LOCUS       NM_033476               3301 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus transcription factor CP2 (Tfcp2), transcript variant
            1, mRNA.
ACCESSION   NM_033476
VERSION     NM_033476.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Luo,X., Ge,J., Liu,J., Liu,Z., Bi,C. and Lan,S.
  TITLE     TFCP2, a binding protein of ATF3, promotes the progression of
            glioma by activating the synthesis of serine
  JOURNAL   Exp Cell Res 416 (1), 113136 (2022)
   PUBMED   35421367
  REMARK    GeneRIF: TFCP2, a binding protein of ATF3, promotes the progression
            of glioma by activating the synthesis of serine.
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Kim,M.Y., Kim,J.S., Son,S.H., Lim,C.S., Eum,H.Y., Ha,D.H.,
            Park,M.A., Baek,E.J., Ryu,B.Y., Kang,H.C., Uversky,V.N. and
            Kim,C.G.
  TITLE     Mbd2-CP2c loop drives adult-type globin gene expression and
            definitive erythropoiesis
  JOURNAL   Nucleic Acids Res 46 (10), 4933-4949 (2018)
   PUBMED   29547954
  REMARK    GeneRIF: Mbd2-CP2c functional loop drives adult-type globin gene
            expression and erythroid differentiation of erythroid cells.
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Zhou,J., Lei,B., Li,H., Zhu,L., Wang,L., Tao,H., Mei,S. and Li,F.
  TITLE     MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and
            PGE2 production in mouse ovarian granulosa cells
  JOURNAL   Cell Death Dis 8 (2), e2597 (2017)
   PUBMED   28182010
  REMARK    GeneRIF: The transcription factor CP2 upregulated miR-144
            expression, which partially contributed to the suppression of COX-2
            in mGCs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Kim,J.S., Chae,J.H., Cheon,Y.P. and Kim,C.G.
  TITLE     Reciprocal localization of transcription factors YY1 and CP2c in
            spermatogonial stem cells and their putative roles during
            spermatogenesis
  JOURNAL   Acta Histochem 118 (7), 685-692 (2016)
   PUBMED   27612612
  REMARK    GeneRIF: that yin yang 1 strongly localizes in the spermatogonial
            stem cells and co-localizes heterogeneously with CP2c to permit
            spermatogenesis
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Rajasekaran,D., Siddiq,A., Willoughby,J.L., Biagi,J.M.,
            Christadore,L.M., Yunes,S.A., Gredler,R., Jariwala,N.,
            Robertson,C.L., Akiel,M.A., Shen,X.N., Subler,M.A., Windle,J.J.,
            Schaus,S.E., Fisher,P.B., Hansen,U. and Sarkar,D.
  TITLE     Small molecule inhibitors of Late SV40 Factor (LSF) abrogate
            hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC
            model
  JOURNAL   Oncotarget 6 (28), 26266-26277 (2015)
   PUBMED   26313006
  REMARK    GeneRIF: Small molecule inhibitors of Late SV40 Factor abrogate
            hepatocellular carcinoma by inducing mitotic arrest and apoptosis.
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Ramamurthy,L., Barbour,V., Tuckfield,A., Clouston,D.R., Topham,D.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Targeted disruption of the CP2 gene, a member of the NTF family of
            transcription factors
  JOURNAL   J Biol Chem 276 (11), 7836-7842 (2001)
   PUBMED   10995745
REFERENCE   7  (bases 1 to 3301)
  AUTHORS   Cunningham,J.M., Vanin,E.F., Tran,N., Valentine,M. and Jane,S.M.
  TITLE     The human transcription factor CP2 (TFCP2), a component of the
            human gamma-globin stage selector protein, maps to chromosome
            region 12q13 and is within 250 kb of the NF-E2 gene
  JOURNAL   Genomics 30 (2), 398-399 (1995)
   PUBMED   8586452
REFERENCE   8  (bases 1 to 3301)
  AUTHORS   Swendeman,S.L., Spielholz,C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Sheffery,M.
  TITLE     Characterization of the genomic structure, chromosomal location,
            promoter, and development expression of the alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 269 (15), 11663-11671 (1994)
   PUBMED   8157699
REFERENCE   9  (bases 1 to 3301)
  AUTHORS   Lim,L.C., Fang,L., Swendeman,S.L. and Sheffery,M.
