LOCUS       NM_001290381            1149 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus TCF3 (E2A) fusion partner (Tfpt), transcript variant
            1, mRNA.
ACCESSION   NM_001290381 XM_006540352
VERSION     NM_001290381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Min,J.N., Tian,Y., Xiao,Y., Wu,L., Li,L. and Chang,S.
  TITLE     The mINO80 chromatin remodeling complex is required for efficient
            telomere replication and maintenance of genome stability
  JOURNAL   Cell Res 23 (12), 1396-1413 (2013)
   PUBMED   23979016
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Franchini,C., Fontana,F., Minuzzo,M., Babbio,F. and Privitera,E.
  TITLE     Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner)
            appears p53 independent, cell type restricted and cell density
            influenced
  JOURNAL   Apoptosis 11 (12), 2217-2224 (2006)
   PUBMED   17041757
  REMARK    GeneRIF: Although p53 is a main regulator of apoptosis in mammalian
            cells, the Tfpt induced apoptosis appears p53-independent.
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Brambillasca,F., Mosna,G., Ballabio,E., Biondi,A., Boulukos,K.E.
            and Privitera,E.
  TITLE     Promoter analysis of TFPT (FB1), a molecular partner of TCF3 (E2A)
            in childhood acute lymphoblastic leukemia
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1250-1257 (2001)
   PUBMED   11700047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171680.5.
            
            On Dec 21, 2021 this sequence version replaced NM_001290381.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155925.1, SRR5189685.42212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AC171680.5         42885-43245         c
            362-620             AC171680.5         42161-42419         c
            621-691             AC171680.5         37932-38002         c
            692-761             AC171680.5         34396-34465         c
            762-998             AC171680.5         34080-34316         c
            999-1149            AC171680.5         33657-33807         c
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.09 cM"
     gene            1..1149
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /note="TCF3 (E2A) fusion partner"
                     /db_xref="GeneID:69714"
                     /db_xref="MGI:MGI:1916964"
     exon            1..361
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1118
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /note="isoform 1 is encoded by transcript variant 1; TCF3
                     fusion partner homolog; protein amida"
                     /codon_start=1
                     /product="TCF3 fusion partner homolog isoform 1"
                     /protein_id="NP_001277310.1"
                     /db_xref="CCDS:CCDS71873.1"
                     /db_xref="GeneID:69714"
                     /db_xref="MGI:MGI:1916964"
                     /translation="MELEQREGTMAAVGFEEFSAPPGSELALPPLFGGHILESELETE
                     VEFVSGGLGDSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNR
                     LHQVQRITRRLQQERRFLMRVLDSYGDDYRDSQFTIVLEDDGSQGTDVPTPGNAENEP
                     PEKEGLSPSQRTTATLDPTSPAPGEGPSGRKRRRAPRVGASLTPELAPVQVGAEGWGQ
                     GVIKVEEDFGFEADEALDSSWVSREPDKLLPYPTLASPPFD"
     exon            362..620
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..691
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..761
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..998
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1149
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1129..1134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /note="hexamer: AATAAA"
     polyA_site      1149
                     /gene="Tfpt"
                     /gene_synonym="2400004F01Rik; Amida; FB1"
                     /note="major polyA site"
ORIGIN      
        1 attagcagcc gcctcgcggg acggcgaccg ggagtgctgg gttctagggc taggggaagt
       61 cgtacgtcgc cgtggattga gcctgctaaa cagagattcg ctttggctag tcgacactgc
      121 gacaagacag gagtaaagaa ggtgacaacg tggacgatcg gtgcaggcgc tagaggataa
      181 accgaaggct tcaagccgca atttggagtc gggtgcaaac gaaggcagag taggaaactt
      241 taattcccag ttttcctgtg tcgcaaggcc tgatgggaga ggtagttttg cgcaagactc
      301 cacctctctg aggcttgagg tgtctcttga ccagagaaat ggagttggaa cagagagagg
      361 ggaccatggc agccgtgggc tttgaagagt tctcagcgcc accaggctca gagctggctc
      421 tgcctcccct gtttggtggc cacatcctag aaagtgagct agagacagaa gtggaatttg
      481 tgtccggtgg tctgggtgat tcaggactcc gggagcgaga tgaagaggaa gaggcagccc
      541 ggggtcgaag gcgtcgccag cgggaactaa atcgtagaaa gtaccaggca ctaggtcggc
      601 gctgccggga gatcgagcag gtgaatgagc gagtcttgaa caggctccat caggtgcaaa
      661 ggataactcg gagactccag caggagcgca ggttcctcat gagggtgctg gactcctacg
      721 gggatgacta ccgagatagc cagttcacca ttgtgttgga ggatgatggc agccaaggca
      781 cagatgtccc taccccaggc aatgctgaga atgaacctcc agagaaagag gggctttccc
      841 catcccaaag gacaactgca accttagacc ccaccagccc agcccctggc gaggggccca
      901 gtgggcggaa gaggcggcgg gcgccacggg tgggggcttc attgactcca gaactggccc
      961 cagtgcaggt gggagccgag ggctggggcc aaggcgtgat taaggttgag gaagactttg
     1021 gctttgaagc agatgaggcc ttggattcaa gttgggtttc ccgagagcca gacaaattgc
     1081 taccctaccc taccctggcc agcccaccct ttgactaacc ctctccccaa taaacagatt
     1141 ccctatgta
//
