LOCUS       NM_001355273            1329 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus tissue factor pathway inhibitor (Tfpi), transcript
            variant 5, mRNA.
ACCESSION   NM_001355273 XM_006499148
VERSION     NM_001355273.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Ma,J.K., Su,L.D., Feng,L.L., Li,J.L., Pan,L., Danzeng,Q., Li,Y.,
            Shang,T., Zhan,X.L., Chen,S.Y., Ying,S., Hu,J.R., Chen,X.Q.,
            Zhang,Q., Liang,T. and Lu,X.J.
  TITLE     TFPI from erythroblasts drives heme production in central
            macrophages promoting erythropoiesis in polycythemia
  JOURNAL   Nat Commun 15 (1), 3976 (2024)
   PUBMED   38729948
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Wittig,J., Drekolia,M.K., Kyselova,A., Delgado Lagos,F.,
            Bochenek,M.L., Hu,J., Schafer,K., Fleming,I. and Bibli,S.I.
  TITLE     Endothelial-dependent S-Sulfhydration of tissue factor pathway
            inhibitor regulates blood coagulation
  JOURNAL   Redox Biol 62, 102694 (2023)
   PUBMED   37030150
  REMARK    GeneRIF: Endothelial-dependent S-Sulfhydration of tissue factor
            pathway inhibitor regulates blood coagulation.
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Maroney,S.A., Siebert,A.E., Martinez,N.D., Rasmussen,M.,
            Peterson,J.A., Weiler,H., Lincoln,J. and Mast,A.E.
  TITLE     Platelet tissue factor pathway inhibitor-alpha dampens cardiac
            thrombosis and associated fibrosis in mice
  JOURNAL   J Thromb Haemost 21 (3), 639-651 (2023)
   PUBMED   36696221
  REMARK    GeneRIF: Platelet tissue factor pathway inhibitor-alpha dampens
            cardiac thrombosis and associated fibrosis in mice.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Marar,T.T., Martinez,N.D., Maroney,S.A., Siebert,A.E., Wu,J.,
            Stalker,T.J., Tomaiuolo,M., Delacroix,S., Simari,R.D., Mast,A.E.
            and Brass,L.F.
  TITLE     The contribution of TFPIalpha to the hemostatic response to injury
            in mice
  JOURNAL   J Thromb Haemost 19 (9), 2182-2192 (2021)
   PUBMED   34160126
  REMARK    GeneRIF: The contribution of TFPIalpha to the hemostatic response
            to injury in mice.
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Chang,J.Y., Monroe,D.M., Oliver,J.A. and Roberts,H.R.
  TITLE     TFPIbeta, a second product from the mouse tissue factor pathway
            inhibitor (TFPI) gene
  JOURNAL   Thromb Haemost 81 (1), 45-49 (1999)
   PUBMED   9974373
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Sok,J., Wang,X.Z., Batchvarova,N., Kuroda,M., Harding,H. and Ron,D.
  TITLE     CHOP-Dependent stress-inducible expression of a novel form of
            carbonic anhydrase VI
  JOURNAL   Mol Cell Biol 19 (1), 495-504 (1999)
   PUBMED   9858573
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Broze,G.J. Jr.
  TITLE     Tissue factor pathway inhibitor gene disruption
  JOURNAL   Blood Coagul Fibrinolysis 9 Suppl 1, S89-S92 (1998)
   PUBMED   9819035
  REMARK    Review article
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Chang,J.Y., Monroe,D.M., Oliver,J.A., Liles,D.K. and Roberts,H.R.
  TITLE     Cloning, expression, and characterization of mouse tissue factor
            pathway inhibitor (TFPI)
  JOURNAL   Thromb Haemost 79 (2), 306-309 (1998)
   PUBMED   9493581
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Huang,Z.F., Higuchi,D., Lasky,N. and Broze,G.J. Jr.
  TITLE     Tissue factor pathway inhibitor gene disruption produces
            intrauterine lethality in mice
  JOURNAL   Blood 90 (3), 944-951 (1997)
   PUBMED   9242522
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845305.5.
