LOCUS       NM_031199               4553 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus transforming growth factor alpha (Tgfa), transcript
            variant 1, mRNA.
ACCESSION   NM_031199
VERSION     NM_031199.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Glover,J.D., Sudderick,Z.R., Shih,B.B., Batho-Samblas,C.,
            Charlton,L., Krause,A.L., Anderson,C., Riddell,J., Balic,A., Li,J.,
            Klika,V., Woolley,T.E., Gaffney,E.A., Corsinotti,A., Anderson,R.A.,
            Johnston,L.J., Brown,S.J., Wang,S., Chen,Y., Crichton,M.L. and
            Headon,D.J.
  TITLE     The developmental basis of fingerprint pattern formation and
            variation
  JOURNAL   Cell 186 (5), 940-956 (2023)
   PUBMED   36764291
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Zhang,X., Xiao,G., Johnson,C., Cai,Y., Horowitz,Z.K., Mennicke,C.,
            Coffey,R., Haider,M., Threadgill,D., Eliscu,R., Oldham,M.C.,
            Greenbaum,A. and Ghashghaei,H.T.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Chen,H., Bai,Y., Kobayashi,M., Xiao,S., Cai,W., Barajas,S.,
            Chen,S., Miao,J., Meke,F.N., Vemula,S., Ropa,J.P., Croop,J.M.,
            Boswell,H.S., Wan,J., Jia,Y., Liu,H., Li,L.S., Altman,J.K.,
            Eklund,E.A., Ji,P., Tong,W., Band,H., Huang,D.T., Platanias,L.C.,
            Zhang,Z.Y. and Liu,Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
  REMARK    Erratum:[Blood. 2024 Jan 25;143(4):376. doi:
            10.1182/blood.2023023174.. PMID: 38270941]
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Zeid,A.M., Lamontagne,J.O., Zhang,H. and Marneros,A.G.
  TITLE     Epidermal growth factor deficiency predisposes to progressive renal
            disease
  JOURNAL   FASEB J 36 (5), e22286 (2022)
   PUBMED   35442545
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Hilakivi-Clarke,L.A., Arora,P.K., Sabol,M.B., Clarke,R.,
            Dickson,R.B. and Lippman,M.E.
  TITLE     Alterations in behavior, steroid hormones and natural killer cell
            activity in male transgenic TGF alpha mice
  JOURNAL   Brain Res 588 (1), 97-103 (1992)
   PUBMED   1393573
REFERENCE   8  (bases 1 to 4553)
  AUTHORS   Halter,S.A., Dempsey,P., Matsui,Y., Stokes,M.K., Graves-Deal,R.,
            Hogan,B.L. and Coffey,R.J.
  TITLE     Distinctive patterns of hyperplasia in transgenic mice with mouse
            mammary tumor virus transforming growth factor-alpha.
            Characterization of mammary gland and skin proliferations
  JOURNAL   Am J Pathol 140 (5), 1131-1146 (1992)
   PUBMED   1316084
REFERENCE   9  (bases 1 to 4553)
  AUTHORS   Breindl,M., Doehmer,J., Willecke,K., Dausman,J. and Jaenisch,R.
  TITLE     Germ line integration of Moloney leukemia virus: identification of
            the chromosomal integration site
  JOURNAL   Proc Natl Acad Sci U S A 76 (4), 1938-1942 (1979)
   PUBMED   287034
REFERENCE   10 (bases 1 to 4553)
  AUTHORS   Eicher,E.M. and Beamer,W.G.
  TITLE     Inherited ateliotic dwarfism in mice. Characteristics of the
            mutation, little, on chromosome 6
  JOURNAL   J Hered 67 (2), 87-91 (1976)
   PUBMED   1270792
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC159549.11.
            
            On Mar 23, 2020 this sequence version replaced NM_031199.4.
            
            Summary: This gene encodes a member of the epidermal growth factor
            (EGF) family of proteins that regulate cellular proliferation. The
            encoded protein undergoes proteolytic processing to generate a
            soluble glycoprotein that is secreted by the cell. The secreted
            protein binds to the EGF receptors to initiate signaling events
            resulting in cellular proliferation, mucous production or
            inhibition of gastric acid secretion. The transgenic expression of
            the encoded protein in mice induces the development of cancers in
            various tissues such as liver, pancreas, skin and mammary glands.
