LOCUS       NM_172472               3293 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus transcription factor E3 (Tfe3), transcript variant 1,
            mRNA.
ACCESSION   NM_172472
VERSION     NM_172472.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3293)
  AUTHORS   Zhu,X., Wu,Y., Li,Y., Zhou,X., Watzlawik,J.O., Chen,Y.M.,
            Raybuck,A.L., Billadeau,D.D., Shapiro,V.S., Springer,W., Sun,J.,
            Boothby,M.R. and Zeng,H.
  TITLE     The nutrient-sensing Rag-GTPase complex in B cells controls humoral
            immunity via TFEB/TFE3-dependent mitochondrial fitness
  JOURNAL   Nat Commun 15 (1), 10163 (2024)
   PUBMED   39580479
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3293)
  AUTHORS   Raynor,J.L., Collins,N., Shi,H., Guy,C., Saravia,J., Ah Lim,S.,
            Chapman,N.M., Zhou,P., Wang,Y., Sun,Y., Risch,I., Hu,H., Kc,A.,
            Sun,R., Shrestha,S., Huang,H., Connelly,J.P., Pruett-Miller,S.M.,
            Reina-Campos,M., Goldrath,A.W., Belkaid,Y. and Chi,H.
  TITLE     CRISPR screens unveil nutrient-dependent lysosomal and
            mitochondrial nodes impacting intestinal tissue-resident memory
            CD8+ T cell formation
  JOURNAL   Immunity 57 (11), 2597-2614 (2024)
   PUBMED   39406246
REFERENCE   3  (bases 1 to 3293)
  AUTHORS   Patel,A.A., Kim,H., Ramesh,R., Marquez,A., Faraj,M.M.,
            Antikainen,H., Lee,A.S., Torres,A., Khawaja,I.M., Heffernan,C.,
            Bonder,E.M., Maurel,P., Svaren,J., Son,Y.J., Dobrowolski,R. and
            Kim,H.A.
  TITLE     TFEB/3 Govern Repair Schwann Cell Generation and Function Following
            Peripheral Nerve Injury
  JOURNAL   J Neurosci 44 (35), e0198242024 (2024)
   PUBMED   39054068
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3293)
  AUTHORS   Oliveira,A.N., Memme,J.M., Wong,J. and Hood,D.A.
  TITLE     Dimorphic effect of TFE3 in determining mitochondrial and lysosomal
            content in muscle following denervation
  JOURNAL   Skelet Muscle 14 (1), 7 (2024)
   PUBMED   38643162
  REMARK    GeneRIF: Dimorphic effect of TFE3 in determining mitochondrial and
            lysosomal content in muscle following denervation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3293)
  AUTHORS   Amarnani,A., Lopez-Ocasio,M., Dilshat,R., Anumukonda,K., Davila,J.,
            Malakhov,N., Huan,C., Magnusdottir,E., Steingrimsson,E. and
            Roman,C.A.
  TITLE     Mitf regulates gene expression networks implicated in B cell
            homeostasis, germinal center responses, and tolerance
  JOURNAL   Front Immunol 15, 1339325 (2024)
   PUBMED   38444862
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3293)
  AUTHORS   Artandi,S.E., Merrell,K., Avitahl,N., Wong,K.K. and Calame,K.
  TITLE     TFE3 contains two activation domains, one acidic and the other
            proline-rich, that synergistically activate transcription
  JOURNAL   Nucleic Acids Res 23 (19), 3865-3871 (1995)
   PUBMED   7479029
REFERENCE   7  (bases 1 to 3293)
  AUTHORS   Macchi,P., Notarangelo,L., Giliani,S., Strina,D., Repetto,M.,
            Sacco,M.G., Vezzoni,P. and Villa,A.
  TITLE     The genomic organization of the human transcription factor 3 (TFE3)
            gene
  JOURNAL   Genomics 28 (3), 491-494 (1995)
   PUBMED   7490085
REFERENCE   8  (bases 1 to 3293)
  AUTHORS   Blair,P.J., Carpenter,D.A., Godfrey,V.L., Russell,L.B.,
            Wilkinson,J.E. and Rinchik,E.M.
