LOCUS       NM_011638               4920 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus transferrin receptor (Tfrc), transcript variant 1,
            mRNA.
ACCESSION   NM_011638
VERSION     NM_011638.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4920)
  AUTHORS   Shojaei,M., Schaefer,R., Schlepckow,K., Kunze,L.H., Struebing,F.L.,
            Brunner,B., Willem,M., Bartos,L.M., Feiten,A., Palumbo,G.,
            Arzberger,T., Bartenstein,P., Parico,G.C., Xia,D., Monroe,K.M.,
            Haass,C., Brendel,M. and Lindner,S.
  TITLE     PET imaging of microglia in Alzheimer's disease using copper-64
            labeled TREM2 antibodies
  JOURNAL   Theranostics 14 (16), 6319-6336 (2024)
   PUBMED   39431020
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4920)
  AUTHORS   Barker,S.J., Thayer,M.B., Kim,C., Tatarakis,D., Simon,M.J.,
            Dial,R., Nilewski,L., Wells,R.C., Zhou,Y., Afetian,M.,
            Akkapeddi,P., Chappell,A., Chew,K.S., Chow,J., Clemens,A.,
            Discenza,C.B., Dugas,J.C., Dwyer,C., Earr,T., Ha,C., Ho,Y.S.,
            Huynh,D., Lozano,E.I., Jayaraman,S., Kwan,W., Mahon,C., Pizzo,M.,
            Robles-Colmenares,Y., Roche,E., Sanders,L., Stergioulis,A.,
            Tong,R., Tran,H., Zuchero,Y., Estrada,A.A., Gadkar,K., Koth,C.M.M.,
            Sanchez,P.E., Thorne,R.G., Watts,R.J., Sandmann,T., Kane,L.A.,
            Rigo,F., Dennis,M.S., Lewcock,J.W. and DeVos,S.L.
  TITLE     Targeting the transferrin receptor to transport antisense
            oligonucleotides across the mammalian blood-brain barrier
  JOURNAL   Sci Transl Med 16 (760), eadi2245 (2024)
   PUBMED   39141703
  REMARK    GeneRIF: Targeting the transferrin receptor to transport antisense
            oligonucleotides across the mammalian blood-brain barrier.
REFERENCE   3  (bases 1 to 4920)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   4  (bases 1 to 4920)
  AUTHORS   Pacella,I., Pinzon Grimaldos,A., Rossi,A., Tucci,G., Zagaglioni,M.,
            Potenza,E., Pinna,V., Rotella,I., Cammarata,I., Cancila,V.,
            Belmonte,B., Tripodo,C., Pietropaolo,G., Di Censo,C., Sciume,G.,
            Licursi,V., Peruzzi,G., Antonucci,Y., Campello,S., Guerrieri,F.,
            Iebba,V., Prota,R., Di Chiara,M., Terrin,G., De Peppo,V.,
            Grazi,G.L., Barnaba,V. and Piconese,S.
  TITLE     Iron capture through CD71 drives perinatal and tumor-associated
            Treg expansion
  JOURNAL   JCI Insight 9 (15), e167967 (2024)
   PUBMED   38954474
  REMARK    GeneRIF: Iron capture through CD71 drives perinatal and
            tumor-associated Treg expansion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4920)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4920)
  AUTHORS   Copp,A.J., Estibeiro,J.P., Brook,F.A. and Downs,K.M.
  TITLE     Exogenous transferrin is taken up and localized by the
            neurulation-stage mouse embryo in vitro
  JOURNAL   Dev Biol 153 (2), 312-323 (1992)
   PUBMED   1397688
REFERENCE   7  (bases 1 to 4920)
  AUTHORS   Hradilek,A., Fuchs,O. and Neuwirt,J.
  TITLE     Inhibition of heme synthesis decreases transferrin receptor
            expression in mouse erythroleukemia cells
  JOURNAL   J Cell Physiol 150 (2), 327-333 (1992)
   PUBMED   1734036
REFERENCE   8  (bases 1 to 4920)
  AUTHORS   Stearne,P.A., Pietersz,G.A. and Goding,J.W.
  TITLE     cDNA cloning of the murine transferrin receptor: sequence of
            trans-membrane and adjacent regions
  JOURNAL   J Immunol 134 (5), 3474-3479 (1985)
   PUBMED   2984291
REFERENCE   9  (bases 1 to 4920)
  AUTHORS   van Driel,I.R., Stearne,P.A., Grego,B., Simpson,R.J. and
            Goding,J.W.