            Mice lacking the encoded protein exhibit a wavy coat and curly
            whiskers phenotype as well as abnormalities in the eye. [provided
            by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162680.1, U65016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC159549.11        122031-122354       c
            325-378             AC159549.11        88092-88145         c
            379-496             AC159549.11        54300-54417         c
            497-646             AC159549.11        47497-47646         c
            647-756             AC159549.11        46087-46196         c
            757-4553            AC159549.11        41832-45628         c
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.62 cM"
     gene            1..4553
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /note="transforming growth factor alpha"
                     /db_xref="GeneID:21802"
                     /db_xref="MGI:MGI:98724"
     exon            1..324
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..764
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; protransforming growth factor alpha"
                     /codon_start=1
                     /product="protransforming growth factor alpha isoform 1
                     preproprotein"
                     /protein_id="NP_112476.1"
                     /db_xref="CCDS:CCDS51832.1"
                     /db_xref="GeneID:21802"
                     /db_xref="MGI:MGI:98724"
                     /translation="MVPATGQLALLALGILLAVCQALENSTSPLSDSPVAAAVVSHFN
                     KCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITAL
                     VVVSIVALAVLIITCVLIHCCQLRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV"
     exon            325..378
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..496
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..646
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..756
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..4553
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4503..4508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /note="hexamer: AATGAA"
     polyA_site      4528
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
                     /note="major polyA site"
     polyA_site      4553
                     /gene="Tgfa"
                     /gene_synonym="wa-1; wa1"
ORIGIN      
        1 agtccccacc cctgcgcctt cgggggcgcc ccatcgcggg agggtggtcc gcctctcccc
       61 ggtcgcctaa ggcagagagg tggcgggaac ctccacctct ttcccgtttc cgccgcgggc
      121 agcgcgccgg ccagtgccac cgggaggcgc ggtcgtccct ccgcccgcgc gccggggggc
      181 cggccctgtc gcctgcgcct ttttcccccg cgcacaccgc ggcggcgcgc ggctactcgc
      241 caaccgcagg gagcgcggtg gctgcagcac cctgcgctcg gaagatggtc cccgcgaccg
      301 gacagctcgc tctgctagcg ctgggtatcc tgttagctgt gtgccaggct ctggagaaca
      361 gcacatcccc cctgagtgac tcacccgtgg cggctgcagt ggtgtctcac ttcaacaagt
      421 gcccagattc ccacactcag tactgcttcc atggaacctg ccggtttttg gtgcaggaag
      481 agaagccagc atgtgtctgc cactctgggt acgtgggtgt tcgctgtgag catgcagacc
      541 tcctggctgt ggtggctgcc agccagaaga agcaagccat cactgccctg gtggtggtct
      601 ccattgtggc cctggctgtc ctcattatca cctgtgtgct gatccactgc tgtcagctcc
      661 gcaaacactg tgagtggtgc cgtgccctcg tctgcagaca tgagaagccc agcgccctcc
      721 tgaagggaag gactgcttgc tgccactctg agacagtggt ctgaagatcc cagaggagga
      781 atttggccag gtggcctatg acagcccaac caagaaaagg catcttggga caacacccct
      841 ggcagtgccc aggcccatgg gacatgctgg gagaccttcc ccctcagtgc acaactgcct
      901 gggcaggctt cttccttgag agtcttcaaa actgtgtgat aaagctgcct gctgggctcg
      961 ctcagtacac ccagagaaga ggccagtgga ccacatttta aagacaagtt gaacacgaac
     1021 ctcaaagggt tggccttctt gctaacccac accgagaatg agctggggct gctgtcccct
     1081 gccagccatg acttccagac tgtttcttct ctatgggcca tctacccccc cgtcccgaga
     1141 ctccatggtt ggtgtacaaa atggacaagg ggaaacgtct attgttcttt gaagacacca
     1201 tggcgtccca tgcgccctga catctcctca ggctgtcgtc aggatgcgtg tcttatttat
     1261 tagatggata acatggtttt atttgtaatc tctttatgtc aatgtcaggc gtccatgcta
