LOCUS       NM_009362                478 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus trefoil factor 1 (Tff1), mRNA.
ACCESSION   NM_009362
VERSION     NM_009362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 478)
  AUTHORS   Ortiz,J.A., Ghazalli,N., Lopez,K., Rawson,J., McCown,E.M., Oh,E.,
            Irimia,J.M., Jou,K., Mares,J., Chen,M.H., Wu,X., Zook,H.N.,
            Quijano,J.C., Erdem,N., Lizarraga,A., Kandeel,F., Fueger,P.T.,
            Thurmond,D.C. and Ku,H.T.
  TITLE     Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is
            Required for the Development of Islets and for beta-Cell Function
            During Aging
  JOURNAL   Diabetes 73 (9), 1447-1461 (2024)
   PUBMED   38905124
REFERENCE   2  (bases 1 to 478)
  AUTHORS   Jinno,T., Yamaguchi,J., Ogura,A., Kokuryo,T., Yokoyama,Y.,
            Sunagawa,M., Baba,T., Murata,Y. and Ebata,T.
  TITLE     Loss of Trefoil Factor 1 Accelerates the Immune Response to
            Colorectal Cancer
  JOURNAL   Anticancer Res 44 (9), 3757-3769 (2024)
   PUBMED   39197918
  REMARK    GeneRIF: Loss of Trefoil Factor 1 Accelerates the Immune Response
            to Colorectal Cancer.
REFERENCE   3  (bases 1 to 478)
  AUTHORS   Yamaguchi,J., Kokuryo,T., Yokoyama,Y., Oishi,S., Sunagawa,M.,
            Mizuno,T., Onoe,S., Watanabe,N., Ogura,A. and Ebata,T.
  TITLE     Trefoil factor 1 suppresses stemness and enhances chemosensitivity
            of pancreatic cancer
  JOURNAL   Cancer Med 13 (11), e7395 (2024)
   PUBMED   38872370
REFERENCE   4  (bases 1 to 478)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 478)
  AUTHORS   Salm,F., Znalesniak,E.B., Laskou,A., Harder,S., Schluter,H. and
            Hoffmann,W.
  TITLE     Expression Profiling along the Murine Intestine: Different Mucosal
            Protection Systems and Alterations in Tff1-Deficient Animals
  JOURNAL   Int J Mol Sci 24 (16), 12684 (2023)
   PUBMED   37628863
  REMARK    GeneRIF: Expression Profiling along the Murine Intestine: Different
            Mucosal Protection Systems and Alterations in Tff1-Deficient
            Animals.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 478)
  AUTHORS   Tomasetto,C., Masson,R., Linares,J.L., Wendling,C., Lefebvre,O.,
            Chenard,M.P. and Rio,M.C.
  TITLE     pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of
            mucins
  JOURNAL   Gastroenterology 118 (1), 70-80 (2000)
   PUBMED   10611155
REFERENCE   7  (bases 1 to 478)
  AUTHORS   Otto,W.R. and Patel,K.
  TITLE     Trefoil factor family (TFF)-domain peptides in the mouse: embryonic
            gastrointestinal expression and wounding response
  JOURNAL   Anat Embryol (Berl) 199 (6), 499-508 (1999)
   PUBMED   10350130
REFERENCE   8  (bases 1 to 478)
  AUTHORS   Cardiff,R.D. and Wellings,S.R.
  TITLE     The comparative pathology of human and mouse mammary glands
  JOURNAL   J Mammary Gland Biol Neoplasia 4 (1), 105-122 (1999)
   PUBMED   10219910
  REMARK    Review article
REFERENCE   9  (bases 1 to 478)
  AUTHORS   Lefebvre,O., Chenard,M.P., Masson,R., Linares,J., Dierich,A.,
            LeMeur,M., Wendling,C., Tomasetto,C., Chambon,P. and Rio,M.C.
  TITLE     Gastric mucosa abnormalities and tumorigenesis in mice lacking the
            pS2 trefoil protein
  JOURNAL   Science 274 (5285), 259-262 (1996)
   PUBMED   8824193
REFERENCE   10 (bases 1 to 478)
  AUTHORS   Lefebvre,O., Wolf,C., Kedinger,M., Chenard,M.P., Tomasetto,C.,
            Chambon,P. and Rio,M.C.
  TITLE     The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit
            distinct patterns of expression
  JOURNAL   J Cell Biol 122 (1), 191-198 (1993)
   PUBMED   8314841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131896.1.
            
            On Aug 1, 2007 this sequence version replaced NM_009362.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131896.1, AK160174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               AK131896.1         2-479
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.8 cM"
     gene            1..478
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /note="trefoil factor 1"
                     /db_xref="GeneID:21784"
                     /db_xref="MGI:MGI:88135"
     exon            1..127
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..297
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /note="protein pS2"
                     /codon_start=1
                     /product="trefoil factor 1 precursor"
                     /protein_id="NP_033388.1"
                     /db_xref="CCDS:CCDS37546.1"
                     /db_xref="GeneID:21784"
                     /db_xref="MGI:MGI:88135"
                     /translation="MEHKVICVLAVVLMLAFGSLAQAQAQAQAQEETCIMAPRERINC
                     GFPGVTAQQCTERGCCFDDSVRGFPWCFHPMAIENTQEEECPF"
     exon            128..280
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..478
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      460..465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /note="putative"
     polyA_site      478
                     /gene="Tff1"
                     /gene_synonym="Bcei; PS2"
                     /note="putative"
ORIGIN      
        1 atccatcact cgtggtcttc ccgtgaagct gccatggagc acaaggtgat ctgtgtcctc
       61 gctgtggtcc tcatgctggc cttcggcagc cttgcccagg cccaggccca ggcccaggcc
      121 caggaagaaa catgtatcat ggccccccgg gagaggataa attgtggctt ccccggtgtc
      181 accgcccagc agtgcacgga gagaggttgc tgttttgatg acagtgtccg gggattcccg
      241 tggtgcttcc accccatggc catcgagaac actcaagaag aagaatgtcc cttctaaggt
      301 ccatcctgag agaactggct acatcaagac ttggcaccct ccacctgggc actggagcca
      361 cctggcccac ctgctacata cacacctatt ctgtggctgg atctggctgg tgacacagtt
      421 caacccctca gacttttagt cctcgaattc ggcctgagaa ttaaaagaga tgaatgtt
//
