LOCUS       NM_001161722            2357 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus transcription factor EB (Tfeb), transcript variant 2,
            mRNA.
ACCESSION   NM_001161722
VERSION     NM_001161722.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Cai,H., Ma,G., Zhang,Z., Liu,G., Lu,R., Liu,Y., Wang,J., Wang,S.,
            Sun,S., E,M., Li,Z., Fang,S. and Yu,B.
  TITLE     A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167238 (2024)
   PUBMED   38759815
  REMARK    GeneRIF: A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation.
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Mao,Y., Jin,Z., Yang,J., Xu,D., Zhao,L., Kiram,A., Yin,Y., Zhou,D.,
            Sun,Z., Xiao,L., Zhou,Z., Yang,L., Fu,T., Xu,Z., Jia,Y., Chen,X.,
            Niu,F.N., Li,X., Zhu,Z. and Gan,Z.
  TITLE     Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse
  JOURNAL   Sci Transl Med 16 (750), eadk9811 (2024)
   PUBMED   38838134
  REMARK    GeneRIF: Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse.
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Xiang,J., Liu,B., Li,Y., Ren,Y., Li,Y., Zhou,M., Yu,J., Luo,Z.,
            Liu,E., Fu,Z. and Ding,F.
  TITLE     TFEB regulates dendritic cell antigen presentation to modulate
            immune balance in asthma
  JOURNAL   Respir Res 25 (1), 182 (2024)
   PUBMED   38664707
  REMARK    GeneRIF: TFEB regulates dendritic cell antigen presentation to
            modulate immune balance in asthma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Ren,X., Wang,J., Wei,H., Li,X., Tian,Y., Wang,Z., Yin,Y., Guo,Z.,
            Qin,Z., Wu,M. and Zeng,X.
  TITLE     Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular
            cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C
            expression and interacting with SNAREs
  JOURNAL   Int J Biol Sci 20 (5), 1905-1926 (2024)
   PUBMED   38481802
  REMARK    GeneRIF: Impaired TFEB-mediated autophagy-lysosome fusion promotes
            tubular cell cycle G2/M arrest and renal fibrosis by suppressing
            ATP6V0C expression and interacting with SNAREs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Forrester,L.M., Nagy,A., Sam,M., Watt,A., Stevenson,L.,
            Bernstein,A., Joyner,A.L. and Wurst,W.
  TITLE     An induction gene trap screen in embryonic stem cells:
            Identification of genes that respond to retinoic acid in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1677-1682 (1996)
   PUBMED   8643689
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Fisher,D.E., Carr,C.S., Parent,L.A. and Sharp,P.A.
  TITLE     TFEB has DNA-binding and oligomerization properties of a unique
            helix-loop-helix/leucine-zipper family
  JOURNAL   Genes Dev 5 (12A), 2342-2352 (1991)
   PUBMED   1748288
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Carr,C.S. and Sharp,P.A.
  TITLE     A helix-loop-helix protein related to the immunoglobulin E
            box-binding proteins
  JOURNAL   Mol Cell Biol 10 (8), 4384-4388 (1990)
   PUBMED   2115126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124830.8, AK078755.1, BC064789.1 and AC113536.10.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001161722.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078755.1, SRR5286961.25575.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC124830.8         47017-47086         c
            71-1090             AK078755.1         3-1022
            1091-2007           BC064789.1         1032-1948
            2008-2008           AC113536.10        124866-124866       c
            2009-2357           BC064789.1         1950-2298
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..2357
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="transcription factor EB"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
     exon            1..280
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            281..512
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1730
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transcription factor EB isoform b"
                     /protein_id="NP_001155194.1"
                     /db_xref="CCDS:CCDS50133.1"
                     /db_xref="GeneID:21425"
                     /db_xref="MGI:MGI:103270"
