LOCUS       NM_001359206            3674 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus transferrin receptor 2 (Tfr2), transcript variant 5,
            mRNA.
ACCESSION   NM_001359206 XM_011240947
VERSION     NM_001359206.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3674)
  AUTHORS   Koury MJ and Haase VH.
  TITLE     Deregulating iron-erythropoiesis regulation: transferrin receptor 2
            as potential target for treating anemia in CKD
  JOURNAL   Kidney Int 104 (1), 25-28 (2023)
   PUBMED   37349056
  REMARK    GeneRIF: Deregulating iron-erythropoiesis regulation: transferrin
            receptor 2 as potential target for treating anemia in CKD.
REFERENCE   2  (bases 1 to 3674)
  AUTHORS   Ledesma-Colunga MG, Baschant U, Weidner H, Alves TC, Mirtschink P,
            Hofbauer LC and Rauner M.
  TITLE     Transferrin receptor 2 deficiency promotes macrophage polarization
            and inflammatory arthritis
  JOURNAL   Redox Biol 60, 102616 (2023)
   PUBMED   36746004
  REMARK    GeneRIF: Transferrin receptor 2 deficiency promotes macrophage
            polarization and inflammatory arthritis.
REFERENCE   3  (bases 1 to 3674)
  AUTHORS   Di Modica SM, Tanzi E, Olivari V, Lidonnici MR, Pettinato M, Pagani
            A, Tiboni F, Furiosi V, Silvestri L, Ferrari G, Rivella S and Nai
            A.
  TITLE     Transferrin receptor 2 (Tfr2) genetic deletion makes
            transfusion-independent a murine model of transfusion-dependent
            beta-thalassemia
  JOURNAL   Am J Hematol 97 (10), 1324-1336 (2022)
   PUBMED   36071579
  REMARK    GeneRIF: Transferrin receptor 2 (Tfr2) genetic deletion makes
            transfusion-independent a murine model of transfusion-dependent
            beta-thalassemia.
REFERENCE   4  (bases 1 to 3674)
  AUTHORS   Schmidt PJ, Fitzgerald K, Butler JS and Fleming MD.
  TITLE     Global loss of Tfr2 with concomitant induced iron deficiency
            greatly ameliorates the phenotype of a murine thalassemia
            intermedia model
  JOURNAL   Am J Hematol 96 (2), 251-257 (2021)
   PUBMED   33180328
  REMARK    GeneRIF: Global loss of Tfr2 with concomitant induced iron
            deficiency greatly ameliorates the phenotype of a murine
            thalassemia intermedia model.
REFERENCE   5  (bases 1 to 3674)
  AUTHORS   Ali MK, Kim RY, Brown AC, Donovan C, Vanka KS, Mayall JR, Liu G,
            Pillar AL, Jones-Freeman B, Xenaki D, Borghuis T, Karim R,
            Pinkerton JW, Aryal R, Heidari M, Martin KL, Burgess JK, Oliver BG,
            Trinder D, Johnstone DM, Milward EA, Hansbro PM and Horvat JC.
  TITLE     Critical role for iron accumulation in the pathogenesis of fibrotic
            lung disease
  JOURNAL   J Pathol 251 (1), 49-62 (2020)
   PUBMED   32083318
REFERENCE   6  (bases 1 to 3674)
  AUTHORS   Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF and
            Koeffler HP.
  TITLE     Regulation of expression of murine transferrin receptor 2
  JOURNAL   Blood 98 (6), 1949-1954 (2001)
   PUBMED   11535534
REFERENCE   7  (bases 1 to 3674)
  AUTHORS   Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung
            TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W and Koop
            BF.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   8  (bases 1 to 3674)
  AUTHORS   Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S,
            Bacon BR and Sly WS.
  TITLE     Transferrin receptor 2: continued expression in mouse liver in the
            face of iron overload and in hereditary hemochromatosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2214-2219 (2000)
   PUBMED   10681454
REFERENCE   9  (bases 1 to 3674)
  AUTHORS   Shivdasani RA and Orkin SH.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   10 (bases 1 to 3674)
  AUTHORS   Muller,R., Verma,I.M. and Adamson,E.D.
  TITLE     Expression of c-onc genes: c-fos transcripts accumulate to high
            levels during development of mouse placenta, yolk sac and amnion
  JOURNAL   EMBO J 2 (5), 679-684 (1983)
   PUBMED   6641714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148018.3.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_001359206.2.
