LOCUS       NM_011549               2298 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus transcription factor EB (Tfeb), transcript variant 1,
            mRNA.
ACCESSION   NM_011549
VERSION     NM_011549.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Cai,H., Ma,G., Zhang,Z., Liu,G., Lu,R., Liu,Y., Wang,J., Wang,S.,
            Sun,S., E,M., Li,Z., Fang,S. and Yu,B.
  TITLE     A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167238 (2024)
   PUBMED   38759815
  REMARK    GeneRIF: A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation.
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Mao,Y., Jin,Z., Yang,J., Xu,D., Zhao,L., Kiram,A., Yin,Y., Zhou,D.,
            Sun,Z., Xiao,L., Zhou,Z., Yang,L., Fu,T., Xu,Z., Jia,Y., Chen,X.,
            Niu,F.N., Li,X., Zhu,Z. and Gan,Z.
  TITLE     Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse
  JOURNAL   Sci Transl Med 16 (750), eadk9811 (2024)
   PUBMED   38838134
  REMARK    GeneRIF: Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse.
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 2298)
  AUTHORS   Xiang,J., Liu,B., Li,Y., Ren,Y., Li,Y., Zhou,M., Yu,J., Luo,Z.,
            Liu,E., Fu,Z. and Ding,F.
  TITLE     TFEB regulates dendritic cell antigen presentation to modulate
            immune balance in asthma
  JOURNAL   Respir Res 25 (1), 182 (2024)
   PUBMED   38664707
  REMARK    GeneRIF: TFEB regulates dendritic cell antigen presentation to
            modulate immune balance in asthma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2298)
  AUTHORS   Ren,X., Wang,J., Wei,H., Li,X., Tian,Y., Wang,Z., Yin,Y., Guo,Z.,
            Qin,Z., Wu,M. and Zeng,X.
  TITLE     Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular
            cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C
            expression and interacting with SNAREs
  JOURNAL   Int J Biol Sci 20 (5), 1905-1926 (2024)
   PUBMED   38481802
  REMARK    GeneRIF: Impaired TFEB-mediated autophagy-lysosome fusion promotes
            tubular cell cycle G2/M arrest and renal fibrosis by suppressing
            ATP6V0C expression and interacting with SNAREs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2298)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (bases 1 to 2298)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (bases 1 to 2298)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (bases 1 to 2298)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (bases 1 to 2298)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146016.1, BC064789.1 and AC113536.10.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_011549.4.
            
            On Jun 12, 2009 this sequence version replaced NM_011549.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064789.1, AK146016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               AK146016.1         26-795
            771-1948            BC064789.1         771-1948
            1949-1949           AC113536.10        124866-124866       c
            1950-2298           BC064789.1         1950-2298
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..2298
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="transcription factor EB"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
     exon            1..453
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1671
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transcription factor EB isoform a"
                     /protein_id="NP_035679.3"
                     /db_xref="CCDS:CCDS28856.1"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
                     /translation="MAQLAQWSWANPFCPDSVSPCAQWEQPYLCQPVLKDYEDDEYFM
                     GLSPLDYREPEPTAAMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQ
                     LGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGN
                     KFAAHVSPAQGSPKPAPAASPGVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDDV
                     IDNIMRLDSVLGYINPEMQMPNTLPLSSSHLNVYSGDPQVTASMVGVTSSSCPADLTQ