                     /translation="MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQL
                     GGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNK
                     FAAHVSPAQGSPKPAPAASPGVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDDVI
                     DNIMRLDSVLGYINPEMQMPNTLPLSSSHLNVYSGDPQVTASMVGVTSSSCPADLTQK
                     RELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTI
                     LKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSG
                     VNMAELAQQVVKQELPSEDGPGEALMLGPEVPEPEQMPALPPQAPLPSAAQPQSPFHH
                     LDFSHGLSFGGGGDEGPTGYPDTLGTEHGSPFPNLSKKDLDLMLLDDSLLPLASDPLF
                     STMSPEASKASSRRSSFSMEEGDVL"
     exon            513..767
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            768..848
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            849..969
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1026
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1102
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1250
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..2332
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="hexamer: AGTAAA"
     polyA_site      2332
                     /gene="Tfeb"
                     /gene_synonym="bHLHe35; Tcfeb"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcagcg ggaagtgggc gcggagtgac agccggagcc caagcgccgg gcgcggggct
       61 aggtgacagc ggaggcggca gctgcgggcg ggacgcagag aacggagacg gcgccgacag
      121 cggcgggaag ggcggacggg gcgggtctgg ctggtggcgc gtagcccgag gagcccgaca
      181 gcgggcggcg ggcgaagctc gggggctggg cacccgaact tgggacaagt tgccggaacc
      241 tcagggcgcc ggcggcggac agattgacct tcagagcgag ggagcccgaa ccaacagctg
      301 ccatggcgtc acgcatcggg ctgcgcatgc agctcatgcg ggagcaggcc cagcaggagg
      361 agcagcgaga gcgcatgcag cagcaggctg tcatgcatta tatgcaacag cagcagcagc
      421 agcagcagca gctgggtggg ccccccaccc cagccatcaa cacccctgtc cacttccagt
      481 cgcccccgcc tgtgcccggg gaggtgctga aggtgcagtc ctacctggag aaccccacct
      541 cctaccacct gcaacagtcc cagcatcaga aggttcggga gtatctgtct gagacctatg
      601 ggaacaagtt tgctgcccac gtgagcccag cccaaggttc cccgaagcct gccccagcag
      661 catccccagg ggtgcgggct ggacacgtac tgtccacctc ggccggcaac agtgctccca
      721 acagtcccat ggccatgcta catatcagct ccaaccccga gaaagagttt gatgatgtca
      781 ttgacaacat tatgcgcctg gacagcgtgc tgggctacat caaccctgag atgcagatgc
      841 ctaacacgct gcccctgtct agcagccacc tgaacgtgta cagcggtgac ccccaggtca
      901 cagcctccat ggtgggtgtc accagcagct cctgccctgc cgacctgact cagaagcgag
      961 agctaacaga tgctgagagc agagccctgg ccaaggagcg gcagaagaaa gacaatcaca
     1021 acctaattga gagaagacgc aggttcaaca tcaatgaccg gatcaaggag ctgggaatgc
     1081 tgatccccaa ggccaacgac ctggacgtgc gctggaacaa aggcaccatc ctcaaggcct
     1141 ctgtggatta catccggagg atgcagaagg acctgcagaa gtcccgggag ctggagaacc
     1201 actcccggcg cctggagatg actaacaagc agctctggct ccgcatccag gagctggaga
     1261 tgcaggcacg cgtgcacggc ctccccacca cctcgccgtc gggtgtgaat atggccgagc
     1321 tggcccagca ggtggtgaag caagagttgc ccagtgagga tggcccaggg gaggcgctga
     1381 tgctggggcc tgaggtccct gagcctgagc aaatgccggc tcttcctccc caggctccgc
     1441 tgccctcggc cgcccagcca cagtctccgt tccatcacct ggacttcagc catggcctga
     1501 gctttggggg tgggggcgac gaggggccca caggttaccc cgataccctg gggacagagc
     1561 acggctcccc attccccaac ctgtccaaga aggatctgga cttaatgctc ctagatgact
     1621 ccctgctccc cctggcctct gaccccctct tttctaccat gtctcctgag gcctccaagg
     1681 ccagcagccg ccggagcagc ttcagcatgg aggagggtga tgttctgtga cgctggctgc
     1741 ccctgtgcca aggagcaggg gatgcctgga ggctgggagg accgagcaga gccctcccat
     1801 ccttcaggct gcacttggtg tgaagtagcc gcctaccctg cctctctcct tccccttggc
     1861 tgctaccccc accctgtttg gacttagtgc ctgcctggca gctgatgggg ctggaggagc
     1921 cctccccctc ggcttcgggc cccctcctct ggcggcagta ctatgactat gatggggaag
     1981 aacaggggtg aggcagaaga gaaataagaa gaaatcctgc taggggagcc cctctcctga
     2041 gcctgggctc tcctgtggag gacattttgg agaaggaggt acaagtacct ctgaggcagc
     2101 agctggtctg ggggtgcccg ggcctgcctt cctgggacta gatggcaccc agcctgtcgc
     2161 cctcagcctg aactccccca caagtggggc atccaccccc atttggtgct aacagctctc
     2221 ccctggtggt atgagggtgg ggtggccaga agaggagtct gggttcaggg tggcgagcac
     2281 ccccaccccc agacctccca ctttgtgcct ttagtaaaca ctgtgctttg taaaaaaaaa
     2341 aaaaaaaaaa aaaaaaa
//
