LOCUS       NM_009375               8462 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thyroglobulin (Tg), mRNA.
ACCESSION   NM_009375
VERSION     NM_009375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8462)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8462)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8462)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8462)
  AUTHORS   Zhang,X., Young,C., Liao,X.H., Refetoff,S., Torres,M., Tomer,Y.,
            Stefan-Lifshitz,M., Zhang,H., Larkin,D., Fang,D., Qi,L. and
            Arvan,P.
  TITLE     Perturbation of endoplasmic reticulum proteostasis triggers tissue
            injury in the thyroid gland
  JOURNAL   JCI Insight 8 (12), e169937 (2023)
   PUBMED   37345654
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8462)
  AUTHORS   Zhang,X., Malik,B., Young,C., Zhang,H., Larkin,D., Liao,X.H.,
            Refetoff,S., Liu,M. and Arvan,P.
  TITLE     Maintaining the thyroid gland in mutant thyroglobulin-induced
            hypothyroidism requires thyroid cell proliferation that must
            continue in adulthood
  JOURNAL   J Biol Chem 298 (7), 102066 (2022)
   PUBMED   35618019
  REMARK    GeneRIF: Maintaining the thyroid gland in mutant
            thyroglobulin-induced hypothyroidism requires thyroid cell
            proliferation that must continue in adulthood.
REFERENCE   6  (bases 1 to 8462)
  AUTHORS   Sugisaki,T., Beamer,W.G. and Noguchi,T.
  TITLE     Microcephalic cerebrum with hypomyelination in the congenital
            goiter mouse (cog)
  JOURNAL   Neurochem Res 17 (10), 1037-1040 (1992)
   PUBMED   1508304
REFERENCE   7  (bases 1 to 8462)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   8  (bases 1 to 8462)
  AUTHORS   Gorman,D.M., Itoh,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Miyajima,A.
  TITLE     Chromosomal localization and organization of the murine genes
            encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3,
            granulocyte/macrophage colony-stimulating factor, and interleukin 5
            receptors
  JOURNAL   J Biol Chem 267 (22), 15842-15848 (1992)
   PUBMED   1386365
REFERENCE   9  (bases 1 to 8462)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   10 (bases 1 to 8462)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK788949.1, BC111467.1, U76389.1 and CK789624.1.
            
            On Feb 3, 2007 this sequence version replaced NM_009375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111467.1, AF076186.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CK788949.1         23-29
            8-6091              BC111467.1         1-6084
            6092-6195           U76389.1           6109-6212
            6196-8433           BC111467.1         6189-8426
            8434-8462           CK789624.1         471-499
FEATURES             Location/Qualifiers
     source          1..8462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.3 cM"
     gene            1..8462
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /note="thyroglobulin"
                     /db_xref="GeneID:21819"
                     /db_xref="MGI:MGI:98733"
     exon            1..92
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..8323
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /note="congenital goiter"
                     /codon_start=1
                     /product="thyroglobulin precursor"
                     /protein_id="NP_033401.2"
                     /db_xref="CCDS:CCDS37091.1"
                     /db_xref="GeneID:21819"
                     /db_xref="MGI:MGI:98733"
