LOCUS       NM_001289507            3408 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus transferrin receptor 2 (Tfr2), transcript variant 1,
            mRNA.
ACCESSION   NM_001289507
VERSION     NM_001289507.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Koury MJ and Haase VH.
  TITLE     Deregulating iron-erythropoiesis regulation: transferrin receptor 2
            as potential target for treating anemia in CKD
  JOURNAL   Kidney Int 104 (1), 25-28 (2023)
   PUBMED   37349056
  REMARK    GeneRIF: Deregulating iron-erythropoiesis regulation: transferrin
            receptor 2 as potential target for treating anemia in CKD.
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   Ledesma-Colunga MG, Baschant U, Weidner H, Alves TC, Mirtschink P,
            Hofbauer LC and Rauner M.
  TITLE     Transferrin receptor 2 deficiency promotes macrophage polarization
            and inflammatory arthritis
  JOURNAL   Redox Biol 60, 102616 (2023)
   PUBMED   36746004
  REMARK    GeneRIF: Transferrin receptor 2 deficiency promotes macrophage
            polarization and inflammatory arthritis.
REFERENCE   3  (bases 1 to 3408)
  AUTHORS   Di Modica SM, Tanzi E, Olivari V, Lidonnici MR, Pettinato M, Pagani
            A, Tiboni F, Furiosi V, Silvestri L, Ferrari G, Rivella S and Nai
            A.
  TITLE     Transferrin receptor 2 (Tfr2) genetic deletion makes
            transfusion-independent a murine model of transfusion-dependent
            beta-thalassemia
  JOURNAL   Am J Hematol 97 (10), 1324-1336 (2022)
   PUBMED   36071579
  REMARK    GeneRIF: Transferrin receptor 2 (Tfr2) genetic deletion makes
            transfusion-independent a murine model of transfusion-dependent
            beta-thalassemia.
REFERENCE   4  (bases 1 to 3408)
  AUTHORS   Schmidt PJ, Fitzgerald K, Butler JS and Fleming MD.
  TITLE     Global loss of Tfr2 with concomitant induced iron deficiency
            greatly ameliorates the phenotype of a murine thalassemia
            intermedia model
  JOURNAL   Am J Hematol 96 (2), 251-257 (2021)
   PUBMED   33180328
  REMARK    GeneRIF: Global loss of Tfr2 with concomitant induced iron
            deficiency greatly ameliorates the phenotype of a murine
            thalassemia intermedia model.
REFERENCE   5  (bases 1 to 3408)
  AUTHORS   Ali MK, Kim RY, Brown AC, Donovan C, Vanka KS, Mayall JR, Liu G,
            Pillar AL, Jones-Freeman B, Xenaki D, Borghuis T, Karim R,
            Pinkerton JW, Aryal R, Heidari M, Martin KL, Burgess JK, Oliver BG,
            Trinder D, Johnstone DM, Milward EA, Hansbro PM and Horvat JC.
  TITLE     Critical role for iron accumulation in the pathogenesis of fibrotic
            lung disease
  JOURNAL   J Pathol 251 (1), 49-62 (2020)
   PUBMED   32083318
REFERENCE   6  (bases 1 to 3408)
  AUTHORS   Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF and
            Koeffler HP.
  TITLE     Regulation of expression of murine transferrin receptor 2
  JOURNAL   Blood 98 (6), 1949-1954 (2001)
   PUBMED   11535534
REFERENCE   7  (bases 1 to 3408)
  AUTHORS   Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung
            TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W and Koop
            BF.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
REFERENCE   8  (bases 1 to 3408)
  AUTHORS   Fleming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S,
            Bacon BR and Sly WS.
  TITLE     Transferrin receptor 2: continued expression in mouse liver in the
            face of iron overload and in hereditary hemochromatosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2214-2219 (2000)
   PUBMED   10681454
REFERENCE   9  (bases 1 to 3408)
  AUTHORS   Shivdasani RA and Orkin SH.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   10 (bases 1 to 3408)
  AUTHORS   Muller,R., Verma,I.M. and Adamson,E.D.
  TITLE     Expression of c-onc genes: c-fos transcripts accumulate to high
            levels during development of mouse placenta, yolk sac and amnion
  JOURNAL   EMBO J 2 (5), 679-684 (1983)
   PUBMED   6641714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148018.3, AK165320.1, AK004848.2 and AV027736.2.
            
            [WARNING] On Nov 20, 2023 this sequence was replaced by
            NM_001289507.3.