  TITLE     Characterization of the molecularly cloned murine alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 268 (24), 18008-18017 (1993)
   PUBMED   8349681
REFERENCE   10 (bases 1 to 3301)
  AUTHORS   Lim,L.C., Swendeman,S.L. and Sheffery,M.
  TITLE     Molecular cloning of the alpha-globin transcription factor CP2
  JOURNAL   Mol Cell Biol 12 (2), 828-835 (1992)
   PUBMED   1732747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146503.1 and AC139571.2.
            
            On Jan 24, 2014 this sequence version replaced NM_033476.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146503.1, AK158682.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2001              AK146503.1         2-2002
            2002-3301           AC139571.2         41788-43087
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.33 cM"
     gene            1..3301
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /note="transcription factor CP2"
                     /db_xref="GeneID:21422"
                     /db_xref="MGI:MGI:98509"
     exon            1..99
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..256
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1643
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-globin transcription factor CP2"
                     /codon_start=1
                     /product="alpha-globin transcription factor CP2 isoform 1"
                     /protein_id="NP_258437.1"
                     /db_xref="CCDS:CCDS27840.1"
                     /db_xref="GeneID:21422"
                     /db_xref="MGI:MGI:98509"
                     /translation="MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVL
                     ALPIFKQEESSLPPDNENEILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDN
                     RKLGELPELNGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGV
                     IDPRANPTQLNTVEFLWDPSKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKE
                     NGNGEYTEHLHSASCQIKVFKPKGADRKQKIDREKMEKRTPHEKEKYQPSYETTILTE
                     CSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQ
                     QWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTI
                     YVCQESLQLREQQPQPQPQPQKQEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSI
                     SPHQISQIYKQGPTGIHVVISDEMVQNFQEEACFILDTMEAETSDSYHVILK"
     exon            257..408
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..485
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..591
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..698
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..851
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..962
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1051
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1100
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1194
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1285
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1410
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1553
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1605
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..3301
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3253
                     /gene="Tfcp2"
                     /gene_synonym="CP-2; CP2; D230015P20Rik; LBP-1c; LBP-1d;
                     LBP1; LSF; Tcfcp2; UBP-1"
                     /note="major polyA site"
ORIGIN      
        1 gggtttgcgc ttcgagtctg cgccgaactt tcgctgtcca cgcttccagg cggtcgtggt
       61 ggctaaggag ggtgtgggga cggctcggag gaaccctggg agccggcgcc tgttggggca
      121 aggaaggagc cgggatggcc tgggctctga agctgccgct agccgacgaa gtgatcgagt
      181 cggggcttgt gcaggacttt gatgctagcc tgtccggcat tggccaggaa ctgggtgctg
      241 gtgcttatag tatgagtgat gtcctcgcat tgcccatttt taagcaagaa gagtcaagtt