                     /translation="MTALVLWVSTLLSSVCLVAANIFEYQVDAQPLRPCELQREKAFL
                     KQAEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPGSRQLGRPTVCLSFCQLHKQ
                     RILLGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYGTRQQGRPTR
                     CPRSCEIRNRRLLHGVGDRSPPQCTADGEFMPVQCKFVNTTDMMIFDLIHNYNRFPDA
                     FVTFSSFRGRFPEVSGYCYCADSQGRELAETGLELLLDEIYDTIFAGLDQASTFTQST
                     MYRILQRRFLAIQLVISGRFRCPTKCEVEQFAATRFGHSYIPRCHRDGHYQTVQCQTE
                     GMCWCVDAQGREVPGTRQQGQPPSCAADQSCALERQQALSRFYFETPDYFSPQDLLSS
                     EDRLAPVSGVRSDTSCPPRIKELFVDSGLLRSIAVEHYQRLSESRSLLREAIRAVFPS
                     RELAGLALQFTTNPKRLQQNLFGGTFLANAAQFNLSGALGTRSTFNFSQFFQQFGLPG
                     FLNRDRVTTLAKLLPVRLDSSSTPETLRVSEKTVAMNKRVVGNFGFKVNLQENQDALK
                     FLVSLLELPEFLVFLQRAVSVPEDIARDLGDVMEMVFSAQACKQMPGKFFVPSCTAGG
                     SYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCEKQRAQMQSLASAQPAGSSF
                     FVPTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVGEAKQCPSVCQLQAEQAFLG
                     VVGVLLSNSSMVPSISNVYIPQCSASGQWRHVQCDGPHEQVFEWYERWKTQNGDGQEL
                     TPAALLMKIVSYREVASRNFSLFLQSLYDAGQQRIFPVLAQYPSLQDVPQVVLEGATT
                     PPGENIFLDPYIFWQILNGQLSQYPGPYSDFNMPLEHFNLRSCWCVDEAGQKLDGTQT
                     KPGEIPACPGPCEEVKLRVLKFIKETEEIVSASNASSFPLGESFLVAKGIQLTSEELD
                     LPPQFPSRDAFSEKFLRGGEYAIRLAAQSTLTFYQSLRASLGKSDGAASLLWSGPYMP
                     QCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLIS
                     AWKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQC
                     PGLCDVLKSRALSRKVGLGYSPVCEALDGAFSPVQCDLAQGSCWCVLGSGEEVPGTRV
                     VGTQPACESPQCPLPFSGSDVADGVIFCETASSSGVTTVQQCQLLCRQGLRSAFSPGP
                     LICSLESQHWVTLPPPRACQRPQLWQTMQTQAHFQLLLPPGKMCSVDYSGLLQAFQVF
                     ILDELIARGFCQIQVKTFGTLVSSTVCDNSSIQVGCLTAERLGVNVTWKLQLEDISVG
                     SLPDLYSIERAVTGQDLLGRFADLIQSGRFQLHLDSKTFSADTTLYFLNGDSFVTSPR
                     TQLGCMEGFYRVPTTRQDALGCVKCPEGSFSQDGRCTPCPAGTYQEQAGSSACIPCPR
                     GRTTITTGAFSKTHCVTDCQKNEAGLQCDQNGQYQASQKNRDSGEVFCVDSEGRKLQW
                     LQTEAGLSESQCLMIRKFDKAPESKVIFDANSPVIVKSSVPSADSPLVQCLTDCANDE
                     ACSFLTVSTMESEVSCDFYSWTRDNFACVTSDQEQDAMGSLKATSFGSLRCQVKVRNS
                     GKDSLAVYVKKGYESTAAGQKSFEPTGFQNVLSGLYSPVVFSASGANLTDTHTYCLLA
                     CDNDSCCDGFIITQVKGGPTICGLLSSPDILLCHINDWRDTSATQANATCAGVTYDQG
                     SRQMTLSLGGQEFLQGLALLEGTQDSFTSFQQVYLWKDSDMGSRPESMGCERGMVPRS
                     DFPGDMATELFSPVDITQVIVNTSHSLPSQQYWLFTHLFSAEQANLWCLSRCAQEPIF
                     CQLADITKSSSLYFTCFLYPEAQVCDNVMESNAKNCSQILPHQPTALFRRKVVLNDRV
                     KNFYTRLPFQKLTGISIRDKVPMSGKLISNGFFECERLCDRDPCCTGFGFLNVSQLQG
                     GEVTCLTLNSMGIQTCNEESGATWRILDCGSEDTEVHTYPFGWYQKPAVWSDTPSFCP
                     SAALQSLTEEKVTSDSWQTLALSSVIVDPSIKHFDVAHISTAATSNFSMAQDFCLQQC
                     SRHQDCLVTTLQIQPGVVRCVFYPDIQNCIHSLRSHTCWLLLHEEATYIYRKSGIPLV
                     QSDVTSTPSVRIDSFGQLQGGSQVIKVGTAWKQVYRFLGVPYAAPPLADNRFRAPEVL
                     NWTGSWDATKPRASCWQPGTRTPTPPQINEDCLYLNVFVPENLVSNASVLVFFHNTME
                     MEGSGGQLTIDGSILAAVGNFIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTW
                     VQSHIGAFGGDPQRVTLAADRSGADVASIHLLISRPTRLQLFRKALLMGGSALSPAAI
                     ISPERAQQQAAALAKEVGCPTSSIQEVVSCLRQKPANILNDAQTKLLAVSGPFHYWGP
                     VVDGQYLRELPSRRLKRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAF
                     YQALQNSLGGEDSDARILAAAVWYYSLEHSTDDYASFSRALENATRDYFIICPMVNMA
                     SLWARRTRGNVFMYHVPESYGHGSLELLADVQYAFGLPFYSAYQGQFSTEEQSLSLKV
                     MQYFSNFIRSGNPNYPHEFSRKAAEFATPWPDFIPGAGGESYKELSAQLPNRQGLKQA
                     DCSFWSKYIQTLKDADGAKDAQLTKSEEEDLEVGPGLEEDLSGSLEPVPKSYSK"
     exon            93..201
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            202..299
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            300..503
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            504..663
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            664..770
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            771..914
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1100
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..2198
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2786
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3026
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3164
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3242
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3355
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3458
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3659
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3869
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4024
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4181
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4397
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4547
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4718
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4835
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4836..4951
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5060
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5252
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5253..5420
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5421..5486
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5487..5561
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5699
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5700..5876
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5877..5988
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            5989..6068
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6069..6212
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6213..6278
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6279..6413
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6414..6578
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6579..6801
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6802..6895
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            6896..7055
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7056..7258
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7259..7423
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7424..7591
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7592..7773
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7774..7881
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            7882..8016
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            8017..8204
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     exon            8205..8437
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8414..8419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /note="hexamer: AATAAA"
     polyA_site      8437
                     /gene="Tg"
                     /gene_synonym="cog; Tgn"
