LOCUS       NM_009364               1550 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus tissue factor pathway inhibitor 2 (Tfpi2), transcript
            variant 1, mRNA.
ACCESSION   NM_009364
VERSION     NM_009364.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1550)
  AUTHORS   Gu,T., Vasilatos,S.N., Yin,J., Qin,Y., Zhang,L., Davidson,N.E. and
            Huang,Y.
  TITLE     Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer
  JOURNAL   Cancer Lett 600, 217182 (2024)
   PUBMED   39154703
  REMARK    GeneRIF: Restoration of TFPI2 by LSD1 inhibition suppresses tumor
            progression and potentiates antitumor immunity in breast cancer.
REFERENCE   2  (bases 1 to 1550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1550)
  AUTHORS   Guan,G., Xie,J., Dai,Y. and Han,H.
  TITLE     TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to
            promote endothelial-mesenchymal transition in diabetic nephropathy
  JOURNAL   J Biol Chem 298 (3), 101725 (2022)
   PUBMED   35157852
  REMARK    GeneRIF: TFPI2 suppresses the interaction of TGF-beta2 pathway
            regulators to promote endothelial-mesenchymal transition in
            diabetic nephropathy.
REFERENCE   4  (bases 1 to 1550)
  AUTHORS   Ali,M.N., Kasetty,G., Elven,M., Alyafei,S., Jovic,S., Egesten,A.,
            Herwald,H., Schmidtchen,A. and Papareddy,P.
  TITLE     TFPI-2 Protects Against Gram-Negative Bacterial Infection
  JOURNAL   Front Immunol 9, 2072 (2018)
   PUBMED   30254643
  REMARK    GeneRIF: TFPI-2 Protects Against Gram-Negative Bacterial Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1550)
  AUTHORS   Marjonen,H., Toivonen,M., Lahti,L. and Kaminen-Ahola,N.
  TITLE     Early prenatal alcohol exposure alters imprinted gene expression in
            placenta and embryo in a mouse model
  JOURNAL   PLoS One 13 (5), e0197461 (2018)
   PUBMED   29763474
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1550)
  AUTHORS   Du,X., Deng,F.M., Chand,H.S. and Kisiel,W.
  TITLE     Molecular cloning, expression, and characterization of bovine
            tissue factor pathway inhibitor-2
  JOURNAL   Arch Biochem Biophys 417 (1), 96-104 (2003)
   PUBMED   12921785
  REMARK    GeneRIF: Bovine TFPI2 was compared to mouse TFPI2.
REFERENCE   7  (bases 1 to 1550)
  AUTHORS   Chaudhuri,M.
  TITLE     Cloning and characterization of a novel serine/threonine protein
            phosphatase type 5 from Trypanosoma brucei
  JOURNAL   Gene 266 (1-2), 1-13 (2001)
   PUBMED   11290414
REFERENCE   8  (bases 1 to 1550)
  AUTHORS   Kazama,Y., Kamei,S., Kuijper,J.L., Foster,D.C. and Kisiel,W.
  TITLE     Nucleotide sequence of the gene encoding murine tissue factor
            pathway inhibitor-2
  JOURNAL   Thromb Haemost 83 (1), 141-147 (2000)
   PUBMED   10669168
REFERENCE   9  (bases 1 to 1550)
  AUTHORS   Huang,Z.F., Higuchi,D., Lasky,N. and Broze,G.J. Jr.
  TITLE     Tissue factor pathway inhibitor gene disruption produces
            intrauterine lethality in mice
  JOURNAL   Blood 90 (3), 944-951 (1997)
   PUBMED   9242522
REFERENCE   10 (bases 1 to 1550)
  AUTHORS   Miyagi,Y., Yasumitsu,H., Mizushima,H., Koshikawa,N., Matsuda,Y.,
            Itoh,H., Hori,T.A., Aoki,I., Misugi,K. and Miyazaki,K.
  TITLE     Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the
            gene to chromosome 6
  JOURNAL   DNA Cell Biol 15 (11), 947-954 (1996)
   PUBMED   8945635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132268.1 and BU755117.1.
