LOCUS       NM_031198               1779 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transcription factor EC (Tfec), mRNA.
ACCESSION   NM_031198
VERSION     NM_031198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1779)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1779)
  AUTHORS   Wang,Y., Zhu,J., Zhang,L., Zhang,Z., He,L., Mou,Y., Deng,Y.,
            Cao,Y., Yang,P., Su,Y., Zhao,J., Zhang,S., Yu,Q., Hu,J., Chen,Z.,
            Ning,Q., Xiang,X., Xu,Y., Wang,C.Y. and Xiong,W.
  TITLE     Role of C/EBP homologous protein and endoplasmic reticulum stress
            in asthma exacerbation by regulating the IL-4/signal transducer and
            activator of transcription 6/transcription factor EC/IL-4 receptor
            alpha positive feedback loop in M2 macrophages
  JOURNAL   J Allergy Clin Immunol 140 (6), 1550-1561 (2017)
   PUBMED   28238747
  REMARK    GeneRIF: Tfec transcribes IL-4 receptor alpha expression to promote
            M2 programming in macrophages
            Erratum:[J Allergy Clin Immunol. 2022 Aug;150(2):491. doi:
            10.1016/j.jaci.2022.05.013.. PMID: 35934683]
REFERENCE   3  (bases 1 to 1779)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1779)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1779)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1779)
  AUTHORS   Rowan,S., Chen,C.M., Young,T.L., Fisher,D.E. and Cepko,C.L.
  TITLE     Transdifferentiation of the retina into pigmented cells in ocular
            retardation mice defines a new function of the homeodomain gene
            Chx10
  JOURNAL   Development 131 (20), 5139-5152 (2004)
   PUBMED   15459106
REFERENCE   7  (bases 1 to 1779)
  AUTHORS   Steingrimsson,E., Tessarollo,L., Pathak,B., Hou,L., Arnheiter,H.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip
            transcription factors, have important but functionally redundant
            roles in osteoclast development
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4477-4482 (2002)
   PUBMED   11930005
REFERENCE   8  (bases 1 to 1779)
  AUTHORS   Rehli,M., Den Elzen,N., Cassady,A.I., Ostrowski,M.C. and Hume,D.A.
  TITLE     Cloning and characterization of the murine genes for bHLH-ZIP
            transcription factors TFEC and TFEB reveal a common gene
            organization for all MiT subfamily members
  JOURNAL   Genomics 56 (1), 111-120 (1999)
   PUBMED   10036191
REFERENCE   9  (bases 1 to 1779)
  AUTHORS   Rehli,M., Lichanska,A., Cassady,A.I., Ostrowski,M.C. and Hume,D.A.
  TITLE     TFEC is a macrophage-restricted member of the microphthalmia-TFE
            subfamily of basic helix-loop-helix leucine zipper transcription
            factors
  JOURNAL   J Immunol 162 (3), 1559-1565 (1999)
   PUBMED   9973413
REFERENCE   10 (bases 1 to 1779)
  AUTHORS   Zhao,G.Q., Zhao,Q., Zhou,X., Mattei,M.G. and de Crombrugghe,B.
  TITLE     TFEC, a basic helix-loop-helix protein, forms heterodimers with
            TFE3 and inhibits TFE3-dependent transcription activation
  JOURNAL   Mol Cell Biol 13 (8), 4505-4512 (1993)
   PUBMED   8336698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102663.6 and AK137141.1.