  TITLE     The receptor for transferrin on murine myeloma cells: one-step
            purification based on its physiology, and partial amino acid
            sequence
  JOURNAL   J Immunol 133 (6), 3220-3224 (1984)
   PUBMED   6092468
REFERENCE   10 (bases 1 to 4920)
  AUTHORS   Trowbridge,I.S., Lesley,J. and Schulte,R.
  TITLE     Murine cell surface transferrin receptor: studies with an
            anti-receptor monoclonal antibody
  JOURNAL   J Cell Physiol 112 (3), 403-410 (1982)
   PUBMED   6290505
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY101284.1, BC054522.1 and
            BF714992.1.
            
            On Mar 13, 2010 this sequence version replaced NM_011638.3.
            
            Summary: This gene encodes a cell surface receptor necessary for
            cellular iron uptake by the process of receptor-mediated
            endocytosis. This receptor is required for erythropoiesis and
            neurologic development. Mice that are deficient in this receptor
            show impaired erythroid development and abnormal iron homeostasis.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.19392.1,
                                           SRR1660819.159193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               BY101284.1         2-126
            126-4910            BC054522.1         11-4795
            4911-4920           BF714992.1         1-10                c
FEATURES             Location/Qualifiers
     source          1..4920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.06 cM"
     gene            1..4920
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /note="transferrin receptor"
                     /db_xref="GeneID:22042"
                     /db_xref="MGI:MGI:98822"
     exon            1..141
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            142..200
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2456
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /note="mammary tumor virus receptor 1"
                     /codon_start=1
                     /product="transferrin receptor protein 1"
                     /protein_id="NP_035768.1"
                     /db_xref="CCDS:CCDS28123.1"
                     /db_xref="GeneID:22042"
                     /db_xref="MGI:MGI:98822"
                     /translation="MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADE
                     EENADNNMKASVRKPKRFNGRLCFAAIALVIFFLIGFMSGYLGYCKRVEQKEECVKLA
                     ETEETDKSETMETEDVPTSSRLYWADLKTLLSEKLNSIEFADTIKQLSQNTYTPREAG
                     SQKDESLAYYIENQFHEFKFSKVWRDEHYVKIQVKSSIGQNMVTIVQSNGNLDPVESP
                     EGYVAFSKPTEVSGKLVHANFGTKKDFEELSYSVNGSLVIVRAGEITFAEKVANAQSF
                     NAIGVLIYMDKNKFPVVEADLALFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNI
                     PVQTISRAAAEKLFGKMEGSCPARWNIDSSCKLELSQNQNVKLIVKNVLKERRILNIF
                     GVIKGYEEPDRYVVVGAQRDALGAGVAAKSSVGTGLLLKLAQVFSDMISKDGFRPSRS
                     IIFASWTAGDFGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTL
                     MGKIMQDVKHPVDGKSLYRDSNWISKVEKLSFDNAAYPFLAYSGIPAVSFCFCEDADY
                     PYLGTRLDTYEALTQKVPQLNQMVRTAAEVAGQLIIKLTHDVELNLDYEMYNSKLLSF
                     MKDLNQFKTDIRDMGLSLQWLYSARGDYFRATSRLTTDFHNAEKTNRFVMREINDRIM
                     KVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLKLRQKNITAFNETLFRNQLAL
                     ATWTIQGVANALSGDIWNIDNEF"
     exon            201..402
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            403..604
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            605..754
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            755..857