  TITLE     The mouse scurfy (sf) mutation is tightly linked to Gata1 and Tfe3
            on the proximal X chromosome
  JOURNAL   Mamm Genome 5 (10), 652-654 (1994)
   PUBMED   7849405
REFERENCE   9  (bases 1 to 3293)
  AUTHORS   Roman,C., Matera,A.G., Cooper,C., Artandi,S., Blain,S., Ward,D.C.
            and Calame,K.
  TITLE     mTFE3, an X-linked transcriptional activator containing basic
            helix-loop-helix and zipper domains, utilizes the zipper to
            stabilize both DNA binding and multimerization
  JOURNAL   Mol Cell Biol 12 (2), 817-827 (1992)
   PUBMED   1732746
REFERENCE   10 (bases 1 to 3293)
  AUTHORS   Roman,C., Cohn,L. and Calame,K.
  TITLE     A dominant negative form of transcription activator mTFE3 created
            by differential splicing
  JOURNAL   Science 254 (5028), 94-97 (1991)
   PUBMED   1840705
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671995.4, AF510653.1 and BC056358.1.
            
            On Sep 20, 2007 this sequence version replaced NM_172472.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063047.1, AK144657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AL671995.4         72307-72464
            159-502             AF510653.1         1-344
            503-3293            BC056358.1         491-3281
FEATURES             Location/Qualifiers
     source          1..3293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.5 cM"
     gene            1..3293
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /note="transcription factor E3"
                     /db_xref="GeneID:209446"
                     /db_xref="MGI:MGI:98511"
     exon            1..400
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..2003
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transcription factor E3 isoform a"
                     /protein_id="NP_766060.2"
                     /db_xref="CCDS:CCDS52984.1"
                     /db_xref="GeneID:209446"
                     /db_xref="MGI:MGI:98511"
                     /translation="MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLL
                     PESGIVADIELENILDPDSFYELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSR
                     TPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGG
                     HTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPP
                     PGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYND
                     EMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISE
                     TEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASV
                     DYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLT
                     TSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHL
                     GDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSF
                     SMEEES"
     exon            401..514
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..815
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1061
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1166
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1284
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1341
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1417
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1565
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..3274
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /note="hexamer: AATAAA"
     polyA_site      3274
                     /gene="Tfe3"
                     /gene_synonym="bHLHe33; F830016E06Rik; mTFE3; Tcfe3;
                     Tfe-3"
                     /note="major polyA site"
ORIGIN      
        1 gtggtcactt cctgtggagt ttccccagcc caaggaggag ggggaagagg acgagaggga
       61 ggcgagcggt cgttcggggt taggttgggg ggtgtcggtc cgttcagggc gggtgatgac
      121 tcacggccca tcccatcttc ccgacgccgc ccgcccacgc agtgctagct ccatggctta
