LOCUS       NM_011577               2191 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus transforming growth factor, beta 1 (Tgfb1), mRNA.
ACCESSION   NM_011577 XM_357724
VERSION     NM_011577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Phuong,N.Q., Bilal,M., Nawaz,A., Anh,L.D., Memoona, Aslam,M.R.,
            Khalid,S., Kado,T., Watanabe,Y., Nishimura,A., Igarashi,Y.,
            Okabe,K., Hirabayashi,K., Yamamoto,S., Nakagawa,T., Mori,H.,
            Usui,I., Fujisaka,S., Hayashi,R. and Tobe,K.
  TITLE     Role of transforming growth factor-beta1 in regulating adipocyte
            progenitors
  JOURNAL   Sci Rep 15 (1), 941 (2025)
   PUBMED   39824986
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Park,C.J., Oh,J.E., Lin,P., Zhou,S., Bunnell,M., Bikorimana,E.,
            Spinella,M.J., Lim,H.J. and Ko,C.J.
  TITLE     A Dynamic Shift in Estrogen Receptor Expression During Granulosa
            Cell Differentiation in the Ovary
  JOURNAL   Endocrinology 166 (2) (2025)
   PUBMED   39834231
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Ling,L., Luo,M., Yin,H., Tian,Y., Wang,T., Zhang,B., Yin,L.,
            Zhang,Y. and Bian,J.
  TITLE     Sinomenine Ameliorated Microglial Activation and Neuropathic Pain
            After Chronic Constriction Injury Via TGF-beta1/ALK5/Smad3
            Signalling Pathway
  JOURNAL   J Cell Mol Med 28 (22), e70214 (2024)
   PUBMED   39586784
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Hossain,M.N., Gao,Y., Li,X., Zhao,L., Liu,X., Marie de Avila,J.,
            Zhu,M.J. and Du,M.
  TITLE     Single-cell RNA transcriptomics in mice reveals embryonic origin of
            fibrosis due to maternal obesity
  JOURNAL   EBioMedicine 109, 105421 (2024)
   PUBMED   39476533
  REMARK    Erratum:[EBioMedicine. 2025 Feb;112:105573. doi:
            10.1016/j.ebiom.2025.105573. PMID: 39874704]
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Riehl,D.R., Sharma,A., Roewe,J., Reinhardt,C., Schafer,K. and
            Bosmann,M.
  TITLE     Reply to Chong et al.: Investigating TGFbeta1 biological activities
            using genetically engineered mouse strains
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2408647121 (2024)
   PUBMED   39423253
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Ferguson,M.W., Sharpe,P.M., Thomas,B.L. and Beck,F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Hannon,K., Smith,C.K. 2nd, Bales,K.R. and Santerre,R.F.
  TITLE     Temporal and quantitative analysis of myogenic regulatory and
            growth factor gene expression in the developing mouse embryo
  JOURNAL   Dev Biol 151 (1), 137-144 (1992)
   PUBMED   1374351
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Liu,Y., Jones,B., Aruffo,A., Sullivan,K.M., Linsley,P.S. and
            Janeway,C.A. Jr.
  TITLE     Heat-stable antigen is a costimulatory molecule for CD4 T cell
            growth
  JOURNAL   J Exp Med 175 (2), 437-445 (1992)
   PUBMED   1346270
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Manova,K., Paynton,B.V. and Bachvarova,R.F.
  TITLE     Expression of activins and TGF beta 1 and beta 2 RNAs in early
            postimplantation mouse embryos and uterine decidua
  JOURNAL   Mech Dev 36 (3), 141-152 (1992)
   PUBMED   1373953
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   de Larco,J.E. and Todaro,G.J.
  TITLE     Growth factors from murine sarcoma virus-transformed cells
  JOURNAL   Proc Natl Acad Sci U S A 75 (8), 4001-4005 (1978)
   PUBMED   211512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC162614.2, AA510019.1,
            CK625059.1, AA821506.1 and BQ030974.1.
