LOCUS       NM_011575                458 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus trefoil factor 3, intestinal (Tff3), mRNA.
ACCESSION   NM_011575
VERSION     NM_011575.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 458)
  AUTHORS   Trinh,L.T., Finnel,R.R., Osipovich,A.B., Musselman,J.R.,
            Sampson,L.L., Wright,C.V.E. and Magnuson,M.A.
  TITLE     Positive autoregulation of Sox17 is necessary for gallbladder and
            extrahepatic bile duct formation
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39745200
REFERENCE   2  (bases 1 to 458)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   3  (bases 1 to 458)
  AUTHORS   Lin,Z., Zhang,J., Duan,T., Yang,J. and Yang,Y.
  TITLE     Trefoil factor 3 can stimulate Th17 cell response in the
            development of type 2 diabetes mellitus
  JOURNAL   Sci Rep 14 (1), 10340 (2024)
   PUBMED   38710764
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 458)
  AUTHORS   Seselja,K., Bazina,I., Vrecl,M., Farger,J., Schicht,M., Paulsen,F.,
            Baus Loncar,M. and Pirman,T.
  TITLE     Tff3 Deficiency Differentially Affects the Morphology of Male and
            Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model
  JOURNAL   Int J Mol Sci 24 (22), 16342 (2023)
   PUBMED   38003531
  REMARK    GeneRIF: Tff3 Deficiency Differentially Affects the Morphology of
            Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse
            Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 458)
  AUTHORS   Kolobaric,N., Mihalj,M., Kozina,N., Matic,A., Mihaljevic,Z.,
            Jukic,I. and Drenjancevic,I.
  TITLE     Tff3-/- Knock-Out Mice with Altered Lipid Metabolism Exhibit a
            Lower Level of Inflammation following the Dietary Intake of Sodium
            Chloride for One Week
  JOURNAL   Int J Mol Sci 24 (8), 7315 (2023)
   PUBMED   37108475
  REMARK    GeneRIF: Tff3[-/-] Knock-Out Mice with Altered Lipid Metabolism
            Exhibit a Lower Level of Inflammation following the Dietary Intake
            of Sodium Chloride for One Week.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 458)
  AUTHORS   Mashimo,H., Wu,D.C., Podolsky,D.K. and Fishman,M.C.
  TITLE     Impaired defense of intestinal mucosa in mice lacking intestinal
            trefoil factor
  JOURNAL   Science 274 (5285), 262-265 (1996)
   PUBMED   8824194
REFERENCE   7  (bases 1 to 458)
  AUTHORS   Lefebvre,O., Chenard,M.P., Masson,R., Linares,J., Dierich,A.,
            LeMeur,M., Wendling,C., Tomasetto,C., Chambon,P. and Rio,M.C.
  TITLE     Gastric mucosa abnormalities and tumorigenesis in mice lacking the
            pS2 trefoil protein
  JOURNAL   Science 274 (5285), 259-262 (1996)
   PUBMED   8824193
REFERENCE   8  (bases 1 to 458)
  AUTHORS   Chinery,R., Poulsom,R. and Cox,H.M.
  TITLE     The gene encoding mouse intestinal trefoil factor: structural
            organization, partial sequence analysis and mapping to murine
            chromosome 17q
  JOURNAL   Gene 171 (2), 249-253 (1996)
   PUBMED   8666281
REFERENCE   9  (bases 1 to 458)
  AUTHORS   Tomita,M., Itoh,H., Ishikawa,N., Higa,A., Ide,H., Murakumo,Y.,
            Maruyama,H., Koga,Y. and Nawa,Y.
  TITLE     Molecular cloning of mouse intestinal trefoil factor and its
            expression during goblet cell changes
  JOURNAL   Biochem J 311 (Pt 1) (Pt 1), 293-297 (1995)
   PUBMED   7575467
REFERENCE   10 (bases 1 to 458)
  AUTHORS   Mashimo,H., Podolsky,D.K. and Fishman,M.C.
  TITLE     Structure and expression of murine intestinal trefoil factor: high
            evolutionary conservation and postnatal expression
  JOURNAL   Biochem Biophys Res Commun 210 (1), 31-37 (1995)
   PUBMED   7741746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D38410.1 and AC167247.2.
            
            On Apr 18, 2009 this sequence version replaced NM_011575.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI894059.1, AA239053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               D38410.1           1-339
            340-458             AC167247.2         89570-89688
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..458
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /note="trefoil factor 3, intestinal"
                     /db_xref="GeneID:21786"
                     /db_xref="MGI:MGI:104638"
     exon            1..120
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..281
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /note="intestinal trefoil factor"
                     /codon_start=1
                     /product="trefoil factor 3 precursor"
                     /protein_id="NP_035705.1"
                     /db_xref="CCDS:CCDS37544.1"
                     /db_xref="GeneID:21786"
                     /db_xref="MGI:MGI:104638"
                     /translation="METRALWLMLLVVLVAGSSGIAADYVGLSPSQCMVPANVRVDCG
                     YPSVTSEQCNNRGCCFDSSIPNVPWCFKPLQETECTF"
     exon            121..267
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /inference="alignment:Splign:2.1.0"
     exon            268..458
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      408..413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /note="hexamer: AATAAA"
     polyA_site      452
                     /gene="Tff3"
                     /gene_synonym="ITF; mITF"
                     /note="major polyA site"
ORIGIN      
        1 atcctgtgca gtggtcctga agcttgcctg ctgccatgga gaccagagcc ctctggctaa
       61 tgctgttggt ggtcctggtt gctgggtcct ctgggatagc tgcagattac gttggcctgt
      121 ctccaagcca atgtatggtg ccggcaaatg tcagagtgga ctgtggctac ccctctgtca
      181 catcggagca gtgtaacaac cgtggctgct gctttgactc cagtatccca aatgtgccct
      241 ggtgcttcaa acctctgcag gagacagaat gcacattttg aagctgtcca ggctccagga
      301 agggagctct gcaccctgga ctcctgctgc tgatggtggc caagggtagc aagcatcccc
      361 gatctgctcc ctgctgcagg ccaataaagg agccaggagt cctgaagaat aaagacctca
      421 cagccaacac aaggctgatc tgattgctga gacctcta
//