                     /note="major polyA site"
ORIGIN      
        1 cttcatccca gtaggggaca ggatgacggc cctggtcttg tgggtctcta ctttgttgag
       61 ctcagtctgc ctggtagcag ccaacatctt tgagtaccag gtagatgcac agccactccg
      121 cccctgtgag ctacaaagag agaaggcctt tctgaagcag gctgaatatg ttccccagtg
      181 ctctgaagat ggaagtttcc agacagtcca atgccaaaat gatggtcaat cttgctggtg
      241 tgtggattct gatggcagag aagtacctgg cagcaggcag ctggggaggc caacagtttg
      301 tctgtccttc tgccagctac acaagcaacg gatcctgctg ggcagctaca ttaacagcac
      361 cgatgctctc taccttcctc agtgccagga ttcagggaac tatgcaccag tgcagtgtga
      421 cctgcagaga gtgcaatgct ggtgtgtaga cacagagggg atggaagtgt atggcacccg
      481 ccagcagggc aggccaactc ggtgtccaag gagctgtgag ataagaaacc ggcgtctcct
      541 ccatggagta ggagacaggt caccacccca gtgcactgca gatggggagt ttatgcctgt
      601 ccagtgcaag tttgtcaata ccacagacat gatgattttt gatctgatcc acaactacaa
      661 caggtttcca gatgcatttg tgaccttcag ttccttccgg ggcaggttcc ctgaagtgtc
      721 tgggtactgt tactgtgctg acagccaggg gcgggagctg gctgagacag gactggaatt
      781 gttactggat gaaatttatg acaccatttt tgctggcttg gaccaggcct cgaccttcac
      841 tcaaagcacc atgtaccgga tattgcagag acgattcctg gccatccaat tagtcatctc
      901 tggcagattt cggtgcccca ctaagtgtga agtagaacag tttgctgcca ccagatttgg
      961 tcattcttac atcccgagat gccacagaga tggtcactac caaacagtac agtgccagac
     1021 agaagggatg tgctggtgtg tggatgccca ggggagagag gtccctggca ctcggcagca
     1081 agggcagcct ccatcttgcg ctgcagatca gtcatgtgcc ttggaaaggc agcaggcctt
     1141 gtctaggttc tactttgaaa ccccagacta cttcagtccg caggaccttt tgtcttcaga
     1201 ggacaggctc gctcctgtga gtggtgtcag atcggacaca tcctgcccac ccagaatcaa
     1261 ggaactcttt gttgactctg gactcctgcg ttcgatagct gtggagcact accaacggct
     1321 ttctgaatcc agaagtctac taagagaagc catcagagca gttttcccct cccgggagct
     1381 ggcagggctt gcccttcagt tcaccaccaa ccccaagcga ctccagcaga acctgtttgg
     1441 agggacattt ttggcgaatg ctgcccagtt taacttgtca ggagcccttg gtacaagaag
     1501 cacatttaac ttcagtcagt ttttccagca gtttggtctc ccaggcttcc tgaatagaga
     1561 cagagttact actcttgcca aactactccc tgtgagattg gactccagtt ctaccccaga
     1621 aactctccgt gtgtctgaga agacagttgc tatgaataaa cgagttgtgg gtaactttgg
     1681 cttcaaagtc aacctacaag agaaccaaga tgccttaaaa tttctcgttt ctctcctgga
     1741 acttccagaa ttccttgtct tcttgcagcg tgctgtttct gtgccggaag atatagcgag
     1801 agatttagga gatgtgatgg aaatggtgtt cagtgctcaa gcctgtaaac agatgcctgg
     1861 gaagttcttt gtcccatcat gcactgctgg aggaagctat gaggatatac agtgctatgc
     1921 tggagaatgc tggtgtgtag attcccgagg caaagaactt gatggctcga gagtcagagg
     1981 tggacgccca agatgtccca ccaagtgtga aaagcagaga gctcagatgc aaagcctcgc
     2041 aagcgctcag cccgccggct ccagcttttt tgttcctact tgtactagag agggatattt
     2101 tctgcctgtc cagtgcttca actcagaatg ttactgtgtg gatactgaag gccaggttat
     2161 tcctgggact caaagtacag ttggagaagc caagcagtgt cccagtgtct gccaattaca
     2221 ggctgaacaa gctttccttg gggtagtagg ggttctgctc tcgaactcca gcatggtgcc
     2281 ctccatctcc aatgtctaca tccctcagtg cagtgccagt ggccagtgga ggcatgtgca
     2341 gtgtgatggg ccccatgagc aggtctttga gtggtatgaa cgatggaaga ctcagaacgg
     2401 tgatggccag gaactgaccc cagccgcact gctaatgaag atcgtgagct acagagaagt
     2461 agcttccaga aacttcagcc tctttcttca aagtctctat gatgctggcc agcaaagaat
     2521 ctttccagtg ctagcacagt acccatctct tcaagatgtt ccacaggtag tgttggaggg
     2581 agccacaact ccgcctgggg agaacatttt cctggatccg tacatctttt ggcagatcct
     2641 aaatggtcag ctcagccaat acccaggtcc ctactcagac tttaacatgc ctttggaaca
     2701 cttcaacctc aggagctgtt ggtgtgtgga tgaggctggc cagaaactgg atggtactca
     2761 gactaagcca ggcgagatcc cagcatgtcc tggcccatgt gaggaagtga aacttcgtgt