            
            On Jul 4, 2018 this sequence version replaced NM_001289507.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013654.1, AF207741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC148018.3         203057-203059
            4-2040              AK165320.1         2-2038
            2041-2806           AK004848.2         2146-2911
            2807-2814           AC148018.3         219562-219569
            2815-3408           AV027736.2         14-607
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.57 cM"
     gene            1..3408
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /note="transferrin receptor 2"
                     /db_xref="GeneID:50765"
                     /db_xref="MGI:MGI:1354956"
     exon            1..67
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2431
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /codon_start=1
                     /product="transferrin receptor protein 2"
                     /protein_id="NP_001276436.2"
                     /db_xref="CCDS:CCDS39333.1"
                     /db_xref="GeneID:50765"
                     /db_xref="MGI:MGI:1354956"
                     /translation="MEQRWGLLRRVQQWSPRPSQTIYRRVEGPQLEHLEEEDREEGAE
                     LPAQFCPMELKGPEHLGSCPGRSIPIPWAAAGRKAAPYLVLITLLIFTGAFLLGYVAF
                     RGSCQACGDSVLVVDEDVNPEDSGRTTLYWSDLQAMFLRFLGEGRMEDTIRLTSLRER
                     VAGSARMATLVQDILDKLSRQKLDHVWTDTHYVGLQFPDPAHANTLHWVDADGSVQEQ
                     LPLEDPEVYCPYSATGNATGKLVYAHYGRSEDLQDLKAKGVELAGSLLLVRVGITSFA
                     QKVAVAQDFGAQGVLIYPDPSDFSQDPHKPGLSSHQAVYGHVHLGTGDPYTPGFPSFN
                     QTQFPPVESSGLPSIPAQPISADIADQLLRKLTGPVAPQEWKGHLSGSPYRLGPGPDL
                     RLVVNNHRVSTPISNIFACIEGFAEPDHYVVIGAQRDAWGPGAAKSAVGTAILLELVR
                     TFSSMVSNGFRPRRSLLFISWDGGDFGSVGATEWLEGYLSVLHLKAVVYVSLDNSVLG
                     DGKFHAKTSPLLVSLIENILKQVDSPNHSGQTLYEQVALTHPSWDAEVIQPLPMDSSA
                     YSFTAFAGVPAVEFSFMEDDRVYPFLHTKEDTYENLHKMLRGRLPAVVQAVAQLAGQL
                     LIRLSHDHLLPLDFGRYGDVVLRHIGNLNEFSGDLKERGLTLQWVYSARGDYIRAAEK
                     LRKEIYSSERNDERLMRMYNVRIMRVEFYFLSQYVSPADSPFRHIFLGQGDHTLGALV
                     DHLRMLRADGSGAASSRLTAGLGFQESRFRRQLALLTWTLQGAANALSGDVWNIDNNF
                     "
     exon            68..314
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..492
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..633
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..745
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..868
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..985
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1125
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1289
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1409
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1492
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1556
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1624
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1701
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1786
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2014
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2155
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..3408
                     /gene="Tfr2"
                     /gene_synonym="Trfr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactacttg cagagttcag gagggggcac aagcatggag caacgttggg gtctacttcg
       61 gagagtgcaa cagtggtccc caagaccctc tcagaccatc tacagacgcg tggaaggccc
      121 tcagctggag cacctggagg aggaagacag ggaggaaggg gcggagcttc ctgcccagtt
      181 ctgccccatg gaactcaaag gccctgagca cttaggctcc tgtcccggga ggtcaattcc
      241 cataccctgg gctgcagcag gtcgaaaggc tgccccctat ctggtcctga tcaccctgct
      301 aatcttcact ggggccttcc tcctaggcta cgtggccttt cgagggtcct gccaggcgtg