            
            On Sep 14, 2017 this sequence version replaced XM_006499148.3.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.103726.1,
                                           SRR7345562.4167878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL845305.5         192393-192461       c
            70-170              AL845305.5         189401-189501       c
            171-281             AL845305.5         173725-173835       c
            282-479             AL845305.5         169502-169699       c
            480-518             AL845305.5         168259-168297       c
            519-695             AL845305.5         160442-160618       c
            696-824             AL845305.5         159712-159840       c
            825-1004            AL845305.5         149944-150123       c
            1005-1329           AL845305.5         148562-148886       c
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.41 cM"
     gene            1..1329
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /note="tissue factor pathway inhibitor"
                     /db_xref="GeneID:21788"
                     /db_xref="MGI:MGI:1095418"
     exon            1..69
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            70..170
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            171..281
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1093
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /note="isoform a precursor is encoded by transcript
                     variant 5; extrinsic pathway inhibitor;
                     lipoprotein-associated coagulation inhibitor"
                     /codon_start=1
                     /product="tissue factor pathway inhibitor isoform a
                     precursor"
                     /protein_id="NP_001342202.1"
                     /db_xref="CCDS:CCDS16185.1"
                     /db_xref="GeneID:21788"
                     /db_xref="MGI:MGI:1095418"
                     /translation="MTYKMKKEYAFWATVCLLLSLVPEFLNALSEEADDTDSELGSMK
                     PLHTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTCIP
                     GYEKTAVKAASGAERPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNN
                     FETLDECKKICENPVHSPSPVNEVQMSDYVTDGNTVTDRSTVNNIVVPQSPKVPRRRD
                     YRGRPWCLQPADSGLCKASERRFYYNSATGKCHRFNYTGCGGNNNNFTTRRRCLRSCK
                     TGLIKNKSKGVVKIQRRKAPFVKVVYESIN"
     exon            282..479
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            480..518
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            519..695
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            696..824
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1004
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1329
                     /gene="Tfpi"
                     /gene_synonym="A630013F22Rik; EPI; LACI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggcca tctgcacacg tgagtgataa agtccttcct cgctgtgaat aaacatggtc
       61 cctcctaaga ctgtatcact ttcgggacct gtctccggat ttcttctgaa gacggtataa
      121 ttttgggacc tcatctccag atctcattta aggactactg actcatcaag aaatgactta
      181 caaaatgaag aaagaatatg ccttttgggc cactgtgtgt ctgttgctta gccttgttcc
      241 cgagtttctt aatgctctgt ctgaggaagc tgatgacaca gattctgagc tggggtcaat
      301 gaaaccgcta catacatttt gtgcaatgaa ggcagatgat ggtccatgca aagcaatgat
      361 aaggagttat tttttcaata tgtatactca tcaatgtgaa gaatttatat acgggggatg
      421 tgaagggaac gagaaccgat ttgataccct ggaagagtgt aagaaaacat gcataccagg
      481 ttatgagaag acagctgtga aggcagcatc tggagcagaa aggccagatt tctgcttctt
      541 ggaagaggac cctggactct gccgaggtta catgaagagg tatctttata acaaccagac
      601 aaagcagtgt gaacgattcg tgtacggtgg ctgcctgggc aaccgcaaca actttgaaac
      661 tttggatgag tgcaagaaga tctgtgagaa tccagtccac tccccttccc cagtgaatga
      721 ggtacagatg agtgactacg taactgatgg aaatactgta actgatcgca gtactgtaaa
      781 taacatcgtg gttccccagt ctcccaaagt gcccaggcgt cgggattatc gtggccgtcc
      841 ctggtgtctt caaccagcag acagtggatt atgtaaagcc agtgagagaa gattctacta
      901 caattcagcc actgggaaat gccaccgatt taactacact ggatgtgggg gaaataataa
      961 taattttact accagaagga gatgtctgag atcatgtaaa acaggtctca tcaaaaacaa
     1021 gtcaaaagga gtagttaaga ttcagagaag aaaggcgccc ttcgtgaaag ttgtatatga
     1081 aagcattaat tagtgctaag atataagcac attaaatttt tacattagtt tcactaaata
     1141 ttcctatacg gtgcttctac tgtgattttt attcttctac aaaccagtgt cttgtttcca
     1201 ttggtgacca tctattagaa gatatatttt cgccagttat gatcacaaac attacatacc
     1261 cttgacagtc taaacctttt cgaatgattt taatttttaa caatgtgaga aataaaatct
     1321 ttcatcctg
//
