LOCUS       NM_009363                571 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus trefoil factor 2 (spasmolytic protein 1) (Tff2), mRNA.
ACCESSION   NM_009363
VERSION     NM_009363.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 571)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
  REMARK    GeneRIF: Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar
            Cells Is Required for the Development of Islets and for beta-Cell
            Function During Aging.
REFERENCE   2  (bases 1 to 571)
  AUTHORS   Znalesniak,E.B., Laskou,A., Salm,F., Haupenthal,K., Harder,S.,
            Schluter,H. and Hoffmann,W.
  TITLE     The Forms of the Lectin Tff2 Differ in the Murine Stomach and
            Pancreas: Indications for Different Molecular Functions
  JOURNAL   Int J Mol Sci 24 (8), 7059 (2023)
   PUBMED   37108221
  REMARK    GeneRIF: The Forms of the Lectin Tff2 Differ in the Murine Stomach
            and Pancreas: Indications for Different Molecular Functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 571)
  AUTHORS   Hasebe,K., Yamaguchi,J., Kokuryo,T., Yokoyama,Y., Ochiai,Y.,
            Nagino,M. and Ebata,T.
  TITLE     Trefoil factor family 2 inhibits cholangiocarcinogenesis by
            regulating the PTEN pathway in mice
  JOURNAL   Carcinogenesis 42 (12), 1496-1505 (2021)
   PUBMED   34644378
  REMARK    GeneRIF: Trefoil factor family 2 inhibits cholangiocarcinogenesis
            by regulating the PTEN pathway in mice.
REFERENCE   4  (bases 1 to 571)
  AUTHORS   Zhang,B., Lapenta,K., Wang,Q., Nam,J.H., Chung,D., Robert,M.E.,
            Nathanson,M.H. and Yang,X.
  TITLE     Trefoil factor 2 secreted from damaged hepatocytes activates
            hepatic stellate cells to induce fibrogenesis
  JOURNAL   J Biol Chem 297 (1), 100887 (2021)
   PUBMED   34146542
  REMARK    GeneRIF: Trefoil factor 2 secreted from damaged hepatocytes
            activates hepatic stellate cells to induce fibrogenesis.
REFERENCE   5  (bases 1 to 571)
  AUTHORS   Sayols,S., Klassek,J., Werner,C., Mockel,S., Ritz,S.,
            Mendez-Lago,M. and Soshnikova,N.
  TITLE     Signalling codes for the maintenance and lineage commitment of
            embryonic gastric epithelial progenitors
  JOURNAL   Development 147 (18) (2020)
   PUBMED   32878924
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 571)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   7  (bases 1 to 571)
  AUTHORS   Ribieras,S., Lefebvre,O., Tomasetto,C. and Rio,M.C.
  TITLE     Mouse Trefoil factor genes: genomic organization, sequences and
            methylation analyses
  JOURNAL   Gene 266 (1-2), 67-75 (2001)
   PUBMED   11290420
REFERENCE   8  (bases 1 to 571)
  AUTHORS   Tomasetto,C., Masson,R., Linares,J.L., Wendling,C., Lefebvre,O.,
            Chenard,M.P. and Rio,M.C.
  TITLE     pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of
            mucins
  JOURNAL   Gastroenterology 118 (1), 70-80 (2000)
   PUBMED   10611155
REFERENCE   9  (bases 1 to 571)
  AUTHORS   Otto,W.R. and Patel,K.
  TITLE     Trefoil factor family (TFF)-domain peptides in the mouse: embryonic
            gastrointestinal expression and wounding response
  JOURNAL   Anat Embryol (Berl) 199 (6), 499-508 (1999)
   PUBMED   10350130
REFERENCE   10 (bases 1 to 571)
  AUTHORS   Tomasetto,C., Rio,M.C., Gautier,C., Wolf,C., Hareuveni,M.,
            Chambon,P. and Lathe,R.
  TITLE     hSP, the domain-duplicated homolog of pS2 protein, is co-expressed
            with pS2 in stomach but not in breast carcinoma
  JOURNAL   EMBO J 9 (2), 407-414 (1990)
   PUBMED   2303034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003093.1.
            
            On Apr 6, 2007 this sequence version replaced NM_009363.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003093.1, CJ043175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AK003093.1         2-572
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..571
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /note="trefoil factor 2 (spasmolytic protein 1)"
                     /db_xref="GeneID:21785"
                     /db_xref="MGI:MGI:1306805"
     exon            1..113
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..424
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /note="spasmolytic polypeptide"
                     /codon_start=1
                     /product="trefoil factor 2 precursor"
                     /protein_id="NP_033389.2"
                     /db_xref="CCDS:CCDS37545.1"
                     /db_xref="GeneID:21785"
                     /db_xref="MGI:MGI:1306805"
                     /translation="MRPRGAPLLAVVLVLGLHALVEGEKPSPCRCSRLTPHNRKNCGF
                     PGITSEQCFDLGCCFDSSVAGVPWCFHPLPNQESEQCVMEVSARKNCGYPGISPEDCA
                     SRNCCFSNLIFEVPWCFFPQSVEDCHY"
     exon            114..263
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            264..410
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            411..571
                     /gene="Tff2"
                     /gene_synonym="mSP; SP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctgcagg ctgcccaggt ccagtggagc agacatgcga cctcgaggtg cccccctgct
       61 ggcagtggtc ctggttttgg gactgcatgc tctggtagag ggcgagaaac cttccccctg
      121 tcggtgctcc aggctgacac cccacaacag aaagaactgt ggcttcccgg gcatcaccag
      181 tgagcagtgc tttgatcttg gatgctgctt tgactctagc gtcgctgggg tcccttggtg
      241 tttccaccca cttccaaacc aagaatcgga gcagtgtgtc atggaagtgt cagctcgcaa
      301 gaattgtggg tacccgggca tcagtcccga ggactgtgcc agtcgaaact gctgcttttc
      361 caacctgatc tttgaagtgc cctggtgttt cttcccacag tctgtggaag attgtcacta
      421 ctgagagttg ctactgccga gccacccgtt ccctgggagc tgcaagccag aagaaagttt
      481 caaccagact tcatcaatct ctggggtttc taaaaccatc ttgaccctta gcagtggcta
      541 gacacagcat tttccaagta aagaaaagtt g
//