     2821 cctgaaattt attaaggaaa cagaagagat tgtctcagcc tccaatgctt cttcatttcc
     2881 actgggagag agtttcttag tggccaaggg aatccagctg accagtgagg agcttgacct
     2941 tcctccccaa ttcccatccc gggatgcttt ctctgagaag tttctacgtg ggggtgaata
     3001 tgccattcgc ttggctgctc agtccacctt gactttctat cagagtctcc gtgcttccct
     3061 gggaaagtcc gatggagcag ccagtcttct gtggtcaggg ccctacatgc cacaatgcaa
     3121 tatgattgga ggctgggaac ctgtgcagtg ccatgctggg acaggacagt gttggtgtgt
     3181 ggatggaagg ggagagttca ttccaggctc gctgatgtca cgctcctcac agatgcccca
     3241 gtgtcccaca aactgtgagc tatccagagc aagtgggttg atttctgcat ggaaacaggc
     3301 tggaccccaa agaaatccag gcccgggaga tctgttcata ccagtctgcc tccagacggg
     3361 agagtatgtc aggaagcaga catcagggac aggaacatgg tgtgtggatc cagcctcagg
     3421 agaagggatg ccagtgaaca caaatggcag tgctcagtgt cctggcctct gtgatgtcct
     3481 caagagcaga gccctgtcca ggaaagtggg tcttggctac tctccagtct gtgaggcact
     3541 ggatggagcc ttctccccag tgcaatgtga cttggcccag ggcagttgtt ggtgtgtcct
     3601 gggaagtgga gaggaagtgc cagggacccg tgtggtaggc acccagcctg cctgtgaaag
     3661 cccacagtgt ccactgccat tctctgggtc agatgtggct gatggagtga tcttctgcga
     3721 gacagcctct agctcaggag tgacgactgt tcagcagtgc cagctgctgt gccgccaggg
     3781 cctccggagt gcgttttcac cagggccact gatttgtagc ctggagagtc agcactgggt
     3841 gacactgcca ccaccccgag cctgtcaaag gcctcagctg tggcagacca tgcaaactca
     3901 agcacacttc cagctcctgc tcccaccagg aaagatgtgc agtgttgact actccggctt
     3961 gctgcaggcc ttccaggtct tcatactgga tgagctgata gcccgtggct tctgccagat
     4021 ccaggtaaag acatttggga ccctggtttc cagcactgtc tgtgacaact cctcaataca
     4081 ggtggggtgt ctgactgcag agcgtttagg agtaaatgtc acgtggaagt tacagcttga
     4141 ggacatctca gtgggctcac ttccagattt gtacagcatt gaaagggcgg taacgggcca
     4201 ggatctcctt gggcgctttg cagatctgat ccaaagtggc aggttccagc ttcatctgga
     4261 ctccaagaca ttctcagcgg acaccacctt gtattttctc aatggtgaca gctttgtcac
     4321 ctctcccagg actcagcttg gatgtatgga agggttctac agagtcccaa ccaccagaca
     4381 ggatgctctg ggctgtgtga aatgccctga aggaagcttc tctcaggatg ggcgatgcac
     4441 tccctgtcct gctggcacct accaagaaca ggcaggcagc tcagcctgca tcccatgccc
     4501 aaggggcaga acaaccatca ccactggagc tttcagcaag acccattgtg tcactgactg
     4561 tcagaagaat gaggctggcc tacagtgtga ccagaatggt cagtaccaag ccagccagaa
     4621 gaacagggac agtggggaag ttttctgcgt ggacagcgag gggcggaaac tacagtggtt
     4681 acagacagag gctggactct cagaatctca gtgtctgatg atacggaaat ttgacaaagc
     4741 tccagaatcg aaggttatct ttgatgctaa ttctcctgtg atagtcaagt ccagtgtccc
     4801 cagtgctgac tccccgctgg tgcagtgctt gacagattgt gcaaatgatg aggcctgcag
     4861 cttccttaca gtgtccacaa tggagtcaga ggtttcatgt gacttttatt cttggacaag
     4921 ggacaacttt gcctgcgtga cttctgacca ggaacaagat gctatgggca gcctgaaggc
     4981 aaccagtttc gggagcctca ggtgccaggt gaaagtgaga aatagtggca aggattctct
     5041 ggctgtgtat gtgaagaaag gctatgaatc tactgcagct ggtcagaaga gcttcgaacc
     5101 aacgggtttt caaaatgtgc tctctgggtt atatagccct gtggtgttct cagcctcagg
     5161 agccaatctg acagatacac acacctactg tctgcttgcc tgtgacaatg attcctgctg
     5221 tgatggcttc atcatcacac aggttaaagg agggcccacc atctgtggac ttctcagttc
     5281 tcctgacatt ctgctttgcc acatcaatga ctggagggat acctctgcta ctcaggccaa
     5341 tgctacatgt gctggggtga catatgacca ggggagccgc cagatgacct tgagtctggg
     5401 aggccaagag ttcctgcagg gtctggcact cttggaagga actcaagaca gctttaccag
     5461 cttccagcag gtctacctct ggaaagattc tgacatgggg tctcggccgg agtctatggg
     5521 atgtgaaagg ggaatggtgc caaggtcaga ctttccagga gatatggcaa cagaactttt
     5581 ttcccctgtg gacattaccc aggtcattgt caacacaagc cattcattgc ccagccagca