            
            On Dec 29, 2017 this sequence version replaced XM_011240947.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155526.1, SRR13861890.163044.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC148018.3         201922-202200
            280-333             AC148018.3         203070-203123
            334-580             AC148018.3         203359-203605
            581-758             AC148018.3         203696-203873
            759-899             AC148018.3         206469-206609
            900-1011            AC148018.3         206690-206801
            1012-1134           AC148018.3         206896-207018
            1135-1251           AC148018.3         209540-209656
            1252-1391           AC148018.3         209748-209887
            1392-1555           AC148018.3         210961-211124
            1556-1675           AC148018.3         212249-212368
            1676-1758           AC148018.3         214671-214753
            1759-1822           AC148018.3         214840-214903
            1823-1890           AC148018.3         215001-215068
            1891-1967           AC148018.3         215156-215232
            1968-2052           AC148018.3         215313-215397
            2053-2280           AC148018.3         215487-215714
            2281-2421           AC148018.3         216008-216148
            2422-3674           AC148018.3         218911-220163
FEATURES             Location/Qualifiers
     source          1..3674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.57 cM"
     gene            1..3674
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:50765"
                     /db_xref="MGI:MGI:1354956"
     exon            1..279
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..333
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2697
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001346135.1"
                     /db_xref="CCDS:CCDS39333.1"
                     /db_xref="GeneID:50765"
                     /db_xref="MGI:MGI:1354956"
                     /translation="MEQRWGLLRRVQQWSPRPSQTIYRRVEGPQLEHLEEEDREEGAE
                     LPAQFCPMELKGPEHLGSCPGRSIPIPWAAAGRKAAPYLVLITLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFA
                     QKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDL
                     RLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     DHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     exon            334..580
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..758
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..899
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1011
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1134
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1251
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1391
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1555
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1675
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1758
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1822
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1890
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1967
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2052
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2280
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2421
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..3674
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtctcctg ggagcatggt ccaagaaacc cagagacctg ttgctgagct gaacttggct
       61 gctgtgtctt cccactcagg actcggcttt gacaggcacg aggcagggac tggggtactg
      121 gtgagcccct acctctcaga tctttctgga cctgggtagg acccgcagtt tcccagggga
      181 aacctggacc agaagtaagg gtgaggtgga ccctgaactt tcccattcac agctgcaggt
      241 cctggtgtct tcgtcgcggc ttggatttca aactggagga gttcaggagg gggcacaagc
      301 atggagcaac gttggggtct acttcggaga gtgcaacagt ggtccccaag accctctcag
      361 accatctaca gacgcgtgga aggccctcag ctggagcacc tggaggagga agacagggag
      421 gaaggggcgg agcttcctgc ccagttctgc cccatggaac tcaaaggccc tgagcactta