      301 tgcctcccga taatgagaac gagattctgc cttttcagta tgtgctctgt gctgccacgt
      361 ctccagcggt gaagctccac gacgagaccc tgacgtacct caatcaagga cagtcttatg
      421 aaatccgaat gctagacaat agaaaactgg gagagcttcc agaactcaac ggcaagctgg
      481 tgaagagcat attccgcgta gtgttccacg acaggcgact gcagtacact gagcaccagc
      541 agctggaggg ctggaggtgg aaccgaccgg gagacaggat tctcgacata gatatcccaa
      601 tgtctgtggg tgtaattgat cccagggcca atcctaccca gctaaacaca gtggagttcc
      661 tgtgggaccc ttcaaagagg acatctgtgt ttattcaggt gcactgcatc agcactgagt
      721 tcaccatgag gaagcatggc ggggagaagg gggtgccgtt ccgagtgcag atcgatacct
      781 tcaaggagaa cgggaacgga gagtacacag agcacttgca ctcggccagc tgccagatca
      841 aagtcttcaa gcctaagggt gcagacagaa aacaaaaaat agatagagag aaaatggaga
      901 aacggacgcc ccatgaaaaa gagaaatatc aaccttctta tgagacaacc atactcaccg
      961 agtgttctcc gtggcctgag atcacctacg tcaacaattc cccatcccct ggcttcaaca
     1021 gctcccatag cagtttctct cttggggaag gaaacggctc gcccaaccac cagccagaac
     1081 caccccctcc agtcacggat aacctcttgc cgacaaccac gcctcaggaa gcccagcaat
     1141 ggctgcatcg aaaccggttc tccacattca cgaggctttt caccaacttc tcaggggcag
     1201 atttactgaa actaactaga gacgacgtga tccaaatctg cggccctgca gatggaatca
     1261 gactctttaa tgcattaaaa ggccggatgg tgcggccaag gctaaccatt tatgtctgcc
     1321 aggagtcgtt gcagttgagg gagcagcagc cgcagccgca gccgcagccg cagaagcagg
     1381 aggatgggga ttcaaacggt actttcttcg tgtaccatgc tatctatctc gaggagctga
     1441 cagctgtcga actcacagaa aaaattgctc agcttttcag catttctcct caccagatca
     1501 gccagattta caagcaaggg ccgacaggga tccatgtggt catcagcgat gagatggtac
     1561 agaacttcca ggaagaagcc tgctttattc tggacacgat ggaagcagaa accagtgaca
     1621 gctatcatgt cattctcaag tagggtgagg ccccgacctt cgacggctgc tgctgccttc
     1681 ccctcttcac cttctgaagg ggacatgact ggagattaaa gggcttcagg aacctggcac
     1741 atctgaatgt tggggggagg ggggaggcgt gtccagtgca gggcgagcag gtcccaagga
     1801 ggaatcccag agtcctgtat tggctcctct gatcactggc tatacatgga gccagcagtt
     1861 tccttacttt ctggcccctg ttgataccag taagaagccc cgtcattagg gtttgtagag
     1921 ggcagagtgg taatgggagt catgtgatgt tttctaggaa gatgtttagt tttgtgatat
     1981 agagctctga cattttactg atataaaagt gaacatctgt cttcataaaa ccaagctctc
     2041 tctcttgcct caagcctgtt ggcagctctg ctctgctctg ttcacaactg tgaggaggag
     2101 aaacagaatc tctccttccc ttttttgaga cagggtttca tgttcttgcc tctacctccc
     2161 aagagctggg atcacaagct tttgccacct ggtctgtttc tgtctgcagt gctgggcttg
     2221 aactcggagc ctcacgtgct aggcaggcac tttctccagc tgagctccag caggccttcc
     2281 ctttagtgct aagacaggct ccagatttct aatttggttc acctgcaata ccacagctga
     2341 gtgtgatttt ggctaatgtg tattggggta gaccgaatga taaatcccac ggacggataa
     2401 tcttctttta tccccttaat aaacccaaaa catctgggga cacagtgact tgagggtgag
     2461 gagacgcaga tgaagtggag gggcttctga caacaccaga tgccaccctt tgctgccagt
     2521 gctcaccact gggtctttct ggggctctgc tggaaactga cggacttccc actgaaggag
     2581 gcaaccatac cttaccactg tagcgataat gaagccccag acagacagac acccaatgtc
     2641 acactaacct cagcccagag ctagaggtga gagagacaag cgtgtctgac cccaggcttc
     2701 gttgttcgtg aatgatattc tcaaaactgt ttaagtaaat gagctattcc gccctgctct
     2761 cccctcccct gtcttgtttt ggcatagtgt ggtgtttttt tttttttttt tgttcttttt
     2821 ttaaaatgta agctttatta aaaaaagaaa aatacattct tttcctattc aaactcacac
     2881 tgtgtttatg ttctgccttt caaatggctg tgtgtctgtg tgcatgtaca gaattgtaaa
     2941 gcacttaggc cctccttttt cacatgaagt ttgttttagc ttggttttcc aagaaaacgt
     3001 ttctctgtgg agccccggct gtcctggaac tcactctgta gaccaggctg gcctcaaact
     3061 cagaaatcca ccttccaagt gctgggaata taggtgtgtg ccactagctt agtcaggcca
     3121 catgtaaagt tttaccagaa attcccttaa attttgttga gatgaacaaa gataatgtta
     3181 aagattctgt attaaatttg aatttatgtg tgtttttgaa gtatttaata aagcttagat
     3241 ttttttatag agagtttttg gttcttgttg ctgttgtcca ttaaaaccaa cctgtaatgt
     3301 g
//