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            858..971
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1070
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1210
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1368
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1491
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1577
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1641
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1709
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1768
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1850
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2072
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2213
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..4914
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4891..4896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /note="hexamer: AATAAA"
     polyA_site      4910
                     /gene="Tfrc"
                     /gene_synonym="2610028K12Rik; CD71; E430033M20Rik; Mtvr1;
                     p90; TFR; TFR1; TR; Trfr"
                     /note="major polyA site"
ORIGIN      
        1 gtgcggaagg aagtgacgta gatccagagg gccggccggg gggtggggcc gagctataag
       61 ctttgggtgg gaggcagcgc tgccttcaga aggcgtgcgg agcgcgggct gctgcattgc
      121 ggactgtaga ggcgcttcct agtactccct tgtagcagct gagaatgatg gatcaagcca
      181 gatcagcatt ctctaacttg tttggtgggg aaccattgtc atacacccgg tttagccttg
      241 ctcggcaagt agatggagat aacagtcatg tggagatgaa actggctgca gatgaagaag
      301 aaaatgccga caataacatg aaggctagtg tcagaaaacc caagaggttt aatggaagac
      361 tctgctttgc agctattgca ctagtcattt tcttcttgat tggattcatg agtggctacc
      421 tgggctattg taagcgtgta gaacaaaaag aggagtgtgt gaaactggct gaaacggagg
      481 agacagacaa gtcagaaacc atggaaacag aggatgttcc tacatcatct cgcttatatt
      541 gggcagacct caaaacactg ttgtcagaga agttgaactc catagagttt gctgacacca
      601 tcaagcagct gagccagaat acatacactc ctcgtgaggc tggatctcaa aaagatgaaa
      661 gtcttgccta ttatattgaa aatcagttcc atgaatttaa attcagcaaa gtctggcgag
      721 atgaacacta tgtgaagatt caagtgaaaa gcagcattgg tcaaaacatg gtgaccatag
      781 tgcagtcaaa tggtaactta gacccagtgg agtctcccga gggttatgtg gcattcagta
      841 aacctacaga agtttctggt aaactggtcc atgctaattt tggcactaaa aaggactttg
      901 aagaactaag ttattctgtg aatggatctt tagtgattgt tagagcaggg gaaattactt
      961 ttgcagaaaa ggttgcaaat gcccaaagct ttaatgcaat tggtgtcctc atatacatgg
     1021 acaagaataa attccccgtt gttgaggcag accttgcact ctttggacat gctcatctag
     1081 gaactggtga tccatacaca cctggctttc cttctttcaa tcatactcag tttccgccat
     1141 ctcagtcatc agggttgcct aatatacctg tgcaaacaat ctcaagagct gctgcagaaa
     1201 agctatttgg aaaaatggaa ggaagctgtc ctgctagatg gaacatagat tcttcatgta
     1261 agctggaact ttcacagaat caaaatgtga agctcattgt gaaaaacgta ctgaaagaaa
     1321 gaagaatact taacatcttt ggagttatta aaggttatga ggaaccagac cgttatgttg
     1381 tagtaggagc ccagagagac gctttgggtg ctggtgttgc ggcgaagtcc agtgtgggaa
     1441 caggtcttct gttgaaactt gcccaagtat tctcagatat gatttcaaaa gatggattta
     1501 gacccagcag aagtataatc tttgccagct ggactgcagg cgactttgga gctgttggtg
     1561 ccactgagtg gttggaggga tacctttcat ctttgcattt aaaagctttc acttatatta
     1621 atttggataa agttgtcctt ggtactagta acttcaaagt ttctgccagc cccttattat
     1681 atacacttat gggaaagata atgcaagatg taaagcatcc agttgatgga aaatctctat
     1741 atagagacag caattggatt agcaaagttg agaaactttc ctttgacaat gctgcatatc
     1801 ctttccttgc atattctgga atcccagcag tttctttttg tttttgtgag gatgcagact
     1861 atccttattt gggcactaga ttggatacct atgaggcatt gactcagaaa gttcctcagc
     1921 tcaaccaaat ggttcgtaca gcagcggaag tggctggtca gctcattatt aaacttaccc
