LOCUS       NM_019678               1948 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus Trk-fused gene (Tfg), transcript variant 1, mRNA.
ACCESSION   NM_019678
VERSION     NM_019678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Steinmetz,T.D., Thomas,J., Reimann,L., Himmelreich,A.K.,
            Schulz,S.R., Golombek,F., Castiglione,K., Jack,H.M., Brodesser,S.,
            Warscheid,B. and Mielenz,D.
  TITLE     Identification of TFG- and Autophagy-Regulated Proteins and
            Glycerophospholipids in B Cells
  JOURNAL   J Proteome Res 23 (5), 1615-1633 (2024)
   PUBMED   38649144
  REMARK    GeneRIF: Identification of TFG- and Autophagy-Regulated Proteins
            and Glycerophospholipids in B Cells.
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Yamamotoya,T., Hasei,S., Akasaka,Y., Ohata,Y., Nakatsu,Y.,
            Kanna,M., Fujishiro,M., Sakoda,H., Ono,H., Kushiyama,A., Misawa,H.
            and Asano,T.
  TITLE     Involvement of neuronal and muscular Trk-fused gene (TFG) defects
            in the development of neurodegenerative diseases
  JOURNAL   Sci Rep 12 (1), 1966 (2022)
   PUBMED   35121777
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Steinmetz,T.D., Schlotzer-Schrehardt,U., Hearne,A., Schuh,W.,
            Wittner,J., Schulz,S.R., Winkler,T.H., Jack,H.M. and Mielenz,D.
  TITLE     TFG is required for autophagy flux and to prevent endoplasmic
            reticulum stress in CH12 B lymphoma cells
  JOURNAL   Autophagy 17 (9), 2238-2256 (2021)
   PUBMED   32910713
  REMARK    GeneRIF: TFG is required for autophagy flux and to prevent
            endoplasmic reticulum stress in CH12 B lymphoma cells.
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Sima,J., Yan,Z., Chen,Y., Lehrmann,E., Zhang,Y., Nagaraja,R.,
            Wang,W., Wang,Z. and Schlessinger,D.
  TITLE     Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling
            complex and initiates gene transcription in skin appendage
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (32), 8173-8178 (2018)
   PUBMED   30037996
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Yamamotoya,T., Nakatsu,Y., Kushiyama,A., Matsunaga,Y., Ueda,K.,
            Inoue,Y., Inoue,M.K., Sakoda,H., Fujishiro,M., Ono,H., Kiyonari,H.,
            Ishihara,H. and Asano,T.
  TITLE     Trk-fused gene (TFG) regulates pancreatic beta cell mass and
            insulin secretory activity
  JOURNAL   Sci Rep 7 (1), 13026 (2017)
   PUBMED   29026155
  REMARK    GeneRIF: TFG in pancreatic beta-cells plays a vital role in
            maintaining both the mass and function of beta-cells, and its
            dysfunction increases the tendency to develop glucose intolerance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Beetz,C., Johnson,A., Schuh,A.L., Thakur,S., Varga,R.E.,
            Fothergill,T., Hertel,N., Bomba-Warczak,E., Thiele,H., Nurnberg,G.,
            Altmuller,J., Saxena,R., Chapman,E.R., Dent,E.W., Nurnberg,P. and
            Audhya,A.
  TITLE     Inhibition of TFG function causes hereditary axon degeneration by
            impairing endoplasmic reticulum structure
  JOURNAL   Proc Natl Acad Sci U S A 110 (13), 5091-5096 (2013)
   PUBMED   23479643
  REMARK    GeneRIF: Inhibition of TFG function causes hereditary axon
            degeneration by impairing endoplasmic reticulum structure.
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Mencinger,M. and Aman,P.
  TITLE     Characterization of TFG in mus musculus and Caenorhabditis elegans
  JOURNAL   Biochem Biophys Res Commun 257 (1), 67-73 (1999)
   PUBMED   10092511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856666.1, BY061830.1, AK158539.1 and BB783895.1.
            
            On Nov 15, 2011 this sequence version replaced NM_019678.2.
