggtttgt caatttcaga aagggcccca ttagcctgga atgtagctct
     1681 cactttgaca tgattctggt tctcttgtct gaccaagtag aggccaggat gtccctgttc
     1741 acccatggca cactattctg tacacatttt tttttctaca aacataaaaa cacactccac
     1801 acttta
//