     1981 atgacgttga attgaacctg gactatgaga tgtataacag caaactactg tcatttatga
     2041 aggatctgaa ccagttcaaa acagatatca gggatatggg tctaagtcta cagtggctgt
     2101 attccgctcg tggagactac ttccgtgcta cttctagact aacaactgat tttcataatg
     2161 ctgagaaaac aaacagattt gtcatgaggg aaatcaatga tcgtattatg aaagtggagt
     2221 atcacttcct gtcgccctat gtatctccaa gagagtctcc tttccgacat atcttctggg
     2281 gctctggctc tcacactctc tcagctttag tggagaactt gaagcttcgt caaaaaaata
     2341 ttactgcttt taatgaaacc ctcttcagaa accagttggc cctggctact tggactattc
     2401 agggagtcgc aaatgccctc tctggtgaca tttggaatat tgacaatgag ttttaaatgt
     2461 aacatgcata attaaataag agcagggtag tctgtttcta gacttgtgtt ggttgtgcta
     2521 aattttcatt agagctctaa aatctaatgt taaaattcta cccaatcatc taatgtctta
     2581 ggcagcagct tttagtgcgg ggttggacct acacttcaag tacaatggat aacactttcc
     2641 atgtttgtga tatcttctca gattatcttt aaaatttttg agtcctttgt aataacttcc
     2701 tctttgcttc atggtcatga aaatgtcaga accagttgta agaacaatgc tatatgtcct
     2761 gagggcatta actagtgtct tttgaggtag gagaaagagt gtgcttgtgg agggtcaacg
     2821 tggtagttgg gtagttggag attgccccgt ctccatctga tcttccattg agctgtatgc
     2881 ccttaaggat gtagctggtt tgcatttccc taaattagac agtaactttc agaagagatg
     2941 gaacttgttt tcttgccagc aaggttgaaa ataggtcctt agctggacca atttgtctgt
     3001 ttacaggaat aagtaaggcc ttactggtta accttggtgt tctttatgat gagaccagaa
     3061 gccaaagacc tcaagttttc tctcctcttg gcatctgccc tatagtcttt agttctttgt
     3121 ttttattttg tttttctttt tttcccaaca ttttctgaaa aagaacaagt tttagactca
     3181 atttgtcaga cttgaaaaga acacactgcc aagttttggc caaagtgtta gtcttcagga
     3241 aagctttcta tcattttggc actgagatat ttattgttta tttatcagtg acagagttca
     3301 ctataaatag tgttgttttt tttttatata tagaagataa ttatcggaag cagtgccttc
     3361 cataattatg acagttatac tgtcgttttc ttttaataaa agcagcatct gctaatgaga
     3421 cccacagata ctggaagttt tgcacttatg gtcagcactt gcaactttag gaaggaagaa
     3481 tgccacaatc caaataatat gagctagaag aggattgggt taaataagag attcctaatt
     3541 gagttgggga aaaaaatgat agttttccta agtgcagtga gttgtggcca agttaaatgt
     3601 catttaaagg ctatggtagt acttacatct acaaaatttt acagctcaat ttattcaaga
     3661 tgtaactcaa aatcaatttt gcaaaatttc cagtaccttt gtcacaaact taactcacat
     3721 tatcgggagc agtgtcttcc ataatgcata aagaacaagg tagtttttgc ctaccacagt
     3781 gtctatatcg gagacagtga tctccatatg ttacactaag ggtgtacgta attatcggga
     3841 acagtgtttc ccataatttt cttcatgcaa tgacatcttc agagcttgaa gatcgttagt
     3901 atctaacatg aattcctaac ttcctgtagc tccttagttt tagttgcaaa aaacatttgt
     3961 ggtcattgag catttggtgg gtaaaatcaa ctgctgtaaa atcattactt ccaagatcct
     4021 tttttaaaat gtgggtattt tgttatctct ggtttatgga ataaaagcat acgtttataa
     4081 tgtttgctgg tgacaaagga atttaactat ctccctttat ttgcatgtta catgttattt
     4141 cctaaatgta gttcttagaa gtttgaattc atttttggtt tttgggaggg tagaaagtag
     4201 agaataatgg gtgttgggaa gacaaagctt gcaaaaggat ctttatgtac ctgctcatca
     4261 ctatggtggc tatgaattat gtaggtaatg agcaagatca cattaacaaa gactagttaa
     4321 ccatcattac gcatctaatc agttttgcca tggggtcagt tcaaagctgc cacctgagaa
     4381 tgtcactagg ctctcagggt cttggcacca ctcgcccaag ttatatccac cagattattt
     4441 tgagcctcac tgagttgttt tgctactcag tcccttcagt cttcacagtg tttctcttgt
     4501 accagtatga gtatcaccgt gcataatggg attccaagtc ttgaatgaag gcatgcattt
     4561 tacatagacg tctctgtgaa ataacctttg ttgtaagtgg tgtttccagt caaagcagta
     4621 agttggtaag gtttagtctt gggtgaaatg tggatctgag taataagtag cttctgctac
     4681 ttatcaggtt attgttggtt aaaatgtaga ttttgaagat aaaaatagat cttttgtcat
     4741 gactcactgc tagaatttgc atgaccttta ctgtgttagc ttttgaatgc cttttggttt
     4801 ggacttgcca acctatactg tctttgctga aatgccctta taaatgtata cagctggtat
     4861 gtaacaatgt gaagattcct tacctgactt aataaaatac ttcgataata ctgaaaaaaa
//