                     KRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGT
                     ILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPS
                     GVNMAELAQQVVKQELPSEDGPGEALMLGPEVPEPEQMPALPPQAPLPSAAQPQSPFH
                     HLDFSHGLSFGGGGDEGPTGYPDTLGTEHGSPFPNLSKKDLDLMLLDDSLLPLASDPL
                     FSTMSPEASKASSRRSSFSMEEGDVL"
     exon            454..708
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            709..789
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            790..910
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            911..967
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1043
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1191
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..2273
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2254..2259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="hexamer: AGTAAA"
     polyA_site      2273
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="major polyA site"
ORIGIN      
        1 gtggactcct gcagtcactg aaggacagtg ttcacctctg gtctagaact cagggaactt
       61 gggttcatgg ctcagctcgc tcagtggtct tgggcaaatc ccttctgccc ggactcagtt
      121 tctccttgtg cacaatggga gcaaccatac ttatgccagc ctgtgcttaa agactacgaa
      181 gatgatgaat acttcatggg cctgtctccc ctcgactaca gggagcccga accaacagct
      241 gccatggcgt cacgcatcgg gctgcgcatg cagctcatgc gggagcaggc ccagcaggag
      301 gagcagcgag agcgcatgca gcagcaggct gtcatgcatt atatgcaaca gcagcagcag
      361 cagcagcagc agctgggtgg gccccccacc ccagccatca acacccctgt ccacttccag
      421 tcgcccccgc ctgtgcccgg ggaggtgctg aaggtgcagt cctacctgga gaaccccacc
      481 tcctaccacc tgcaacagtc ccagcatcag aaggttcggg agtatctgtc tgagacctat
      541 gggaacaagt ttgctgccca cgtgagccca gcccaaggtt ccccgaagcc tgccccagca
      601 gcatccccag gggtgcgggc tggacacgta ctgtccacct cggccggcaa cagtgctccc
      661 aacagtccca tggccatgct acatatcagc tccaaccccg agaaagagtt tgatgatgtc
      721 attgacaaca ttatgcgcct ggacagcgtg ctgggctaca tcaaccctga gatgcagatg
      781 cctaacacgc tgcccctgtc tagcagccac ctgaacgtgt acagcggtga cccccaggtc
      841 acagcctcca tggtgggtgt caccagcagc tcctgccctg ccgacctgac tcagaagcga
      901 gagctaacag atgctgagag cagagccctg gccaaggagc ggcagaagaa agacaatcac
      961 aacctaattg agagaagacg caggttcaac atcaatgacc ggatcaagga gctgggaatg
     1021 ctgatcccca aggccaacga cctggacgtg cgctggaaca aaggcaccat cctcaaggcc
     1081 tctgtggatt acatccggag gatgcagaag gacctgcaga agtcccggga gctggagaac
     1141 cactcccggc gcctggagat gactaacaag cagctctggc tccgcatcca ggagctggag
     1201 atgcaggcac gcgtgcacgg cctccccacc acctcgccgt cgggtgtgaa tatggccgag
     1261 ctggcccagc aggtggtgaa gcaagagttg cccagtgagg atggcccagg ggaggcgctg
     1321 atgctggggc ctgaggtccc tgagcctgag caaatgccgg ctcttcctcc ccaggctccg
     1381 ctgccctcgg ccgcccagcc acagtctccg ttccatcacc tggacttcag ccatggcctg
     1441 agctttgggg gtgggggcga cgaggggccc acaggttacc ccgataccct ggggacagag
     1501 cacggctccc cattccccaa cctgtccaag aaggatctgg acttaatgct cctagatgac
     1561 tccctgctcc ccctggcctc tgaccccctc ttttctacca tgtctcctga ggcctccaag
     1621 gccagcagcc gccggagcag cttcagcatg gaggagggtg atgttctgtg acgctggctg
     1681 cccctgtgcc aaggagcagg ggatgcctgg aggctgggag gaccgagcag agccctccca
     1741 tccttcaggc tgcacttggt gtgaagtagc cgcctaccct gcctctctcc ttccccttgg
     1801 ctgctacccc caccctgttt ggacttagtg cctgcctggc agctgatggg gctggaggag
     1861 ccctccccct cggcttcggg ccccctcctc tggcggcagt actatgacta tgatggggaa
     1921 gaacaggggt gaggcagaag agaaataaga agaaatcctg ctaggggagc ccctctcctg
     1981 agcctgggct ctcctgtgga ggacattttg gagaaggagg tacaagtacc tctgaggcag
     2041 cagctggtct gggggtgccc gggcctgcct tcctgggact agatggcacc cagcctgtcg
     2101 ccctcagcct gaactccccc acaagtgggg catccacccc catttggtgc taacagctct
     2161 cccctggtgg tatgagggtg gggtggccag aagaggagtc tgggttcagg gtggcgagca
     2221 cccccacccc cagacctccc actttgtgcc tttagtaaac actgtgcttt gtaaaaaaaa
     2281 aaaaaaaaaa aaaaaaaa
//