      181 acggaggagg cagcggcaaa cagggggagg gggactctta ttttgttagg gggaccgggc
      241 caaggcccga ccggcctggc agggctcgcc cggagccggg cgtcatgtct catgcagccg
      301 agccagctcg ggacgccgta gaggccagcg cggagggccc tcgagccgtg ttcctgctat
      361 tggaagagcg caggccagct gagtcggccc agctgctcag cctgaattct ttgcttccgg
      421 aatccgggat tgttgctgat atcgagttag aaaacatcct cgatcctgac agcttctacg
      481 agctcaaaag ccaaccccta tccctccgct ccagcctccc aatatcactg caggccacac
      541 cgaccacccc agctacactc tctgcgtcgt cttctgcagg gggctcccgg acccctgcca
      601 tgtcatcttc ttcatcacgg gtcttgctgc gtcagcagct tatgagggcc caggctcagg
      661 aacaggagag gcgtgagcgg cgggaacagg cagcggccgc tcccttcccc agccctgcgc
      721 ccgcctcacc agccatctct gtgattggcg tgtctgctgg tggccacaca ctgagtcgtc
      781 cacctcctgc tcaggtgccc agggaggtac tcaaggttca gacccacctc gagaacccta
      841 cacgctacca cctgcagcaa gctcgccggc agcaggtcaa acagtacttg tctaccacac
      901 ttgggcccaa gctggcttcc caggctctca ccccaccacc agggccttcc agtgcccagc
      961 cacttcctgc ccctgaaact gctcatgcca ccggtcctac aggcagtgct cctaacagcc
     1021 ccatggcgct gctcaccatt gggtccagct cagaaaagga gattgatgat gtcattgatg
     1081 agatcatcag cctggagtcc agttacaacg atgagatgct cagctatctt ccaggaggca
     1141 ctgcagggct gcagctcccc agcacgctgc cggtgtctgg aaatctactt gatgtgtaca
     1201 gcagtcaggg agtggctacc ccagctatca ccgtcagcaa ttcctgtcca gctgagctgc
     1261 ctaacatcaa acgcgagatc tccgaaaccg aggcaaaggc ccttttgaag gagcgacaga
     1321 agaaagacaa tcacaaccta attgaacgac gcaggcgatt caacattaac gataggatca
     1381 aagagctggg caccctcatc cccaagtcca atgatccgga gatgcgctgg aacaagggca
     1441 ccatcctgaa ggcatctgtg gattacatcc gcaaattaca gaaggaacag caacgctcca
     1501 aagacctgga gagccggcag cggtccctgg aacaagccaa ccgaagcctg cagctccgga
     1561 ttcaggagct agaactgcag gcccagatcc atggtctgcc agtccctccc aacccaggac
     1621 tgctctccct aaccacgagt tcggtctctg acagcctcaa gccagaacag ctggacattg
     1681 aggaggaggg caggcctagc acaacgttcc atgtatcggg aggacctgcc cagaacgctc
     1741 ctccacaaca gcctccagca ccaccttcgg atgcccttct ggacctacac tttcccagcg
     1801 accacttggg agacctgggg gaccccttcc acctagggct agaggacatt ctgatggagg
     1861 aggaggggat ggtgggagga ctgtcagggg gtgccctgtc cccactgcgg gctgcttctg
     1921 accccctgct ttcttcagta tccccggctg tttccaaggc cagcagccgc cgtagcagct
     1981 tcagcatgga agaggagtcc tgatcaggcc tcactcctcc ccctggatga gaccctgcct
     2041 tttttcccta ccctcctgtg agactgtcct gtccaggaaa tctgggggaa gaggagttgc
     2101 aatcaggccc caaccctgta ataggcaagg aggaggaatc aggtgaggcc ctgccccctt
     2161 tccattcgtg gggaagaagg caggagagag ctgggaaatc acagttcatc acttgagcat
     2221 catagcctta cccctcgccc ctggtcctac tcctgcctcg gtgatagaag gaggcagggt
     2281 aagggtatgc ccctggccac tagagatcct tagaaacagg tctctgaagg aaaggagatg
     2341 ccaggatgct actccattcc ttctctggga attgccagtc caacttttcc tggcactgga
     2401 agaaaaaaaa taagtgtccc acccctggag ggttaatccc tatctcttcc ttttgacccc
     2461 tgacttgttc tggcaaggaa cagaagtaag ggtgtgatcc agcccgtccc cctgggaccc
     2521 atcccttctc tataggaaaa gctcagcgca ggtattacag gtatggagga attactaggc
     2581 tctgatctcc catgtagagg ccccagtcct aaccctgacc cttagcagga caccgtgcaa
     2641 gcattccatt cggcagggag gatcagttcc ttagctccct gccttaacct aggaccaacc
     2701 tgggacctga cctgtgagga ctctgtgctg accttattct tggggaaggg aacagatttt
     2761 gacctagatc aagtgtaact taggtcctca cccttgggac gaccttgcct tttctgcctt
     2821 gaggggcagt tttgggagat gaaagggatt agtgtggacc cagtctaggc accccagtac
     2881 ttcccttcac cttgtagaaa atggtaatga aagggcatgc ccaggctctt tagcagccca
     2941 gggaaacaga gaagtctccc ttaaaggcag ggcctgggag gaatggtggc aaaggtataa
     3001 tgtatccgtg ttttgtttgt gaatttttta ttgaacccac ccactcagat gctaagtcaa
     3061 ccctgacctc tgccccatcc acaccattct ccattcgaga gactacccct gtttcagagc
     3121 cagtccccac ctagtcccgt ccctgccacc tacacccaag gtcttcagct ttaagttgct
     3181 ggggccaggc cccgaggagg gtttactgag gggtctgtag gtttgactaa aataataaat
     3241 gctaggcgtg tttgatgcgc ttttaacttt ggcaaaaaaa aaaaaaaaaa aaa
//