            
            On Sep 29, 2015 this sequence version replaced NM_011577.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate a latency-associated peptide
            (LAP) and a mature peptide, and is found in either a latent form
            composed of a mature peptide homodimer, a LAP homodimer, and a
            latent TGF-beta binding protein, or in an active form consisting
            solely of the mature peptide homodimer. The mature peptide may also
            form heterodimers with other TGF-beta family members. This encoded
            protein regulates cell proliferation, differentiation and growth,
            and can modulate expression and activation of other growth factors
            including interferon gamma and tumor necrosis factor alpha. Mice
            lacking a functional copy of this gene develop severe multifocal
            inflammatory disease, yolk sac defects and colon cancer. [provided
            by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ009862.1, BC013738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC162614.2         86406-86729         c
            325-751             AA510019.1         1-427
            752-1239            CK625059.1         1-488
            1240-1645           AA821506.1         1-406
            1646-2191           BQ030974.1         1-546               c
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.98 cM"
     gene            1..2191
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /note="transforming growth factor, beta 1"
                     /db_xref="GeneID:21803"
                     /db_xref="MGI:MGI:98725"
     exon            1..1222
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             868..2040
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /note="transforming growth factor beta-1 proprotein"
                     /codon_start=1
                     /product="transforming growth factor beta-1 proprotein
                     preproprotein"
                     /protein_id="NP_035707.1"
                     /db_xref="CCDS:CCDS20993.1"
                     /db_xref="GeneID:21803"
                     /db_xref="MGI:MGI:98725"
                     /translation="MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRK
                     RIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEAD
                     YYAKEVTRVLMVDRNNAIYEKTKDISHSIYMFFNTSDIREAVPEPPLLSRAELRLQRL
                     KSSVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFR
                     FSAHCSCDSKDNKLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRH
                     RRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDT
                     QYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS"
     exon            1223..1383
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1501
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1579
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1727
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1881
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2175
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /note="hexamer: ATTAAA"
     polyA_site      2175
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /note="major polyA site"
ORIGIN      
        1 cgccgccgcc gccgcccttc gcgccccagg ccgtccccct cctcctcccg ccgcggatcc
       61 tccagacagc caggcccccg gccggggcag gggggacgcc ccttcggggc acccccggct
      121 ctgagccgca ctcggagtcg gcctccgctg ggagccggca aaggagcagc cgaggagccg
      181 tccgaggccc cagagtctga gaccagccgc cgccgcaggg aggaggggga ggaggagtgg
      241 gaggagggac gagctggttg agagaagagg aaaaaagttt tgagactttt ccgctgctac
      301 tgcaagtcag agacgtgggg acttcttggc actgcgctgt ctcgcaagga ggcaggacct
      361 gaggactcca gacagccctg ctcaccgtcg tggacactcg atcgctaccc ggcgttcctc
      421 agacgcccct attccggacc agccctcggg agccacaaac cccgcctccc gcgaagactt
      481 caccccaaag ctggggcgca ccccttgcac gccgccctcc ccccagcctg cctcttgagt
      541 ccctcgcatc ccaggaccct ctctcccccg agaggcagat ctccctcgga cctgctggca
      601 gtagctcccc tatttaagaa cacccacttt tggatctcag agagcgctca tctcgatttt
      661 taccctggtg gtatactgag acaccttggt gtcagagcct caccgcgact cctgctgctt
      721 tctccctcaa cctcaaatta ttcaggacta tcacctacct ttccttggga gaccccaccc
      781 cacaagccct gcaggggcgg ggcctccgca tcccaccttt gccgagggtt cccgctctcc
      841 gaagtgccgt ggggcgccgc ctcccccatg ccgccctcgg ggctgcggct actgccgctt
      901 ctgctcccac tcccgtggct tctagtgctg acgcccggga ggccagccgc gggactctcc
      961 acctgcaaga ccatcgacat ggagctggtg aaacggaagc gcatcgaagc catccgtggc
     1021 cagatcctgt ccaaactaag gctcgccagt cccccaagcc agggggaggt accgcccggc
     1081 ccgctgcccg aggcggtgct cgctttgtac aacagcaccc gcgaccgggt ggcaggcgag
     1141 agcgccgacc cagagccgga gcccgaagcg gactactatg ctaaagaggt cacccgcgtg
     1201 ctaatggtgg accgcaacaa cgccatctat gagaaaacca aagacatctc acacagtata
     1261 tatatgttct tcaatacgtc agacattcgg gaagcagtgc ccgaaccccc attgctgtcc
     1321 cgtgcagagc tgcgcttgca gagattaaaa tcaagtgtgg agcaacatgt ggaactctac
     1381 cagaaatata gcaacaattc ctggcgttac cttggtaacc ggctgctgac ccccactgat
     1441 acgcctgagt ggctgtcttt tgacgtcact ggagttgtac ggcagtggct gaaccaagga
     1501 gacggaatac agggctttcg attcagcgct cactgctctt gtgacagcaa agataacaaa
     1561 ctccacgtgg aaatcaacgg gatcagcccc aaacgtcggg gcgacctggg caccatccat
     1621 gacatgaacc ggcccttcct gctcctcatg gccacccccc tggaaagggc ccagcacctg
     1681 cacagctcac ggcaccggag agccctggat accaactatt gcttcagctc cacagagaag
     1741 aactgctgtg tgcggcagct gtacattgac tttaggaagg acctgggttg gaagtggatc
     1801 cacgagccca agggctacca tgccaacttc tgtctgggac cctgccccta tatttggagc
     1861 ctggacacac agtacagcaa ggtccttgcc ctctacaacc aacacaaccc gggcgcttcg
     1921 gcgtcaccgt gctgcgtgcc gcaggctttg gagccactgc ccatcgtcta ctacgtgggt
     1981 cgcaagccca aggtggagca gttgtccaac atgattgtgc gctcctgcaa gtgcagctga
     2041 agccccgccc cgccccgccc ctcccggcag gcccggcccc gcccccgccc cgcccgcagc
     2101 gcccggggct gtatttaagg acacctgcac cccccctcaa gcccacctgg ggggcccatt
     2161 aaaggtgaca gaggaaaaaa aaaaaaaaaa a
//
