LOCUS       NM_031182               2175 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transcription factor AP4 (Tfap4), transcript variant
            1, mRNA.
ACCESSION   NM_031182 XM_358751
VERSION     NM_031182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2175)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2175)
  AUTHORS   Han,C., Sheng,Y., Wang,J., Zhou,X., Li,W., Guo,L., Yang,Y. and
            Cao,C.
  TITLE     TFAP4 promotes the progression of liver fibrosis through regulating
            double-negative T cell differentiation via OX40
  JOURNAL   Int Immunopharmacol 119, 110164 (2023)
   PUBMED   37060810
  REMARK    GeneRIF: TFAP4 promotes the progression of liver fibrosis through
            regulating double-negative T cell differentiation via OX40.
REFERENCE   3  (bases 1 to 2175)
  AUTHORS   Potts,M.A., Mizutani,S., Garnham,A.L., Li Wai Suen,C.S.N.,
            Kueh,A.J., Tai,L., Pal,M., Strasser,A. and Herold,M.J.
  TITLE     Deletion of the transcriptional regulator TFAP4 accelerates
            c-MYC-driven lymphomagenesis
  JOURNAL   Cell Death Differ 30 (6), 1447-1456 (2023)
   PUBMED   36894688
  REMARK    GeneRIF: Deletion of the transcriptional regulator TFAP4
            accelerates c-MYC-driven lymphomagenesis.
REFERENCE   4  (bases 1 to 2175)
  AUTHORS   Chou,J., Kaller,M., Jaeckel,S., Rokavec,M. and Hermeking,H.
  TITLE     AP4 suppresses DNA damage, chromosomal instability and senescence
            via inducing MDC1/Mediator of DNA damage Checkpoint 1 and
            repressing MIR22HG/miR-22-3p
  JOURNAL   Mol Cancer 21 (1), 120 (2022)
   PUBMED   35624466
  REMARK    GeneRIF: AP4 suppresses DNA damage, chromosomal instability and
            senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1
            and repressing MIR22HG/miR-22-3p.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2175)
  AUTHORS   Tonc,E., Takeuchi,Y., Chou,C., Xia,Y., Holmgren,M., Fujii,C.,
            Raju,S., Chang,G.S., Iwamoto,M. and Egawa,T.
  TITLE     Unexpected suppression of tumorigenesis by c-MYC via
            TFAP4-dependent restriction of stemness in B lymphocytes
  JOURNAL   Blood 138 (24), 2526-2538 (2021)
   PUBMED   34283887
  REMARK    GeneRIF: Unexpected suppression of tumorigenesis by c-MYC via
            TFAP4-dependent restriction of stemness in B lymphocytes.
REFERENCE   6  (bases 1 to 2175)
  AUTHORS   Aranburu,A., Carlsson,R., Persson,C. and Leanderson,T.
  TITLE     Transcription factor AP-4 is a ligand for immunoglobulin-kappa
            promoter E-box elements
  JOURNAL   Biochem J 354 (Pt 2), 431-438 (2001)
   PUBMED   11171123
REFERENCE   7  (bases 1 to 2175)
  AUTHORS   Dear,T.N., Hainzl,T., Follo,M., Nehls,M., Wilmore,H., Matena,K. and
            Boehm,T.
  TITLE     Identification of interaction partners for the
            basic-helix-loop-helix protein E47
  JOURNAL   Oncogene 14 (8), 891-898 (1997)
   PUBMED   9050988
REFERENCE   8  (bases 1 to 2175)
  AUTHORS   Steingrimsson,E., Sawadogo,M., Gilbert,D.J., Zervos,A.S., Brent,R.,
            Blanar,M.A., Fisher,D.E., Copeland,N.G. and Jenkins,N.A.
  TITLE     Murine chromosomal location of five bHLH-Zip transcription factor
            genes
  JOURNAL   Genomics 28 (2), 179-183 (1995)
   PUBMED   8530024
REFERENCE   9  (bases 1 to 2175)
  AUTHORS   Hu,Y.F., Luscher,B., Admon,A., Mermod,N. and Tjian,R.
  TITLE     Transcription factor AP-4 contains multiple dimerization domains
            that regulate dimer specificity
  JOURNAL   Genes Dev 4 (10), 1741-1752 (1990)
   PUBMED   2123466
REFERENCE   10 (bases 1 to 2175)
  AUTHORS   Mermod,N., Williams,T.J. and Tjian,R.
  TITLE     Enhancer binding factors AP-4 and AP-1 act in concert to activate
            SV40 late transcription in vitro
  JOURNAL   Nature 332 (6164), 557-561 (1988)
   PUBMED   2833704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157597.4.