      361 tggggactcc gtgttggtgg tcgatgaaga tgtcaaccct gaggactccg gccggaccac
      421 gttgtactgg agcgacctcc aggccatgtt tctccggttc cttggggagg ggcgcatgga
      481 agacaccatc aggctgacca gcctccggga acgcgtggct ggctcagcca gaatggccac
      541 cctggtccaa gatatcctcg ataagctctc gcgccagaag ctggaccacg tgtggactga
      601 cacgcactac gtgggacttc agttcccaga tccggctcac gctaacaccc tgcactgggt
      661 ggatgcagac gggagcgtcc aggagcagct accgctggag gatccggaag tctactgtcc
      721 ctacagcgcc accggcaacg ccacgggcaa gctggtgtac gcccactacg ggcggtcgga
      781 ggacctacag gacctaaaag ccaagggcgt ggagctggcc ggcagcctcc tgctagtgcg
      841 agttggaatt actagcttcg cccagaaggt agccgttgcc caggactttg gggctcaagg
      901 agtgctgata taccctgacc catcagactt ctcccaggat ccccacaagc caggcctgtc
      961 tagccaccag gctgtgtacg gacatgtgca cctgggaact ggagaccctt acacacctgg
     1021 cttcccgtcc ttcaatcaaa cccagttccc tccagtagaa tcatcaggcc ttcccagcat
     1081 ccccgcccag cccatcagtg ctgacattgc tgatcaattg ctcaggaaac tcacaggccc
     1141 cgtggctccc caggagtgga aaggtcacct ctcaggctct ccttatcggc tgggacctgg
     1201 gcccgactta cgccttgtgg tcaacaacca cagagtctct acccccatca gtaacatctt
     1261 tgcgtgcatc gagggctttg cagagccaga tcactatgtt gtcattgggg cccagaggga
     1321 tgcatggggc ccaggagcag ccaagtctgc agtggggact gccatcctgc tggagctggt
     1381 tcggaccttc tcttccatgg tcagcaatgg gttcagacct cgaagaagtc ttttgttcat
     1441 cagctgggac ggaggtgact ttggcagcgt gggagccaca gagtggttgg agggctacct
     1501 cagcgtgcta cacctcaaag ctgttgtgta cgtgagcctg gacaactccg tgttgggaga
     1561 tggcaaattc catgctaaga ccagccccct tctcgtcagc ctcattgaga atatcttgaa
     1621 gcaggtggac tcccctaacc atagtggaca gaccctctat gaacaagtgg cactcaccca
     1681 ccccagctgg gatgctgaag tgattcagcc cctgcccatg gacagcagtg catattcctt
     1741 cacagccttt gcgggggtcc cagctgtgga gttctccttc atggaggatg atcgggtgta
     1801 cccattcctg cacacgaagg aggacacata tgagaatctg cacaagatgc tgcgaggtcg
     1861 cctgcccgcc gtggtccagg cagtggctca gctcgcgggc cagctcctca tccgactgag
     1921 ccacgatcac ctactgccgc tagacttcgg ccgctatgga gacgtggttc tcaggcacat
     1981 cggcaacctc aatgagttct ctggggacct caaggagcgc gggctgaccc tgcagtgggt
     2041 gtactctgca aggggggact acatccgtgc ggcggaaaag ctgcggaagg agatttacag
     2101 ctcggagcgg aacgatgagc gtctgatgcg catgtacaac gtgcgcatca tgagggtgga
     2161 gttctacttc ctgtcccagt atgtgtcgcc agccgactcc ccattccgcc acattttcct
     2221 aggccaaggc gaccacactt tgggtgccct ggtagaccac ctgcggatgc tgcgcgccga
     2281 tggctcagga gccgcctctt cccggttgac agcaggtctg ggcttccagg agagtcgctt
     2341 ccggcgccag ctggcgctgc tcacctggac actgcagggg gcagccaacg ctctcagtgg
     2401 cgacgtttgg aacattgaca ataacttttg aagccaaaag ccctccatgg gccccacgtg
     2461 attctccttt ctccctcttt gagtggtgca ggcaaaggag gtgcctgaga ttgtaaccta
     2521 ttcttaacac ccttggtcct gcaatgctgg tgcgccatat tttctcagtg tggttgtcat
     2581 gccgttgctt acccagaaag cggttttctt cccatcacag gcccttctgt cttcaggagc
     2641 aaagttcccc atatctagag actatctaga tgctgggatc tgatcagctc tcttagagag
     2701 tgagatggac agcgtcatta ttttatgaca catgagctac ggtatgtgag cagcccaagg
     2761 ggattagatg tcaataaacc aattgtaacc cctgttgtcc atacgcaatt tagcttcctc
     2821 ttcatgccgt acccactcct catatccgcc ttgagactag ggaagaaggc acagaaggca
     2881 cctgacagca tgcttgcaag atgctatcca catgggaaaa ataactgttc tgatgtctaa
     2941 gaaaactgcc taaagataat ggataggagg tggggcagtg gggataactc atcaggaatg
     3001 ggtgattgcg gccaagcctg atgacctgag tttaatcccc aggaccaaca tggcaaaagg
     3061 agagaactag ttcccacaag ttttcctata tcctccaaat gtatgcccat aaaagcacaa
     3121 atagataaat gtttttgctt ttgtttttta aagtggcttt gtggttaaga gcactggatg
     3181 ccattctaga agacaccggt tcgattccca gcacccacat ggccgcttac aactgtctgt
     3241 aactccagtt gctggggatc agatgccctc ttctggtatg gtgtacgact gcatgcatgt
     3301 agtatacata caagcaggca aaatacccat acatgtaaaa tttttaaaaa atagtttaaa
     3361 ttataaatta atttaaagaa caaataaaag attaatgcct ttaatccc
//
