LOCUS       NM_146074               1382 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus transcription factor B1, mitochondrial (Tfb1m), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_146074
VERSION     NM_146074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1382)
  AUTHORS   Son,J.S., Chae,S.A., Zhao,L., Wang,H., de Avila,J.M., Zhu,M.J.,
            Jiang,Z. and Du,M.
  TITLE     Maternal exercise intergenerationally drives muscle-based
            thermogenesis via activation of apelin-AMPK signaling
  JOURNAL   EBioMedicine 76, 103842 (2022)
   PUBMED   35081489
REFERENCE   2  (bases 1 to 1382)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1382)
  AUTHORS   Gomez-Del Arco,P., Perdiguero,E., Yunes-Leites,P.S., Acin-Perez,R.,
            Zeini,M., Garcia-Gomez,A., Sreenivasan,K., Jimenez-Alcazar,M.,
            Segales,J., Lopez-Maderuelo,D., Ornes,B., Jimenez-Borreguero,L.J.,
            D'Amato,G., Enshell-Seijffers,D., Morgan,B., Georgopoulos,K.,
            Islam,A.B., Braun,T., de la Pompa,J.L., Kim,J., Enriquez,J.A.,
            Ballestar,E., Munoz-Canoves,P. and Redondo,J.M.
  TITLE     The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle
            Identity and Metabolic Homeostasis
  JOURNAL   Cell Metab 23 (5), 881-892 (2016)
   PUBMED   27166947
REFERENCE   4  (bases 1 to 1382)
  AUTHORS   Lee,S., Rose,S., Metodiev,M.D., Becker,L., Vernaleken,A.,
            Klopstock,T., Gailus-Durner,V., Fuchs,H., Hrabe De Angelis,M.,
            Douthwaite,S. and Larsson,N.G.
  TITLE     Overexpression of the mitochondrial methyltransferase TFB1M in the
            mouse does not impact mitoribosomal methylation status or hearing
  JOURNAL   Hum Mol Genet 24 (25), 7286-7294 (2015)
   PUBMED   26464487
REFERENCE   5  (bases 1 to 1382)
  AUTHORS   Sharoyko,V.V., Abels,M., Sun,J., Nicholas,L.M., Mollet,I.G.,
            Stamenkovic,J.A., Gohring,I., Malmgren,S., Storm,P., Fadista,J.,
            Spegel,P., Metodiev,M.D., Larsson,N.G., Eliasson,L., Wierup,N. and
            Mulder,H.
  TITLE     Loss of TFB1M results in mitochondrial dysfunction that leads to
            impaired insulin secretion and diabetes
  JOURNAL   Hum Mol Genet 23 (21), 5733-5749 (2014)
   PUBMED   24916378
  REMARK    GeneRIF: Loss of TFB1M results in mitochondrial dysfunction that
            leads to impaired insulin secretion and diabetes.
REFERENCE   6  (bases 1 to 1382)
  AUTHORS   Koeck,T., Olsson,A.H., Nitert,M.D., Sharoyko,V.V., Ladenvall,C.,
            Kotova,O., Reiling,E., Ronn,T., Parikh,H., Taneera,J.,
            Eriksson,J.G., Metodiev,M.D., Larsson,N.G., Balhuizen,A.,
            Luthman,H., Stancakova,A., Kuusisto,J., Laakso,M., Poulsen,P.,
            Vaag,A., Groop,L., Lyssenko,V., Mulder,H. and Ling,C.
  TITLE     A common variant in TFB1M is associated with reduced insulin
            secretion and increased future risk of type 2 diabetes
  JOURNAL   Cell Metab 13 (1), 80-91 (2011)
   PUBMED   21195351
REFERENCE   7  (bases 1 to 1382)
  AUTHORS   Metodiev,M.D., Lesko,N., Park,C.B., Camara,Y., Shi,Y., Wibom,R.,
            Hultenby,K., Gustafsson,C.M. and Larsson,N.G.
  TITLE     Methylation of 12S rRNA is necessary for in vivo stability of the
            small subunit of the mammalian mitochondrial ribosome
  JOURNAL   Cell Metab 9 (4), 386-397 (2009)
   PUBMED   19356719
REFERENCE   8  (bases 1 to 1382)
  AUTHORS   Thundathil,J., Filion,F. and Smith,L.C.
  TITLE     Molecular control of mitochondrial function in preimplantation
            mouse embryos
  JOURNAL   Mol Reprod Dev 71 (4), 405-413 (2005)
   PUBMED   15895466
REFERENCE   9  (bases 1 to 1382)
  AUTHORS   Rantanen,A., Gaspari,M., Falkenberg,M., Gustafsson,C.M. and
            Larsson,N.G.
  TITLE     Characterization of the mouse genes for mitochondrial transcription
            factors B1 and B2
  JOURNAL   Mamm Genome 14 (1), 1-6 (2003)
   PUBMED   12532263
  REMARK    GeneRIF: Metazoans have two TFBM genes, suggesting that a
            duplication of the gene has permitted a more flexible regulation of
            mtDNA.