            
            Transcript Variant: This variant (1) encodes isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.270124.1,
                                           SRR1660811.157109.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BB856666.1         4-4
            2-135               BY061830.1         1-134
            136-1943            AK158539.1         2-1809
            1944-1948           BB783895.1         434-438
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.22 cM"
     gene            1..1948
                     /gene="Tfg"
                     /note="Trk-fused gene"
                     /db_xref="GeneID:21787"
                     /db_xref="MGI:MGI:1338041"
     exon            1..266
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            267..496
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1506
                     /gene="Tfg"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein TFG isoform 1"
                     /protein_id="NP_062652.1"
                     /db_xref="CCDS:CCDS28224.1"
                     /db_xref="GeneID:21787"
                     /db_xref="MGI:MGI:1338041"
                     /translation="MNGQLDLSGKLIIKAQLGEDIRRIPIHNEDITYDELVLMMQRVF
                     RGKLLSNDEVTIKYKDEDGDLITIFDSSDLSFAIQCSRILKLTLFVNGQPRPLESSQV
                     KYLRRELVELRNKVNRLLDSLEPPGEPGPSTSIPENDTVDGREEKPAASDSSGKQSTQ
                     VMAASMSAFDPLKNQDEINKNVMSAFGLTDDQVSGPPSAPTEDRSGTPDSIASSSSAA
                     HPAVQPQQPPYAGAQTQAGQIEGQMYQQYQQQAGYSAQQPQAPPQQYGVQYSASYSQQ
                     TGPQQPQQFQGYGQQPTSQAPAPAFSGQPQQLPAQPPQQYQASTYPPQTYTTQPSQPA
                     NYTVPPGSQPGMAPSQPGAYQPRPGFTPSPASTMTPPSSGANPYARNRPPFGQGYAQP
                     GPGYR"
     exon            497..580
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            581..727
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            728..895
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1033
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1123
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1948
                     /gene="Tfg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1925..1930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfg"
                     /note="hexamer: AATAAA"
     polyA_site      1945
                     /gene="Tfg"
                     /note="major polyA site"
ORIGIN      
        1 cttgtgcgcc tggaggcggg gcgccagggc agtttttttt tttctcccct tcgctcccgc
       61 ccctgcgctt cccacctgcc acgtacggga ccgtggctgt cgctaggctc gtcgggtgcg
      121 tgcgattggc cagctctgcg cagcctgcag ctcggcgagg ctcggcggac ggcggcggag
      181 cggacggggt ttggaagcct cctctgcgac accgagtgag cccgcagcgg ccgggtcagc
      241 tgaggtggac ggcctcggca agcgggtttt tttcccctag agttgtatat atagagcatc
      301 ctggactcca caatgaacgg acagttggac ctaagtggga agctgattat caaagctcaa
      361 cttggggaag atatccgacg aattcccatt cataatgaag acattactta cgatgaatta
      421 gtgctaatga tgcagcgagt attcagagga aagcttctga gtaatgatga agttacaata
      481 aagtataagg atgaagatgg agatcttata acaatttttg atagttctga cctttccttt
      541 gcaattcagt gtagtagaat actgaaactg acattatttg ttaatggcca gccaagaccc
      601 cttgaatcaa gtcaggtgaa atatcttcgt cgagaactgg tagaacttcg aaataaagtg
      661 aatcgcttat tggatagctt agaaccacct ggagaaccag gaccttccac cagtattcct
      721 gaaaatgata ctgtggatgg cagggaagag aagcctgccg cttctgactc ttctgggaaa
      781 cagtcaactc aggttatggc agcaagtatg tcagcttttg atcctctgaa aaaccaagat
      841 gaaatcaaca aaaacgtcat gtcagcattt ggattaacag atgaccaggt ttcaggccca
      901 cccagtgccc ctacagaaga ccgctccgga acacctgaca gcattgcttc ttcctcctca
      961 gcagcacacc cagcagttca gccgcagcaa cctccctatg caggagctca gacacaagca
     1021 ggtcagattg aaggtcagat gtaccagcag taccagcagc aggctggcta cagtgcccag
     1081 cagcctcagg cccctcctca gcagtatggt gttcagtact cagctagtta cagccagcag
     1141 actggacccc aacaacctca gcagttccag ggatatggcc aacaaccaac ttcccaggca
     1201 ccggctcctg ccttttctgg ccagccacaa caactgcctg ctcaaccacc acagcagtac
     1261 caggcgagca cttaccctcc acaaacgtat actacccaac catctcagcc tgccaactat
     1321 actgttcccc ctggctctca gcctggaatg gctccaagcc aacctggtgc ttaccaacca
     1381 agaccaggtt ttacgccatc tcctgcaagt accatgaccc ctccttctag tggggctaac
     1441 ccttatgctc gtaaccgtcc tccttttggt caggggtatg cccaacctgg acctggttat
     1501 cgataaggag gttcagccac actaataata atggctgatt gcctcccaaa agactataca
     1561 atactatttt gtttcaattt gtattgtatt gaagtttaaa aatttaaaaa gcagagcatt
     1621 tttttatgat atcattgttg ctgttaattg aaaatataat ttaccagaat acagacacaa
     1681 aaagaccaaa atgaatattg tttcctcccc tgcttaaaat tgtagccgct tcctagttat
     1741 tttggaacac tactcttaca tgcgtgtaaa atgattggct ttctagtttc ccagagaata
     1801 ttaaaaagct aggctaaggt atagccatca cacttggcta tttactgtta acatgatgta
     1861 ctaaaaatag agccctctga gaagatgact agacattatg tataaaatgt aacattgata
     1921 ggctaataaa ggtgattgaa tccaactg
//
