LOCUS       NM_029578               2265 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TDP-glucose 4,6-dehydratase (Tgds), mRNA.
ACCESSION   NM_029578
VERSION     NM_029578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Geister,K.A., Timms,A.E. and Beier,D.R.
  TITLE     Optimizing Genomic Methods for Mapping and Identification of
            Candidate Variants in ENU Mutagenesis Screens Using Inbred Mice
  JOURNAL   G3 (Bethesda) 8 (2), 401-409 (2018)
   PUBMED   29208648
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB953719.1, BY710811.1, AK165955.1 and AK165685.1.
            
            On Mar 24, 2009 this sequence version replaced NM_029578.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154341.1, AK165955.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CB953719.1         4-15
            13-651              BY710811.1         1-639
            652-1018            AK165955.1         636-1002
            1019-2265           AK165685.1         902-2148
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 61.74 cM"
     gene            1..2265
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /note="TDP-glucose 4,6-dehydratase"
                     /db_xref="GeneID:76355"
                     /db_xref="MGI:MGI:1923605"
     exon            1..122
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1104
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /EC_number="4.2.1.46"
                     /codon_start=1
                     /product="dTDP-D-glucose 4,6-dehydratase"
                     /protein_id="NP_083854.3"
                     /db_xref="CCDS:CCDS27332.1"
                     /db_xref="GeneID:76355"
                     /db_xref="MGI:MGI:1923605"
                     /translation="MSAASREERSGPPGSFAKRVLVTGGAGFIASHVIVSLVEDYPDY
                     MIVNLDKLDYCASLKNLEPVSNKQNYKFIQGDICDSHFVKLLFEVEKIDIVLHFAAQT
                     HVDLSFVRAFEFTYVNVYGTHVLVNAAYEAGVEKFIYVSTDEVYGGSLDQEFDESSPK
                     QPTNPYASSKAAAECFVQSYWERYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNR
                     KCCIHGSGLQRRNFLYAADVVEAFLTVLTKGEPGEIYNIGTNFEMSVVQLAKELIQLI
                     KETNSESETESWVDYVSDRPHNDMRYPMKSEKIHSLGWKPKVPWEEGIKKTVEWYRKN
                     FHNWKNAEKALEPFPVQPPFM"
     exon            123..189
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            190..258
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            259..349
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            350..492
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            493..591
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            592..651
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            652..695
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..861
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            862..920
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1018
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..2265
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1703
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /note="major polyA site"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /note="hexamer: AATAAT"
     polyA_site      1765
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1849
                     /gene="Tgds"
                     /gene_synonym="2610017J16Rik; 2610025M23Rik"
ORIGIN      
        1 gccgcgcttt acggcgctgg ctctgcagag ctgaagatgt ccgctgcgag ccgggaggag
       61 cgttctggtc ctcccggcag cttcgcgaag cgggtcctgg tgaccggggg tgctggtttc
      121 attgcgtccc atgtgattgt ctccctagta gaggattatc ccgactatat gatcgtaaat
      181 ctagacaagc tggattactg tgcaagcttg aagaatctgg aaccagtctc taacaagcaa
      241 aactacaagt ttatacaggg tgacatttgt gattctcact ttgtgaagtt gctgtttgaa
      301 gtggagaaaa tagatatagt actgcacttt gctgcacaga cacatgtaga tctttcattt
      361 gtccgtgcct ttgagtttac gtacgtcaat gtttatggta ctcatgtttt ggtaaatgct
      421 gcttatgaag ccggagtgga gaaatttatt tacgtcagca cagatgaagt ttatggtggc
      481 agtctcgacc aggagtttga tgaatcgtcc cccaaacaac ctacaaaccc ttacgcttca
      541 tccaaggcag ctgctgaatg ttttgtgcag tcttactggg aaaggtacaa gttcccagtt
      601 gtcatcacga gaagcagcaa cgtctatgga ccacatcagt atccagaaaa ggttattcca
      661 aagttcatat ccttgctgca gcacaacagg aagtgctgta ttcatggatc agggcttcaa
      721 aggagaaact tcctctatgc tgctgatgtg gtagaagcct tcctcactgt cctcacaaag
      781 ggcgagccag gcgagatcta caacatcggg accaactttg agatgtcggt cgtccagctt
      841 gcgaaagagc taatacagct gatcaaagag accaattcag agtctgaaac ggagagctgg
      901 gtggactatg ttagtgacag acctcacaat gacatgagat atccaatgaa gtctgaaaaa
      961 attcacagtt taggatggaa gcccaaagtg ccatgggaag aaggaataaa gaaaacagtt
     1021 gagtggtacc gaaagaattt tcacaactgg aagaatgcag aaaaggcatt agagcccttt
     1081 ccagtccagc caccatttat gtaactgccg ttgcagagac gaagacatca tcctacctca
     1141 gacagcgatg tgaatcaagt gcctaaagca gtgccatctt ctctccgggg ctgcgctcga
     1201 tgccctcacc actgggtggg atacagagtc ttcagcagtt tcagtattgg tccagcattc
     1261 actgtggagt ttctcttggc caacttctcc tagaactcag gcagtggtcc agcaggacag
     1321 ggccctggct ctgagaacaa aggcaggaag tggtactttg tggatggcat cctgggctgc
     1381 tttggacttc tgctggctcc cagccttccc tagtacctgg tggtctcaga ttttctgtcc
     1441 tgccaatctt tcctagggtc tgatgatgta aaagttgagc aaaatggaag actatctagc
     1501 atttttaaac ttttggtaat tgtataaaat taagttaaat ggattttaaa ggtaaaatgt
     1561 aaatttctta catttttaaa atcagttgat tttatataac ccatatcaga aattttatca
     1621 tgtatctaca acttataatg gttttattta tgaaagtgtc aatatatttt aatatattaa
     1681 atgcagattg tggctttttt ttagtaatgt ctttttattt tgttgtaatt tttaaaaaaa
     1741 taatcatgca tttttaatct ctgtatccta aagatttcag tgcaactttg aaaagtaact
     1801 gagctgatat tgggtgggca aaagtaaagg ttgctctgtt gtgaatgtag atttcatctt
     1861 agggtttcca tggctgtaaa gagacactgt gaccacagca gcttctagaa aggacatttc
     1921 attgtggctg gcttacagtg tcagaggttc agtccattat cactgtgtgg catgcaggca
     1981 gacatggtac tagaggaccc aaaagttcta catcttgatt caaagccagc cagaaggagt
     2041 ctgtatgtca cactaggagt agcttgagca taggagacct caaagccctc ctacatagtg
     2101 acacacttct tcctacaagg ccacacctac tccaagaagg ccatacctcc tgatagtgcc
     2161 actctctatg ggcctttcat acaaatgcat taatgtggtg gtatccattc cttgtcaatt
     2221 tgacacacag tcatatctcc ttatgaataa atgaaaatgc taacc
//