      481 ggctcctgtc ccgggaggtc aattcccata ccctgggctg cagcaggtcg aaaggctgcc
      541 ccctatctgg tcctgatcac cctgctaatc ttcactgggg ccttcctcct aggctacgtg
      601 gcctttcgag ggtcctgcca ggcgtgtggg gactccgtgt tggtggtcga tgaagatgtc
      661 aaccctgagg actccggccg gaccacgttg tactggagcg acctccaggc catgtttctc
      721 cggttccttg gggaggggcg catggaagac accatcaggc tgaccagcct ccgggaacgc
      781 gtggctggct cagccagaat ggccaccctg gtccaagata tcctcgataa gctctcgcgc
      841 cagaagctgg accacgtgtg gactgacacg cactacgtgg gacttcagtt cccagatccg
      901 gctcacgcta acaccctgca ctgggtggat gcagacggga gcgtccagga gcagctaccg
      961 ctggaggatc cggaagtcta ctgtccctac agcgccaccg gcaacgccac gggcaagctg
     1021 gtgtacgccc actacgggcg gtcggaggac ctacaggacc taaaagccaa gggcgtggag
     1081 ctggccggca gcctcctgct agtgcgagtt ggaattacta gcttcgccca gaaggtagcc
     1141 gttgcccagg actttggggc tcaaggagtg ctgatatacc ctgacccatc agacttctcc
     1201 caggatcccc acaagccagg cctgtctagc caccaggctg tgtacggaca tgtgcacctg
     1261 ggaactggag acccttacac acctggcttc ccgtccttca atcaaaccca gttccctcca
     1321 gtagaatcat caggccttcc cagcatcccc gcccagccca tcagtgctga cattgctgat
     1381 caattgctca ggaaactcac aggccccgtg gctccccagg agtggaaagg tcacctctca
     1441 ggctctcctt atcggctggg acctgggccc gacttacgcc ttgtggtcaa caaccacaga
     1501 gtctctaccc ccatcagtaa catctttgcg tgcatcgagg gctttgcaga gccagatcac
     1561 tatgttgtca ttggggccca gagggatgca tggggcccag gagcagccaa gtctgcagtg
     1621 gggactgcca tcctgctgga gctggttcgg accttctctt ccatggtcag caatgggttc
     1681 agacctcgaa gaagtctttt gttcatcagc tgggacggag gtgactttgg cagcgtggga
     1741 gccacagagt ggttggaggg ctacctcagc gtgctacacc tcaaagctgt tgtgtacgtg
     1801 agcctggaca actccgtgtt gggagatggc aaattccatg ctaagaccag cccccttctc
     1861 gtcagcctca ttgagaatat cttgaagcag gtggactccc ctaaccatag tggacagacc
     1921 ctctatgaac aagtggcact cacccacccc agctgggatg ctgaagtgat tcagcccctg
     1981 cccatggaca gcagtgcata ttccttcaca gcctttgcgg gggtcccagc tgtggagttc
     2041 tccttcatgg aggatgatcg ggtgtaccca ttcctgcaca cgaaggagga cacatatgag
     2101 aatctgcaca agatgctgcg aggtcgcctg cccgccgtgg tccaggcagt ggctcagctc
     2161 gcgggccagc tcctcatccg actgagccac gatcacctac tgccgctaga cttcggccgc
     2221 tatggagacg tggttctcag gcacatcggc aacctcaatg agttctctgg ggacctcaag
     2281 gagcgcgggc tgaccctgca gtgggtgtac tctgcaaggg gggactacat ccgtgcggcg
     2341 gaaaagctgc ggaaggagat ttacagctcg gagcggaacg atgagcgtct gatgcgcatg
     2401 tacaacgtgc gcatcatgag ggtggagttc tacttcctgt cccagtatgt gtcgccagcc
     2461 gactccccat tccgccacat tttcctaggc caaggcgacc acactttggg tgccctggta
     2521 gaccacctgc ggatgctgcg cgccgatggc tcaggagccg cctcttcccg gttgacagca
     2581 ggtctgggct tccaggagag tcgcttccgg cgccagctgg cgctgctcac ctggacactg
     2641 cagggggcag ccaacgctct cagtggcgac gtttggaaca ttgacaataa cttttgaagc
     2701 caaaagccct ccatgggccc cacgtgattc tcctttctcc ctctttgagt ggtgcaggca
     2761 aaggaggtgc ctgagattgt aacctattct taacaccctt ggtcctgcaa tgctggtgcg
     2821 ccatattttc tcagtgtggt tgtcatgccg ttgcttaccc agaaagcggt tttcttccca
     2881 tcacaggccc ttctgtcttc aggagcaaag ttccccatat ctagagacta tctagatgct
     2941 gggatctgat cagctctctt agagagtgag atggacagcg tcattatttt atgacacatg
     3001 agctacggta tgtgagcagc ccaaggggat tagatgtcaa taaaccaatt gtaacccctg
     3061 ttgtccatac gcaatttagc ttcctcttca tgccgtaccc actcctcata tccgccttga
     3121 gactagggaa gaaggcacag aaggcacctg acagcatgct tgcaagatgc tatccacatg
     3181 ggaaaaataa ctgttctgat gtctaagaaa actgcctaaa gataatggat aggaggtggg
     3241 gcagtgggga taactcatca ggaatgggtg attgcggcca agcctgatga cctgagttta
     3301 atccccagga ccaacatggc aaaaggagag aactagttcc cacaagtttt cctatatcct
     3361 ccaaatgtat gcccataaaa gcacaaatag ataaatgttt ttgcttttgt tttttaaagt
     3421 ggctttgtgg ttaagagcac tggatgccat tctagaagac accggttcga ttcccagcac
     3481 ccacatggcc gcttacaact gtctgtaact ccagttgctg gggatcagat gccctcttct
     3541 ggtatggtgt acgactgcat gcatgtagta tacatacaag caggcaaaat acccatacat
     3601 gtaaaatttt taaaaaatag tttaaattat aaattaattt aaagaacaaa taaaagatta
     3661 atgcctttaa tccc
//