     5641 gtactggctc ttcacacacc tgttttcagc agagcaggca aacctgtggt gcctttctcg
     5701 gtgtgcccag gagcccattt tctgtcaact tgcagacata acaaaaagtt catctttgta
     5761 tttcacctgc ttcctatacc cagaagctca ggtctgtgac aatgtcatgg aatctaatgc
     5821 caagaactgc agtcagattc tgccccacca accaacggcc ctcttccgga ggaaagttgt
     5881 gctgaatgat agagtgaaga acttttatac tcgcctgcca ttccaaaagc tcacagggat
     5941 ttccatcaga gacaaagtcc ccatgtctgg aaaactcatt tccaatgggt tctttgagtg
     6001 tgagcggctc tgtgacaggg acccttgctg cactggcttt ggttttctaa atgtctccca
     6061 gctgcaagga ggagaggtga cctgtctgac tctgaacagc atggggattc aaacatgcaa
     6121 tgaggagagt ggagcaacct ggcgcatttt ggactgtggc tctgaggaca cagaagtcca
     6181 cacctatccc tttgggtggt accagaagcc tgctgtatgg agtgacactc ctagcttctg
     6241 cccttctgct gccctgcaat ccctcactga ggagaaggtt acttcggact cttggcagac
     6301 cctggccctg tcttcagtga ttgtagatcc atccatcaag cactttgatg ttgcccacat
     6361 cagcactgca gccaccagta acttctccat ggcccaagac ttctgcttac agcaatgttc
     6421 ccgtcaccag gactgccttg tcactaccct gcagatccag cctggggttg tgagatgtgt
     6481 gttctaccct gatatacaga actgcataca cagtctacgg agccacacgt gctggcttct
     6541 gctccatgaa gaggctacct acatctaccg gaagtctgga atccctttgg tccaatctga
     6601 tgtaacatcc acaccttctg tacgcattga ttcctttggc cagcttcagg gtgggtccca
     6661 ggtcatcaag gtgggcactg cctggaagca agtataccgg ttccttggag ttccatatgc
     6721 tgccccaccc ttggcagaca accgcttccg ggcaccagag gtcttgaatt ggacaggttc
     6781 atgggatgct accaagccaa gggccagctg ctggcagcca ggtacccgta cccccacacc
     6841 tccacaaatc aatgaagact gcttatatct caatgtgttt gtccctgaga acctggtctc
     6901 caatgcatca gttctggtgt ttttccacaa taccatggag atggaaggca gtggtggtca
     6961 gctgaccatt gatggctcca tcctggctgc agttggcaac ttcatcgtag tcactgctaa
     7021 ctacagactg ggggtcttcg gcttcctgag ttcaggctct gatgaagtag ctggcaactg
     7081 ggggctgctg gaccaagtgg cagctctaac gtgggtgcag tcccacattg gagcatttgg
     7141 tggggaccct cagcgtgtga cactggcagc agaccgtagt ggggctgatg tggccagcat
     7201 acaccttctc atcagcaggc ctacaaggct ccagctcttc aggaaggcac tgcttatggg
     7261 aggctctgca ctgtccccgg ctgcaattat cagcccagag agggcccaac agcaagctgc
     7321 agccttggca aaggaggttg gatgccctac ttcatccatc caggaagtgg tatcatgtct
     7381 ccgccagaag cctgccaaca ttctcaatga tgctcagacc aagctcctgg ctgtgagtgg
     7441 ccctttccac tactggggcc ctgtggtcga tggccagtac ctccgtgaac ttccatccag
     7501 acggttgaag aggcctctgc cagtgaaggt ggatctactc ataggagggt cccaggatga
     7561 tgggcttatc aatagggcaa aggctgtgaa gcaatttgaa gagagccaag gccgaaccaa
     7621 cagcaaaaca gccttttacc aggcactgca gaattcactc ggtggtgagg actcagatgc
     7681 ccgcatcctt gctgctgctg tatggtatta ctccttggag cactccacag acgactatgc
     7741 ctccttctct cgggcactgg agaatgccac ccgggactac tttatcatct gtcccatggt
     7801 caacatggcc agcctctggg caaggagaac ccgtggaaat gtcttcatgt accatgtccc
     7861 cgaaagctat ggccatggca gcctagaatt gctggcagat gttcaatatg cttttggact
     7921 gcccttctac tctgcctacc agggccagtt ttcaacggag gagcagagcc tgtccctgaa
     7981 agtcatgcag tatttctcca acttcatcag atcaggaaat cctaactacc cacatgagtt
     8041 ctcaaggaag gcagctgagt ttgccacacc ttggccagac tttattcctg gagctggagg
     8101 agagagctac aaggagctca gcgcccagct tcccaatcgg cagggcctca aacaagctga
     8161 ctgctccttc tggtccaagt acatccagac tctgaaggat gcagatggag ccaaggatgc
     8221 acagttaacc aagagtgaag aggaagactt ggaagttgga cctggattag aagaagacct
     8281 ctcaggctca ctggagcctg tccccaagag ctacagcaaa tgaccaaccc tgagacctcc
     8341 catcttccct gccagttcca tcctgaactg cctgtcatgg tgattttact atatatagca
     8401 accatttgct ttcaataaag tatatgcata caacaaaaaa aaaaaaaaaa aaaaaaaaaa
     8461 aa
//