            
            On Oct 29, 2009 this sequence version replaced NM_031198.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137141.1, AF077742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC102663.6         207627-207662       c
            37-1779             AK137141.1         2-1744
FEATURES             Location/Qualifiers
     source          1..1779
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 7.61 cM"
     gene            1..1779
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /note="transcription factor EC"
                     /db_xref="GeneID:21426"
                     /db_xref="MGI:MGI:1333760"
     exon            1..181
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     exon            182..433
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1207
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /note="TFE-C; mTFEC"
                     /codon_start=1
                     /product="transcription factor EC"
                     /protein_id="NP_112475.1"
                     /db_xref="CCDS:CCDS19920.1"
                     /db_xref="GeneID:21426"
                     /db_xref="MGI:MGI:1333760"
                     /translation="MTFDCRVCDQTLKRAQPPAASCMPLAEHEPMSPDSDAGCAGNPF
                     TNLLALGKKDGAEKWHLSGSILDVYSDEQGISSANAGLTDAPCPSILPMRKEIAETDG
                     RALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVDYI
                     KWLQKEQQRARELEHRQKKLEHANRQLRLRIQELEIQARAHGLPILASLGTADVGTHI
                     TKQQTHPERNLGGCCLQLTPTQGTSPEFYEQAVAFSDPLSHFTDLSFSAALKEEQRLD
                     GMLLSDTICPFGTDPLLSAISPAVSKASSRSSLSSEDGDEL"
     exon            434..548
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     exon            549..605
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     exon            606..681
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     exon            682..829
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1779
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="Tfec"
                     /gene_synonym="bHLHe34; Tcfec"
                     /note="major polyA site"
ORIGIN      
        1 gaaatgccct aatgggtgac ttctcttttc tccttcctca actaagcgga ttccaagctg
       61 ttcaaaccat ttattcttct tgagcagacc cttgactttt gtgcttaggt tatgagacga
      121 ggggctgtaa tttggagctg tttgtagccg cgatgacaca cctagaatcc aatcagtgct
      181 ggtccaggca cacgtagaaa cctctacgaa gcctcagcta cagaaggctc aaacacaaca
      241 agtaactcct ttcatgacct ttgactgtcg ggtatgcgac cagactctca agagagcgca
      301 gcctccagca gccagctgca tgcctctggc agagcatgaa cccatgagcc cagacagtga
      361 tgctggctgt gcaggaaacc cattcacaaa tctgctggct cttgggaaaa aagatggtgc
      421 tgagaaatgg catttatctg ggagtatttt ggatgtgtac agtgatgagc agggcatttc
      481 ttcagctaat gctggtctca cggatgctcc ttgtccaagt attctaccca tgagaaagga
      541 aattgcagaa actgatggta gagctttggc aaaggagaga cagaaaaagg acaaccacaa
      601 cctcattgaa agaagaagaa ggtataatat taattaccga atcaaggagc ttggcactct
      661 tattccaaag tctaatgatc ctgatatgcg ctggaacaaa gggaccattc taaaggcatc
      721 agtggactac atcaagtggc tacaaaaaga acaacagaga gcccgggagt tagaacacag
      781 acagaagaaa ttagaacatg ctaaccgtca gcttaggctc cggattcagg aactagaaat
      841 acaagcacgt gctcatggtc taccaatcct ggcttcactc ggcacagctg atgttggtac
      901 ccacatcacc aagcagcaga cccatcctga gaggaactta ggaggctgtt gcttacaact
      961 gactccaact caggggacaa gcccggagtt ctatgagcaa gctgtggctt tctctgatcc
     1021 attgtctcac ttcacagatt tatcctttag tgccgctttg aaagaggaac aaagattgga
     1081 tggcatgcta ctaagtgata caatatgccc ctttgggacg gacccactac tctctgccat
     1141 ttcccctgca gtttccaaag ctagcagccg aagcagcctt agctcagagg atggtgatga
     1201 gttgtaagcc gcaaacaggc tcaagacatc aaccaggaag caactctctg ctggtgctac
     1261 tcaattgtga tctgcctttc ataccttgct ttcacttaac tctctgaaag gaattatatt
     1321 ggccgagggg gaggggtggc gtgtgtttag aagtgctgga agaattcatg ggaagaagaa
     1381 acatgatgtg aaagaatcat tgaagatcac agttgtctac cgagttcaga tttccttaca
     1441 tttatttttt tttctggaaa atggtccagc ttgataacgg ctctagtgtt gatactttca
     1501 gagcagtgac atgctaggat attgctggag ctaaggtcct tcaaaagact gcaacatccc
     1561 actcccctct cactcacgtc caaatcctgt gttactttct acaacatcat tttctaaaga
     1621 ttcacgacta acaaatttgg tgataatttc ttttcctttg tcgggtggac atactatgta
     1681 tggttgaatc cttgtcgggg gaaaaaaaaa gtataaattt tttttcattt aaacttgaaa
     1741 ctaagtctga aataaacatg atttttttca aaatagagc
//