REFERENCE   10 (bases 1 to 1382)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098838.3 and AC122350.4.
            
            On Jun 24, 2019 this sequence version replaced NM_146074.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032930.1, AF508971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC098838.3         54110-54284         c
            176-327             AC098838.3         51461-51612         c
            328-436             AC122350.4         192120-192228       c
            437-588             AC122350.4         189634-189785       c
            589-708             AC122350.4         182615-182734       c
            709-836             AC122350.4         168182-168309       c
            837-1382            AC122350.4         165787-166332       c
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 2.01 cM"
     gene            1..1382
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /note="transcription factor B1, mitochondrial"
                     /db_xref="GeneID:224481"
                     /db_xref="MGI:MGI:2146851"
     exon            1..175
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1080
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /EC_number="2.1.1.-"
                     /note="mitochondrial 12S rRNA dimethylase 1;
                     S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
                     dimethyltransferase 1"
                     /codon_start=1
                     /product="dimethyladenosine transferase 1, mitochondrial"
                     /protein_id="NP_666186.1"
                     /db_xref="CCDS:CCDS28363.1"
                     /db_xref="GeneID:224481"
                     /db_xref="MGI:MGI:2146851"
                     /translation="MAASGKLGTFRLPPLPTIREIIKLFGLRAVKQLSQNFLLDLRLT
                     DKIVRKAGSLADVYVYEVGPGPGGITRSILNANVAELLVVEKDTRFIPGLQMLSDAAP
                     GKLRIVHGDVLTYKIEKAFPGNIRRQWEDDPPNVHIIGNLPFSVSTPLIIKWLENISL
                     KDGPFVYGRTKMTLTFQKEVAERLVATTGSKQHSRLSIMAQYLCNVEHLFTIPGKAFV
                     PKPKVDVGVVHLTPLIEPKIKQPFKLVEKVVQNAFQFRRKYCHRGLGMLFPEAQRLES
                     TGRLLQLADIDPTLRPTHLSLMHFKSLCDVYRKMCDEDPQLFTYNFREELKQKKSKGQ
                     EKDGDPESCGF"
     exon            176..327
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..436
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..588
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..708
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..836
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1382
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1356..1361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /note="hexamer: AATAAA"
     polyA_site      1382
                     /gene="Tfb1m"
                     /gene_synonym="mtTFB1"
                     /note="major polyA site"
ORIGIN      
        1 acctttccag ccgctgcgcg tggctgtgta tgtgggtctc tcatggctgc ctcggggaag
       61 ctcggcactt tccgccttcc cccgttgccc accattcggg agatcattaa gttgttcgga
      121 ctgcgagcgg tgaaacagct ttcccagaat ttcctcctgg acttgaggct gacagacaag
      181 attgtaagga aagctggcag tctagcagat gtttatgttt atgaagtggg tcctgggccc
      241 gggggaatca caagatccat cctgaatgcc aacgttgctg agcttctggt ggttgaaaag
      301 gacactcgct ttatcccagg gttacagatg ctctctgatg cagcacctgg aaaactccga
      361 attgttcatg gagatgtgct gacatacaag atagaaaagg cttttccagg caacattaga
      421 agacagtggg aagatgatcc tccaaatgta cacattattg gaaatctacc ttttagtgtt
      481 tcaactccac tgattatcaa gtggcttgaa aatatttctc ttaaagatgg ccctttcgtt
      541 tatggcagaa ctaagatgac gttaacgttt caaaaggaag tggctgagag acttgtagcc
      601 actacaggaa gcaaacagca cagtcgcctt tccattatgg cccagtacct ctgcaatgtt
      661 gaacacctct ttacaatccc aggaaaagct tttgttccca aaccaaaagt tgatgtagga
      721 gtggtgcacc ttacgccctt gatagagccc aagatcaagc agccattcaa gctggtagaa
      781 aaagttgtcc agaatgcgtt tcagtttcga aggaaatatt gccaccgagg gcttggaatg
      841 ttattccctg aagcacaacg cctcgaaagc actggaaggc tgttacagtt ggcagacatt
      901 gatccaactc tccggcccac ccacctctcg ctcatgcatt ttaagagttt gtgtgatgta
      961 tacagaaaaa tgtgtgatga agacccacaa ctctttactt ataacttcag agaggagctc
     1021 aagcaaaaga aaagtaaagg ccaagaaaaa gatggtgacc cagaaagctg cgggttctaa
     1081 ttgctgcctt agggctcccg cctgccagga caccctgtgg acagtgtgca tccccacaga
     1141 tgagtgtgca tctccctacc tctctgtaaa gacagatacc gatgacctcg tgactttact
     1201 atccagcttg gtaagaaaag aaataccaag tagatacagt gcaagctttc ctttaatgta
     1261 tatactgcat aggtacgaca tgtttagtaa aaatagcatt tatgacaacc ttctaaaatg
     1321 aaatatctgt acgttgtgcc tctaaaccat gtaaaaataa aagtgcttta aataaagcaa
     1381 aa
//