            
            On Mar 31, 2023 this sequence version replaced NM_031182.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047270.1, AF161262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AC157597.4         149761-150117       c
            358-523             AC157597.4         142268-142433       c
            524-622             AC157597.4         142079-142177       c
            623-793             AC157597.4         141563-141733       c
            794-934             AC157597.4         139664-139804       c
            935-1090            AC157597.4         137588-137743       c
            1091-2175           AC157597.4         134996-136080       c
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.45 cM"
     gene            1..2175
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /note="transcription factor AP4"
                     /db_xref="GeneID:83383"
                     /db_xref="MGI:MGI:103239"
     exon            1..357
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1285
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor AP-4 (activating enhancer-binding
                     protein 4)"
                     /codon_start=1
                     /product="transcription factor AP-4 isoform 1"
                     /protein_id="NP_112459.1"
                     /db_xref="CCDS:CCDS27919.1"
                     /db_xref="GeneID:83383"
                     /db_xref="MGI:MGI:103239"
                     /translation="MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQ
                     ERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQE
                     KTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQ
                     QLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQH
                     LRTQLLPPPAPTHHPTVIVPAPAPPSSHHINVVTMGPSSVINSVSTSRQNLDTIVQAI
                     QHIEGTQDKQELEEEQRRAVIVKSVRSCPDAHTSDTASDSEASDSDAMDQSREEPLGD
                     GELP"
     exon            358..523
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     exon            524..622
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     exon            623..793
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..934
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1090
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..2175
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /note="hexamer: AATAAA"
     polyA_site      2175
                     /gene="Tfap4"
                     /gene_synonym="AP-4; bHLHc41; D930048N17Rik; Tcfap4"
                     /note="major polyA site"
ORIGIN      
        1 agacatctga tcagctgcaa acacacacac acacacacac acacacacac acacacatac
       61 acacgcccgg ggaggcaggc tggagagacc tcccgcccgc ccctcccgcc cgcctccctc
      121 ccctcgccgc tgctgctgct gccgccagca tctgggaccg gccgattctg cacctccgtc
      181 cggcgctgcc ctttgattcg gatttccatc ttgcattctc cggctgaccg cgagacctgg
      241 ctcgtgcaca ggaggggggc ctatcgctat ggagtatttc atggtgccca ctcagaaggt
      301 gccctctttg caacatttca ggaaaacaga gaaagaagtg ataggagggc tctgtagcct
      361 agccaacatt ccactgaccc ccgagaccca gagggaccag gaaaggcgga ttcgacgcga
      421 gattgccaac agcaacgagc ggaggcgcat gcagagtatc aacgcgggct tccagtccct
      481 caagaccctc attccccaca cagatggaga gaagctcagc aaggcagcca ttctccagca
      541 gacagcagaa tacatcttct ctcttgaaca ggagaagact agactcctgc agcagaacac
      601 acagctcaag cgctttatcc aggagctgag tggctcatcc ccgaagcggc ggcgggcgga
      661 agacaaggat gagggcattg gctcacccga catctgggag gatgagaagg ctgaggacct
      721 taggagagag atgatcgagc tgcgacaaca gctggacaag gagcgctccg tgcggatgat
      781 gctggaagag caggtgcgct ccctcgaggc ccacatgtac ccggaaaaac tcaaggtgat
      841 tgcccagcag gtgcagctgc agcagcagca ggagcaggtg cggctgctgc accaggagaa
      901 gctagagcgg gaacagcagc acctacggac ccagctcctg cctcctccag cccccaccca
      961 ccaccccaca gtgatcgtgc ctgcaccagc cccgccttcc tcccaccaca tcaatgttgt
     1021 caccatgggt ccctcctcag tcatcaactc tgtctctaca tcccggcaaa atctggacac
     1081 cattgtgcag gccatccagc acattgaggg cacccaggac aaacaggagc tggaagagga
     1141 acagaggcga gcagttatcg tgaagtctgt ccgcagctgc ccagacgccc acacctctga
     1201 taccgcctcg gactccgagg cctcggacag cgacgccatg gaccagagcc gggaggagcc
     1261 tttgggggac ggggagcttc cctgaccacc cccagccctc ctctccctcc tgggggctag
     1321 agggggccgg ggtaacaaca gggagaaaca tgggtgaatg agaaattttt acaaaattat
     1381 gatgtcattt gggtctcttt tatgacctcc ttttcaatac tgtaagtcga cctttgatcg
     1441 aagccaccgg agcccaggtc ccggggttgt ggtggtatat agcacgcgtg ggagcatcgg
     1501 gactccaggg ctggacctcg gccctggggc cagggaagct gacactgagg tgcctagcct
     1561 ctctcgccaa aaagcttttt tatttttgtt ttgtttttgt tttttccttc catttaaacg
     1621 tgtttttaag aacagggaaa atcaaacaaa accccaaggt atttgctccc gccccagagc
     1681 cagcccgagg ctgtcgttcc tcaccccttc cctctgtcgg gttatctttt tctcttttaa
     1741 gcacttacat gggttggggt caggctgggt tggggcgttc tggggacccg ggggatgggg
     1801 gatggggatc ggtgatcgac attgcttctc agttggggtt tgctgctgca gttgtcccct
     1861 ccctctcccc acctcagcac cagaattggc cactctctgc cttcccctcc agggttcctg
     1921 ttattgaccc caaaaatgtc tttgtctctc tttttgtttt gtttgttgtt ggttttattt
     1981 tggttttggt ttctgtattt ttttaatttt aatttttctt ttcttttttt tcttttcttt
     2041 tttacaattt tgaggtcttt gtgtccaagg agaagctatt atattttgtt aagaaaatgg
     2101 gggtagggaa caaaatacca agaggccatt gtgcctttgt aaagaaacaa aataaagttt
     2161 gtacttggtt tttta
//