     1321 gcgatgcatg agtggcgggc cgtgaagtta caccaaatag aaatgtccag ccactttgat
     1381 aaagtaaggc tgcagggagg ggagcctccg gggggccgta gagacagaat tcagatgtgc
     1441 atcctgctgg gaaccaacct gctatcccaa ggctgtgccc cctcaggcaa gaaagtccct
     1501 ggatacatgc tgtagcaaac ttagcaaggc caatggcaga gagtgtcccc cttgtgggga
     1561 caagaggaca aaagagcctg tgtgggcacc taggaaggat gcacacccca acccttgatt
     1621 aagtggatta gcgtcctcgt gagcccagct ccagcatcag caatgagctg tgagccaaat
     1681 ccatgaaggg gaccagccct ttattggctt ttgcttattt ttagaaggag aaatttgcct
     1741 ttcctattta ttttcaagca ttaagaaaaa tagcccactg ttttgttttg tttccccttt
     1801 aataatgttg gcattattaa caaaatcgct accaagcctc tccacccctc tctggggaag
     1861 gaaatgtgtt ccctgagcac ccgaagatgc tctgacccat tgagcccacc cttgttcctg
     1921 ggctgcttgg gactgtcagg agacagaata cattcagttg catattaaag agaccattct
     1981 ccaactcaga agtgaaaagt ctgccccctc ggccctccag ggcctctgaa gtaaggcatg
     2041 agggaagggg tactgggcat accaagttgg tttgaagctt ctgtcagaag ctgcctgttc
     2101 ctcattcttc tcctttatga atttttctcc tctcatatga tctaggcatt gatctgccca
     2161 ggtcttaacc ctttgttcac aaggcctgaa gccctgaaag aagaacctga aactgttcag
     2221 tgctgtcctc taactgctta gctgacacag ctccaggcag aagttgtcat tcttgctatt
     2281 attttggttt gatgctttat cttgttttgt gagacaaggt cttgctgtgt agcccaggtt
     2341 gacctttaag ttaagatcct gcttcagcaa cctggaagct gggcttacag atgtgcacca
     2401 ccacgcccag cactttttga ttactagaga aaataggtta agtttgcttt ccttgggtca
     2461 tacaagtggg tcaaggccaa gtgtcacctg ctgctcagac accaatcaac ctcactggac
     2521 ttcagccctc tattggcccc cagtgctctc agtagacccc gcctgaagta ctggctcact
     2581 ggagggcagg gagcaacaca aatggaggag atgtggggct tgttttagtt tagttcacac
     2641 tgttagcttc tgatgacagg tcttttctgg tctgctggag gctcctgggt gtctgacttc
     2701 ttttaaagag tttgaactga tatcaaaata tcattgggaa cttcctcact taatatccca
     2761 tcctgaagat gttgtcatcc aagactaagc agaggtggta aacgcttagc acgagcactc
     2821 gatggtgaag gcagaggatc tcgggaggac ctcagcttta gtgtccaaac ggtcctgttc
     2881 tcaggtccag ccagtcgcag cagccagtac catcccagtg cctgtacaca gatgcagctg
     2941 gctcaaacac ctcccagaag tgccttccca tcagtctacc ctttgcagag tcagaggctg
     3001 agactaggtt gagacaagtc cggttggaca tcgtccctgc cccgacgtat gacagccctg
     3061 ctgcgttggt gactttgatt ttggaagtca gtcagacaaa cgctgtgtac cttctcctgt
     3121 gccatgtcac agcacagatg ggcctggtta gctgtaccag cgccctcctg tcagttcaca
     3181 ctggccctct cttgatattt agtacagcta cttaatcagg agcactctta gcagctaggc
     3241 aggtcagagg gcagtacagt tgattcagtg actcagggga ctagggccat tcccattaaa
     3301 tgagctgaaa ttaattctag agacattgag acagctcagt tagcaatggc acttaccaaa
     3361 atcccagata acctgaattc aatcccctgg gatcccatct ggtggaagga gagaaccggc
     3421 ttgcccagga tgtcttctga tttctacgta cacgcacacg cacacacacg cacgcgcaca
     3481 cacacgcaca cacacgcaca tatgagtaca cacaaagtct aagtttttaa aataaaaatt
     3541 ctagaaagac ctctacacct ctagctataa ctttaaacac accatgggac atgttttctc
     3601 cacggaaaag cacaattgga gacccagtct gaaatgaaag atagattcca ggtggacata
     3661 cacagaacca aaccatgagt tagtttgtca tgtgccccag aaaaaggtgg gaacaataat
     3721 cccaacatcc ctttcctctc cccccccaaa aaaggggggg aggaggcatg gttggtaccc
     3781 acccacctgc actggtgagg gaagtgacta tgtccctgag tcctagatgg tgacgttggt
     3841 cccttcaagt ccccaggcca ggtttcctag tgcctatgag gcactggata gaccagcaac
     3901 actctgacac tgcctacagg ccccagtcct gtaatgagta ataaacttgt ctctctccca
     3961 aggccaaagg gaggccaccc cagacaacac atttttcaca cagggttgta ctctatagcc
     4021 caggccaacc ttgaacccat gattcccccg cctcagccta ttggagtaca ggtgtgtacc
     4081 tccatacctg gcttatgttt gttttctaat gttctggtgt cagatgtatt ccctgaagcc
     4141 attgatctat ctcaaagaca cagtgttgca cgcacacatg tgtgcatgta cacacacaca
     4201 actggaaagt aactcctctc cacagtgtaa taagtttatt ataaggaacc tgatgctgtt
     4261 tttagaactc atctttctga cttctgtata tgatgcactg aaggttaata tgtaatgttt
     4321 taatttattt tatgtggtaa gttaattttg gttttctgta atgtattaat gtgattagaa
     4381 gctttcttcc ttaatatctg aattatactt aaaagagtag tgagaaatat aagatactgt
     4441 tgtgtttttc agagtgtgta ttgttactca gttgtattgt accttgtttg gaaggatgaa
     4501 ggaatgaact cttttttttt ttcctaaatc tcaagactga agtttttctt taa
//