            
            On Sep 13, 2016 this sequence version replaced NM_009364.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132268.1, D50586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1530              AK132268.1         2-1531
            1531-1550           BU755117.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     gene            1..1550
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /note="tissue factor pathway inhibitor 2"
                     /db_xref="GeneID:21789"
                     /db_xref="MGI:MGI:108543"
     exon            1..139
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..744
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="tissue factor pathway inhibitor 2 isoform 1
                     precursor"
                     /protein_id="NP_033390.1"
                     /db_xref="CCDS:CCDS19892.1"
                     /db_xref="GeneID:21789"
                     /db_xref="MGI:MGI:108543"
                     /translation="MDPAMPLQLWNLPLLLVGSVLGLTSVSAQGNNLEICLLPLDAGP
                     CQALIPKFYYDRDQQKCRRFNYGGCLGNANNFHSRDLCQQTCGSIEKVPPVCRSELKT
                     YPCDKPNIRFFFNLNTMTCEPLRPGLCSRTINVFSEEATCKGLCEPRKHIPSFCSSPK
                     DEGLCSANVTRFYFNSRNKTCETFTYTGCGGNENNFYYLDACHRACVKGWKKPKRWKI
                     GDFLPRFWKHLS"
     exon            140..322
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..505
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..676
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1535
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /note="hexamer: AATAAA"
     polyA_site      1535
                     /gene="Tfpi2"
                     /gene_synonym="PP5/TFPI-2"
                     /note="major polyA site"
ORIGIN      
        1 agcactctcc tccctccagg cgtccagaga accacagcac cacccaacac tatggaccct
       61 gctatgcccc tgcaactgtg gaatttgccg ctgctcctgg tgggctccgt tcttggtctc
      121 acttcagtgt ctgcccaagg gaataattta gagatctgcc tcttgccctt ggacgcagga
      181 ccttgtcagg ccctcatccc caagttctac tatgacagag accagcaaaa gtgccgcaga
      241 ttcaactatg gaggctgctt gggcaatgcc aacaatttcc acagtcggga cctctgccaa
      301 cagacttgcg gaagtatcga gaaagttcct ccagtttgtc gatcagagct aaaaacatat
      361 ccatgtgata agcccaatat acggtttttc ttcaacctga ataccatgac atgtgagccc
      421 cttaggcctg gtctgtgtag caggactata aatgtattct ctgaggaagc tacatgtaag
      481 ggcttgtgtg aaccacggaa acatattcca tcattttgct ccagtccaaa ggatgaaggt
      541 ctgtgttctg ccaatgtgac acgcttttat tttaattcaa gaaacaaaac atgtgagact
      601 ttcacctata ctggctgtgg tgggaatgag aataactttt attacctgga tgcttgccac
      661 cgtgcctgcg ttaaaggctg gaagaagccc aagagatgga agataggtga cttcctgccc
      721 agattttgga agcatctttc ttaagcattt tctcatactg aaggaaacaa atcattagta
      781 atttgctcct ctgattttac tgatctgtta ttttttttaa tctgtgtgct tttattcata
      841 ccaagctgcc ttccaaatgt gaaattatca ttttcgatgt actgttcaaa tgtctaagag
      901 actgaatcct tgtgatgtat ccgatatgaa tgtgaacatg acttgcccaa cttcttggga
      961 tagctagtac taatttcaga agacaacagt tactaaaata acagaaaaca atttagatgt
     1021 gcagttttaa cctacatggg catcattagg aatggcaaaa ccacttcatt atgaacttaa
     1081 aggtttagat tgcattttag gctccaggag accagtaacc gattcatgaa cactttattc
     1141 aatcattcca ctgaggtatt acttattcct tgccaagtgt ccttgaattc ctttcttgcc
     1201 atattgcaat attatgaaga ataagagtta ttacaaaaaa gagctataat tgttattgga
     1261 tgaatttaaa atgttggtga tttatgaaaa gaaacacatt tttcctagaa aaaaatcatt
     1321 atatatttaa ttctgtgtct ctttattttt ccacatttga caagtaaatc ttctttgacc
     1381 atatgtgcta cagtattccc tcagacaaaa tgtttgggag aatagaaatt tctggatctt
     1441 ttgtactatg taagatatat cctgcaccaa aatgcatgta tgctttgact tgaatttcac
     1501 aaataaatta tttttaaaag tggttattac aataaaaaaa aaaaaaaaaa
//
